영구형 항서맥 심박조율기 환자의 장기추적관찰

최현석,이무용,최영진,최성준,김효수,손대원,오병희,이명묵,박영배,최윤식,이영우,이명용 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.5

한번의 간질발작 후 혈청 Neuron-Specific Enolase 농도 변화

최승호,박영춘,이장준,임정근,김지언,이상도 啓明大學校 醫科大學 1999 계명의대학술지 Vol.18 No.4

An increase in neuron-specific enolase (NSE) levels in serum and CSF has been shown to be an useful marker of brain damage after stroke, global ischemia, and coma. We report the changes of serum NSE levels after seizure attacks in epileptic patients compared with the levels in normal controls and epileptic patients without seizure attack at least 7 days (epileptic controls). Twenty-four seizures were included in this study. Blood was drawn within 1 hour, at 12 hour, 24 hour, and 48 hour after seizure attack. Serum NSE levels were measured with radioimmunoassay. The mean NSE levels for normal controls and epileptic controls were 6.94 ng/ml and 7.46 ng/ml, respectively. There were significant increase in level of serum NSE measured within 1 hour after seizure attack in epileptics compared with the level in normal controls (15.10ng/ml versus 6.94ng/ml, p<0.05) and epileptic controls (15.10ng/ml versus 7.46ng/ml, p<0.05). Serum NSE measured at 12 hours after seizure also increased compared with normal controls (12.32ng/ml versus 6.94ng/ml, p<0.05) and epileptic controls (12.43ng/ml versus 7.46ng/ml, p<0.05). Between normal controls and epileptic controls, there were no significant difference in serum NSE levels. We conclude that serum NSE level was elevated in epileptic patients who had seizure attack within 12 hours. Serum NSE levels can be useful marker for seizure within 12 hours after onser. The elevated serum NSE level after single seizure attack may suggest that the brain was injured in single seizure.

방진 보링바의 성능 향상에 관한 연구

최춘규,이동주,이우영 忠南大學校 産業技術硏究所 1998 산업기술연구논문집 Vol.13 No.1

This paper analyzes high efficiency anti-vibration boring bars which increase stability against chatter vibration in boring operations. Structural analysis and mathematical modeling with considering dynamic properties for three types of existing boring bars are peformed to search for optimal design parameters. The purpose of this paper is to find out design parameters for high efficiency anti-vibration boring bar.

大韓民國의 民族史的 正統性에 關한 考察

崔春泳 군산대학교 1985 群山水産專門大學 硏究報告 Vol.19 No.2

In Subject : the meaning of the condition under which a nation has to live divided into two different sicuak systems was logically examined, after which the concept of legitimacy, where come together the subjectivity from the viewpoints of a nation and the legitimacy from those of a state, was made clear in its meaning. By doing this way, it was also attempted to confirm the legitimacy of the Republic of Korea based on the national history from idverse aspects. In the end, both of South and North Koreas have the elements obits legitimacy. But, North Korea plans a artificial differentiation, so - called "reform in humanity". While on the other, South Korea succeeds to the traditional culture and develops it. So, it is definite that South Korea has more legitimacy than North Korea.

조직구성 수성망상증 2예

최연수,박일,죄희충,김원식,양태영,허경,안기완,정춘해 조선대학교 1993 The Medical Journal of Chosun University Vol.18 No.2

Histiocytic medullary reticulosis (HMR) is a malignant noeplastic process, with tumor cells belonging to the histiomonocytic line, and originally described by Scott and Robb-Smith in 1939 characterized by its acute onset, progression to death within a few months and its clinical features are fever, lymphadenopathy, hepatosplenomegaly, jaundice, and purpura common laboratory findings are characterized by severe anemia, leukopenia, thrombocytopenia and histologically by systemic progressive invasion of morphologically atypical histiocytes or of their precursor. 61 and 37-year-old males were admitted with camplaints of high fever and chilling sensation and were treated by cyclophosphamide, vincristine, prednison and antiobiotics, but patients all died 17 and 14 days after admission due to probably sepsis and respiratory failure.

키에르케고어의 역설과 비트겐슈타인의 '새장'에 관한 고찰 : 키에르케고어의 사회성을 중심으로 with the problems concerning Kierkegaard's sociality in the center

최춘영,송은재 군산대학교 현대이념연구소 1996 現代理念硏究 Vol.11 No.-

Kierkegaard has been criticized by many commentators on account of being a thinker lacking sociality. That is to say, they think one couldn't find out the concern for society in which we live or social consciousness in Kierkegaard's thought. But is such a criticism undoubtedly right? This treatise is conceived to doubt this criticism in such a way that it could compare Kierkegaard's methodology with Wittgenstein's.

Benz[f]indole-4,9-dione 유도체의 Topoisomerase I-DNA에 대한 결합형태와 저해작용 간의 상관관계

최인희,우선아,박혜숙,박혜영,김춘미 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.16

We present binding modes of newly eethesized benzlflindole4,94ione analogs with topoisomerase I (TOPI)-DNA complex The compounds were tested for cytotoxicity and 10pl inhibitory activity in our previous study. Camptothecin (CPI) and each of the 15 analogs were docked into the X-ray crystal stucture of human TOPI-DNA binary complex to develop the temary complex of TOP1-DNA-ligand using FlexiDock The results demonstrated that two compounds with N_(1)-attached halogens intercalated exactly between the -1 and +1 DNA bases, deeply toward the cleavage site and were stabilized by three H-bonds each and an array of hydrophobic interactions with both the enzyme and the DNA. The most potent intbiery activities they showed in the test agree well with the proper docking results. Six compounds which did not intenalate and formed no H-bond showed no or very low inhibitory activities. Seven compounds that intercalated between the bases with one to four H-bonds but not deeply enough toward the cleavage site showed intermediate activities. The structure-activity relationship was consistent with the experimental data The ternary complex presented potential binding mode of each compound and thus could provide a rational basis far novel inhibitor design to develop potent anticancer drugs targeting TOP1 enz[f]indole-4,9-dione 유도체와 topoisomerase I(TOP1)-DNA 복합체의 결합형태를 규명하기 위해 세포독성과 TOP1저해작용이 검사된 15개의 유도체와 camptothecin을 TOP1-DAN복합체의 X-선 구조에 FlexiDock을 사용하여 docking하였다, 그결과 N_(1)에 할고겐 이 결합된 두화합물은 -1/+1 염기 사이에 끼어들어 깊숙이 결합되었고 각각 3개의 수고결합과 다수의 소수성 상호작용으로 안정화되었다. 활성검사에서 가장 강한 작용이 나타나 고유한 docking결과와 잘 부합되었다. 염기사이에 끼어들지 않고 수소결합도 형성하지 않은 6개의 화합물에서는 활성이 거의 나타나지 않았다. 한개 내지 4개의 수소결합을 형성하면서 염기 사이에 끼어들었으나 TOP1에 의해 잘라지는 위치에 깊게 결합하지 못한 7개의 화합물은 중간 정도의 활성을 나타내어 구조 활성 관계가 실험 치와 잘 일치 하였다, 이 결과는 TOP1을 목표로 하는 새로운 항암제의 구조를 고안하는데 합리적인 근거를 제공할 것이다.

金日成 主體社想과 이데올로기的 誤謬에 關한 考察

崔椿泳 군산대학교 1983 群山水産專門大學 硏究報告 Vol.17 No.2

When Kim IL Sung's Juche (self-reliance) was suggested first in 1950, it was only a simple thought and a vain idea. But it has been developed systematically as having been endowed with concrete contents and arranged theoretically under the necessity of keeping to the authority of the party and having Ideological armaments. Kim IL Sung's Juche (self-reliance) is a theoretical and methodological base of his revolutionary thought and "All Policies and Avtivities guide principle" in North Korea. North Korea Communists insist that Kim IL Sung's Juche (self-reliance) is a practical Ideology represented by [self-reliance of Idea]. [Independence of politics] [self-support of economy] [self-protection of national defense] and that as if only they were the successors of fat ional Identity and orthodoxy. But all their insistence is nothing but a disguised slogan and falsified subjecthood for Kim IL Sung's personal worshsip and the establishment of the hereditary dynasty by rewriting History and maximizing the public's mobilization.

정치와 종교의 관계에 관한 철학적 고찰 : 키에르케고어에 대한 올바른 이해를 위한 하나의 시도

崔春永,林圭廷 군산대학교 1993 群山水産專門大學 硏究報告 Vol.28 No.1

In this treatise we tried to make clear the right relationship between politics and ethico-religion. To start with, we studied Kierkegaard's political views. In general, Kierkegaard's existential philosophy has been thought of as anti-political. We tried to refute this general but unreflected view and, thereby, to estabilish right understanding of Kierkegaard. Concretely, we tried to make clear that Kierkegaard viewed(ideal) politics positively. We think that could enable us to truely understand the ideal relationship between political and ethico-religious issues.

全北道內 專門大學生의 統一安保意識에 關한 調査硏究

崔春泳 군산대학교 1984 群山水産專門大學 硏究報告 Vol.18 No.2

The primary aim of this study is to grasp the consciousness that junior college students hold on the national unification and security, through the survey and analysis of their consciousness on it, and to explore ways toward the national unification and security by establishing the priper conscious-ness on it. In the approaches of this study, I refered to the data of the preceding work and analyzed it according to the conceptional model. The model is classified into cognition, affection and will in the level of behavior and it is also divided into anticommunism, National unification and National Security in the level of contents. In the process of collecting questionaires, 610 students' question aires were collected, but 605 students were actually examined in this investigation. The questionaire is composed of total 22 entries for answer, including Anti-Communism items are 8, National Unification items are 7, National Security items are 7. When we synthesize the collected materials and analyze them, we can see the following facts. The first, in he level of Anti-Communism, the students had a correct understanding of North Korea's political reality (81.5%), North Korea's economic reality (87.2%), North Korea's educational goal (87%), etc. They made a negative response to the possibility of living in North Korea (70.5%) and North Korea's political propaganda (77.5%). The second, in the level of the National Unification, the students had a high understanding of the plan toward peaceful unification of our government (know certainly: 33%, a little: 53%, don't know: 4%) and North Korea's plan toward armed unification (know certinly: 8%, well: 21%. a little: 48.5%, don't know: 23%). They anticipated the exchange between south and north Korea (90%). They thought that the obstructive factor of the national unification was owing to North Korea (75.5%) and their will of unification was strong (60.5%). The third, in the level of the National security, the students showed a high reaction to the possibility of North Korea's aggression (85%). They guessed that North Korea's military power was superior to, South Korea. (71.5%) and they thought that a initiative country among China and Soviet Union will support North Korea if North Korea invades our country (42%). As a result, the above statistical data show that whole level of congition junior college students hold on the National Unification and Security is relatively high, but whole level of affection and ill is low, compared with that of congition.