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Jo, Yun Kee,Choi, Bong-Hyuk,Zhou, Cong,Ahn, Jin-Soo,Jun, Sang Ho,Cha, Hyung Joon The Royal Society of Chemistry 2015 Journal of Materials Chemistry B Vol.3 No.41
<P>Successful titanium implantation strongly depends on early fixation through an osseointegration between the titanium fixture and adjacent bone tissue. From a clinical perspective, rapid recruitment of functional biomolecules from the blood and osteogenic cell binding is critical for osseointegration immediately after implant insertion. Thus, surface modifications aiming to improve the interactions between the blood and implant and to enhance the binding of osteogenic cells onto the implant surface can contribute to successful osseointegration. Mussel adhesive proteins (MAPs) derived from marine mussels have been considered as promising bioadhesives that have strong adhesion and coating abilities onto organic and inorganic surfaces, even in wet environments. Here, we investigated the<I>in vitro</I>and<I>in vivo</I>osteostimulating ability of the bioengineered mussel glue MAP-RGD, which is a recombinant MAP fused with an Arg-Gly-Asp (RGD) peptide, an effective cell recognition motif for activating intracellular signaling pathways, using a titanium mesh (Ti-mesh) as a model titanium implant. We found that the<I>in vitro</I>cell behaviors of pre-osteoblast cells, such as attachment, proliferation, spreading, and osteogenic differentiation, increased significantly on the MAP-RGD-coated Ti-mesh surface.<I>In vitro</I>blood responses including blood wetting, blood clotting, and platelet adhesion were also highly enhanced on the MAP-RGD-coated surface. Importantly, implantation of the MAP-RGD-coated Ti-mesh resulted in a remarkable acceleration of<I>in vivo</I>bone regeneration and maturation of a new bone in a rat calvarial defect. Consequently, the bioengineered mussel glue can be successfully utilized as an osteostimulating bone bioadhesive for titanium implant applications with further expansion to general bone tissue engineering.</P>
Pham-Cong, De,Choi, Jun Hee,Yun, Jeongsik,Bandarenka, Aliaksandr S.,Kim, Jinwoo,Braun, Paul V.,Jeong, Se Young,Cho, Chae Ryong American Chemical Society 2017 ACS NANO Vol.11 No.1
<P>As potential high-performance anodes for Li-ion batteries (LIBs), hierarchical heteronanostructures consisting of TiNb2O7 nanofibers and ultrathin MoS2 nanosheets (TNO@MS HRs) were synthesized by simple electrospinning/hydrothermal processes. With their growth mechanism revealed, the TNO@MS HRs exhibited an entangled structure both for their ionic and electronic conducting pathways, which enabled the synergetic combination of one-and two-dimensional structures to be realized. In the potential range of 0.001-3 V vs Li/Li+, the TNO@MS HR-based LIBs exhibited high capacities of 872 and 740 mAh g(-1) after 42 and 200 cycles at a current density of 1 A g(-1), respectively, and excellent rate performance of 611 mAh g(-1) at 4 A g(-1). We believe that the fabrication route of TNO@MS HRs will find visibility for the use of anode electrodes for high capacity LIBs at low cost.</P>
Predictive Tile Selection for 360-Degree VR Video Streaming in Bandwidth-Limited Networks
Nguyen, Thanh Cong,Yun, Ji-Hoon IEEE 2018 IEEE communications letters Vol.22 No.9
<P>To stream 360-degree video bandwidth-efficiently to virtual reality users, only a subset of a video’s spatial tiles corresponding to the current viewport of a user can be transferred, but tile selection is challenging since a user’s viewport keeps moving over time. In this letter, we find that the error distribution of fixation point prediction is formally derived as a normal distribution. Based on this theoretical finding, the region where a user’s future viewport is likely to reside with a given confidence level is obtained in a closed form and the proposed algorithm selects tiles covering the region.</P>
A methodology for design of metallic dampers in retrofit of earthquake-damaged frame
Chao Zhang,Yun Zhou,De H. Lu,Cong X. Wu,Da G. Weng 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.56 No.4
A comprehensive methodology is proposed for design of metallic dampers in seismic retrofit of earthquake-damaged frame structures. It is assumed that the metallic dampers remain elastic and only provide stiffness during frequent earthquake (i.e., earthquake with a 63% probability of exceedance in 50- year service period), while in precautionary earthquake (i.e., earthquake with a 10% probability of exceedance in 50-year service period), the metallic dampers yield before the main frame and dissipate most of the seismic energy to either prevent or minimize structural damages. Therefore by converting multi-story frame to an equivalent single-degree-of-freedom system, the added stiffness provided by metallic dampers is designed to control elastic story drifts within code-based demand under frequent earthquake, and the added damping with the combination of added stiffness influences is obtained to control structural stress within performance-based target under precautionary earthquake. With the equivalent added damping ratio, the expected damping forces provided by metallic dampers can be calculated to carry out the configuration and design of metallic dampers along with supporting braces. Based on a detailed example for retrofit of an earthquake-damaged reinforced concrete frame by using metallic dampers, the proposed design procedure is demonstrated to be simple and practical, which can not only meet current China’s design codes but also be used in retrofit design of earthquake-damaged frame with metallic damper for reaching desirable performance objective.