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- 저자 : Clelia (검색결과 5 건)
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Clelia Callegari,Paola Algeri,Antonella Buzzi,Teresio Motta,Cinzia Manfredini,Sonia Maria Rota 대한산부인과학회 2019 Obstetrics & Gynecology Science Vol.62 No.6
Endometrial glassy cell carcinoma (EGCC) is a rare neoplasm, accounting for 0.5% of the carcinomas in theendometrium, composed of cells with granular eosinophilic or amphophilic cytoplasm, giving it a ground glassappearance. Till date, only 14 cases of this carcinoma have been reported. In this report, we have described a caseof EGCC to help define standard diagnostic criteria and better understand the course, ideal treatment, and accurateprognosis of this disease. We report a case of a 64-year-old woman diagnosed with EGCC after an abnormal papsmear. She underwent a hysteroscopy, which led to the histological diagnosis. Laparotomic total hysterectomy andbilateral salpingo-oophorectomy were performed with pelvic lymphadenectomy and peritoneal and omental biopsies. Final pathological examination confirmed the initial diagnosis. Pelvic nodes removed during surgery and peritonealand omental biopsies were negative for tumor cells. Treatment was considered appropriate and the patient did notrequire additional therapies. She was subsequently assigned to clinical follow-up and is alive, with no evidence of thedisease.
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Giuseppe Valacchi,Giuseppe Belmonte,Clelia Miracco,Hyeyoon Eo,Yunsook Lim 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.1
Obesity is an epidemic disease characterized by an increased inflammatory state and chronic oxidative stress with high levels of pro-inflammatory cytokines and lipid peroxidation. Moreover, obesity alters cholesterol metabolism with increases in low-density lipoprotein (LDL) cholesterols and triglycerides and decreases in high-density lipoprotein (HDL) cholesterols. It has been shown that mulberry leaf and fruit ameliorated hyperglycemic and hyperlipidemic conditions in obese and diabetic subjects. We hypothesized that supplementation with mulberry leaf combined with mulberry fruit (MLFE) ameliorate cholesterol transfer proteins accompanied by reduction of oxidative stress in the high fat diet induced obesity. Mice were fed control diet (CON) or high fat diet (HF) for 9 weeks. After obesity was induced, the mice were administered either the HF or the HF with combination of equal amount of mulberry leaf and fruit extract (MLFE) at 500mg/kg/day by gavage for 12 weeks. MLFE treatment ameliorated HF induced oxidative stress demonstrated by 4-hydroxynonenal (4-HNE) and modulated the expression of 2 key proteins involved in cholesterol transfer such as scavenger receptor class B type 1 (SR-B1) and ATP-binding cassette transporter A1 (ABCA1) in the HF treated animals. This effect was mainly noted in liver tissue rather than in cutaneous tissue. Collectively, this study demonstrated that MLFE treatment has beneficial effects on the modulation of high fat diet-induced oxidative stress and on the regulation of cholesterol transporters. These results suggest that MLFE might be a beneficial substance for conventional therapies to treat obesity and its complications.
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Phytochemical Composition and Antioxidant Activity of Laurus nobilis L. Leaf Infusion
Dall'Acqua, Stefano,Cervellati, Rinaldo,Speroni, Ester,Costa, Stefano,Guerra, Maria Clelia,Stella, Laura,Greco, Emanuela,Innocenti, Gabbriella The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.4
Laurus nobilis L. (laurel) leaves are frequently used as a spice for cooking purposes. Folk medicine in many countries uses the infusion of the plant in stomachic and carminative remedies, as well as for the treatment of gastric diseases. Little information is available about the phytochemical composition of the infusion of dried leaves, which is a way to consume this aromatic and medicinal plant. Phytochemical investigations on the infusion were performed by high-performance liquid chromatography (HPLC) with a diode array detector (DAD) and direct electrospray ionization-tandem mass spectrometry. Several flavonoid derivatives were detected. Semipreparative HPLC from the infusion of laurel leaves isolated 10 flavonoid O-glycosides, one flavonoid C-glycoside, catechin, and cinnamtannin B1. Structures of the isolated compounds were computed on the basis of spectral measurements including high-resolution mass spectrometry spectroscopy and one- and twodimensional nuclear magnetic resonance techniques. The amount of the flavonoids was also determined by HPLC-DAD. The antioxidant activity of the tea and the isolated compounds was also measured using two different in vitro methods: the Briggs-Rauscher oscillating reaction test, at a pH similar to that of the gastric juice, and the Trolox equivalent antioxidant capacity assay, at the pH of blood. For the infusion and the methanol extract the total phenolic content was also measured using the Folin-Ciocalteu reagent.
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Gastroprotective Effect and Antioxidant Properties of Different Laurus nobilis L. Leaf Extracts
Ester Speroni,Rinaldo Cervellati,Stefano Dall’Acqua,Maria Clelia Guerra,Emanuela Greco,Paolo Govoni,Gabbriella Innocenti 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.5
Laurus nobilis L. (Family Lauraceae) is an evergreen tree widely distributed in the Mediterranean area and Europe. It is used in folk medicine of different countries as a stomachic and carminative as well as in treatment of gastric diseases. Extracts obtained with different methods (methanol and chloroform) from laurel leaves were evaluated for their gastroprotective activities in the rat. The antioxidant capacity of the different extracts has been also measured in vitro. In order to confirm the activities investigated, histological observations were performed. The gastric damage was significantly reduced by all extracts administered. The more effective protection was produced by chloroformic and methanolic crude extracts. The results obtained after oral administration of L. nobilis leaf extracts are in good agreement with their antioxidant capacity, confirming the relationship between pharmacological efficacy and antiradical activity. Histological evidences confirm the results evaluated with the animal procedures.
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Phytochemical Composition and Antioxidant Activity of Laurus nobilis L. Leaf Infusion
Stefano Dall'Acqua,Rinaldo Cervellati,Ester Speroni,Stefano Costa,Maria Clelia Guerra,Laura Stella,Emanuela Greco,Gabbriella Innocenti 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.4
Laurus nobilis L. (laurel) leaves are frequently used as a spice for cooking purposes. Folk medicine in many countries uses the infusion of the plant in stomachic and carminative remedies, as well as for the treatment of gastric diseases. Little information is available about the phytochemical composition of the infusion of dried leaves, which is a way to consume this aromatic and medicinal plant. Phytochemical investigations on the infusion were performed by high-performance liquid chromatography (HPLC) with a diode array detector (DAD) and direct electrospray ionization-tandem mass spectrometry. Several flavonoid derivatives were detected. Semipreparative HPLC from the infusion of laurel leaves isolated 10 flavonoid O-glycosides, one flavonoid C-glycoside, catechin, and cinnamtannin B1. Structures of the isolated compounds were computed on the basis of spectral measurements including high-resolution mass spectrometry spectroscopy and one- and two-dimensional nuclear magnetic resonance techniques. The amount of the flavonoids was also determined by HPLC-DAD. The antioxidant activity of the tea and the isolated compounds was also measured using two different in vitro methods: the Briggs-Rauscher oscillating reaction test, at a pH similar to that of the gastric juice, and the Trolox equivalent antioxidant capacity assay, at the pH of blood. For the infusion and the methanol extract the total phenolic content was also measured using the Folin-Ciocalteu reagent.
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