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Nguyen, Dang Hai Dang,Park, Jong-Tae,Shim, Jae-Hoon,Tran, Phuong Lan,Oktavina, Ershita Fitria,Nguyen, Thi Lan Huong,Lee, Sung-Jae,Park, Cheon-Seok,Li, Dan,Park, Sung-Hoon,Stapleton, David,Lee, Jin-Sil American Society for Microbiology 2014 Journal of Bacteriology Vol.196 No.11
<P>We studied the activity of a debranching enzyme (TreX) from <I>Sulfolobus solfataricus</I> on glycogen-mimic substrates, branched maltotetraosyl-β-cyclodextrin (Glc<SUB>4</SUB>-β-CD), and natural glycogen to better understand substrate transglycosylation and the effect thereof on glycogen debranching in microorganisms. The validation test of Glc<SUB>4</SUB>-β-CD as a glycogen mimic substrate showed that it followed the breakdown process of the well-known yeast and rat liver extract. TreX catalyzed both hydrolysis of α-1,6-glycosidic linkages and transglycosylation at relatively high (>0.5 mM) substrate concentrations. TreX transferred maltotetraosyl moieties from the donor substrate to acceptor molecules, resulting in the formation of two positional isomers of dimaltotetraosyl-α-1,6-β-cyclodextrin [(Glc<SUB>4</SUB>)<SUB>2</SUB>-β-CD]; these were 6<SUP>1</SUP>,6<SUP>3</SUP>- and 6<SUP>1</SUP>,6<SUP>4</SUP>-dimaltotetraosyl-α-1,6-β-CD. Use of a modified Michaelis-Menten equation to study substrate transglycosylation revealed that the <I>k</I><SUB>cat</SUB> and <I>K<SUB>m</SUB></I> values for transglycosylation were 1.78 × 10<SUP>3</SUP> s<SUP>−1</SUP> and 3.30 mM, respectively, whereas the values for hydrolysis were 2.57 × 10<SUP>3</SUP> s<SUP>−1</SUP> and 0.206 mM, respectively. Also, enzyme catalytic efficiency (the <I>k</I><SUB>cat</SUB>/<I>K<SUB>m</SUB></I> ratio) increased as the degree of polymerization of branch chains rose. In the model reaction system of <I>Escherichia coli</I>, glucose-1-phosphate production from glycogen by the glycogen phosphorylase was elevated ∼1.45-fold in the presence of TreX compared to that produced in the absence of TreX. The results suggest that outward shifting of glycogen branch chains via transglycosylation increases the number of exposed chains susceptible to phosphorylase action. We developed a model of the glycogen breakdown process featuring both hydrolysis and transglycosylation catalyzed by the debranching enzyme.</P>
Truong Giang Nguyen,Thanh Khiem Nguyen,Ham Hoi Nguyen,Hong Son Trinh,Tuan Hiep Luong,Minh Trong Nguyen,Van Duy Le,Hai Dang Do,Kieu Hung Nguyen,Van Minh Do,Quang Huy Tran,Cuong Thinh Nguyen 한국간담췌외과학회 2024 Annals of hepato-biliary-pancreatic surgery Vol.28 No.1
Backgrounds/Aims: Parenchymal-sparing anatomical hepatectomy (Ps–AH) based on portal ramification of the right anterior section (RAS) is a new technique to avoid unnecessarily transecting too much liver parenchyma, especially in cases of major anatomical hepatectomy. Methods: We prospectively assessed 26 patients with primary hepatic malignancies having undergone major Ps–AH based on portal ramification of the RAS from August 2018 to August 2022 (48 months). The perioperative indications, clinical data, intra-operative index, pathological postoperative specimens, postoperative complications, and follow-up results were retrospectively evaluated. Results: Among the 26 patients analyzed, there was just one case that had intrahepatic cholangiocarcinoma The preoperative level of α– Fetoprotein was 25.2 ng/mL. All cases (100%) had Child–Pugh A liver function preoperatively. The ventral/dorsal RAS was preserved in 19 and 7 patients, respectively. The mean surgical margin was 6.2 mm. The mean surgical time was 228.5 minutes, while the mean blood loss was 255 mL. In pathology, 5 cases (19.2%) had microvascular invasion, and in the group of HCC patients, 92% of all cases had moderate or poor tumor differentiation. Six cases (23.1%) of postoperative complications were graded over III according to the Clavien–Dindo system, including in three patients resistant ascites or intra-abdominal abscess that required intervention. Conclusions: Parenchymal-sparing anatomical hepatectomy based on portal ramification of the RAS to achieve R0-resection was safe and effective, with favorable short-term outcomes. This technique can be used widely in clinical practice.
Two New C-Glucosyl Benzoic Acids and Flavonoids from Mallotus nanus and Their Antioxidant Activity
Phan Van Kiem,Nguyen Thi Mai,Chau Van Minh,Nguyen Huu Khoi,Nguyen Hai Dang,Nguyen Phuong Thao,Nguyen Xuan Cuong,Nguyen Hoai Nam,Nguyen Xuan Nhiem,Yvan Vander Heyden,Joëlle Quetin-Leclercq,김교남,장해동,김영호 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.2
Two new 2-C-β-D-glucopyranosyl benzoic acid derivatives named mallonanosides A (1) and B (2) were isolated from the methanolic extract of the leaves of Mallotus nanus along with five known flavonoids, kaempferin (3), juglanin (4), quercitrin (5), myricitrin (6), and rhoifolin (7). Their structures were established on the basis of spectral and chemical evidence. Their antioxidant activities were shown to depend on the number of hydroxyl groups, and the location and species of sugar moiety.
Camber effect on the stability and power performance of a right-swing hydrofoil turbine
Nguyen Le Dang Hai,Le Tuyen Quang,Jeong Dasom,고진환 대한조선학회 2022 International Journal of Naval Architecture and Oc Vol.14 No.1
In this study, performance of a right-swing turbine with a cambered hydrofoil was analyzed by CFD numerical simulations to assess its stability and power efficiency. It is found from the analysis that the right-swing trajectory, which is close to the kinematics of flying or swimming creatures, has advantages over the left-swing trajectory in terms of stability with a slight loss of the power efficiency. A cambered hydrofoil can be utilized to offset this loss, but doing so negatively affects the stability at the turning positions of the flapping motion. Consequently, in order to guarantee stability and high efficiency of a right-swing hydrofoil turbine, camber shapes adjustable at the positions of flapping motion, which is an excellent feature of flight and swimming creatures, are mandatory. Eventually, the analysis results of this study will be utilized to develop a high-performance flapping hydrofoil turbine.
Inhibitory Constituents against Cyclooxygenases from Aralia cordata Thunb
Nguyen Hai Dang,XinFeng Zhang,MingShan Zheng,손건호,장현욱,김현표,배기환,강삼식 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.1
Seven diterpenes, four polyacetylenes, a lipid glycerol, and two sterols were isolated from the methylene chloride fraction of the root of Aralia cordata. Their chemical structures were determined as (-)-pimara-8(14),15-dien-19-oic acid (2), pimaric acid (3), (-)-kaur-16-en-19-oic acid (4), 17-hydroxy-ent-kaur-15-en-19-oic acid (9), 7α-hydroxy-(-)-pimara-8(14),15-dien-19-oic acid (10), 16α,17-dihydroxy-(-)-kauran-19-oic acid (11), 16-hydroxy-17-isovaleroyloxy-ent-kauran-19- oic acid (12), falcarindiol (5), dehydrofalcarindiol (6), dehydrofalcarindiol-8-acetate (7), falcarindiol- 8-acetate (8), alpha-mono palmitin (13), stigmasterol (1), and daucosterol (14) by the spectral evidences. These compounds were tested with COX-1 and COX-2 inhibition assays. This study found that compounds 2, 4, 5, 6, 7, 8, and 10 inhibited COX-1 dependent conversion of the exogenous arachidonic acid to PGE2 in a dose-dependent manner with IC50 values of 134.2 µM, 121.6 µM, 170 µM, 50.4 µM, 11.7 µM, 99.6 µM, and 69.6 µM, respectively. But, most of these compounds weakly inhibited COX-2 dependent PGE2 generation. Among them, only compound 4 showed relatively significant inhibitory activity (IC50: 127.6 µM).
Two New Triterpene Glycosides from the Vietnamese Sea Cucumber Holothuria scabra
Nguyen Hai Dang,Nguyen Van Thanh,Phan Van Kiem,Le Mai Huong,Chau Van Minh,김영호 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.11
Two new triterpene glycosides, namely holothurin A3 (1) and A4 (2) were isolated from the methanol extract of the sea cucumber, Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 2D NMR, ESI-MS and HRESI-MS). Compounds 1 and 2 were found to be strongly cytotoxic to both cancer cell lines, KB and Hep-G2, with 50% inhibitory concentrations (IC50) of 0.87 and 0.32 µg/mL (for compound 1) and of 1.12 and 0.57 µg/mL (for compound 2), respectively.
Key Determinants for Users Intention to Use Smarthome Devices in Vietnam
Nguyen, Thi-Hong-Linh,Duong, Minh-Hung,Nguyen, Hai-Dang,Vo, Dang-HongNgan,Vu, Duy-Phuong-Trinh,Le, Hoanh-Su Korea Multimedia Society 2018 The journal of multimedia information system Vol.5 No.4
Smarthome is one of the remarkable fields of the industrial revolution 4.0, which are popular in many countries such USA, EURO, Japan and Korea. However, how Vietnamese people are considering and having intension to use smarthome devices is still a question for marketers and researchers. This study develops a comprehensive research model that can explain potential customers' behavioral intentions to adopt and use Smarthome services in Viet Nam and figure which key factors affect the intention. This study proposes and validates a new theoretical model that extends the Unified Theory of Acceptance and Use of Technology 2 (UTAUT2). The model consists of eight factors that affect one element (Behavioral Intention), specifically: Habits, Perceived usefulness, Perceived ease of use, Trust, Innovativeness Personal, Perceived value, Hedonic motivations and Social influences. Data were collected from 304 Vietnamese citizens by sending the email to survey questionnaire, direct contact with the experienced smarthome users. Through regression analysis, data from samples were analysed with SPSS 20 software and verification of hypotheses, the results show the key determinants affecting the intention to use smarthome appliances in Vietnam: Perceived Value, Social Influence, Perceived Usefulness, Perceived Ease of Use and Trust. From this result, several recommendations have been suggested to to smarthome devices vendors and marketer to improve products as well as marketing approaches to meet customer needs.
The Role of Education in Young Household Income in Rural Vietnam
NGUYEN, Hai Dang,HO, Kim Huong,CAN, Thi Thu Huong Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.2
The purpose of the research is to evaluate how education influences the income of household heads, who are young adult in rural Vietnam. In order to examine the impact of education on the households where their heads are young adults, in this paper, the authors employ two research methods. First, ordinary least squares (OLS) regression is used to study the impact of education on different groups of income; second, quantile regression is applied to find out how education influences the income of households. The dataset includes a survey of 800 young households aged between18 and 35 who are the head of agricultural farms in rural areas. The findings indicate that education has a positive impact on income of young households. Furthermore, the results prove that the longer schooling years, the higher income youth can attain. The results showed that, at the survey time (Sep 2019), the average monthly income of rural young adults who are joining the production process shows a big gap between low and high incomes. Moreover, the study has revealed that other factors positively affect the incomes, namely, joining job-related associations, land resource, hired labour, hi-tech application as well as extension of producing unit.
Two New Triterpene Glycosides from the Vietnamese Sea Cucumber Holothuria scabra
Dang, Nguyen Hai,Thanh, Nguyen Van,Kiem, Phan Van,Huong, Le Mai,Minh, Chau Van,Kim, Young-Ho 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.11
Two new triterpene glycosides, namely holothurin $A_3$ (1) and $A_4$ (2) were isolated from the methanol extract of the sea cucumber, Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 20 NMR, ESI-MS and HRESI-MS). Compounds 1 and 2 were found to be strongly cytotoxic to both cancer cell lines, KB and Hep-G2, with 50% inhibitory concentrations $(IC_{50})$ of 0.87 and $0.32{\mu}g/mL$ (for compound 1) and of 1.12 and $0.57{\mu}g/mL$ (for compound 2), respectively.