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Patricia Cincotto dos Santos Bueno,Sandra Maria Barbalho,Elen Landgraf Guiguer,Maricelma da Silva Soares de Souza,Isabela Ramos Arau´jo de Medeiros,Isabella Vasconcelos Zattiti,Manuela dos Santos Buen 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.12
Studies have shown that the consumption of a diet containing whole grains may improve metabolic homeostasis and is related to the reduction of risk factors for the development of obesity, diabetes, cardiovascular diseases, and cancer. We aimed to investigate the effects of Triticum aestivum and Triticum turgidum on the metabolic profile of Wistar rats. Animals were divided into G1 (control group), G2 (T. turgidum), and G3 (T. aestivum). Anthropometric and biochemical parameters were evaluated after 45 days of treatment with both types of wheat. Our results showed that the use of the common or green wheat improved body weight percentage, visceral fat, glycemia, low-density lipoprotein cholesterol, triglycerides, and atherogenic indices such as atherogenic index, CCR1, and CCR2. Furthermore, wheat may also improve high-density lipoprotein cholesterol levels. The health-promoting properties of wheat occur probably due to the content of phytochemicals, antioxidants, and fibers. We suggest that the intake of T. aestivum and T. turgidum may be helpful in the prevention or treatment of obesity, diabetes and cardiovascular diseases.
Antidiabetic and Antilipidemic Effects of Manilkara zapota
Sandra Maria Barbalho,Patrı´cia Cincotto dos Santos Bueno,De´bora Souza Delazari,Elen Landgraf Guiguer,,Daniel Pereira Coqueiro,Adriano Cressoni Arau´jo,Maricelma da Silva Soares de Souza,Fla´via M.V. 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.3
Manilkara zapota is a tropical evergreen tree belonging to the Sapotaceae family; its parts are used in alternative medicine to treat coughs and colds and possess diuretic, antidiarrheal, antibiotic, antihyperglycemic, and hypocholesterolemic effects. There are no studies on metabolic profile after using the fruit, and this study aimed at evaluating the effects of the leaf and pulp of M. zapota fruit on the metabolic profile of Wistar rats. Male rats were treated for 50 days with M. zapota leaf juice or fruit juice, after which their biochemical and body composition profiles were analyzed (glycemia, triglycerides, high-density lipoprotein cholesterol (HDL-c), insulin, leptin, aspartate transaminase, alanine aminotransferase, Lee Index, and body mass index). Our results indicate significantly lower levels of glycemia, insulin, leptin, cholesterol, and triglycerides and augmented levels of HDL-c in animals treated with the leaves or fruit of this plant. The percentage of weight gain also declined in animals treated with M. zapota fruit pulp. The use of the M. zapota may be helpful in the prevention of obesity, diabetes, dyslipidemia, and their complications.
Annona montana Fruit and Leaves Improve the Glycemic and Lipid Profiles of Wistar Rats
Sandra Maria Barbalho,Maricelma da Silva Soares de Souza,Patrı´cia Cincotto dos Santos Bueno,Elen Landgraf Guiguer,,Fla´via Maria Vasques Farinazzi-Machado,Adriano Cressoni Arau´jo,Carla Omete Menegui 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.10
Species of the family Annonaceae has been used traditionally as a medicinal plant in tropical regions of South and North America and in Africa. Annona montana is known popularly as false graviola and originates from tropical America and can be cultivated throughout Brazil. There are no studies in the literature that associate A. montana with the metabolic profile of animals. Therefore, the purpose of this work was to assess the effects of the consumption of pulp and leaves of this plant on the metabolic profile of Wistar rats. The animals, which were treated for 40 days, were divided into two control groups—treated with water via gavage and ad libitum, respectively, and two treated groups—one treated with leaf juice and the other with pulp juice of the fruit. Glycemia, lipids, and body weight were found to decrease and high density lipoprotein-cholesterol (HDL-c) levels to increase in the animals treated with leaf juice. The group treated with pulp juice showed a reduction in lipids and augmented HDL-c. The use of A. montana may have beneficial effects in the prevention of diabetes mellitus and dyslipidemia and may thus contribute to the prevention of cardiovascular diseases.
Pereskia aculeata Miller Flour: Metabolic Effects and Composition
Sandra Maria Barbalho,Elen Landgraf Guiguer,Paulo Sergio Marinelli,Patrı´cia Cincotto do Santos Bueno,Leticia Maria Pescinini-Salzedas,Mirele Cristine Batista dos Santos,Marie Oshiiwa,Claudemir Gregor 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.9
Pereskia aculeata Miller is known in Brazil as ora-pro-nobis (OPN) and has been used commonly in the folklore medicine. The purpose of our study was to evaluate the composition and the effects of OPN flour on the metabolic profile and intestinal motility of Wistar rats. Animals were divided randomly into five groups (n = 10): G1 (control group) and G2 (treated with OPN flour). For the intestinal motility: G3 (control group), G4 (treated with senne), and G5 (treated with OPN flour). After 40 days, G1 and G2 were euthanized and metabolic profiles were analyzed (glycemia, cholesterol, triglycerides, high density lipoprotein [HDL-c], C reactive protein, AST, ALT, Lee Index, weight, and visceral fat). The flour of OPN was effective in reducing percentage of weight gain, visceral fat, levels of total cholesterol, triglycerides, low density lipoprotein, very low density lipoprotein, and increased HDL-c. Significance was also found in the distance covered by the activated charcoal from the pylorus to the beginning of the cecum, which was higher in animals treated with OPN. Our results indicate that OPN flour may bring health benefits, as the improvement of the intestinal motility, and it is associated with reduction of visceral fat and lipid profile, as well as the increase of HDL-c levels. With these results, we may suggest that the incorporation of this flour in different industrial products may be a convenient and effective way for the intake of healthier products.
Cleber da Silveira Torres,Francisnaira da Silva Santos,Elen Landgraf Guiguer,Adriano Cressoni de Araujo,Sandra Maria Barbalho,Patricia Cincotto dos Santos Bueno,Maricelma Silva Soares de Souza,Danilo 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.1
Morinda citrifolia (MC) and Annona muricata (AM) are popularly used for the treatment of several diseases, including cancer. Our objective was to evaluate the effects of the juice of the MC fruit, and the ethanolic extract of AM leaves on Erhlich tumor cells, in mice and in vitro fibroblastic cells. The animals were divided into G1 and G2: controls; G3: treated with AM, and G4 juice: treated with MC. The animals were subjected to intraperitoneal inoculation of 103 tumor cells and then treated with the plants. G1 and G2 received a saline solution. Cells were grown in RPMI 1640 medium, supplemented with 10% fetal bovine serum, and maintained at 37°C in 5% CO2 atmosphere. After growth, the cells were trypsinized and incubated again. Subsequently, serial dilution of extracts and juice was performed and incubated again for 48 h. We evaluated the ascites growth, the survival rate, and cytotoxicity in fibroblast cells. AM and MC did not interfere in the ascites pattern. MC, but not AM showed significance in the survival rate. Both AM and MC produced cytotoxicity activity in T3T cells. Despite advances in medicine, cancer is still one of the leading causes of death in the world and traditional medications are not always effective. The use of MC may bring beneficial effects to patients since they interfere with different mechanisms of action during carcinogenesis. However, we suggest that further investigations should be performed.
Victor Myung Joon Bang,Ana Luisa de Carvalho Arana˜o,Bruna Zampieri Nogueira,Adriano Cressoni Arau´jo,Patricia Cincotto dos Santos Bueno,Sandra Maria Barbalho,Maricelma da Silva Soares de Souza,Elen L 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.10
Adaptogen-based plant formulations play an important role in traditional medicine and have been used in medical practice to increase the resistance of individuals. Rhodiola rosea (RR) and Panax ginseng (PG) exhibit adaptogenic properties and are related to the recovery of homeostasis and strengthen systems impaired by stress. This study aimed to evaluate the effects of RR and PG on metabolic profile and muscle damage parameters in Wistar rats submitted to swimming. Animals were divided according to the following: G1: control group; G2: group that was submitted to swimming; G3: group treated with PG; G4: group treated with PG and submitted to swimming; G5: treated with RR; and G6: treated with RR and submitted to swimming. At the end of the experimental protocol, groups G2, G4, and G6 practiced swimming for a period five times longer than during the previous 30 days. Anthropometric and biochemical parameters were investigated, and no significant results were found in the groups. Nevertheless, animals treated with PG and RR reduced the levels of creatine phosphokinase (CPK) and lactic dehydrogenase (LDH). Our findings demonstrate that both PG and RR produced a significant reduction in the levels of CPK and LDH after physical stress, suggesting that they can be used to improve physical performance. For these reasons, we may say that these plants may be used to minimize the stress promoted by the practice of physical exercises.
Henrique Bosso,Giovanna Emanuella Piffer Soares Arantes,Sandra Maria Barbalho,Elen Landgraf Guiguer,Maricelma da Silva Soares de Souza,Patrıcia Cincotto dos Santos Bueno,Agnaldo Bruno Chies,Priscilla 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.4
Many studies have shown that plants can be therapeutic alternatives in the prevention or treatment of various diseases. Among these, green coffee may present different pharmacological effects related to the regulation of glycemia and lipid metabolism and is related to the prevention of cardiovascular diseases. The objective of our study was to evaluate the effects of using green and ripe coffee on the metabolic profile and muscular enzymes after the practice of physical exercises in Wistar rats. We included six groups: G1 (control group), G2 (group submitted to swimming), G3 (group that consumed green coffee), G4 (group that consumed green coffee and was submitted to swimming), G5 (group that consumed ripe coffee), and G6 (group that consumed ripe coffee and was submitted to swimming). Our results showed that there was a significant reduction in the percentage of visceral fat in G3, G5, and G6. We did not observe significant modifications in glycemia, lipids, lactate dehydrogenase, ferric reducing ability of plasma, and ferric-xylenol orange. The levels of creatine phosphokinase showed a reduction in the groups G2 and G4. No significant differences were found in the atherogenic indices. There is a global demand for natural compounds that can be safe, cheap, related to minimum side effects, and provide health benefits. Our results show that the use of green or ripe coffee may contribute to reduce the percentage of visceral fat and consequently may protect against further complications once this tissue produces proatherogenic hormones. Furthermore, green coffee may play a role in protecting muscle injury after the practice of physical exercises.