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      • KCI등재후보

        Characterization of Focal Liver Lesions with Superparamagnetic Iron Oxide-Enhanced MR Imaging: Value of Distributional Phase T1-Weighted Imaging

        JeongMinLee,ChongSooKim,JiHyunYouk,MiSukLee 대한영상의학회 2003 Korean Journal of Radiology Vol.4 No.1

        Objective: To determine the potential value of distributional-phase T1-weighted ferumoxides-enhanced magnetic resonance (MR) imaging for tissue characterization of focal liver lesions. Materials and Methods: Ferumoxides-enhanced MR imaging was performed using a 1.5-T system in 46 patients referred for evaluation of known or suspected hepatic malignancies. Seventy-three focal liver lesions (30 hepatocellular carcinomas [HCC], 12 metastases, 15 cysts, 13 hemangiomas, and three cholangiocarcinomas) were evaluated. MR imaging included T1-weighted double-echo gradient-echo (TR/TE: 150/4.2 and 2.1 msec), T2 -weighted gradient-echo (TR/TE: 180/12 msec), and T2-weighted turbo spin-echo MR imaging at 1.5 T before and after intravenous administration of ferumoxides (15 mmol/kg body weight). Postcontrast T1-weighted imaging was performed within eight minutes of infusion of the contrast medium (distributional phase). Both qualitative and quantitative analysis was performed. Results: During the distributional phase after infusion of ferumoxides, unique enhancement patterns of focal liver lesions were observed for hemangiomas, metastases, and hepatocellular carcinomas. On T1-weighted GRE images obtained during the distributional phase, hemangiomas showed a typical positive enhancement pattern of increased signal; metastases showed ring enhancement; and hepatocellar carcinomas showed slight enhancement. Quantitatively, the signal-to-noise ratio of hemangiomas was much higher than that of other tumors (p < .05) and was similar to that of intrahepatic vessels. This finding permitted more effective differentiation between hemangiomas and other malignant tumors. Conclusion: T1-weighted double-echo FLASH images obtained soon after the infusion of ferumoxides, show characteristic enhancement patterns and improved the differentiation of focal liver lesions.

      • KCI등재후보

        Curved Planar Reconstruction of MR Images in Focal Cortical Dysplasia of the Brain

        GyungHoChung,SangYongLee,ChongSooKim,YoungKonKim,YoungHwanLee,SuHyunJeong 대한영상의학회 2002 대한영상의학회지 Vol.46 No.5

        Purpose: To describe curved planar reconstruction imaging (CPRI) and determine its usefulness in the evaluation of focal cortical dysplasia of the brain. Materials and Methods: In 17 cases of focal cortical dysplasia [cortical dysplasia (n=9), schizencephaly (n=5), and heterotopia (n=3)], CPR images were created using a multiplanar reconstruction program and imaging data obtained during T1 magnetizationprepared rapid acquisition gradient-echo MR imaging. We assessed the precise configuration of abnormalities and their relation to adjacent gyri and sulci. Results: CPRI showed the brain cortex as a 2D panoramic image, demonstrating the precise configurations and locations of dysplasia-associated abnormalities and their relation to adjacent gyri and sulci, and the precise shape of the gray-white matter interface. Conclusion: CPRI can provide important radiological information about the extension and configuration of focal cortical dysplasia, and its relation to neighboring cortical structures. We believe that CPRI should form an essential part of the routine investigation of suspected cases of focal cortical dysplasia. 목적: 3차원 MR영상법으로 촬영된 MR데이터를 사용하여 곡면재구성영상을 얻어 국소적 뇌피질 이형성증을 평가하는데 유용성을 알아 보았다. 대상과 방법: 국소적 뇌피질 이형성증 17명을 대상으로 하였고 뇌피질 이형성증(cortical dysplasia, n=9), 분열뇌증(schizencephaly, n=5), 이소성 회질증(gray matter heterotopias, n=3)이었다. 곡면재구성영상은 자화준비고속경사 에코획득을 이용하여 얻은 영상에서 곡면재구성프로그램을 이용하여 만들었다. 곡면재구성영상에서 병변의 범위, 모양, 주위 정상 대뇌이랑, 고랑과의 관련성을 분석하였다. 결과: 곡면재구성영상은 뇌표면을 파노라믹 모양의 2차원으로 벌려 놓은 모양이었다. 17예의 국소적 뇌피질 이형성증 환자에서 곡면재구성영상은 이형성된 뇌피질의 위치와 모양, 그리고 주위의 정상 대뇌 이랑과 고랑과의 관계를 잘 보여 주었다. 결론: 곡면재구성영상은 국소적 뇌피질 이형성증 환자에서 병변의 위치와 범위 그리고 주위 구조물사이의 중요한 방사선과적 그리고 해부학적 정보를 제공했다. 국소적 뇌피질 이형성증이 의심될 때 곡면재구성영상은 일반적인 영상방법과 함께 포함되어야 할 검사법이다.

      • KCI등재후보

        Detection of Hepatic VX2 Tumors in Rabbits:Comparison of Conventional US and Phase-Inversion Harmonic US During the Liver-Specific Late Phase of Contrast Enhancement

        JeongMinLee,JiHyunYouk,YoungHwanLee,YoungKonKim,ChongSooKim,ChunAiLi 대한영상의학회 2003 Korean Journal of Radiology Vol.4 No.2

        Objective: To compare phase-inversion sonography during the liver-specific phase of contrast enhancement using a microbubble contrast agent with conventional B-mode sonography for the detection of VX2 liver tumors. Materials and Methods: Twenty-three rabbits, 18 of which had VX2 liver tumor implants, received a bolus injection of 0.6 g of Levovist (200 mg/ml). During the liver-specific phase of this agent, they were evaluated using both conventional sonography and contrast-enhanced phase-inversion harmonic imaging (CEPIHI). Following sacrifice of the animals, pathologic analysis was performed and the reference standard thus obtained. The conspicuity, size and number of the tumors before and after contrast administration, as determined by a sonographer, were compared between the two modes and with the pathologic findings. Results: CE-PIHI demonstrated marked hepatic parenchymal enhancement in all rabbits. For VX2 tumors detected at both conventional US and CE- PIHI, conspicuity was improved by contrast-enhanced PIHI. On examination of gross specimens, 52 VX2 tumors were identified. Conventional US correctly detected 18 of the 52 (34.6%), while PIHI detected 35 (67.3%) (p < 0.05). In particular, conventional US detected only three (8.3%) of the 36 tumors less than 10 mm in diameter, but CE-PIHI detected 19 such tumors (52.8%) (p < 0.05) . Conclusion: Compared to conventional sonography, PIHI performed during the liver-specific phase after intravenous injection of Levovist is markedly better at detecting VX2 liver tumors.

      • KCI등재후보

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