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Crytography Bases Solution FOR Distributed Denial of Service Attack in Manet
Darshan Meena,Priya Pathak,Sandeep Gupta 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.6
In mobile ad-hoc network nodes communicate with each other or forward data by making route with the help of other nodes. Infrastructure of the network does not fix topology change due to movability of nodes that’s why attacking condition in this network become high. There are lots of attacks for this network. In this paper we study about denial of service attack and its prevention and detection technique, in our propose work we give a novel solution to detect or prevent denial of service attack we implement our work in NS-2.35. Efficiency of our work we proof with the help of results.
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( Darshan Mehta ),( Jeffrey Mccombs ),( Yuri Sanchez Gonzalez ),( Steven Marx ),( Sammy Saab ),( Yongkyun Won ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The World Health Organization [WHO] has set a goal of having 90% of the world’s population screened for chronic hepatitis C (HCV) infection by 2030. Starting from 2014 in the United States (US) 5 states (NY, CA, CT, MA, CO) implemented new HCV screening policies. This study assesses the effectiveness of these screening laws and projects states’ progress toward the WHO target. Methods: Claims data for 2010-2016 from Optum Clinformatics ® Data Mart, a de-identified claims database from the US were analyzed. HCV screening was identified by paid claims for CPT codes 86803, 86804, or G0742. Logistic regression models of the likelihood of a patient being screened were estimated, controlling for patient demographic and clinical characteristics. Three time periods [2010; 2011-13 and 2014-16] were used to measure the effect on screening of the availability of the newer curative agents. Variables identifying states with screening policies were entered as interaction terms with the post-2014 time period to test if new screening policies enhanced screening rates, independent of the availability effect of the newer agents. Further, the proportion of the population screened in each state was extrapolated to 2050 using each state’s 2014-16 screening rates applied to an assumed baseline diagnosis rate of 50%. Results: Relative to the annual screening rate in 2010, annual screening rates were increased by 19.9% post 2014. In the states that passed screening laws, the annual post 2014 screening rates were increased by an additional 6.4%. Among the states that passed screening laws, MA and CT increased annual screening rates but policies in NY, CA and CO had no significant effect. Other factors that increased the likelihood of a patient being screened were female gender, Medicare enrollment and presence of comorbidities like chronic kidney disease, mixed cryoglobulinemia, fatigue and coinfection with HIV and/ or HBV. Projections of screening rates suggest that NY and 4 other states without screening laws were on track to reach the WHO target by 2030 with 8 additional states attaining WHO target by 2040. 29 states would not attain this target by 2050. Conclusions: The availability of curative therapies has increased the likelihood of screening for HCV. While current efforts to increase annual HCV screening have had positive impact, over 90% of states in the US are still not on track to reach WHO target by 2030.
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IT Model to Calculate Required Equipments for Excavation Work in Construction Projects
Mahajan, Darshan A.,Rajput, Babalu L. Korea Institute of Construction Engineering and Ma 2013 Journal of construction engineering and project ma Vol.3 No.4
Excavation is most commonly used activity in all construction projects. All contracting agencies prefer to use bigger and heavier excavators and dumpers on site to do excavations if quantity of excavation is huge. Estimation of required number of excavators and dumpers for completion of excavation could be rather a tedious process involving repetitive calculation on which professionals spend their valuable time. As the Information Technology is highly involved in construction section there os need to have IT model for estimation of number of excavators and dumpers. The developed model is useful to calculate required equipments within short period of time. The purpose of the developed IT model is to save the time and efforts of the construction professional. The paper discusses about model which can be used on site to estimate numbers of excavators and dumpers required for completion of certain quantity of excavation within the given time. The calculation considers various existing formulas and method to generate the output. This information could certainly be useful in planning equipments on construction project sites. The tool is user friendly where any non IT background person can use it on construction sites.
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Angadi Darshan S.,Macdonald Hamish,Atwal Navraj 대한슬관절학회 2020 대한슬관절학회지 Vol.32 No.-
Background: There is paucity in the current literature regarding clinical outcomes of autologous cell-free serum preparations. The objective of this paper is to collate the clinical evidence and review the results of intraarticular injections of autologous cell-free serum preparations in the management of knee osteoarthritis (OA). Methods: A comprehensive English literature search was undertaken using the healthcare database website (https://hdas.nice.org.uk/). The PubMed, Medline, CINAHL, Embase and the Cochrane library databases were searched to identify all studies of autologous protein solution/autologous conditioned serum (ACS/APS) in the management of knee OA. We evaluated the reported clinical outcomes with respect to pain, function, morbidity, adverse effects and complications. Results: Fifteen relevant articles were identified in the current literature. Outcomes following injection of ACS/APS have been reported in patients with age range (34–87 years) and unilateral or bilateral knee OA. Seven studies reported improvement in visual analog scale (VAS) whereas the Western Ontario and McMaster Universities osteoarthritis instrument (WOMAC) score improved in nine studies. Considerable variation was noted in the injection technique and duration of post-procedure assessment with only one study reporting long-term follow-up beyond 24 months. Joint swelling and injection-site pain were reported to be the most common complications; only one study reported a case of septic arthritis. However, no evidence is available to clearly identify factors that may predict the outcomes following this procedure. Conclusion: Current data from the clinical studies would suggest that the intraarticular administration of autologous cell-free serum preparations, such as ACS/APS, in patients with knee OA may improve pain and function, with limited morbidity. High-quality clinical trials with stratified patient cohorts, longer follow-up duration and robust reporting of outcome measures are essential to improve the understanding of the indications and clinical effectiveness of these novel products.
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Atish Darshan Bajracharya,Suniti Shrestha,Hyung Sun Kim,Ji Hae Nahm,Kwanhoon Park,Joon Seong Park 한국간담췌외과학회 2023 Annals of hepato-biliary-pancreatic surgery Vol.27 No.3
Backgrounds/Aims: This is a retrospective analysis of whether the 8th edition American Joint Committee on Cancer (AJCC) was a significant improvement over the 7th AJCC distal extrahepatic cholangiocarcinoma classification. Methods: In total, 111 patients who underwent curative resection of mid-distal bile duct cancer from 2002 to 2019 were included. Cases were re-classified into 7th and 8th AJCC as well as clinicopathological univariate and multivariate, and Kaplan-Meier survival curve and log rank were calculated using R software. Results: In patient characteristics, pancreaticoduodenectomy/pylorus preserving pancreaticoduodenectomy had better survival than segmental resection. Only lymphovascular invasion was found to be significant (hazard ratio 2.01, p = 0.039) among all clinicopathological variables. The 8th edition AJCC Kaplan Meier survival curve showed an inability to properly segregate stage I and IIA, while there was a large difference in survival probability between IIA and IIB. Conclusions: The 8th distal AJCC classification did resolve the anatomical issue with the T stage, as T1 and T3 showed improvement over the 7th AJCC, and the N stage division of the N1 and N2 category was found to be justified, with poorer survival in N2 than N1. Meanwhile, in TMN staging, the 8th AJCC was able differentiate between early stage (I and IIA) and late stage (IIB and III) to better explain the patient prognosis.
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Patel, Darshan H,Cho, Eun Jin,Kim, Ho Myeong,Choi, In Seong,Bae, Hyeun-Jong Oxford University Press 2012 Protein engineering, design & selection Vol.25 No.7
<P>Mutation in active site would either completely eliminate enzyme activity or may result in an active site with altered substrate-binding properties. The enzyme xylose isomerase (XI) is sterospecific for the α-pyranose and α-fructofuranose anomers and metal ions (M1 and M2) play a pivotal role in the catalytic action of this enzyme. Mutations were created at the M2 site of XI of Thermus thermophilus by replacing D254 and D256 with arginine. Mutants D254R and a double mutant (D254R/D256R) showed complete loss of activity while D256R showed an increase in the specificity on D-lyxose, L-arabinose and D-mannose which are non-preferential substrates for XI. Both wild type (WT) and D256R showed higher activity at pH 7.0 and 85C with an increase in metal requirement. The catalytic efficiency Kcat/Km (S(-1) mM(-1)) of D256R for D-lyxose, L-arabinose and D-mannose were 0.17, 0.09 and 0.15 which are higher than WT XI of T.thermophilus. The altered catalytic activity for D256R could be explained by the possible role of arginine in catalytic reaction or the changes in a substrate orientation site. However, both the theories are only assumptions and have to be addressed with crystal study of D256R.</P>
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Statistical learning and its consolidation in persons with aphasia
Hosaholalu Sarvajna Darshan,Satyapal Puri Goswami 한국언어재활사협회 2021 Clinical Archives of Communication Disorders Vol.6 No.1
Purpose: The present study aimed to investigate statistical learning abilities and its consolidation in Persons with Aphasia (PWA). Methods: Ten PWA following stroke and Ten Neuro-Typical Individuals (NTI) were recruited for the study. Serial Reaction Time Task (SRTT) was used in the study. Sequence and random pattern blocks were used within the paradigm. The task was administered in three sessions, learning session (day 1), second session (24 hours after learning session), and third session (two days after the second session). In the third session, a recall block was introduced. Reaction time served as the outcome measure from the task administered. Results: The results revealed that NTI outpaced the PWA in learning from SRTT. A statistically significant difference was found (p<0.05) for sequence patterns between groups measured across three sessions, but it was not the same for random patterns. Index of sequence learning was derived, and no significant effect (p>0.05) was found on Mixed ANOVA. Consolidation of learning between groups was analyzed using an Independent t-test for the second session and third sessions. It was found a significant difference between groups for the second session but not for the third session. A significant difference (p<0.05) between groups was found for recall scores. Conclusions: According to the study’s results, even though PWA did not perform at the level of NTI in all measures, PWA demonstrated learning, and its memory traces were consolidated. Retention of learning was observed even though it was learned implicitly. PWAs were able to recall the implicitly acquired information explicitly.
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