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        • Knowledge about Cervical Cancer Risk Factors and Pap Smear Testing Behavior among Female Primary Health Care Workers: A Study from South Turkey

          Coskun,,Savas,Can,,Huseyin,Turan,,Sercan Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

          Background: Cervical cancer is one of the ten most frequent cancers in Turkey. We here examined knowledge about cervical cancer in relation to Papanicolaou (Pap) testing among female primary health care workers in Hatay, a city is located in the south of Turkey. Materials and Methods: The study was completed on 261 women healthcare workers who were or had been sexually active and who accepted to participate to the study. The participants gave verbal informed consent and thereafter questionnaires prepared by the investigators were administered by personal interview. Results: Only 30.3% (n=79) of the participants regularly had a gynecologic examination. While 87.4% (n=228) of the participants reported that they had already heard about the Pap smear test, only 45.2% (n=118) had undergone this test. It was determined that had undergone an average of $1.66{\pm}0.89$ times (1-4) within the last five years. Some 56.0% (n=117) of the participants were well informed about the Pap smear test (p<0,001) and 81.1% (n=63) of the participants who regularly had gynecological examinations (p<0,001) had this test. Conclusions: For the early diagnosis of the cervical cancer, regularly having a Pap smear test is crucial. Healthcare workers should also demonstrate sensitivity about this issue. We think that the importance of the issue should be re-highlighted by organizing in-service training for female primary healthcare workers. Studies are warranted to determine the psychosociological factors that cause individuals to not have the test.

        • SCIESCOPUSKCI등재후보

          Response of a finite beam on a tensionless Pasternak foundation under symmetric and asymmetric loading

          Coskun,,Irfan,Engin,,Hasan,Ozmutlu,,Aydin Techno-Press 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.30 No.1

          The static response of a finite beam resting on a tensionless Pasternak foundation and subjected to a concentrated vertical load is assessed in this study. The concentrated vertical load may be applied at the center of the beam, or it may be offset from the center. The tensionless character of the foundation results in the creation of lift-off regions between the beam and the foundation. An analytical/ numerical solution is obtained from the governing equations of the contact and lift-off regions to determine the extent of the contact region. Although there is no nonlinear term in the equations, the problem shows a nonlinear character since the contact region is not known in advance. Due to that nonlinearity, the essentials of the problem (the coordinates of the lift-off points) are calculated numerically using the Newton-Raphson technique. The numerical results are presented in figures to illustrate the behaviours of the free-free and pinned-pinned beams under symmetric or asymmetric loading. The figures illustrate the effects of the shear foundation parameter and the symmetric and asymmetric loading options on the variation of the contact lengths and the displacement of the beam.

        • SCIESCOPUSKCI등재

          Free Fatty Acid Accumulation by Mesophilic Lactic Acid Bacteria in Cold-Stored Milk

          Coskun,,Hayri,Ondul,,Eda The Microbiological Society of Korea 2004 The journal of microbiology Vol.42 No.2

          This study was aimed to determine the accumulation of free fatty acid by mesophilic lactic acid bac-teria (Lactococcus lactis subsp. lactis 1471, Lactococcus lactis subsp. cremoris 1000 and Lactobacillus casei 111) in cold-stored milk. According to the results, all cold-stored milks had higher acid degree val-ues than those of fresh milk. This phenomenon showed that a slight increase occurred in the accumulation of free fatty acids as a result of spontaneous lipolysis during cold storage. All lactic acid bacteria showed good performance in production of titratable acidity, which increased during fermentation of the milk (fresh and stored milks). Moreover, as the storage time was prolonged, more free fatty acid accumulation was obtained from the fermentation of the cold-stored milk by the investigated lactic acid bacteria. The control milk, which was without lactic acid bacteria, showed no change in the accumulation of free fatty acid during fermentation. From this result, it can be suggested that longer cold-storage time can induce higher free fatty acid accumulation in milk by lactic acid bacteria.

        • SCOPUSSCIEKCI등재

          Three-dimensional assessment of the temporomandibular joint and mandibular dimensions after early correction of the maxillary arch form in patients with Class II division 1 or division 2 malocclusion

          Coskuner,,Hande,Gorucu,Ciger,,Semra The Korean Association Of Orthodontists 2015 대한치과교정학회지 Vol.45 No.3

          Objective: This study aimed to assess three-dimensional changes in the temporomandibular joint positions and mandibular dimensions after correction of dental factors restricting mandibular growth in patients with Class II division 1 or division 2 malocclusion in the pubertal growth period. Methods: This prospective clinical study included 14 patients each with Class II division 1 (group I) and Class II division 2 (group II) malocclusions. The quad-helix was used for maxillary expansion, while utility arches were used for intrusion (group I) or protrusion and intrusion (group II) of the maxillary incisors. After approximately 2 months of treatment, an adequate maxillary arch width and acceptable maxillary incisor inclination were obtained. The patients were followed for an average of 6 months. Intraoral and extraoral photographs, plaster models, and cone-beam computed tomography (CBCT) images were obtained before and after treatment. Lateral cephalometric and temporomandibular joint measurements were made from the CBCT images. Results: The mandibular dimensions increased in both groups, although mandibular positional changes were also found in group II. There were no differences in the condylar position within the mandibular fossa or the condylar dimensions. The mandibular fossa depth and condylar positions were symmetrical at treatment initiation and completion. Conclusions: Class II malocclusion can be partially corrected by achieving an ideal maxillary arch form, particularly in patients with Class II division 2 malocclusion. Restrictions of the mandible in the transverse or sagittal plane do not affect the temporomandibular joint positions in these patients because of the high adaptability of this joint.

        • SCIESCOPUSKCI등재

          Dynamic response of a Timoshenko beam on a tensionless Pasternak foundation

          Coskun,,Irfan,Engin,,Hasan,Tekin,,Ayfer Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.37 No.5

          The dynamic response of a Timoshenko beam on a tensionless Pasternak foundation is investigated by assuming that the beam is subjected to a concentrated harmonic load at its middle. This action results in the creation of lift-off regions between the beam and the foundation that effect the character of the response. Although small displacements for the beam and the foundation are assumed, the problem becomes nonlinear since the contact/lift-off regions are not known at the outset. The governing equations of the beam, which are coupled in deflection and rotation, are obtained in both the contact and lift-off regions. After removing the coupling, the essentials of the problem (the contact regions) are determined by using an analytical-numerical method. The results are presented in figures to demonstrate the effects of some parameters on the extent of the contact lengths and displacements. The results are also compared with those of Bernoulli-Euler, shear, and Rayleigh beams. It is observed that the solution is not unique; for a fixed value of the frequency parameter, more than one solution (contact length) exists. The contact length of the beam increases with the increase of the frequency and rotary-inertia parameters, whereas it decreases with increasing shear foundation parameter.

        • KCI등재SCOPUS

          Dynamic contact response of a finite beam on a tensionless Pasternak foundation under symmetric and asymmetric loading

          Coskun,,Irfan Techno-Press 2010 Structural Engineering and Mechanics, An Int'l Jou Vol.34 No.3

          The dynamic response of a finite Bernoulli-Euler beam resting on a tensionless Pasternak foundation and subjected to a concentrated harmonic load is investigated in this study. This load may be applied at the center of the beam, or it may be offset from the center. Since the elastic foundation is assumed to be tensionless, the beam may lift off the foundation, resulting in contact and non-contact regions in the system. An analytical/numerical solution is obtained from the governing equations of the contact and non-contact regions to determine the coordinates of the lift-off points. Although there is no nonlinear term in the equations, the problem appears to be nonlinear since the contact regions are not known in advance. Due to that nonlinearity, the essentials of the problem (the coordinates of the lift-off points) are calculated numerically using the Newton-Raphson technique. The results, which represent the symmetric and asymmetric responses of the beam, are presented graphically in this work. They illustrate the effects of the forcing frequency and the beam length on the extent of the contact regions and displacements.

        • KCI등재SCOPUS

          Response of a finite beam on a tensionless Pasternak foundation under symmetric and asymmetric loading

          Irfan,Coskun,Hasan,Engin,Ayd,n,Özmutlu 국제구조공학회 2008 Structural Engineering and Mechanics, An Int'l Jou Vol.30 No.1

          The static response of a finite beam resting on a tensionless Pasternak foundation and subjected to a concentrated vertical load is assessed in this study. The concentrated vertical load may be applied at the center of the beam, or it may be offset from the center. The tensionless character of the foundation results in the creation of lift-off regions between the beam and the foundation. An analytical/ numerical solution is obtained from the governing equations of the contact and lift-off regions to determine the extent of the contact region. Although there is no nonlinear term in the equations, the problem shows a nonlinear character since the contact region is not known in advance. Due to that nonlinearity, the essentials of the problem (the coordinates of the lift-off points) are calculated numerically using the Newton-Raphson technique. The numerical results are presented in figures to illustrate the behaviours of the free-free and pinned-pinned beams under symmetric or asymmetric loading. The figures illustrate the effects of the shear foundation parameter and the symmetric and asymmetric loading options on the variation of the contact lengths and the displacement of the beam.

        • KCI등재후보SCOPUS

          Obesity does not affect the number of retrieved lymph nodes and the rate of intraoperative complications in gynecologic cancers

          Mehmet,Coskun,Alp,Usubutun,Tulay,Ozlu,Kubra,Boynukalin,Kunter,Yuce 대한부인종양학회 2010 Journal of Gynecologic Oncology Vol.21 No.1

          Objective: Lymphadenectomy, in general, is a safe and well-tolerated procedure in gynecologic oncology. However,some technical difficulties may be experienced in obese women which may result in inadequate lymphadenectomy and increased complications. The purpose of this study is to retrospectively evaluate the effect of obesity on lymph node counts retrieved and complication rates observed during lymphadenectomy in gynecologic cancers. Methods: Patients with ovarian, endometrial or cervical cancers treated with initial surgery including bilateral pelvic and paraaortic lymph node dissection were grouped as non-obese and obese. These two groups were compared in terms of the number of retrieved lymph nodes and the rate of intraoperative complications directly related to lymph node dissection. Results: One hundred twenty-three patients were eligible with a mean age of 55.1 years and mean body mass index of 29.2 kg/m2. Fifty-nine patients were obese while 64 were non-obese. Lymph node counts obtained in different stations and in total were similar among non-obese and obese patients. Rates of lymphadenectomy-related intraoperative complications including vascular, neural, intestinal, and bladder injury were also similar in non-obese and obese patients. Conclusion: The obesity does not affect the lymph node counts and intraoperative complication rates adversely in women with gynecologic cancers. Therefore, adequate lymph node dissection should not be omitted based solely upon obesity in gynecologic oncology patients.

        • KCI등재후보SCOPUS

          Comparison of WHO and endometrial intraepithelial neoplasia classifications in predicting the presence of coexistent malignancy in endometrial hyperplasia

          Mehmet,Coskun,Salman,Alp,Usubutun,Kubra,Boynukalin,Kunter,Yuce 대한부인종양학회 2010 Journal of Gynecologic Oncology Vol.21 No.2

          Objective: The most commonly used classification system for endometrial hyperplasia is the World Health Organization system which is based on subjective criteria. Another classification system is endometrial intraepithelial neoplasia (EIN) system which uses diagnostic criteria including cytological demarcation, crowded gland architecture,minimum size of 1 mm, and careful exclusion of mimics, and aims to identify a precancer or cancer. The objective of this study was to compare the two classification systems in terms of predicting the presence of a coexistent cancer in surgically treated patients. Methods: Biopsy and hysterectomy specimens of 49 women who were subjected to surgery with a preoperative diagnosis of endometrial hyperplasia (EH) according to the WHO system were re-evaluated retrospectively by using EIN system. Results: Among the 49 patients, 69.4% had complex atypical EH and 75.5% had EIN at biopsy specimens. EIN was detected in 94.1% of complex atypical EH, and 41.7% of non-atypical EH. Nine women (18.4%) had endometrial cancer. Among women with cancer, all had complex atypical EH or EIN. The rate of coexistent endometrial cancer was 26.5% in women with complex atypical EH and 24.3% in women with EIN. Conclusion: Diagnoses of atypical or complex atypical EH and EIN had similar sensitivities and negative predictive values in predicting the coexistent endometrial cancer. Either of these two classification systems may be used safely when an experienced pathologist is available. However, use of the objective EIN system may be preferred whenever possible to prevent diagnostic errors in centers where an experienced pathologist is not available.

        • KCI등재SCOPUS

          Psychiatric Co-morbidity and Efficacy of Mirtazapine Treatment in Young Subjects With Chronic or Cyclic Vomiting Syndromes: A Case Series

          ( Murat Coskun ), ( Behiye Alyanak ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2011 Journal of Neurogastroenterology and Motility (JNM Vol.17 No.3

          The aim of this case report was to evaluate the psychiatric co-morbidity and efficacy of mirtazapine treatment in young subjects with chronic or cyclic vomiting syndromes. This is a case series of 8 young subjects (age range of 6-16 years, 11.12 ± 3.52 years) who were referred or consulted to child psychiatry department. They were referred or consulted by pediatric gastroenterology or surgery departments for the presence of non-remitting and medically unexplained vomiting. They were investigated for co-morbid psychiatric disorders using a structured psychiatric interview. An open trial of mirtazapine was conducted for the treatment and/or prevention of vomiting. Primary outcome measure was Clinical Global Impression-Improvement scale. Subjects were diagnosed with chronic (n = 5) or cyclic (n = 3) vomiting syndromes. Duration of vomiting ranged from 6 months to 10 years (3.5 ± 3.2 years). All subjects received multiple psychiatric diagnoses with anxiety disorders being the most frequent. Maximum mirtazapine dosage was 7.5-30 mg/day (16.00 ± 6.16 mg/day). Three subjects showed complete remission and 5 subjects showed much to very much improvement in vomiting. Most frequent side effects were increased appetite, weight gain and sedation. Young subjects with chronic or cyclic vomiting may frequently suffer anxiety and/or depressive symptoms or disorders. Mirtazapine could be an effective treatment option for the treatment of vomiting and co-morbid anxiety or depressive disorders in these subjects. More systematic research are needed on this topic.

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