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Leandro C. Luiz,Francisco J.O. Ferreira,Verginia R. Crispim 한국원자력학회 2017 Nuclear Engineering and Technology Vol.49 No.4
The presence of crust on the inner walls of metallic ducts impairs transportation becausecrust completely or partially hinders the passage of fluid to the processing unit and causesdamage to equipment connected to the production line. Its localization is crucial. With thedevelopment of the electronic imaging system installed at the Argonauta/Nuclear EngineeringInstitute (IEN)/National Nuclear Energy Commission (CNEN) reactor, it becamepossible to visualize crust in the interior of metallic piping of small diameter using realtimeneutron radiography images obtained with a low neutron flux. The obtained imagesshowed the resistance offered by crust on the passage of water inside the pipe. Nodiscrepancy of the flow profile at the bottom of the pipe, before the crust region, wasregistered. However, after the passage of liquid through the pipe, images of the disturbancesof the flow were clear and discrepancies in the flow profile were steep. This showsthat this technique added the assembled apparatus was efficient for the visualization ofthe crust and of the two-phase flows.
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The rs2304256 Polymorphism in TYK2 Gene Is Associated with Protection for Type 1 Diabetes Mellitus
Felipe Mateus Pellenz,Cristine Dieter,Guilherme Coutinho Kullmann Duarte,Luís Henrique Canani,Bianca Marmontel de Souza,Daisy Crispim 대한당뇨병학회 2021 Diabetes and Metabolism Journal Vol.45 No.6
Background: Tyrosine kinase 2 (TYK2) is a candidate gene for type 1 diabetes mellitus (T1DM) since it plays an important role in regulating apoptotic and pro-inflammatory pathways in pancreatic β-cells through modulation of the type I interferon signaling pathway. The rs2304256 single nucleotide polymorphism (SNP) in TYK2 gene has been associated with protection for different autoimmune diseases. However, to date, only two studies have evaluated the association between this SNP and T1DM, with discordant results. This study thus aimed to investigate the association between the TYK2 rs2304256 SNP and T1DM in a Southern Brazilian population.Methods: This case-control study comprised 478 patients with T1DM and 518 non-diabetic subjects. The rs2304256 (C/A) SNP was genotyped by real-time polymerase chain reaction technique using TaqMan minor groove binder (MGB) probes.Results: Genotype and allele frequencies of the rs2304256 SNP differed between T1DM patients and non-diabetic subjects (P<0.0001 and P=0.001, respectively). Furthermore, the A allele was associated with protection against T1DM under recessive (odds ratio [OR], 0.482; 95% confidence interval [CI], 0.288 to 0.806) and additive (OR, 0.470; 95% CI, 0.278 to 0.794) inheritance models, adjusting for human leukocyte antigen (HLA) DR/DQ genotypes, gender, and ethnicity.Conclusion: The A/A genotype of TYK2 rs2304256 SNP is associated with protection against T1DM in a Southern Brazilian population.
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