위암환자의 복강내에 투여한 Mitomycin C-Carbon Particle의 Mitomycin 용출에 관한 연구

노승무,조영훈,정경수,오정연,김진향,양준묵,강대영,송규상,조준식,최선웅,이진호,민병무,김용백,김창식,박근성,인현빈,정현용,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Locoregional recurrence is the most common type of recurrence in surgical operation of gastric adenocarcinoma, and peritoneal dissemination is one of the most difficult problems in advanced gastric adenocarcinoma treatment. Because the peritoneal cavity is the most common site of the first recurrence after gastric cancer resection, intraperitoneal chemotherpy seems a logical choice for cancer chemotherapy. The Mitomycin C(MMC) adsorbed by the activated charcoal particles(CH) is relatively released when the drug concentration surrounding the carbon particles becomes low in the peritoneum of the peritoneal cavity. For the intraperitoneal chemotherapy on the advanced gastric adenocarcnoma, mitomycin C adsorbed on activated carbon particles was administered in the peritoneal cavity just before abdominal wall closure. The closed drainage tubes were inserted in the peritoneal cavity and clamped for tuo hours after completion of operation. MMC concentrations were serially measured in peritoneal fluid, plasma and urine at 2hour, 48 hour, 72 hour and 168 hour following its administration in order to study the efficacy of the MMC-CH as a drug delivery system. There were minimal toxicities in born marrow, liver, and gastrointestinal system after intraperitoneal MMC-CH administration. The data of this study suggested that MMC-CH may have a somewhat more beneficial effect than surgery alone when administered in optimal dose and schedules, but the MMC concentration of the peritoneal fluid was not sufficient to eradicate remnant cancer cells, and effective duration of maintenance was only below 24 hours in the peritoneal fluid and plasma.

PMDA-ODA 폴리이미드의 합성 및 특성에 관한 연구

정용재,한태성,최성부,남석태,김병식 동국대학교 산업기술연구원 1996 산업기술논문집 Vol.8 No.-

Pyromellitic dianhydride(PMDA) 와 Oxydianiline(ODA)를 N, N-dimethylacetamide (DMAc)에 녹여 Polyamic acid(PAA)를 2단계 열이미드화법으로 제조하였다. 제조된 폴리이미드 막의 이미드화도는 FT-IR에 의하여 분석되었다. 또한 PAA의 농도를 10~30wt%로 변화시키며 합성하여 열이미드화 시킨 후 농도에 따른 단면의 상태를 SEM사진을 통하여 관찰하였다. 농도 변화에 따른 밀도와 T_g의 변화는 혼합액체부상법과 DSC로 분석되었다. 열처리 온도를 증가시킬수록 이미드화도는 증가되었고 PAA의 농도가 증가할수록 필름의 단면이 치밀해짐을 알 수 있었다. 또한 제조된 PMDA-ODA 폴리이미드의 T_g는 215℃ 이었다. Polyamic acid(PAA) was synthesised with Pyromellitic dianhydride(PMDA) and Oxydianiline (ODA) in N, N-dimethylacetamide(DMAc). PMDA-ODA polyimide membranes were obtained by two step thermal imidization, and the degree of imidization of polyimide membranes was observed by the FT-IR. After the thermal imidization through the concentration of varied synthesis of PAA, 10~30wt%, SEM photographies of section state were observed. The density and glass transition temperature on the varied concentration were replace with investigated test of density and Differential Scanning Calorimetry (DSC). With increasing thermal treatment temperature, the degree of imidization was increased. While the concentration of PAA increases, the section of membrane was densed. The glass transition temperature was maintained to be constant(215℃) within the PAA concentration range.

수술후 경막외강에 주입한 ketamine의 진통효과에 관한 연구

정기호,조남수,임경준,유병식,정종달,김용일 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1

Author divided 60 patients who got lower abdomen or lower extremity surgical operation into three groups. Each group consisted of 20 patients. We injected ketamine 10㎎, 20㎎, and 30㎎ respectively into the epidural space when the patient complained of pain postoperatively and observed the postoperative analgesic effect of ketamine. Finally, we concluded the following : 1) The onset time of analgesic effect. : The analgesic effect appeared within 10 minutes in 3 groups and the significant difference among them was not seen. 2) The duration of analgesic effect : The duration of analgesia was relatively short with less than 1 hour on an average in all 3 groups and was not constant. 3) Cardiopulmonary system. : The significant change of blood pressure, pulse and respiratory rate was not seen in all three groups and and the difference among them also was not seen. 4) Side effects. : Sedative action(16%), nausea(10%), dizziness(5%), headache(3.3%) From above results, the epidural administration of ketamine is not suitable for postoperative pain management because of a lot of side effects as well as short and inconstant duration of analgesic effeet.

한국 재원 정신분열병환자의 사회경제적 특성에 관한 역학적 조사 : 일일 시정조사 Point Prevalence Study

정인원,김용식,이정균 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

1984년 2월 27일 현재 전국 정신과 병·의원의 입원환자를 대상으로 일일시정조사를 시행하였다. 자료분석 때까지 도착한 자료중 ICD-9의 진단기준에 의하여 정신질환의 범주에 속하는 2,895명을 1:1 쌍쌍대응법으로 분석하여 거주지별로 정신분열병군과 대조군간의 사회경제적 특성을 비교하였다. 분석결과는 다음과 같았다. 1. 정신분열병환자의 결혼상태는 두 지역 모두에서 독신이 많았고 odd ratio는 각각 5.33과 3.56이었다. 농ㆍ어촌의 정신분열병환자가 독신이 더 많았다. 2. 교육수준은 양 군에서 뚜렷한 차이는 없었다. 3. 직업은 도시의 정신분열병환자에서 무직이 많았고 odd ratio는 1.90이었다. 4. 경제수준은 도시의 정신분열병환자에서 낮은 층이 많았고 odd ratio는 1.65이었다. 5. 그외 가족구조와 종교, 부모의 결혼상태에서는 유의한 차이를 보이지 않았다. Aiming at suggestion the possible ways to improve psychiatric care, rehabilitation, and mental health services in Korea, this nation-wide hospital study was intended to explore the socioeconomical status of mental in-patients. This point prevalence study was conducted to patients who were in psychiatric wards at Feb. 27th. 1984 using mailing questionnaire. The number of hospitals and clinics answered was 88 and the patients, 3,300. Among them, we selected the 2,895 patients who were included in mental disorders (290-319) by ICD-9. Finally we compared the socioeconomical status between schizophrenia and non-schizophrenia in rural and urban area with the method of Fleiss. The results were as follows; 1. The relative proportions of single persons in schizophrenia were higher in both areas, and their odds ratios were 5.33 and 3.56, respectively. There were more single schizophrenics in rural than urban. 2. In educational levels, there were no significant differences between schizophrenia and control. 3. In urban area, the jobless persons were more in schizophrenia than control, and its odd ratio was 1.90. 4. The urban schizophrenics were significantly lower than the urban control in economical levels, and its odd ratio was 1.65. 5. About family structure, religion, and marital status of parents, there were no significant differences between schizophrenia and control.

中共의 政治性向

鄭然植,尹龍熙 慶北大學校 東洋文化硏究所 1978 東洋文化硏究 Vol.5 No.-

Since Chinese vice Premier Teng Hsiao-pin recovered his power there has been Much change in chinese political sphere such as domestic affairs, economics, military, culture and foreign relations as well. Therefore this paper aims at trying to figure out an inclination of recent Chinese politics and to examin how does inclination effect the relation-ship with the major powers surounding Korean peninsular. Untill the mid 1970's Mao's teaching had been a only dominant doctrine in the field of Chinese political ideology but recently it shows us some symptoms of reassessment of Mao's thought under the Hua ana Teng's leadership. Therefore the theoretical basis of Sino-Soviet dispute lanunched by Khrushchev's destalinization and peaceful coexistence will be gradually discolored by it's pragmatic professionalism which inclined to bring industrialization and modernization to china. In the economic aspect china has blaimed foreign investment as a comparador capital during more than two decades. Now they are willing to accept foreign investment and technical co-operation program from western countries including U.S. and Japan for the fulfilment of their recent modernization program While China defines Russia as a main enemy she is willing to maintain reliable relationship with U.S. and to have technical assistance of nuclear power and highly developed electronic equipment for modernization of their military. Thus Chinese political inclination has effected role of the major powers. In other words China needed to promote relation with U.S., Japan and Western European countries and U.S.-Sino relation stimulated Japan to normalize relation with China. During this process Russia has maid enormous efforts to hinder the normalization of Sino-Japan relation and Russia on the other hand presented favourable attitude to the Taiwan and South Korea. It means there has been a Keen competition among Major powers and China more likely to promote relations with U.S. Japan and western European countries in the near future.

구속된 비행 청소년들의 특성 및 석방 후 6개월간 재범여부와 관련된 변인

정선주,김원식,고승희,구영진,김홍창,서동혁 대한소아ㆍ청소년정신의학회 1999 소아청소년정신의학 Vol.10 No.2

백서 뇌에서 전기경련 충격에 의해 발현이 조절되는 새로운 유전자

정선주,박정은,강웅구,구영진,박주배,김용식 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구목적: 이 연구는 백서 뇌에서 전기경련 충격(Electroconvulsive shock, ECS)에 의해 발현이 조절되는 새로운 유전자를 검색하고, 발달단게 및 뇌 조직에 따른 발현양상을 관찰하기 위하여 시행되었다. 방법: 생후 7일, 21일된 어린 웅성 백서에 전기경련 충격을 가한 후 mRNS differential display-PCR(DD-PCR) 기법을 시행하여 발현의 차이를 나타내는 유전자를 검색한 후 서열분석을 실시하였다. 생후 7일 및 21일된 백서의 뇌와 성년 백서의 대뇌피질, 해마를 이용한 Northern blot 분석을 시행하여 검색된 유전자의 ECS 처치 후 시간경과에 따른 유전자 발현양상을 관찰하였다. 결과: ECS 처치군과 위충격군간에 발현의 차이를 나타낸 유전자 4개를 검색할 수 있었으며, 이중 ECS에 의해 발현이 증가되는 1개의 유전자를 선정하여 서열분석을 실시한 결과 EST 서열만이 보고된 새로운 유전자임이 밝혀졌다. 이 유전자는 생후 7일된 백서의 뇌에서는 ECS 처치 후 180분에 발현양의 증가가 최고치에 도달하였으나, 생후 21일된 백서의 뇌와 성년백서의 대뇌피질 및 해마에서는 360분 경과시까지 지속적으로 발현 양이 증가하였다. 결론: 이같은 결과는 ECS에 의해 생체 내에서 유전자 발현의 조절이 이루어짐을 시사하며, 향후 이러한 유전자의 세포 내 기능에 관한 연구를 시행함으로써, ECS에 의한 생체의 반응과 치료기전에 대한 이해를 넓힐 수 있을 것으로 기대된다. 중심단어:전기경련 충격·DD-PCR·유전자·백서 뇌. Objectives: This study was performed to identify genes regulated by electroconvulsive shock (ECS) and to observe the pattern of expression of genes according to different developmental stages and brain regions. Method: ECS(130V, 0.5 sec) was given to male Sprague-Dawley rats with age of postnatal day 7 and 21(P7, P21 respectively). After screening genes regulated by ECS with mRNA diffe-rential display-PCR(DD-PCR), we selected one clone among them and observed the induction of this gene after ECS by time-dependent Northern blot analysis of rat brain of P7, P21 and adult rat cortex and hippocampus. Results: By DD-PCR method, we have identified four clones whose expression was regulated by ECS. Among them, one(CP 10-2) was proved to be a new gene by sequencing and BLAST search. Its expression was increased after ECS in P7, P21, and adult rat brain. The expression of CP 10-2 reached peak level at 180 minutes after ECS in P7 rat brain, but was further increased until 360 minutes after ECS in P21 and adult rat brain. Conclusion: In this study, a new gene was identified in rat brain which showed up-regulated expression in response to ECS. Cloning and characterization of this new gene would be helpful to elucidate the effect of ECS in rat brain. KEY WORDS:Electroconvulsive shock·Differential display-PCR·Gene·Rat brain.

精神分裂病의 5年 追跡調査 : 後向性 硏究 Retrospective Study

李定均,金容植,崔珍淑 大韓神經精神醫學會 1987 신경정신의학 Vol.26 No.4

To explore the possible factors affecting the course of schizophrenia and to clarify some questions on the nature of schizophrenia, a structured retrospective study was carried out to 142 patients (male 74, female 68) discharged from psychiatric department of Seoul National University Hospital during July, 1st 1981 - June, 30th 1982. The study group consisted of 97 patients diagnosed as schizophrenia according to DSM-Ⅲ and 45 controls, who met the following screening criterias, i.e., ⅰ) between the ages of 16 and 65, ⅱ) no evidence of organic, drug related or alcoholdisorder, iii) psychotic symptoms not due to any other mental disorders, such as manic episode, or atypical psychosis, or factitious disorder, etc. The data at index discharge were obtained from clinical records and filled up by one of researchers. Five year follow-up assessment was performed by 4 trained medical students, blind to clinical records, from Jan, 20th through Feb, 28th 1987. Among them 78 patients (male 40, female 38) were able to be traced and successfully interviewed. The average duration of follow-up was 62.2±7.2months(mean±S.D.). To investigate the prognostic significance and specific relations between predictors and outcome variables, 49 predictor variables were chosen from clinical records and 18 outcome variables were selected and grouped by 5-outcome dimensions. Outcome variables were length of rehospitalization during follow-up period, rehospitalization during the last one year, quality of social contact during the last one year, deterioration of work performance during the last one year, severity of psychopathology during the last one year. Results demonstrated some differences between schizophrenia and control groups in clinical records and follow-up assessments. Schizophrenia group definitely showed poorer outcomes than control group. Correlations of individual predictor variables with outcome were calculated, although significant statistically (P<0.05) were modest in their magnitude. Multiple regression analysis of the presenting predictor variables to the outcome dimensions showed correlation .29 -.77, thus explaining statistically about 8-59% of the outcome variance in schziophrenia group. Among them some predictor variables, i.e, work performance during the last one year, social contacts during the last one year, etc, presented high correlations with these outcome variables. Intercorrelations among the 5 outcome dimensions for schizophrenia group were calculated, dimensions correlated each other to a minimal or moderate degrees. Among them social contact correlated highly with individual outcome dimensions.

생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

水 海洋係 專門大學 通信科 敎育課程 開發 硏究

金永煜,金秀植,高南泳,梁義藏,金圭煥,文建,鄭東洙 군산대학교 1984 群山水産專門大學 硏究報告 Vol.18 No.1

We have studied on the curriculum to develop the communication department of the inter-related fisheries and marine junior college groups and abridged them as follows. (1) A vessel communication has the special characteristics compared with general communication field and also it has an aim to protect the lives and the property from dangerous navigation. For these reasons we must educate many competent graduates who are versed in business and accustom themselves to necessary knowledge of communication and can be adapted them selves to the advanced communication method, techniques and international information on the communication. (2) Training goal and way of thinking of students were rearranged and the occupational cluster in the electronic-communication field was fractionated to develop the curriculum. Especially regarding operator's duty served the above purpose as a occupational cluster, we analyzed their job in accordance with it. (3) International convention on standards of training certification and watchkeeping for seafarers, 1978 was reflected, also international telecommunication convention was referred so that it might be satisfied with the condition to be observed. (4) Developing the curriculum, we responed and analyzed the questions from scientific world, industrial organizations and graduates and provide their advice and suggestions form consultive committee and reflected them to develop the curriculum