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김대산 서울여자대학교 자연과학연구소 1990 자연과학연구논문집 Vol.1 No.-
F=F_(q)가 유한체이고, χ가 F의 곱지표, λ가 F의 자명하지 않은 합지표라고 하자. 이때 G₁(χ, λ)=∑□χ(u)λ(u)가 통상적인 가우스 합이고, G_(n)(χ, λ)=1/q□∑□χοdet(u)λοtr(u)가 지료들을 일반선형군으로 끌어올림으로써 얻어진 새로운 가우스 합이라고 할 때 G_(n)(χ, λ)=G₁(χ, λ)^(n)이 성립함을 보였다. 이 항등식은 고전적인 Davenport-Hasse 정리와 유사하며 이것은 일반선형군의 분해공식을 유도하여 바닥 최대포물부분군만이 합에 기여한다는 것을 이용하여 밝힐 수 있다.
C.V.D. 방법에 의한 Cd_0.78Zn_0.22 S박막 성장과 광전기적 특성연구
유상하,이상렬,홍광준,서상석,김혜숙,전승룡,윤은희,문종대 조선대학교 기초과학연구소 1993 自然科學硏究 Vol.16 No.1
We had grown Cd_0.78Zn_0.22S polycrystal thin films on slide substrate using chemical vapour deposition(CVD) method. We measured X-ray diffraction patterns in order to study Cd_0.78Zn_0.22S polycrystal structure. We studied its band gap using transmission curves and photocurrent and also analyzed photoluminescence using configurational coordinate model. We measured Hall effect·on this sample by Van der Pauw method and studied on carrier density and mobility depending on temperature.
유연하고 신속한 표면미세가공기술을 이용한 Micro-fluidic Channel 제작
김진산,성인하,김대은 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.4
Recently, the need for transporting and manipulating minute amount of fluids in microscale channels (so-called micro-fluidics) has been increasing, especially in biotechnology and biochemical processing. This work demonstrates that the so-called mechano-chemical process which consists of mechanical abrasive action combined with chemical process can be used to fabricate micro-fluidic channels more rapidly and cost effectively than other methods. In this work, capillary filling of fluids in micro-channels was investigated by theoretical approaches and experiments. From the experimental results, it is expected that a complex micro-fluidic system can be fabricated using the micro-fabrication technique and microsystem packaging method described in this work.
강현식,김대년,김상연,강인산,박은규,서용원 대구보건대학 1999 대구보건대학 論文集 Vol.19 No.-
As the results of measurement of the radius of corneal curvature by keratometry for the right eye of 100 subjects, the steep meridian radius is 7.21㎜ to 8.27㎜ and flat meridian is 7.45㎜ to 8.65㎜, for the left eye the steep meridian radius is 7.30㎜ to 8.35㎜, and flat meridian is 7.45㎜ to 8.72㎜. The mean value of radius of corneal curvature is 7.8㎜ for night eye, 7.8㎜ for left eye. The results of measurement of P-value by topography, it is ranged from 0.45 to 0.91 for the night eye, 0.55 to 0.90 for the left eye, mean value is 0.756 for right eye, 0.735 for left eye respectively. That means the corneal shape is ellipses. The corneal thickness is measured 0.69㎜ 10°degree to the nasal, 0.76㎜ 20°degree to the nasal, 0.66㎜ 10°degree to the temporal, 0.72㎜ 20° degree to the temporal from the visual axis and 0.60㎜ at the central position. The horizontal size of corneal is 11.34㎜ for the night eye, 11.373㎜ for left eye. Those data can be used for contact lens design and fitting.
생쥐 안구에서 산화적 손상에 의한 superoxide dismutases와 metallothionein의 나이에 따른 유도의 차이
이홍영,이태범,안춘산,변익건,최석민,권대승,최철희 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2
The basal levels and inducibility of superoxide dismutases (SODs; Mn-SOD and Cu/Zn-SOD) and metallothionein (MT) was investigated in the eyes of mice with age. Oxidative stress was induced by paraquat, an intracellular superoxide generator, in 1, 4, 8, and 12 months of age and then mRl\As of SODs and MT in the eyes were determined by RT-PCR assay. The basal level of Mn-SOD mRNA increased from 1 month to 8 months but decreased thereafter. Mn-SOD mRNA was induced by paraquat until 4 month but not after 8 months. On the other hand, the basal level of Cu/Zn-SOD mRNA decreased with age. Cu/Zn-SOD mRNA was not induced by paraquat until 4 months. The basal level of MT mRNA declined with age whereas its inducibility by paraquat was intact at all ages. Taken together, the results indicate that SODs and MT are differentially expressed and induced according to the age. It could be also implicated that failure in induction of Mn-SOD with age may be one of causative factors in the aging process whereas induction of Cu/Zn-SOD and MT may be one of important factors in defense against oxidative stress in the eyes. 서론: 최근 노화는 반응성 산소종에 의한 산화적 손상의 축적결과라는 설이 각광을 받고 있다. 노화과정에서 노화와 관련된 질병을 비교적 잘 나타내는 안구를 선정하고, 정상생쥐의 안구에서의 superoxide dismutases (SODs) 와 metallothionein (MT) 의 함량 뿐 아니라 산화성 스트레스를 유발하는 paraquat에 의한 SODs와 MT의 유도능과 나이와의 상호관계를 조사하여 이들의 노화과정에서의 역할을 규명하고자 하였다. 재료 및 방법 : 본 연구에서 1, 4, 8, 12개월된 정상생쥐의 안구에서 반응성 산소종 생성의 초기에 중요한 방어기전인 SODs mRNA와 hydroxy radical (OH·)에 의한 산화적 손상의 마지막 방어기전인 MT mRNA의 함량과 산화성 스트레스를 유발하는 paraquat에 의한 유도능을 역전사 중합효소 연쇄반응 (RT-PCR) 으로 조사하였다. 결과: 정상생쥐의 안구의 노화과정에서 Mn-SOD와 Cu/Zn-SOD, 그리고 MT mRNA의 항정상태 함량을 조사한 결과, Mn-SOD mRNA는 8개월까지는 증가하다가 12개월에서 감소하였으나, Cu/Zn-SOD mRNA는 나이와 함께 감소하였다. 그러나 MT mRNA 는 8개월까지는 감소하다가 12개월에서 약간 증가하였다. 산화성 스트레스를 유발하는 parraquat에 의하여 Mn-SOD mRNA는 1개월과 4개월에서만 유도되었고, Cu/Zn-SOD mRNA는 8개월과 12개월에서만 유도되었으며, MT mRNA는 관찰한 전 기간에서 유도되었다. 결론: 이상의 결과를 종합하면 SODs와 MT는 안구에서 나이에 따라 서로 다르게 발현되고 유도되는 것으로 생각되며, 노화과정에서 Mn-SOD유도의 이상이 노화의 원인이 되는 인자로 작용하고, 반면에 Cu/Zn-SOD와 MT의 정상적인 유도능이 산화적 스트레스에 대하여 방어역할을 하는 것으로 생각된다. 이와 같이 연령이 증가함에 따라 Mn-SOD, Cu-Zn-SOD, 및 MT의 발현과 유도능의 차이가 있게 되고, 그 결과 반응성 산소종에 의한 산화적 손상의 정도의 차이로 노화의 속도가 조절되지 않나 생각된다.
장정욱,박춘식,손대산 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-
This study analyzed characteristics of soft ground consolidation according to depths of vertical drain. As the result, when the depth ratio of vertical drains (L/D) were 0.5, 0.7, and 1.0, consolidation characteristics were similar up to 70% in consolidation degree under one-dimensional drain condition. However, above this degree, consolidation speed became slower as L/D became smaller. Two-dimensional drain condition also showed a similar tendency, but when L/D was 1.0, the consolidation speed was relatively higher.
A case of poikilodermatous mycosis fungoides: rare disease entity and a diagnostic challenge
( Dae San Yoo ),( Seong Hoon Seo ),( Jee Eun Kim ),( Ji Young Choi ),( Soo-chan Kim ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1
Poikilodermatous mycosis fungoides (MF) is a rare variant of MF. Clinically, poikilodermatous MF presents as reticulated hypo- and hyperpigmentaed patches that accompany atrophy and telangiectasia. Histopathological features resemble those of classic MF, such as epidermotropism. Additional features such as epidermal atrophy, basal hydrophic changes, lichenoid lymphocytic infiltration with pigment incontinence and telangiectasia are more prominent in poikilodermatous MF. Immunohistochemical studies for CD3 and CD45RO show positive results while stains for CD2, CD5 and CD7 may show loss of positivity. Herein, we report a case of poikilodermatous MF in a 31-year-old Korean man. The patient visited our clinic with reticulated violaceous patches with atrophy on the axillae, lower back and inguinal areas. The skin biopsy revealed epidermal atrophy with severe basal hydropic degeneration, and some epidermotropic atypical lymphocytes on the dermo-epidermal junction. Dense lichenoid lymphocytic infiltration, dilated capillaries and dermal melanophages were also found in the upper dermis. Immunohistochemical stains for CD3, 4, 5 and 8 were positive. Although T cell receptor-gamma gene rearrangement did not showed clonal gene rearrangement, the diagnosis of poikilodermatous MF was made based on the clinical and histopathological features. The patient showed good response to narrow band UVB (311nm) phototherapy with topical potent steroid.