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Potassium alum과 비우식성 감미료의 병용이 Streptococcus mutans의 성장에 미치는 영향
김윤정,차정단,김지영,김강주,이흥수 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.3
Traditionally, Koreans have used potassium alum by mouth rinse when they suffered from stomatitis. This study was carried out to investigate the combined effect of potassium alum with aspartame, sorbitol and xylitol on the growth of Streptococcus mutans (S. mutans). The relative growth ratio of S. mutans JC-2 cultured at different concentrations of potassium alum and different concentrations of aspartame, sorbitol and xylitol was examined. The combined effect of different concentrations of potassium alum with 0.5% and 10.0% of aspartame, sorbitol and xylitol was examined. The lowest minimum inhibitory concentration of potassium alum was 5.0mg/ml against S. mutans JC-2. The relative growth ratio of potassium alum on S. mum JC-2 was affected at the concentration of 2.0mg/ml. The growth of S. mutans JC-2 decreased at the concentration of 10.0% of aspartame and sorbitol. Also, a combination of potassium alum and sugar substitutes was more effective against S. mum than the use of one sugar substitute alone. The inhibitory effect of potassium alum and sugar substitutes on S. mutans may be an important mechanism of caries prevention by potassium alum.
양단희,이종연 三陟大學校 2000 論文集 Vol.33 No.1
When we use a machine learning mechanism for natural language processing, unsupervised methods are confronted with data sparseness and supervised methods have difficulties in constructing sufficient training data. These problems come from the fact that we do not have sufficient training resources necessary to training. After discussing such problems specifically, we suggest a method to construct extensive training resources, not in an academic view of natural language processing, but in a practical one.
( Yun Dan Kang ),( Soo Mi Kim ),( Ye Kyu Park ),( Jong Soo Kim ),( Jin Wan Park ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
In this study, collagen hydrogel has been evaluated as a stem cell carrier by a number of different criteria. First, we tested whether collagen hydrogel induced the secretion of neurotropic factors from UBC-MSCs. Second, by utilizing a 3-D co-culture with neuronal precursors, we tested the efficiency with which the neurotropic factors from UBC-MSCs were delivered to nearby neural precursors. We first tested whether the cell population that proliferated attached to the bottom of the plastic culture dish out of a mononuclear fraction obtained from the umbilical cord blood was enriched with mesenchymal stem cells by flow cytometric analysis. Next, we performed a RT-PCR analysis to examine neurotrophic factor and growth factor expression in the mesenchymal cell-enriched cell population of the umbilical cord blood. And we compared the 2-D culture of UBC-MSCs with the 3-D culture of UBC-MSCs in terms of neurotropic factor expression. We conducted co-culture experiments to examine whether UBS-MSCs in a collagen gel were capable of stimulating outgrowth and neuronal differentiation of human neuronal precursor cells (hNPCs). In comparison with 2-dimensional (2-D) liquid culture, 3-D culture of UCB-MSCs in a collagen-based hydrogel significantly enhanced the expression of various neutropic factors including neurotrophin-4, nerve growth factor, brain-derived neurotropic factor, and ciliary neurotropic factor as verified by the gene and protein analysis. In addition, a co-culture with human neuronal precursor cells significantly enhanced neurite outgrowth and neural differentiation of hNPCs as evidenced by enhanced expression of β-III tubulin and NeuN. Our results demonstrate that the collagen-based hydrogel is excellent at inducing the neurotrophic factor release from UBC-MSCs and providing a tropic support to hNPCs, suggesting the possibility that 3-D UBC-MSC culture in the collagen hydrogel could be a promising strategy for nerve regenerative medicines.
정윤희 ( Yun Hee Jeong ),양정선 ( Jeoung Sun Yang ),강윤단 ( Yun Dan Kang ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.3
Sweet`s syndrome is also called acute febrile neutrophilic dermatosis and this disease is characterized by an abrupt onset of fever, leukocytosis and tender erythematous plaques that are infiltrated by neutrophils. It most commonly occurs in women who are between 30 to 50 years of age. About 50% of the cases are associated with autoimmune disease, sarcoidosis, Behcet`s disease, and pregnancy. We report a case of Sweet`s syndrome associated with pregnancy with such a stormy clinical course requiring elective termination of gestation by induction of labor.
산전 부신피질호르몬 일회 투여 후 분만까지 기간이 조산아 예후에 미치는 영향
강윤단 ( Yun Dan Kang ),박만철 ( Man Chul Park ) 대한산부인과학회 2009 Obstetrics & Gynecology Science Vol.52 No.1
목적: 산전에 투여한 부신피질호르몬 일회 요법의 장점이 시간이 지남에 따라 어떻게 변하는지 알아보기 위함이다. 연구 방법: 본원 산부인과에서 산전 부신피질호르몬 일회 요법의 전 과정을 투여받은 후, 임신 26주 이후 및 35주 이내에 분만하였던 신생아 203명을 대상으로 신생아 입원 차트를 후향적으로 검토하였다. 첫 부신피질호르몬 투여부터 분만까지의 기간이 48시간 후 7일 이내군 (78예), 8일에서 14일 사이군 (65예) 및 15일 이상군 (60예)으로 구분하여 신생아 이환율을 비교하였다. 결과: 각 군의 임상적 특징 및 산전 부신피질호르몬 투여 적응증의 분포, 분만을 시도하게 된 적응증의 분포에 차이는 없었다. 24시간 이상 인공호흡기 부착률은 7일 이내군이 32.1% (25/78)로 8~14일군의 50.8% (33/65)(P=0.023) 및 15일 이상군의 51.7% (31/60)(P=0.02)보다 의미 있게 낮았으며, 8~14일군과 15일 이상군 사이에 유의한 차이는 없었다. 그러나 평균 인공호흡기 부착 기간, 표면활성제 투여율, 임신 연령 36주에 산소의존율, 분만 후 28일에 산소의존율, 뇌실내출혈 발생 빈도, 괴사소장 대장염 발생 빈도, 패혈증 발생 빈도 및 입원 기간 등에서는 차이가 없었다. 모든 군에서 뇌측실부 백질 연화증과 신생아 사망은 없었다. 결론: 산전 부신피질호르몬 투여 후 7일이 지나면 24시간 이상 인공호흡기 부착률이 증가할 수 있으나, 다른 모든 이환율엔 차이가 없었다. Objective: To determine whether the beneficial effects of a single course of antenatal corticosteroids for neonatal morbidity change with time Methods: A retrospective chart review was performed of women who received a single complete course of antenatal corticosteroid and delivered a viable singleton infant between 26 and 35 weeks of gestation. Patients were divided into 1 of 3 groups on the basis of the interval from first corticosteroid dose to delivery (48 hr~7 days, 8~14 days and ≥15 days). Neonatal morbidities were compared between each groups. Results: Two hundred three pregnancies were included, of which 78 women delivered at 48 hr-7 days, 65 women delivered at 8~14 days and 60 women delivered at ≥15 days. The 3 groups were similar in clinical characteristics and indications for antenatal steroids and delivery. Neonates delivered within 7 days had a lower incidence of receiving ventilatory support for more than 24 hours than 8~14 days group (32.1% vs 50.8%, P=0.023) and ≥15 days group (32.1% vs 51.7%, P=0.02). But there were no significant differences between the groups in ventilator days, surfactant use, oxygen dependency at 36 weeks of gestation, oxygen dependency at 28 days after delivery, intraventricular hemorrhage, necrotizing enterocolitis, sepsis and length of hospital days. There were no periventricular leukomalacia and neonatal death in all groups. Conclusion: Neonates delivered more than 7 days after first corticosteroid dose needed more short-term ventilatory support, but there were no differences in other neonatal outcomes.