단무지 공장에서 발생한 질식 사고의 원인과 방사선학적 소견: 중례보고 및 가스분석 결과

박충기,김만구,김흥철,안범규,박만수,황우철,최철순,강익원 江原大學校 附設 環境硏究所 1994 環境硏究 Vol.11 No.-

목 적:단무지 공장에서 질식사고를 일으켰던 가스의 종류를 알아내고, 이러한 가스중독의 방서선학적 소견을 소개하기 위하여 본 연구를 하였다. 대상 및 방법:단무지 공장에서 발생한 질식 사고자 3예중 생존자 1예를 대상으로 단순흥부X-선검사와 CT 소견을 분석하였으며, 가스의 종류를 알아내기 위하여 단무지를 유리병에 넣어 발생된 가스를 가스크로마토그래픽을 이용하여 분석하였다. 결 과:단무지 공장에서 발생한 질식사고자중 생존한 1명의 방사선학적 검사에서 신속히 호전되는 폐경결(consolidation)을 볼 수 있었으며 이는 폐부종의 소견임을 알 수 있었다. 협기성 상태에서 단무지를 담은 유리병의 상층부 가스를 실험 분석한 결과 이산화탄소, 에칠알코올이 다량으로 검출되었으나 독성가스는 주로 황화수소이였다. 결 론:단무지 공장의 질식 사고자에서 폐방사선학적 소견은 폐경결을 보이는 폐부증으로서 이는 실험을 통해 단무지에서 발생되는 유독가스인 황화수소 때문임을 입증하였다. Purpose: To identify the main toxic gas released from salted radish in rice bran(Dan-M-Ji) and to introduce the radiological findings of the patient who was exposed to the gas. Materials and Methods: Chest radiographs and CT scans of one survivor among three men who were exposed to the gas from Dan-Mu-Ji were reviewed. Gas obtained from the closed bottle containing Dan-Mu-Ji was analized by using the gas chromatography. Results: The radiographlc examinations of the survivor were suggestive of pulmonary edema with it's rapidly improving consolidations in both lung. The headapace gas within the bottle containing Dan-Mu-Ji was mainly composed with carbon dioxide, ethyl alcohol and hydrogen sulfide, of which hydrogen sulfide was considered the main toxic gas released. Conclusion: Under the anaerobic condition, Dan-Mu-Ji released toxic hydrogen sulfide. Inhalation of hydrogen sulfide might produce non-cardiogenic pulmonary edema.

맹출 장애를 가진 상악 제1대구치의 외과적 노출을 이용한 치험례

석충기,남동우,김현정,김영진,남순현 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.1

치아의 맹출이란 구강내로 치아가 출현하기 전의 악골 내에서의 이동, 구강에 출현하여 교합면에 이르기까지의 이동, 그리고 교합면 도달이후의 추가적인 이동 등 모두를 포괄적으로 의미하는 용어이다. 맹출은 대부분 유전적으로 결정되며 치아가 성장 발육 과정에 따라 구강내로 맹출되는 과정은 preeruptive alveolar bone stage, alveolar bone stage와 mucosal Stage로 구분할 수 있는데, 이들 과정의 어느 단계에서도 장애가 발생하면 치아가 맹출하지 않는다. 맹출 장애의 원인으로는 치배의 부정위, 정상 맹출로의 방해, 치낭 혹은 치주인대의 손상 등이 있다. 맹출 장애 치료에는 유치발거 및 맹출 공간확보, 외과적 노출, 외과적 정위, 외과적 노출 후 견인이 있고, 이 중 외과적 노출이 가장 기본적인 술식이다. 외과적 노출은 영구치를 둘러싸는 점막, 골, 병소, 경우에 따라 치낭 등을 제거하여 개방된 맹출로를 확보하는 것이고, 형성된 맹출로는 레진관(celluloid crown)의 접착, 거타 퍼챠 혹은 산화 아연 유지놀 시멘트, 치 주 포대 등을 노출된 부위 에 충전하여 개방성을 유지하여야 한다. 외과적 노출시에는 치경부 치근의 백악질을 노출시키지 않도록 하여야 하며, 인접치아의 치주 조직이나 치근의 손상도 피 해야 한다 또한 노출 후 치아는 각화된 치은에 위치하여야 한다. 외과적 노출 중에 가해진 손상의 정도는 치아의 병리, 생리 학적 이상의 발현에 영향을 미치므로 주의하여야 한다. 본 증례들은 상악 제1대구치가 맹출 장애를 가긴 증례들이었으며, 이를 개선하기위해 위의 사항을 고려하여 외과적 노출을 시행하였고, 맹출 장애를 효과적으로 개선할 수 있었다. The eruption of permanent teeth represents the movement in the alveolar bone before appearance in oral cavity, to the occlusal plane after appearance in oral cavity, and additive mevement after reaching th the occlusal plane. Tooth eruption is mostly controlled by genetic signals. The eruption stage is divided to preeruptive alveolar stage. alveolar bone stage, mucosal stage according to the process of growth and development. If the disturbance is occured in any stage of eruption, tooth does not erupt. The cause of eruption disturbance are eclopic position of the tooth germ, obstruction of the eruption path and defects in the follicle or PDL. In the treatment of eruption disturbance, surgical procedures are commonly used. There are three kind of surgical procedure surgical exposure, surgical repositioning, surgical exposure and traction Surgical exposure is basic procedure. This involves removal of mucosa, bone, lesion that are surrounding the teeth, dental sac when necessary to maintain a patent channel between the crown and the normal eruptive path into the oral cavity. To ensure this patency, many techniques including cementation of a celluloid crown, packing with gutta-percha or zinc oxide eugenol, or a surgical pack, are used. When surgical exposure is conducted, operators should not expose any part of cervical root cement and not in jure periodontium or root of adjunct tooth. After surgical exposure, tooth should be surrounded by keratinized gingiva. There is direct relationship between the extent of development of pathophysiologic aberrations and the intensity of the manipulative injury inflicted on the tooth by surgical treatment, so operator should consider this thing. In these cases surgical exposure is conducted on Maxillary 1st milars that have a eruption disturbance and improve the eruption disturbance effectively.

Methylmethacrylate와 n-Butylalcohol의 에스테르 교환반응에 관한 연구

鄭舜旭,朴根浩,孫秉淸,金忠一 弘益大學校 1988 弘大論叢 Vol.20 No.2

The transesterification reaction between methylmethacrylate and n-butyl alcohol was kinetically investigated in the presence of constant quantity of inhibitor and various metal acetate catalyst at 120℃. The quantity of n-butylmethacrylate produced in the reaction flask was measured by gas-chromatography, and the reaction rate was investigated by measuring of the quantity of the product the reaction under various catalysts. The transesterification was carried out in the first order reaction kinetics with respect to the concentration of methylmethacrylate and n-buty1 alcohol, respectively. The linear relationship was show between rate constant and absolute temperatures, and the activation energy of 14.7Kcal for the reaction with zinc acetate catalyst was calculated. The maximum reaction rate was appeared at the range of 1.5 to 1.6 of electro-negativity of metal ions.

이식증이 있는 정신박육지연 환자들과 연폭로 근로자들에 대한 연폭로 지표와 혈액학적 소견에 관한 연구

이충순,이성수,안규동,이병국 순천향대학교 1994 논문집 Vol.17 No.2

In order 1) to invesgate the possible relationship between lead exposure indices, hematologic findings and pica, and to compare the frequency of anemia or iron deficiency in mentally-retarded patients who have the symptom of pica with other study subjects, and 2) to find out the most reliable and feasible test method for the biological monitoring of lead in lead-exposed workers, PbB, ZPP, urine σ-LAL, RBC, Hgb, Hct, MCV, iron, TIBC, sex, age, and duration of work of admission were measured and checked in 50 lead-exposed workers, 118 lead-unexposed subjects and 32 mentally-retarded patients with pica. The results observed were as follows : 1. The means of Hgb, Hct, MCV and calcium of mentally-retarded patients with pica were lower than other two groups and the means of PbB, urine σ-ALA and ZPP of lead-exposed workers were higher than other two groups. 2. The means of PbB and ZPP of mentally-retarded patients with pica were higher, but the means of Hgb, Hct, MCV and calcium of mentally-retarded patients with pica were lower than mentally-retarded patients without pica. 3. While PbB had close correlation with ZPP,the ZPP had negative correlation with Hgb, Hct, MCV and iron in mentally-retarded patients with pica. 4. While PbB had close correlation with ZPP, urine δ-ALA and Hct, the ZPP had negative correlation with Hct, MCV and duration of work in lead-exposed workers. 5. While the means of PbB and urine δ-ALA were higher in male than female, there was no difference of ZPP in lead-exposed workers whose PbB was higher than 40 ㎍/dl. 6. The mean of urine δ-ALA level was higher in the group of highest blood lead level group(>60 ㎍/dl), and in the group of highest ZPP level group(>150 ㎍/dl). 7. Stepwise multiple regression of mentally-retarded patients indicated that pica was very significantly contributed to the dependent variables(PbB, ZPP, Hgb, Hct, MCV, anemia). 8. Stepwise multiple regression of mentally-retarded patients with pica indicated that iron was significantly contributed to the dependent variables(PbB, ZPP, RBC). 9. Stepwise multiple regression of lead-exposed workers indicated that sex was significantly contributed to the dependent variables(PbB, urine δ-ALA, Hgb, Hct ), and duration of work significantly contributed to the dependent variables (ZPP, urine δ-ALA, MCV).

정신병원과 의료법

이충순 용인정신의학연구소 1994 용인정신의학보 Vol.1 No.1

말초혈액 단핵구와 단핵구 유래 세포주 THP1에서 FcrR 자극에 의해 유도되는 염증반응의 조절기전

윤강순,윤석란,이충은,김형순,변광호 大韓免疫學會 1993 大韓免疫學會誌 Vol.15 No.-

Regulation mechanisms of inflammatory responses induced by FcrR stimulation in human monocytes and monocytic cell line THP1 were investigated. Release of arachidonic acid, which is the precusor for inflammatory mediators, was induced by FcrR stimulation with its ligand human IgG or with anti FcrR mAbs. This response was further increased when FcrR was cross-linked with in-soluble anti-IgG-agarose and soluble anti-IgG Fc specific Fab fragments. These phenomena were shown in both monocyte and THP1. Oxidative burst activity, resulting from generation of reactive oxygen speices, was also induced by FcrR stimulation and further enhanced by cross-linking of Fcr R. Induction mechanisms of inflammatory responses caused by PMA or FcrR stimulations were then examined by measurements of release of arachidonic acid and oxidative burst activity. The results demonstrate that monocytes utilize different signaling pathways for FcrR or PMA stimulation. Signaling mechanism of PMA stimulation is especially dependent on Ca}+/calmodulin dependent kinase in arachidonic acid release, but not in oxidative burst activity. Meanwhile, signaling pathways of FcrR are dependent on tyrosine kinase but independent of protein kinase C both in the release of arachidonic acid and oxidative burst activity. The results suggest that in monocytes, there is a not only functional but also mechanistic link between arachidonic acid release and oxidative burst activity induced upon FcrR stimulation. Distinct signaling pathways seem to be operating in transformed monocytic cell line THP-1 cells, and no mechanistic link was found between arachidonic acid release and oxidative burst activity induced after FcrR stimulation.

병인론에 근거한 성인 골격성 Ⅲ급 부정교합자의 분류와 그 prototype 제시를 위한 연구

홍순재,이충국 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.4

Skeletal class Ⅲ had been classified by the position of the maxilla, the mandible, the maxillary alveolus, the mandibular alveolus and vertical development. This morphologic approach is simple and useful for clinical use, but it is insufficient to permit understanding of the pathophysiology of dysmorphoses. The author hypothesizes that there are different patterns of mutual relation of the skeletal components which have contributed pathologic equilibrium of skeletal class Ⅲ. The purpose of this study are threefold: 1) to classify skeletal class Ⅲ in subgroups, which can show the architectural characteristics of the deformity, 2) to analyse the craniofacial architecture of each subgroup on etio-pathogenic basis, and 3) to characterize and visualize the pattern as a prototype. Materials used in this study were lateral cephalograms of 106 skeletal class Ⅲ adults, which were analysed with modified Delaire's architectural and structural analysis. Linear and angular measurements of the individual subject were obtained and cluster analysis was used for the subgrouping. Data were evaluated for verification of the statistical significances. The following results were obtained. 1.By the modified Delaire's architectural and structural analysis and cluster analysis, skeletal class Ⅲ adults were classified into 7 clusters and presented as prototypes, which could show the pathophysiology of the skeletal architecture 2.There was significant relationship in measurement variables of each cluster, which could reflect characteristics of the skeletal pattern of growth. 3.The flexure of cranial base had a close relationship to the anterior rotational growth of the maxilla and contributes to understand the etio-pathology of skeletal class Ⅲ. 4.The proportion of craniospinal area in cranial depth, craniocervical angle and vertical position of point Om had a close relationship to rotational growth of the mandible and direction of condylar growth. They contribute to understand the etio-pathology of skeletal class Ⅲ. In summary, the cranium and the craniocervical area must be considered in diagnosis and treatment planning of dentofacial deformity. And the occlusal plane can be considered as a representative which shows the mutual relationships of the skeletal components.

기능적 악정형 장치를 이용한 기능성 전치부 반대교협의 치료효과

박충제,남순현,김현정 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.1

기능적 악정형 장치에 의한 가능성 전치부 반대교합의 치료효과를 평가하기 위하여 기능성 전치부 반대교합으로 진단된 환자들 중 Activator를 이용하여 치료하였던 35명과 FR-Ⅲ를 이용하여 치료하였던 17명의 치료전후 측모두부방사선 규격사진상에 계측항목을 설정하고 각 항목들의 변화량을 반대교합의 치료를 연기하고 관찰한 대조군의 성장량과 비교, 분석하여 다음과 같은 결론을 얻었다. ·두 치료군 모두 상악골의 전방 성장은 관찰되지 않았다. ·두 치료군 모두 하악골의 후하방 회전이동을 나타내었으며 그 회전량에 있어 Activator군이 다소 많은 경향을 보였다. ·두 치료군 모두 전방안면고는 다소 증가하였으나 유의성은 없었으며(p>0.05), 후방안면고는 대조군에 비해 상대적으로 증가가 미약하였다.(p<0.05). ·전, 후방안면고의 수직적 비율은 대조군에서 일정하게 유지되는데 비해 두 치료군은 감소되었다.(Ar-Go/ANS-Me : p<0.01, S-Go/N-ME : p<0.05). ·Activator군은 상악 전치의 순측 경사(p<0.01) 및 하악 전치의 설측 경사(p<0.05)에 있어 현저한 증가를 보였고, FR-Ⅲ군은 대조군에 비해 유의한 차이가 없었다.(p>0.05). ·두 치료군 모두 overjet이 증가하였고(p<0.01), overbite는 다소 감소하였으나 유의성은 없었다.(p>0.05). This study investigated the treatment effects produced by two types of functional orthopedic appliance, one primarily tooth-borne(Activator) and one primarily tissue-borne(FR-Ⅲ of Frankel). The pre- and post-treatment lateral skull radiographs from 35 patients who had been treated with the Activator and from 17 patients who had been treated with the FR-Ⅲ were compared with 15 untreated persons with functional anterior crossbite. The findings in this investigation were as follows : ·Insignificant maxillary changes were noted in both treatment groups. ·The mandible was rotated backward and downward in both treatment groups, but the distance of the Activator group was greater than that of the FR-Ⅲ group. ·The increase in the anterior facial height was found to be insignificant and the increment of the posterior facial height had a stagnant tendency in both treatment groups. ·Control group had a strong tendency to maintain the ratio of anteroposterior facial height through observed period. In contrast, the ratio of anteroposterior facial height was decreased in both treatment groups. ·The Activator group had a greater treatment effect in upper incisor proclination and lower incisor retroclination than did the FR-Ⅲ group. ·The negative overjet that was present at the beginning of the treatment has been converted into a positive overjet but the reduction in overbite was found to be insignificant in both treatment groups.

枳實의 一般藥理作用

林中基,趙台淳,李善美 成均館大學校 1982 論文集 Vol.32 No.-

To elucidate the pharmacological actions of Ponicir, the effects of the fluid extract on isolated guinea pig ileum, blood vessel permeability in mice, granuloma formation in rats and swelling of rat hind paw were examined. The histamine induced contraction of isolated ileum was significantly blocked by Ponicir fluid extract and the blood vessel permeability was also significantly inhibited. In the experiments on granuloma formation only the exudate formation was inhibited. Forthermore, swelling of hind paw induced by 1% carageenin was also significantly inhibited by Ponicir fluid extract.

폐결핵 초치료 환자들의 치료 결과에 영향을 주는 요인

김경순,조영하,전진호,조은희,은충기 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.3

Objectives : To figure out the factors related to the failure of primary pulmonary tuberculosis(Tb) treatment and to enhance the efficiency of the treatment. Methods and Materials : The subjects were 137 Tb patients composed of the two groups; 44 failure cases and 93 success cases who admitted in National Masan Tuberculosis Hospital during 2001. The failure means no improvement with the standard short term regimen of INH and RFP. Patients' informations were gathered through medical records and face-to-face interview survey, and, the data were analyzed with SPSS(ver 10.0). Results : Mean age of the subjects were 47.6 years. Most cases were diagnosed at clinics or hospitals at first, due to the symptoms. No difference in smoking and alcohol habits between the two groups. The cases who got the informations about the whole process of treatment, and following regular regimens were more in the success group. The proportion of multi-drug resistance to the regular primary Tb regimen was higher in the failure group 8 cases out of 25 detectable failure cases. 0 case among 46 successful cases. And the four regular regimen(INH, RFP, EMB, PZA) was popular type of the resistance. In chest X-ray, multiply involved lesion(≥ two lobes), atelectasis and pleurisy were more frequent in the failure group. Conclusion : The major factors that enhance the efficiency of Tb treatment were the informations and compliance. Enough explanation about the whole process would be essential during Tb treatment, and, in case of MDR-Tb, susceptible regimen and surgical therapy should be considered.