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- 저자 : Chim-ong, (검색결과 4 건)
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SLC35B2 Expression is Associated with a Poor Prognosis of Invasive Ductal Breast Carcinoma
Chim-ong, Anongruk,Thawornkuno, Charin,Chavalitshewinkoon-Petmitr, Porntip,Punyarit, Phaibul,Petmitr, Songsak Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
Background: Breast cancer is the most common malignancy in women worldwide, including Thailand, and is a major cause of mortality and morbidity, despite advances in diagnosis and treatment. Novel gene expression in breast cancer is a focus in searches for prognostic biomarkers and new therapeutic targets. Materials and Methods: The mRNA expression of novel B4GALT4, SLC35B2, and WDHD1 genes in breast cancer were examined in invasive ductal breast carcinoma (IDC) patients using quantitative real-time reverse transcription polymerase chain reaction (QRT-PCR). Results: Among these genes, increased expression of SLC35B2 mRNA was significantly associated with TNM stage III + IV of IDC (p<0.001). Hence, up-regulation of SLC35B2 may serve as a prognostic biomarker for poor prognosis, and is also a potential therapeutic target in breast cancer.
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Tan, Bien-Keem,Chim, Harvey,Ng, Zhi Yang,Ong, Kong Wee Korean Society of Plastic and Reconstructive Surge 2014 Archives of Plastic Surgery Vol.41 No.4
Background The advent of skin-sparing mastectomy has allowed for the reconstruction of the breast and nipple with improved cosmesis. However, the nipple-areolar complex (NAC) in Asian patients is more pigmented and scars easily. Therefore, commonly described incisions tend to result in poor aesthetic outcomes in Asian patients with breast cancer. Methods We describe an algorithmic approach to skin-sparing mastectomy incisions in Asian patients on the basis of the location of the biopsy scar and the tumor site and size. Four incision types are described: peri-areolar, a peri-areolar incision with a second distant skin paddle, "racquet handle," and peri-areolar with adjacent skin excision. Results 281 immediate breast reconstructions were performed between May 2001 and February 2012 after skin-sparing mastectomy. The mastectomy incisions used included the peri-areolar design (n=124, 44%), peri-areolar design with a second distant skin paddle (n=39, 14%), "racquet handle" (n=21, 7.5%), and peri-areolar design with adjacent skin excision (n=42, 14%). The traditional elliptical incision and other variants where the NAC outline was not preserved were performed in the remaining 55 patients. The average follow-up was 44.7 months during which there was 1 case of total flap loss and 7 cases of partial flap necrosis; all remaining flaps survived. 24% of the patients (68/281) underwent subsequent nipple reconstruction. Conclusions Our algorithm avoids breast incisions that are randomly placed or excessively long and prevents the unnecessary sacrifice of normal breast skin. This allows skin-sparing mastectomy and immediate breast reconstruction to be performed with a consistently achievable aesthetic result in Asian women without neglecting oncological safety.
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Bien-Keem Tan,Harvey Chim,Zhi Yang Ng,Kong Wee Ong 대한성형외과학회 2014 Archives of Plastic Surgery Vol.41 No.4
Background: The advent of skin-sparing mastectomy has allowed for the reconstruction ofthe breast and nipple with improved cosmesis. However, the nipple-areolar complex (NAC) inAsian patients is more pigmented and scars easily. Therefore, commonly described incisionstend to result in poor aesthetic outcomes in Asian patients with breast cancer. Methods: We describe an algorithmic approach to skin-sparing mastectomy incisions inAsian patients on the basis of the location of the biopsy scar and the tumor site and size. Four incision types are described: peri-areolar, a peri-areolar incision with a second distantskin paddle, “racquet handle,” and peri-areolar with adjacent skin excision. Results: 281 immediate breast reconstructions were performed between May 2001 andFebruary 2012 after skin-sparing mastectomy. The mastectomy incisions used included theperi-areolar design (n=124, 44%), peri-areolar design with a second distant skin paddle(n=39, 14%), “racquet handle” (n=21, 7.5%), and peri-areolar design with adjacent skinexcision (n=42, 14%). The traditional elliptical incision and other variants where the NACoutline was not preserved were performed in the remaining 55 patients. The average followupwas 44.7 months during which there was 1 case of total flap loss and 7 cases of partial flapnecrosis; all remaining flaps survived. 24% of the patients (68/281) underwent subsequentnipple reconstruction. Conclusions: Our algorithm avoids breast incisions that are randomly placed or excessivelylong and prevents the unnecessary sacrifice of normal breast skin. This allows skin-sparingmastectomy and immediate breast reconstruction to be performed with a consistentlyachievable aesthetic result in Asian women without neglecting oncological safety.
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이어도 종합해양과학기지의 비디오 이미지를 이용한 Whitecap coverage 관측 기법 수립
김선신(Sun-Sin Kim),민용침(Yong-chim Min),정종민(ong-min Jeong),민인기(In-Ki Min),정진용(Jin-Yong Jeong),심재설(Jae-Seol Shim) 한국연안방재학회 2016 한국연안방재학회지 Vol.3 No.4
Result from the global environmental changes represented by global warming, environmental variables including the sea temperature and sea surface height rise, ocean acidification, etc are reported to being in progress rapidly. Many studies have been carried out to understand the cause of the environmental changes and to deal with the impact. The environmental changes are closely related to the interaction between the ocean and atmosphere, especially in the boundary layer between them. So many studies on the energy and material, such as carbon dioxides, exchanges between the ocean and atmosphere are under going. In recent years, whitecap is recognized as the important parameters for the interaction between the ocean and atmosphere. There have been many efforts to observe and qualifying variables related to whitecap. Whitecap is the direct result from the wave breaking which have large temporal and spatial variability, and it is very hard to do quantitative observation. Previous studies have suggested the analytical solution, which defined the whitecap coverage, calculated from the wind, as a primary variable. Recently, owing to development in the image processing technologies, videos and still images are being used to observe whitecap coverage. But it has been very hard to obtain the continuous, precise wave images in the ocean. In this study, wave image obtained in the Ieodo Ocean Research Station were used to reduce the error of the conversion from image to whitecap coverage, and the formula which suggested by Sugihara et al. (2007). Specifically, it presented Pixel intensity threshold determination method and criteria image sampling frequency of Whitecap.
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