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Ni, Dalong,Jiang, Dawei,Im, Hyung-Jun,Valdovinos, Hector F.,Yu, Bo,Goel, Shreya,Barnhart, Todd E.,Huang, Peng,Cai, Weibo Elsevier 2018 Biomaterials Vol.171 No.-
<P><B>Abstract</B></P> <P>Radiolabeled nanoprobes for positron emission tomography (PET) imaging has received special attention over the past decade, allowing for sensitive, non-invasive, and quantitative detection of different diseases. The rapidly renal clearable nanomaterials normally suffer from a low accumulation in the tumor through the enhanced permeability and retention (EPR) effect due to the rapidly reduced concentration in the blood circulation after renal clearance. It is highly important to design radiolabeled nanomaterials which can meet the balance between the rapid renal clearance and strong EPR effect within a suitable timescale. Herein, renal clearable polyoxometalate (POM) clusters of ultra-small size (∼1 nm in diameter) were readily radiolabeled with the oxophilic <SUP>89</SUP>Zr to obtain <SUP>89</SUP>Zr-POM clusters, which may allow for efficient staging of kidney dysfunction in a murine model of unilateral ureteral obstruction (UUO). Furthermore, the as-synthesized clusters can accumulate in the tumor through EPR effect and self-assemble into larger nanostructures in the acidic tumor microenvironment for enhanced tumor accumulation, offering an excellent balance between renal clearance and EPR effect.</P> <P><B>Graphical abstract</B></P> <P>Herein, renal clearable polyoxometalate clusters (POM) were readily radiolabeled with the oxophilic <SUP>89</SUP>Zr to allow for efficient staging of kidney dysfunction in a murine model. Furthermore, the as-synthesized clusters can accumulate in the tumor through enhanced permeability and retention (EPR) effect and self-assemble into larger nanostructures in the acidic tumor microenvironment for enhanced tumor accumulation, offering an excellent balance between renal clearance and EPR effect.</P> <P>[DISPLAY OMISSION]</P>
Influence of Cutting Tools on Filter Cake Formation during Slurry Shield Tunnelling
Jiahua Mao,Dajun Yuan,Dalong Jin,Shengnan Liu 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.6
The filter cake on excavation face would be destructed periodically by cutting tools during slurry shield tunneling. The broken filter cake has a risk for face stability. The influence of cutting tools on filter cake was studied in this paper. A slurry-soil interaction model based on a multiphase flow theory which considers the solid particles and fluid in slurry was developed. The whole process of slurry penetration and filter cake formation on the excavation face of slurry shield can be described by this model. The motion state of cutting tools can be combined with this model and the effect of cutting tools on the slurry-soil interaction and pressure transfer mechanism was analyzed. Subsequently, the comparative calculations were presented to discuss the influence of tunneling parameters and the design of cutting wheel on filter cake formation during slurry shield tunnelling. The results indicate that the total area of filter cake on excavation face increases with the decreasing of revolutions per minute of cutting wheel and shield machine advance rate. The area ratio of filter cake on the center of excavation face always larger than other zone due to the lesser amount of cutting tools within one track in the center of cutting wheel. The results can provide a better understanding of how to set the shield tunneling parameters and design the layout of cutting tools for the stability of tunnel face.
Face Stability Analysis of Slurry Shield Tunnels in Rock–Soil Interface Mixed Ground
Ping Lu,Da-Jun Yuan,Jian Chen,Dalong Jin,Jun Wu,Weiping Luo 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.6
When shield tunneling in rock-soil interface (RSI) mixed ground, maintaining the stability of the tunnel face is very challenging. This study aims at the investigation of the face stability of slurry shield tunnels in RSI mixed ground. A new apparatus was developed to simulate pressurized slurry supporting the tunnel face in centrifuge tests. The progressive failure of the tunnel face was triggered with slow decrease of slurry pressure. With two equivalent model tunnels of circular shape and semicircular shape, the variations of soil (water) pressure and the displacement field in front of the tunnel can be obtained simultaneously. The face failure was found to be a local collapse in the upper soil layer. The limit support pressure was picked out at the sudden change of the measured soil or water pressures. Then the classical wedge-prism model was introduced and modified to calculate the limit support pressure for slurry shield tunnels in RSI mixed ground considering the partial collapse. Numerical analysis was applied to verify the theoretical analysis and sensitivity analysis was performed to estimate the influence of different parameters on the theoretical solutions.
Plate, Markus,Li, Ting,Wang, Yu,Mo, Xiaoning,Zhang, Yingmei,Ma, Dalong,Han, Wenling Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.29 No.4
Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during e volution. CMTM4-v1 and -v2 a re broadly expressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an important gene involved in cell growth and cell cycle regulation.
Markus Plate,Ting Li,Yu Wang,Xiaoning Mo,Yingmei Zhang,Dalong Ma,Wenling Han 한국분자세포생물학회 2010 Molecules and cells Vol.29 No.4
Human CMTM is a novel gene family consisting of CKLF and CMTM1-8. CMTM4 is the most conserved gene and has three RNA splicing forms designated as CMTM4-v1, -v2 and -v3, but in many types of tissue and cell lines, only CMTM4-v1 and -v2 could be detected. CMTM4-v2 is the full length cDNA product, which has been highly conserved during evolution. CMTM4-v1 and -v2 are broadly ex-pressed in normal types of tissue. They are distributed on the cell membrane and across the cytoplasm in a speckled pattern. Overexpression of CMTM4-v1 and -v2 can inhibit HeLa cell growth via G2/M phase accumulation without inducing apoptosis. Therefore, CMTM4 might be an impor-tant gene involved in cell growth and cell cycle regulation.
Characterization and Expression Profile of CMTM3/CKLFSF3
Zhong, Ji,Wang, Yu,Qiu, Xiaoyan,Mo, Xiaoning,Liu, Yanan,Li, Ting,Song, Quansheng,Ma, Dalong,Han, Wenling Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.5
CMTM/CKLFSF is a novel family of proteins linking chemokines and TM4SF. In humans, these proteins are encoded by nine genes, CKLF and CMTM1-8/CKLFSF1-8. Here we report the characteristics and expression profile of CMTM3/CKLFSF3. Human CMTM3/CKLFSF3 has a high sequence identity among various species and similar characteristics as its mouse and rat homologues. Established by results both of RT-PCR and Quantitative Real-time PCR, the gene is highly transcribed in testis, leukocytes and spleen. For further verification, we generated a polyclonal antibody against human CMTM3/CKLFSF3 and found that the protein is highly expressed in the testis and some cells of PBMCs. Therefore, CMTM3/CKLFSF3 is an evolutionarily conserved gene that may have important roles in the male reproductive system and immune system. Further studies are necessary to validate its functions in the two systems.