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      • Passaged Human Nasal Epithelial Cell Monolayers for In vitro Drug Transport Studies

        Dae-Duk.Kim 大韓藥學會 2006 大韓藥學會 總會 및 學術大會 Vol.2006 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

      • KCI등재

        Coacervate microcapsules of vitamin U optimized by central composite design (CCD)

        Dae‑Duk,Kim,Ji‑Su,Kim,Ki‑Taek,Kim,Ju‑Hwan,Park,Jae‑Young,Lee,Min-Hwan,Kim,Hyung,Geun,Min,Ik‑Hwan,Moon,Choon‑Young,Choi,Bo,Hyun,Kim 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.3

        The purpose of this study was to prepare microcapsules encapsulating vitamin U (VU, S-methylmethionine) by complex coacervation. Multiple emulsion method was applied for encapsulating highly water-soluble VU. The composition of microcapsules was optimized using central composite design (CCD). The weight ratio of gelatin to gum arabic (X1) and the volume of oil phase (X2) were set as two independent variables to obtain the maximum weight of microcapsules (Y1) and the content of VU (Y2) in microcapsules higher than 2.5%. When the microcapsules were prepared based on the optimized composition, its actual Y1 and Y2 values were 95% of the predicted values. Morphology of microcapsules observed by the optical and the fluorescence microscopes was round shape. Scanning electron microscopy (SEM) image of internal particles also confirmed that the multiple emulsions were encapsulated in the microcapules. Mean particle size of microcapsules measured by the laser diffraction particle size analyzer was 79.17 μm. Differential scanning calorimetry (DSC) showed that VU exists in an amorphous state in the coacervate microcapsules. Thus, it can be concluded that hydrophilic VU was successfully encapsulated in the coacervate microcapsules using the multiple emulsion method, and the design of experiment (DoE) technique was useful to optimize the formulation.

      • KCI등재

        In Vitro Transport of Fexofenadine HCl in Deformable Liposomes Across the Human Nasal Epithelial Cell Monolayers

        Dae-Duk,Kim,Hongxia,Lin,Chi-Ho,Lee,Chang-Koo,Shim,Suk-Jae,Chung 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.6

        Fexofenadine • HCl is non-sedating histamine H1 receptor antagonist that can be used for the treatment of seasonal allergic rhinitis. The objective of this study was to investigate whether the carriers of deformable liposomes can enhance the transepithelial permeability of fexofenadine • HCl across the in vitro ALI human nasal monolayer model. Characterization of this model was achieved by bioelectric measurements and morphological studies. The passage 2 and 3 of cell monolayers exhibited the TEER value of 2852482 ohm´cm2 on 11 days of seeding and maintained high TEER value for 5 days. The deformable liposome of fexofenadine • HCl was prepared with phosphatidylcholine (PC) and cholic acid using extruder method. The mean particle size was about 200 nm and the maximum entrapment efficiency of 33.0% was obtained in the formulation of 1% PC and 100 mg/ml fexofenadine • HCl. The toxicity of the deformable liposome to human nasal monolayers was evaluated by MTT assay and TEER value change. MTT assay showed that it has no toxic effect on the nasal epithelial cells in 2-hour incubation when the PC concentration was below 1%. However, deformable liposome could not enhance the transepithelial permeability (Papp) and cellular uptake of fexofenadine • HCl. In conclusion, the in vitro model could be used in nasal drug transport studies and evaluation of transepithelial permeability of formulations.

      • KCI등재

        Comparison of saline vs. blood replenishment after blood sampling in a rat pharmacokinetic study

        Dae‑Duk,Kim,Sang‑Bum,Kim,Kyu‑Sang,Kim,Heon‑Min,Ryu,In‑Soo,Yoon,Hyun‑Jong,Cho,Suk‑Jae,Chung,Saeho,Chong 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.5

        The objective of this study was to examine the effect of reduced hematocrit and plasma protein levels, which may occur in rats after normal saline replenishment, on the pharmacokinetics of a few model drugs with different RBC (red blood cell) distribution behaviors (i.e., high vs. low). Male Sprague-Dawley rats received either saline or donor blood immediately after each blood sampling following the intravenous administration of model drugs at either 5 or 10 mg/kg. Two drugs with extensive red blood cell distribution, acetazolamide (ACE) and methazolamide (MET), and two additional drugs with negligible RBC distribution, verapamil (VER) and tolbutamide (TOL), were tested. Hematocrit, total plasma protein concentration, and drug concentration were determined after saline or donor blood replenishment. Hematocrit gradually decreased after saline replenishment (30% reduction after 6 h). Consistently, the total plasma protein concentration also decreased after saline replenishment (16% reduction at 6 h). In contrast, hematocrit and total plasma concentration remained unaltered when donor blood was used to replenish the blood volume removed after sampling. Despite the reduction of hematocrit and plasma protein concentration during the course of sampling, the pharmacokinetic profiles of all four drugs tested were similar, regardless of the method of fluid replenishment.

      • KCI등재

        2003 대구하계유니버시아드대회 선수촌병원내 한방의료지원 분석

        손대용 ( Dae Yong Son ), 김민수 ( Min Su Kim ), 김상진 ( Sang Jin Kim ), 김종대 ( Jong Dae Kim ), 김근모 ( Geun Mo Kim ), 안희덕 ( Hee Duk An ) 한방재활의학과학회 2004 한방재활의학과학회지 Vol.14 No.2

        Objective: This study was designed to find out characteristics of patients who had visited oriental medical clinic in athletes` village during the 22nd Universiade 2003 Daegu Korea and provide basic data for planning future sports events. Methods: We statistically analyzed characteristics and medical data in 570 patients who had visited oriental medical clinic in athletes` village during the 22nd Universiade 2003 Daegu Korea from 14, August, 2003 to 3, September, 2003.Results & Conclusions: 1. In distribution of sex, the rate of male was 49.3%, and that of female was 50.7%. 2. In distribution of nationality, most of patients were korean and the patients of Ireland, Mexico, Portugal were also many. In distribution of Continent, most of patients were Asian and most of countries were Europe. 3. In distribution of patient`s type, most of patients were official, followed by athlete. 4. In distribution of the first visiting date, the most of patients had visited on 18, August. and after 28, August, the number of first visiting patient was decreased. 5. In distribution of the days of treatment, the rate of patients had treated only onetime was 62.5%, and that of patients had treated over-twice was 37.5%. 6. In the sports event distribution of athletes, the number of athletics was the most, followed by football. 7. In distribution of disease, the number of low back pain was the most, followed by shoulder joint pain.8.In distribution of treatment method, the number of Acupuncture, cupping & physical treatment was the most, followed by Acupuncture & physical treatment.9.In distribution of treatment effect according to Roubin`s Diagnosis, the rate of `fair` was the most, followed by `good`. In distribution of treatment effect according to Visual Analogue Scale(VAS), the rate of VAS 5 was the most, followed by VAS 7.

      • KCI등재후보
      • Transport of anti-allergic drugs across the passage cultured human nasal epithelial cell monolayer

        Kim,Dae-Duk,Lee,Chi-Ho,Yoo,Jin-Wook,Lin,Hongxia 大韓藥學會 2003 大韓藥學會 總會 및 學術大會 Vol.2003 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

      • 논문(論文) : 독립운동가 윤희순(尹熙順)의 국내,외 항일독립운동

        강대덕 ( Dae Duk Kang ) 강원대학교 사학회 2011 江原史學 Vol.0 No.25

        19세기 말 일제침략으로부터 우리나라를 지키기 위해 올바로 인식한 대응책으로 다양한 형태와 방식의 하나로 전통적 가치관에 기반을 둔 민족주의 적인 위정척사사상이었고 이를 행동화시킨 민족운동이 바로 항일 의병운동이고 독립운동이었다. 우리나라 여성으로서 한말 최초 여성의병장 윤희순(1860~1935)은 華西學派의 華·重·省·毅門에서 함께 수학한 畏堂 柳弘錫의 며느리이고 지식인의 夫人으로서 抗日 女性義兵運動을 주도하였으며, 활발하게 抗日獨立運動을 전개하였던 대표적인 여성 독립운동가였다. 화서학파 지식인들은 男·女구분 없이 행동으로 실천하는 민족독립운동의 중심지로 매우 중요한 역할을 하였다. 민족의 항일독립운동은 그 목표의강도와 성취도와 민족구성원의 감정상태에 따라서 다양하게 나타났었다. 특히 윤희순은 행동하는 지성으로 강원지역 전·후기 항일의병운동에서 여성의병장으로서 활동은 그 후 만주에서 민족학교를 설치 운영하여 항일독립운동에 앞장 설 청년들을 배출하는 교육운동과 나라를 빼앗긴 민족에 대한 계몽운동 등 국외에서 항일독립운동이었다. 그는 일본의 침략으로 이루어진 갑오왜란, 을미사변, 갑오·을미개혁, 단발령시행, 태양력사용, 을사늑약체결, 고종퇴위, 군대해산, 한일병탄 등 기존질서의 위기상황에 직면하여 개항전후 나타난 화서학파의 民族意識, 즉 對外危機意識에 따라서 형성된 尊華攘夷·衛正斥邪論의 논리를 배경으로 전개된 민족운동의 연장이었다. 19세기말 서구문물의 팽창이 가져다주는 민족의 정체성위기 앞에서 우리민족은 그때까지 지켜온 민족의 정체성을 확인하고 일제 침략에 대항하여 국권회복을 위하여 독립운동으로 승화시킨 국내 抗日義兵運動 속에서 女性義兵將으로서 부녀의병대를 조직하여 전개한 의병활동과 만주지역 등 국외에서 민족학교 설립과 교육철학, 학교경영, 항일독립운동 등에서 그의 역할을 통해 독립운동가 윤희순의 성격과 의의를 규명하였다. 윤희순의 항일의병활동은 朝鮮中華의 自尊意識이 지니는 민족주체성을 남성만이 아닌 여성도 함께 지키기 위한 실천운동이었다고 평가 할 수 있다. 우리 민족의 주체성은 민족내부를 통합할 수 있는 통합의 원리를 통하여 민족의 역량이 결집되고 그것이 민족의식으로 定礎되어야만 진정한 의미를 지니는 것이다. 본 연구는 한말 항일의병운동의 전개과정을 통해 국내의 특히, 강원여성의병은 근대적인 민족의식과 자주적인 주체성을 형성하게 하였으며, 국권회복과 민족국가 수립을 위해 항일독립운동을 전개토록 하였던 保國實踐運動으로 화서학파의 활동 중심지였던 강원 춘천지역 여성에 대한 여성독립운동사 연구이다. 이는 새로운 자료발굴과 새로운 시각에서 재해석이 그 어느 때 보다도 절실히 요구되는 시기에 독립운동가 尹熙順의 국내 抗日 婦女義兵隊 活動과 국외에서의 민족학교 경영 등을 통한 항일독립운동 활동은 한국 항일독립운동사의 역사적 의의가 있는 여성독립운동이었다. One of the Korean responses for protecting the country from the japanese invasion at the end of the 19th century was "defending orthodoxy andrejecting heterodoxy thought"(wijung chuksa sasang) based on Korean traditional value. And national movement to embody it was anti-japanese righteous army and independent movement. Yoon Hui-sun, the first Korean woman leader of righteous army, was a daughter- in-law of Yoo Hong-seok who was a confusion scholar of Yi Hwa-su school and wife of Yoo Je-won who was an intellectual. She was a representative independent fighter. Intellectuals of Yi Hwa-su school had key roles in national independent movement without division of sex. National anti-japanese independent movement varied according to the intensity of the purpose, levels of attainment and feeling of the people. Yoon Hui-sun was a leader of the former and latter anti-japanese righteous army in Kangwon province. And later, she founded and ran a school in Manjuria and fostered many future independence fighters. Moreover, she engaged in enlightenment movement for Korean immigrants who lost their country. Her anti-japanese activities in abroad were one of the national movements that developed based on the logic of national consciousness of Yi Hwa-su school that appeared in a dangerous situation including the Gabo Reform, the assassination of empress Myeongseong, the Ulmi reform, the ordinance prohibiting topknots, using of the solar calendar, Ulsa Illeagal Treaty, deposing of emperor, disbanding of national army, annexation of the country by the japanese invasion. When national identity confronted with a crisis by extension of western civilization in the end of the 19th century, Korean people confirmed their identity. When the country was invaded by Japan, activities of righteous army were developed into independence movement for recovering the country. At that time, Yoon Hui-sun organized righteous army with women in the country and founded a school in abroad. So, this paper determines her characters and importance as a Korean independent fighter. Her activities as an anti-japanese righteous solder showed that not only men but also women tried to keep their national identity of emphasizing independence. Korean national identity can get a meaning when all the people become one, their capacity is concentrated and it is set up as national consciousness. Through the developing process of anti-japanese righteous army in the end of the Choseon, this paper shows that women righteous army in Kangwon province helped to form modern national consciousness and independent national identity. Also, this discovers activities of Yoon Hui-sun as the first woman leader of righteous army and her activities as an anti-japanese independent fighter in Manjuria and determines her importance in the history of Korean independence movement.

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