Escherichia coli 패혈증 환자에 합병된 대칭적 하지 말단 괴사증 1예

남해성,유진홍,권순석,민준기,조현선,박민경,심병주,남유정,이지인,김진수,길욱현,조근종,신완식 대한감염학회 2005 감염과 화학요법 Vol.37 No.6

We have encountered a rare case of symmetrical peripheral gangrene complicating Escherichia coli sepsis in a 47-years-old male. He was successfully treated with antibiotics, anticoagulants, and vasodilator. To our knowledge, this is the first report on symmetrical peripheral gangrene complicating E. coli sepsis in Korea.

기-액계면 흡착에 의한 계면활성제 및 중금속분리

이근희,남상진,김병조,박경기,박종태,신정호 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-

CTAB에 의한 CuS 침전 미립자의 응집과 기포 흡착특성을 고찰하였다. CTAB의 기포흡착은 Langmuir흡착식을 따르며, 포말간 본체액의 동반을 고려한 회분해석으로부터 구한 흡착열은 3700cal/mol로 나타났다. CTAB에 의한 CuS미립자의 기포흡착은 기포-입자간 충돌흡착으로 설명되었고, 흡착분리에 대한 최적 농도비는 CuS의 최적 응집농도비와 일치하였으며, 그 값은 [CTAB] 대 [CuS]가 0.1로 얻어졌다. 기포에 의한 포집효율은 pH와 CTAB농도 등에 의존하나 공기의 유량에는 무관하였으며, 최대 포집효율은 최적 첨가농도에서 0.0002로 나타났다. 또한 Cu-Cd-Zn 황화물의 혼합계에서 CTAB를 사용한 기포흡착의 경우 ZnS의 선택적 분리가 가능하였다. The characteristics of the bubble adsorptive separation of CTAB(cetyltrimethyl- ammonium bromide) and CuS precipitates was investigated. The Langmuir adsorption equation was adequate at very low concentration of CTAB, and the adsorption heat was determined from the batch analysis considering the bulk liquid accompanied between bubbles. The adsorption mechanism was explained with the collision adsorption between bubbles and precipitate particles. The optimum concentration ratio of [CTAB] to [CuS] for adsorptive separation was 0.1 and coincided with the ratio for the coagulation of particles. The collection efficiency was depended on pH and CTAB concentration but not the air flow rate, and the maximum efficiency was 0.0002. The selective separation of ZnS from the mixture of Cu-Cd-Zn sulfides was able by the bubble adsorption with CTAB.

컴퓨터 赤外線 全身體熱撮影과 FNT을 통해 살펴본 Bell's palsy에 대한 침치료의 臨床的 考察

尹敏永,趙恩嬉,許泰永,趙南根,文炯喆 한국전통의학연구소 2001 한국전통의학지 Vol.11 No.1

Object : This study is designed to evaluate the clinical therapy of acupuncture by the data of DITI(Digital Infrared Thermographic Imaging) and FNT(Facial Nerve stimulation Test) examination and the changes of clinical symptoms after the therapy of acupuncture in the patients with Bell's palsy. Contents : The conservative therapy with acupuncture was performed during 1-8weeks. The acupuncture points of S4, S6, G14, S2, BL2, SI18, TE23, LI4 and S36 were used. In the pre- and post therapy, DITI examinations was performed in patients who had Bell's palsy and were treated by acupuncture, and then tried to correlate the results of clinical symptoms with the difference of thermographic findings. And FNT examinations were performed in the same patients above, and then tried to correlate the results of clinical symptoms with the difference of nerve response findings. Setting : The standard routine thermographic examination with thermography (DITI) and nerve response with FNT(Facial Nerve Stimulation Test) were performed in the 16 patients with Bell's palsy at pre- and post acupuncture. Patients : Thermographic imaging of 16cases was analyzed. They had diagnosed Bell's palsy. They were treated by acupuncture and moxibustion therapy in Wonkwang Oriental Hospital from Jauary, 1999 to February, 2000. Results : 1) The results of treatment showes that 56.25% of patients achieved clinical excellent recovery and 31.25% achieved good recovery. After compairing the DITI results before and after treatment, we found 43.75% of patients achieved excellent recovery and 43.75% achieved good recovery. 2) After compairing the FNT results before and after treatment, we found 25% of patients achieved excellent recovery and 56.25% achieved good recovery. Conclusion : 1) Acupuncture showed good results over 87.5% in clinical evaluation and 87.5% in DITI. Thermographic examination showes terapeutic effect of acupuncture treatment. 2) Acupuncture showed good results over 87.5% in clinical evaluation and 81.25% in FNT. FNT showes nerve response recovery effect of acupuncture treatment.

數種 漢藥材가 肝癌細胞(Hep G2)와 마우스 腹腔 大食細胞에 미치는 影響

康城溶,韓宗鉉,趙南根 대한본초학회 1997 大韓本草學會誌 Vol.12 No.1

The action mechanism of herb drugs on the cytotoxicity and apoptosis in tumors undoubtedly are diverse. Apoptosis often is particularly prominent near foci of confluent necrosis, where mild ischemia is likely to be involved in its initiation. Apoptosis in tumors found in living body is occured by cytokines released from macrophage or cytotoxic T-lymphocyte, but the mechanism is not known accurately. A variety of cancer chemotherapeutic agents have been shown to induce extensive apoptosis in rapidely proliferating normal cell population, lymphoid tissues and tumors. The way in which anti-cancer drugs induce apoptosis is unknown. However, there is an additional important consequence of the realization that anti-cancer drugs mediate their therapeutic affects by triggering apoptosis. The activated macrophage can selectively destroy tumor cells Therefore, macrophage-mediated tumor cytotoxicity can have a important significance. Recently, it has been reported that some crude drugs stimulates IFN-v production in T-lymphocyte, and IFN-v stimulate nitric oxide production in peritoneal macrophage. The nitric oxide can affect the cytotoxicity and apoptosis in tumor cells. In this study, antineoplastic activity against human hepatocellular carcinoma cell line(Hep G2) was tested in four species of herb drugs. The plant materials were extracted with water, and the cytotoxic activity was tested using a calorimetric tetrazolium assay(MTT assay), the apoptosis was tested using a DNA electrophoresis and flow cytometry. The nitric oxide production from mouse peritoneal macrophage was tested using a Griess method. The four species of herb drugs were Arisaemitis Tuber, Bupleuri Radix and Coptidis Rhizoma extracts against the proliferation of Hep G2 cells showed cytotoxicity at the concentration of less than 100ug/㎖, and Bupleuri Radix and Coptidis Rhizoma extracts increased the cytotoxicity of mitomycin C and Coptidis Rhizoma extracts increased the cytotoxicity of cisplatin on Hep G2 cells. Bupleuri Radix and Coptidis Rhizoma extracts against the proliperation of BALB/c 3T3 cells showed cytotoxicity, and Coptidis Rhizoma extracts aginist the proliperation of mouse thymocytes showed cytotoxicity at the concentration of less than 100ug/㎖. Arisaemitis Tuber extracts increased nitric oxide production from macrophage.

아몰퍼스 자왜 와이어의 제작과 센서특성

신용진,임재근,조남희 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

In this paper, we describe fabrication method and sensing functions of amorphous magnetostrictive wire. (Fe,Co)77Si8B5 chosen as nonstoichometric composition, is melted under high frequency induced furnance and then the melted composition is injection-quenched on water-flow at high speed revolution through the nozzle. As the result amorphous magnetostrictive-wires whose diameters are about 125㎛ are obtained On investigation of characteristics of the amorphous wires, a sharp Matteucci effect occurs even by low external magnetic field. It occurs by large Barkhausen jump due to magnetostriction of the amorphous wire. As the results of experiments, we find that amorphous-wires have sufficient characteristics needed as high sensitive security sensor material.

복어중독에 의한 가사 상태에서 소생한 1예

송승찬,신진호,강석우,박경남,최호순,박근태,문희식,기춘석,이성희,윤병철,노우균,조균석,이민호 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Tetrodotoxin is a neurotoxin produced by about 90 species of puffer fish and causes paralysis of central nervous system and peripheral nerves by blocking the movement of all monovalent cation. Ingestion of tetrodotoxin produces clinical manifestations such as paresthesias(within 10-45 min), vomiting, lightheadedness, salivation, muscle twitching, dysphagia, difficulty in speaking, convulsion and death that expressed by cardiopulmonary arrest with loss of brain stem reflex sometimes. Tetrodotoxin prevents or delays ischemia induced neuronal death by way of following 3 mechanisms. Firstly, it reduces the energy demand of the brain tissues. Secondly, it delays or even prevents anoxic depolarization. Finally, it deminishes ischemia induced cell swelling and cerebral edema. We report a case of puffer fish poisoning which presented with cardiopulmonary arrest and loss of brain stem reflex, but completely recovered by aggressive cardiopulmonary resuscitation.

Percutaneous Radiofrequency Facet Rhizotomy for Cervical Dorsal Ramus Syndrome

Cho, Tack-Geun,Hwang, Sung-Nam,Park, Seung-Won,Nam, Taek-Kyun,Hong, Hyun-Jong,Kim, Young-Baeg The Korean Neurosurgical Society 2006 Journal of Korean neurosurgical society Vol.40 No.6

Objective : Radiofrequency facet rhizotomy[RFFR] has been widely performed for treatment of chronic neck pain caused by cervical dorsal ramus syndrome[CDRS]. To evaluate the therapeutic effectiveness of RFFR in the patients with CDRS, we analyzed patients with various cervical pathologic conditions. Methods : The therapeutic results in forty-four patients who underwent RFFR for CDRS from January, 2000 to December, 2002 were analyzed according to the underlying pathologic conditions causing CDRS. The pathologic conditions were sprain [33 cases], herniated nucleus pulposus [6], foraminal stenosis [4], and compression fracture [1]. The therapeutic results were evaluated one month after the operation and graded as excellent, good, fair of poor. Treatments were considered successful if the therapeutic results were graded as either excellent of good. Results : The overall success rate in all patients was 72.7%. The success fate for treatment of cases with cervical sprain was 87.9%, but treatment of cases with herniated nucleus pulposus, foraminal stenosis, and fracture showed unsatisfactory results [mean success rate was 27.3%]. Some patients complained of transient hypesthesia [4 cases] of transient dull pain at the electrode insertion sites [2 cases]. Conclusion : RFFR is an effective and safe treatment for CDRS caused by cervical sprain, regardless of the patient's age, the duration of the symptoms, and the presence of radiating pain.

Glossopharyngeal Neuralgia Caused by Arachnoid Cyst in the Cerebellopontine Angle

Cho, Tack-Geun,Nam, Taek-Kyun,Park, Seung-Won,Hwang, Sung-Nam The Korean Neurosurgical Society 2011 Journal of Korean neurosurgical society Vol.49 No.5

Glossopharyngeal neuralgia is a relatively rare condition characterized by severe, paroxysmal episodes of lancinating pain in the tongue, throat, ear, and tonsil. This disorder is assumed to be due to compression of the glossopharyngeal nerve by vascular structures. A 47-year-old woman complaining of sharp and lancinating pain in the right periauricular and submandibular areas visited our hospital. Swallowing, chewing, and lying on her right side triggered the pain. Her neurologic examination revealed no specific abnormalities. The results of routine hematologic and blood chemistry studies were all within normal limits. Carbamazepine and gabapentin were given, but her symptoms persisted. Her pain was temporarily relieved only by narcotic pain medication. MRI showed an arachnoid cyst located in the right cerebellomedullary cistern extending to the cerebellopontine cistern. Cyst removal was performed via a right retrosigmoid approach. Lateral suboccipital craniotomy was performed using the right park-bench position. After opening the dura and cerebellopontine angle, the arachnoid cyst was exposed. The arachnoid cyst was compressing the flattened lower cranial nerves at the right jugular fossa. Her symptoms resolved postoperatively. Two months after the operation, she was completely free from her previous symptoms.

공항포장 개별결함에 대한 KPCI 민감도 분석연구

조남현(Cho, Nam-Hyun),김장락(Kim, Jang-Rak),조남근(Jo, Nam-Geun),김진영(Kim, Jin-Young),김세령(Kim, Se-Ryong) 대한토목학회 2016 대한토목학회 학술대회 Vol.2016 No.10

Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor

Sung Min Nam,Jong Hee Choi,Sun-Hye Choi,Hee-Jung Cho,Yeon-Jin Cho,Hyewhon Rhim,Hyoung-Chun Kim,Ik-Hyun Cho,Do-Geun Kim,Seung-Yeol Nah 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.3

Background: We recently showed that gintonin, an active ginseng ingredient, exhibits antibrain neurodegenerative disease effects including multiple target mechanisms such as antioxidative stress and antiinflammation via the lysophosphatidic acid (LPA) receptors. Amyotrophic lateral sclerosis (ALS) is a spinal disease characterized by neurodegenerative changes in motor neurons with subsequent skeletal muscle paralysis and death. However, pathophysiological mechanisms of ALS are still elusive, and therapeutic drugs have not yet been developed. We investigate the putative alleviating effects of gintonin in ALS. Methods: The G93A-SOD1 transgenic mouse ALS model was used. Gintonin (50 or 100 ㎎/㎏/day, p.o.) administration started from week seven. We performed histological analyses, immunoblot assays, and behavioral tests. Results: Gintonin extended mouse survival and relieved motor dysfunctions. Histological analyses of spinal cords revealed that gintonin increased the survival of motor neurons, expression of brain-derived neurotrophic factors, choline acetyltransferase, NeuN, and Nissl bodies compared with the vehicle control. Gintonin attenuated elevated spinal NAD(P) quinone oxidoreductase 1 expression and decreased oxidative stress-related ferritin, ionized calcium-binding adapter molecule 1-immunoreactive microglia, S100b-immunoreactive astrocyte, and Olig2-immunoreactive oligodendrocytes compared with the control vehicle. Interestingly, we found that the spinal LPA1 receptor level was decreased, whereas gintonin treatment restored decreased LPA1 receptor expression levels in the G93A-SOD1 transgenic mouse, thereby attenuating neurological symptoms and histological deficits. Conclusion: Gintonin-mediated symptomatic improvements of ALS might be associated with the attenuations of neuronal loss and oxidative stress via the spinal LPA1 receptor regulations. The present results suggest that the spinal LPA1 receptor is engaged in ALS, and gintonin may be useful for relieving ALS symptoms.