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宋坰松,申喆均,朱榮丞 대한본초학회 2004 大韓本草學會誌 Vol.19 No.1
Objectives : This study was designed to establish a characteristic discrimination of internal and external morphological standard of original plants and herbal states in Polygoni Multiflori and Cynanchi Wilfordii Radix. Methods : In this studies, the external-internal morphological standards were determined by using stereoscope and butanol series. Results : 1. The external characteristics of original plants: Polygonum multiflorum has alternate leaves, and its flower with white color blooms at the shoot apex or leaf axil. In the other hand, Cymchum wilfor&i has opposite leaves, and its flower with yellowish green color blooms at the leaf axil. 2. The physical characteristics of herbal states: Polygoni Multiflori Radix is red-brown in outer surface, pink-brown in section. In the other hand, Cynanchi Wilfordii Radix is earthly-brown in outer surface, greyish white in section. 3. The physical characteristics according to the place of production: Demonstrable difference according to the place of production is not seen. Polygoni Multiflori Radix is brown or dark brown in outer surface, soft yellow-dark brown in section. In the other hand, Cynanchi Wilfordii Radix is white in outer surface, white-weak red in section, and has power type. 4. The internal characteristics: Pofygonum mulQt7orum has hetero-vascular bundle and lignification of cork layer is progressive. In the other hand, cynanchum wilfordii has not hetero-vascular bundle, and lignification of cork layer is weak. Conclusion : In the future, many fundamental study such as how to discriminate between Polygoni Multiflori Radix and Cynanchi Wilfordii Radix in origin and efficacy will be necessary. Also the standard of discrimination must be specific and distinct in that several kinds of fo-ti has been traded.
Susceptibility of Oral Bacteria to Essential Oil of Artemisia capillaris Thunb.
Kim Kyong-Heon,Kim Baek-Cheol,Shin Chol-Gyun,Jeong Seung-Il,Kim Hong-Jun,Ju Young-Sung The Society of Korean Medicine 2004 대한한의학회지 Vol.25 No.4
Objective : The aim of this work is to investigate the antibacterial activity of the essential oil obtained from Artemisia capillaris (A. capillaris), as the development of microbial resistance to antibiotics make it necessary to constantly look for new and active compounds effective against pathogenic bacteria. Methods : The crushed materials of A. capillaris (1 kg) were subjected to steam distillation for 3 h, using a modified Clevenger type apparatus in order to obtain essential oil. Diethyl ether was the extracting solvent kept at 25°.... The essential oil was analyzed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The essential oil and the composition were tested for antimicrobial activities against 15 different genera of oral bacteria. Results and Conclusion : The components of the essential oil identified were: β-pinene (9.36%), camphor (3.32%), 1,8cineole (4.38%), artemisia alcohol (3.32%), β-caryophyllene (11.08%), γ-cadinene (4.23%), and capillene (32.74%). The essential oil of A. capillaris exhibited considerable inhibitory effects against all oral bacteria tested, while their major components demonstrated various degrees of growth inhibition.
Clinical safety and effectiveness of the Genoss drug-eluting stent in real-world clinical practice
( Young Jin Youn ),( Jun-won Lee ),( Sung Gyun Ahn ),( Seung-hwan Lee ),( Junghan Yoon ),( Jae Hyoung Park ),( Sang-yong Yoo ),( Woong Chol Kang ),( Nam Ho Lee ),( Ki Hwan Kwon ),( Joon Hyung Doh ),( 대한내과학회 2023 The Korean Journal of Internal Medicine Vol.38 No.5
Background/Aims: The Genoss DES™ is a novel, biodegradable, polymer-coated, sirolimus-eluting stent with a cobalt-chromium stent platform and thin strut. Although the safety and effectiveness of this stent have been previously investigated, real-world clinical outcomes data are lacking. Therefore, the aim of this prospective, multicenter trial was to evaluate the clinical safety and effectiveness of the Genoss DES™ in all-comer patients undergoing percutaneous coronary intervention. Methods: The Genoss DES registry is a prospective, single-arm, observational trial for evaluation of clinical outcomes after Genoss DES™ implantation in all-comer patients undergoing percutaneous coronary intervention from 17 sites in South Korea. The primary endpoint was a device-oriented composite outcome of cardiac death, target vessel-related myocardial infarction (MI), and clinically driven target lesion revascularization (TLR) at 12 months. Results: A total of 1,999 patients (66.4 ± 11.1 years of age; 72.8% male) were analyzed. At baseline, 62.8% and 36.7% of patients had hypertension and diabetes, respectively. The implanted stent number, diameter, and length per patient were 1.5 ± 0.8, 3.1 ± 0.5 mm, and 37.0 ± 25.0 mm, respectively. The primary endpoint occurred in 1.8% patients, with a cardiac death rate of 1.1%, target vessel-related MI rate of 0.2%, and clinically driven TLR rate of 0.8%. Conclusions: In this real-world registry, the Genoss DES™ demonstrated excellent safety and effectiveness at 12 months among all-comer patients undergoing percutaneous coronary intervention. These findings suggest that the Genoss DES™ may be a viable treatment option for patients with coronary artery disease.
이상인(Sang In Lee),최세식(Se Seek Chol),배무현(Mu Hyun Bae),김종훈(Jong Hoon Kim),최익수(Ik Su Choi),김천환(Chun Whan Kim),구호성(Ho Sung Goo),이민기(Min Ki Lee),나산균(San Gyun Rha),허갑도(Gap Do Hur) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.2
Primary malignant melanoma of esophagus is rare and its symptoms are similar to those of squamous cell carcinoma. In general, this tumor tends to be polypoid with smooth intact overlying mucosa or be pediculated and irregular. Microscopically, characteristic features are junctional lenti- ginous growth pattern and tendency to expand and fill the submucosa without invading the muscularis. Primary malignant melanoma should be radiologically differentiated with unusual esophageal tumor, particularly if the lesion is polypoid. Because of the patentially widespread intramural component, surgical treatment requires a radical procedures with a far greater margin than for the usual squamous cell carcinoma. Despite these measures, however the prognosis is poor, with a 5 year survival of 4.2%. It is usually fatal within one year. The case of a 64-year-old man with esophageal malignant melanoma is described, and review of the llterature in presented related studies. (Korean J Gastroenterol 1995;27:245 - 250)
서명원 ( Myung Won Seo ),정승일 ( Seung Il Jeong ),신철균 ( Chol Gyun Shin ),주영승 ( Young Sung Ju ) 대한본초학회 2003 大韓本草學會誌 Vol.18 No.1
N/A Objectives : The purpose of the study is to enhance the objectivity and availability of the oriental herb medicine by formulating the morphological standard and isolation and structure elucidation of radical scavengers from Chrysanthemum indicum L. These intents are expected to be useful in the examination of several physiochemical and biological reactions, determination of indicator material, and identification of gene with basic sources in the future. Methods : In order to develop the standard formulas and isolation and structure elucidation of radical scavengers from Chrysanthemum indicum L., the experimental examinations of the original herbs have been carried out. The morphological standard was divided into 4 parts as plant · external · internal · powder shape. Three antioxidative compouds were isolated by a bioassay using a 1, 1-diphenyl-2-picrydrazyl(DPPH) free radical. They were identified as luteolin, apigenin and linarin (acacetin-7-O-rutinoside) on the basis of 1H and 13C-NMR and MS data. Results and Conclusions : 1. The plant shape : The color of the slender-hair in its stem is purple-black. The leaf is oval-orbicular shape and has the slender-hair in both sides and its petiole has pseudo-stipule. The entire diameter of flower is 2~2.5cm. The lingulate flower is yellow and the siphonoic flower is deep-yellow color. 2. The external shape of herb: It is a globular-like type, 2~3cm in diameter and brown-yellow to yellow color. The lingulate flower is yellow-white color haved one layer and the siphonoic flower is deep-yellow color. The external layer is oval-velvet and the internal layer is long-oval shape in the bracteole. 3. The internal shape of herb: The change of the petal is relatively large, the upper epidermal cell is irregular oval or sphere shape and the lower epidermal cell is regular sphere shape. The lower epidermal cell has occasionally trichomes or a few air pores. the mesophyll tissue has small thin-walled cells which are relatively dense, and the secretory tissue and reserve substances of the pipe type. The vascular bundle which has reticulate vessel is distributed near to lower epidermis cells. 4. The powder shape of herb: The color of the powder sample is yellow-brown. The fragments of parenchyma, vessel and the calcium oxalate crystal are observed. In the sample of maceration, the epidermal cell of petal is various, the epidermal cell of filament is many side shape. The parenchyma is mostly oval shape which occasionally concludes the calcium oxalate crystal. The vessel has uniforation plate at each edge, which is a spiral vessel, and the type of the pit of lateral wall is alternate shape 5. Isolation and Structure Elucidation of Radical Scavengers: The DPPH radical scavenging activity (RC_50: 13.3㎍) of apigenin was similar to that of α-tocopherol (12.1㎍) and L-ascobic acid (9.8㎍).