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( Darae Kim ),( Young Eun Chon ),( Sang Hoon Ahn ),( Hana Park ),( Seung Up Kim ),( Do Young Kim ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Jun Yong Park ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Entecavir (ETV) and adefovir (ADV) combination can be used as a rescue therapy for patients who had failed nucleos(t)ide analogues where tenofovir has not been introduced. We evaluated the efficacy of ETV and ADV combination therapy in patients who had failed to previous nucleos(t)ide analogue (NA). Methods: This study included consecutive 66 compensated chronic hepatitis B (CHB) patients who have failed to previous NAs. All patients received ETV and ADV combination therapy for at least 6 months. While all of the patients had experienced lamivudine (LAM), 48 (72.7%) had experienced ADV and 53 (80.3%) had been treated with ETV. Genetic resistance to LAM, ADV, and ETV at baseline were detected in 65 (98.5%), 12 (18.2%), and 36 (54.5%), respectively. Results: Median HBV DNA level was 5.63 (1.86∼8.23) log IU/mL and fifty nine patients had HBeAg positivity. During a median of 15 (6-38) months of ETV and ADV combination therapy, virological response (VR, < 60 IU/mL by PCR assay) was achieved in 18 of 66 (27.3%) patients. Cumulative VR rates were 21.5%, 28.4%, 36.6% and 36.6% at 6, 12, 24 and 36 months, respectively. When we investigated predictors for VR, baseline ADV resistance along with low baseline ALT level (p=0.027) were significantly associated with decreased VR from multivariate analysis. Conclusions: ETV and ADV combination rescue therapy showed limited efficacy for CHB patients who had failed to previous NAs, however, it can be considered as a rescue therapy in patients who do not have resistance to ADV and high baseline ALT level.
Darae Kim,Minjeong Kim,Jae Berm Park,Juhan Lee,Kyu Ha Huh,Geu-Ru Hong,Jong-Won Ha,Jin-Oh Choi,Chi Young Shim 한국심초음파학회 2023 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.31 No.2
BACKGROUND: We aimed to investigate left ventricular (LV) global longitudinal strain (GLS) in end-stage renal disease patients and its change after kidney transplantation (KT). METHODS: We retrospectively reviewed patients who underwent KT between 2007 and 2018 at two tertiary centers. We analyzed 488 patients (median age, 53 years; 58% male) who had obtained echocardiography both before and within 3 years after KT. Conventional echocardiography and LV GLS assessed by two-dimensional speckle-tracking echocardiography were comprehensively analyzed. Patients were classified into three groups according to the absolute value of pre-KT LV GLS (|LV GLS|). We compared longitudinal changes of cardiac structure and function according to pre-KT |LV GLS|. RESULTS: Correlation between pre-KT LV EF and |LV GLS| were statistically significant, but the constant was not high (r = 0.292, p < 0.001). |LV GLS| was widely distributed at corresponding LV EF, especially when the LV EF was > 50%. Patients with severely impaired pre-KT |LV GLS| had significantly larger LV dimension, LV mass index, left atrial volume index, and E/e’ and lower LV EF, compared to mildly and moderately reduced pre-KT |LV GLS|. After KT, the LV EF, LV mass index, and |LV GLS| were significantly improved in three groups. Patients with severely impaired pre-KT |LV GLS| showed the most prominent improvement of LV EF and |LV GLS| after KT, compared to other groups. CONCLUSIONS: Improvements in LV structure and function after KT were observed in patients throughout the full spectrum of pre-KT |LV GLS|.
Darae Jeong,In-Suk Wee,Junseok Kim 한국산업응용수학회 2011 한국산업응용수학회 학술대회 논문집 Vol.6 No.1
This paper presents an accurate and efficient numerical method for solving the Black-Scholes equation. The method uses an adaptive grid technique which is based on a far-field boundary position of the equation and also the Peclet condition. For a given error tolerance, we determine a priori a suitable far-field boundary location and then put a uniform fine grid around the non-smooth points and a non-uniform grid in the remaining regions. Numerical tests are presented to demonstrate the accuracy and efficiency of the proposed method. The results show that the computational times using this new adaptive grid method are reduced substantially when compared to those of a uniform grid method with a similar magnitude of error.
A NUMERICAL METHOD FOR THE PHASE-FIELD MODEL OF THE VESICLE DYNAMICS
Darae Jeong,Yibao Li,Junseok Kim 한국산업응용수학회 2013 한국산업응용수학회 학술대회 논문집 Vol.8 No.1
In this paper, we propose an accurate and robust numerical method for the phase-field model of the Willmore flow with area conservation and interface length constraint in two-dimensional space. Our method is similar to the one used by Du et al. [A phase field approach in the numerical study of the elastic bending energy for vesicle membranes, J. Comput. Phys. 198 (2004) 450?468] with a key difference. Here, we use a space-time dependent Lagrange multiplier to accurately conserve the area of vesicle membranes while Du et al. introduced a penalty term to roughly enforce the area conservation. We also derive the phase-field model for the Willmore functional using a simple argument. The proposed numerical method is based on an unconditionally gradient stable scheme and a direct area correction algorithm. The accuracy and effectiveness of the proposed model and numerical algorithm are demonstrated through numerical examples.
Corpus luteal cyst Rupture with Tubal Abortion
( Darae Lee ),( Yoon Hyeon Hu ),( Chorong Kim ),( Tae Gyu Ahn ),( Hyang Ah Lee ),( Sunghun Na ),( Jong Yun Hwang ),( Dong Hun Lee ),( Se Jin Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Corpus luteum cyst rupture with consequent hemoperitoneum is a common disorder in women in their reproductive age. And ectopic pregnancy has also hemoperitoneum. Tubal abortion, which is a rare type of ectopic pregnancy, is characterized by the extrusion of an ectopic product of conception implanted in the fallopian tube through the abdominal ostium into the peritoneal cavity. A 39-year-old woman visited emergency room because of abnormal bleeding and lower abdominal pain since 3 days ago. She was an infertile patient. She had In vitro fertilization and embryo transfer a month ago, but she failed pregnancy and continued to had vaginal bleeding. In urine test, human chorionic gonadotropin (hCG) was positive. Ultrasonographic findings showed that the absence of an intrauterine gestational sac, with bilateral ovarian anechoic cyst and small echogenic free fluid in posterior Cul-de-Sac(PCDS). According to the blood test, beta-hCG was 3,679 mIU/mL and hemoglobin was 8.4 g/dL. The vital sign was stable. She was hospitalized and monitored, and the next morning on a blood test, beta-hCG dropped to 2,905mIU/mL and hemoglobin 7.3 g/dL. Ultrasound findings, fluid collection was increased, and emergency surgery was determined. In the surgical findings, hematoma of the right fallopian tube was observed, cyst rupture was found in the right ovary, and ovarian cyst was also observed in the left ovary. She had right salpingectomy, bilateral ovarian cystectomy, and dilatation and curettage with biopsy. Pathologic results were hematoma in tubal lumen, hemorrhagic corpus luteal cyst. In uterine endometrium, there are proliferative glands with predecidualized stroma. After surgery, she was received routine post-operation care and discharged home. We report a rare hemoperitoneum case in which both hemorrhagic corpus luteal cyst and tubal abortion developed simultaneously.
A FAST AND ROBUST NUMERICAL METHOD FOR OPTION PRICES AND GREEKS IN A JUMP-DIFFUSION MODEL
DARAE JEONG,김영록,이승규,최용호,이웅기,Jae-Man Shin,Hyo-Rim An,Hyeongseok Hwang,김준석 한국수학교육학회 2015 純粹 및 應用數學 Vol.22 No.2
We propose a fast and robust finite difference method for Merton's jump diffusion model, which is a partial integro-differential equation. To speed up a computational time, we compute a matrix so that we can calculate the non-local integral term fast by a simple matrix-vector operation. Also, we use non-uniform grids to increase effiency. We present numerical experiments such as evaluation of the option prices and Greeks to demonstrate a performance of the proposed numerical method. The computational results are in good agreements with the exact solutions of the jump-diffusion model.