台灣對管制規範的改革 : 以對電子媒體核發臨時執照的運用為核心

吳志光 梨花女子大學校 法學硏究所 2015 法學論集 Vol.19 No.4

For the purposes of legal norms, all regulations are to overall efficiency, but excessive regulation will be mutual interference as to obstruct efficiency. The regulatory reform has become a responsibility of guarantor state. But for the fair competition or maintenance of social diversity shall be means special permission of regulation, this is the concerns of economic administrative law and Fair Trade Act. In particular, for regulation of electronic media involves freedom of expression and make it easier for controversial issue. In July 2005 Taiwan’s Government unprecedentedly rejected seven satellite broadcasting and television operator's application for the renewal of the operation license. At the time it caused much controversy. In support of the rule of law and procedures, which has a certain worth exploring. How to avoid producing all or none as a result of regulation, traditionally mainly to make administrative disposition with the incidental provision of agrees to the application licensing, mostly is the "conditions" or "burden" manner. But this way is not without controversy, in particular administrative discretion often become the focus of controversy. In 2007 the Cable Radio and Television Act amendments to new articles 35-1,1) it is creation of the "temporary operation license” as a new models of regulation. The regulatory reform is also as a responses of controversy in 2005. The temporary operation license could replace direct refused to apply for the renewal of the operation license, and also can be replaced by making a provisional injunction of Administrative Court. More importantly, the temporary operation license created the regulatory measures for the time foresee the possibility, this is the lack of the administrative disposition with incidental provision by the advantages. After all the purpose of regulation to public interests. At the same time how to balance the rights of the applicant of operation license, the temporary operation license should be the greatest common divisor.

Functional Biodegradable Polylactide and Polycarbonate for Biomedical Applications

Chih-Kuang Chen,Zheng-Ian Lin 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2

Polylactide and polycarbonate, FDA-approved synthetic polymers, have been extensively used in the biomedical field owing to their favorable biodegradability. However, the lack of hydrophilicity and functionality has limited the biomedical applicability. To address this issue, functional polylactide and polycarbonate have been developed in our laboratory. Utilizing a ring-opening polymerization (ROP) procedure, functional polylactide polymers such as charged polylactides, drug-conjugated polylactides and inorganic carbon dot/polylactide hybrids have been synthesized in advance, followed by converting them into different particulate objects, including nanoparticles, micelles and nanocapsules. Moreover, due to the functionality, cross-linkages, stimuli-responsiveness and targeting ability can be endowed into these particulate objects. This further enhances their biomedical applicability. In addition to polylactide, CO₂-based alicyclic polycarbonates have been prepared via dinuclear nickel nitrophenolate-based catalysis, followed by a chemical modification treatment on the resulting polymer for creating a hydrophilic polycarbonate polymer. Due to the improved water solubility, the hydrophilic polycarbonate polymer thus is able to be used in drug and gene delivery applications.

A Distributed and Scalable Time Slot Allocation Protocol for Wireless Sensor Networks

Chih-Kuang Lin,Zadorozhny, Vladimir I,Krishnamurthy, Prashant V,Ho-Hyun Park,Chan-Gun Lee IEEE 2011 IEEE TRANSACTIONS ON MOBILE COMPUTING Vol.10 No.4

<P>There are performance deficiencies that hamper the deployment of Wireless Sensor Networks (WSNs) in critical monitoring applications. Such applications are characterized by considerable network load generated as a result of sensing some characteristics of the monitored system. Excessive packet collisions lead to packet losses and retransmissions, resulting in significant overhead costs and latency. In order to address this issue, we introduce a distributed and scalable scheduling access scheme that mitigates high data loss in data-intensive sensor networks and can also handle some mobility. Our approach alleviates transmission collisions by employing virtual grids that adopt Latin Squares characteristics to time slot assignments. We show that our algorithm derives conflict-free time slot allocation schedules without incurring global overhead in scheduling. Furthermore, we verify the effectiveness of our protocol by simulation experiments. The results demonstrate that our technique can efficiently handle sensor mobility with acceptable data loss, low packet delay, and low overhead.</P>

Keratanase II Digestion Accompanied with a Liquid Chromatography/Tandem Mass Spectrometry for Urinary Keratan Sulfate Quantitative Analysis

Chuang, Chih-Kuang,Lin, Hsiang-Yu,Wang, Tuen-Jen,Huang, Sung-Fa,Lin, Shuan-Pei Association for Research of MPS and Rare Diseases 2017 Journal of mucopolysaccharidosis and rare disease Vol.3 No.1

Purpose: Mucopolysaccharidosis IV (MPS IV) is a disease characterized by deficient activity of N-acetylgalactosamine-6-sulfatase (GALNS) causing excessive lysosomal storage of keratan sulfate (KS). The identification of the relevant disaccharide units of KS after keratanase II digestion followed by liquid chromatography/tandem mass spectrometry detection (LC-MS/MS) is validated and applicable for the preliminary diagnosis of MPS IV. Methods: A total of 67 urine samples were collected and analyzed from 11 MPS IV patients comprising 10 MPS IVA and one MPS IVB patients, and 56 normal controls. Urinary glycosaminoglycan was first precipitated by the Alcian blue method followed by a digestion of keratanase II. The protonated species of the digested disaccharide products were detected by using multiple reaction monitoring experiment. Results: One particular disaccharide of KS was selected. The transition mass-to-charge (m/z) of the parent ion and its daughter ion after collision was $462.0{\rightarrow}97.0$, whereas the chondrosine used as an internal standard in this assay was m/z $353.9{\rightarrow}73.0$. The results corresponded well with the two-dimensional electrophoresis method. The quantities of urinary KS were significantly raised in confirmed MPS IV patients when comparing with those of normal controls ($170.2{\pm}81.1$ vs. $4.06{\pm}1.92{\mu}g/mL$). Conclusion: The LC-MS/MS method for MPS IVA determination is specific, sensitive, validated, and applicable for urinary KS quantification. This method can be used not only as a first-line biochemistry examination of MPS IVA, but also as an outcome survey after enzyme replacement therapy.

Simulation of Poultry House Ventilation using Computational Fluid Dynamics

( Chih-hsiang Hsu ),( Sumingchen ),( Kuang-wen Hsieh ),( Chao-yin Tsai ),( Rou-yan Peng ),( Jin-ming Tsai ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

Poultry output value in Taiwan takes a large proportion of whole livestock production. However, in 2014, it was suffered from a serious bird flu invasion in Taiwan, culling a large number of poultries. Take geese as an example, almost 90% of the geese were culled in 2014. As a result, it caused serious losses to livestock industry. In order to prevent outbreak of bird flu, the government has stipulated that poultry houses must be rebuilt as non-open poultry houses and rehabilitated. Therefore, the development of the design in closed poultry houses is important. In this study, Computational Fluid Dynamics (CFD) was used to simulate a 30 m ^* 8.5 m ^* 3.6 m closed poultry house. There are two suction fans used for longitudinal ventilation. Through the different circulation fan setups to evaluate for the growth conditions of poultry and improve the ventilation of closed poultry houses, and reduce the possibility of invasion of pathogenic sources at the same time. The results showed when a circulation fan was not placed, there was a phenomenon of non-uniform airflow distribution within 6 m near water-cooled wall. When a circulation fan was placed 3 m away from the water-cooled wall, some parts of the airflow concentrated near the fan and caused non-uniform airflow distribution within 9 m near the water-cooled wall, which may be unsuitable for poultries living. The study showed that simulation of flow field facilitates designs of non-open poultry houses.

Common Neurological Disorders Involving Inpatient Liaisons at a Secondary Referral Hospital in Taiwan: A Retrospective Cross-Sectional Study

Chih-Yang Liu,Han-Lin Chiang,Ser-Chen Fu,Yu-Chin Su,Cheng-Lun Hsiao,Fu-Yi Yang,Shinn-Kuang Lin 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.1

Background and Purpose Te requirement for neurology liaison is increasing in accordance with the growing health care demands associated with aging populations. Te aim of this study was to characterize the nature of neurological inpatient liaisons (NILs) to help plan for the appropriate use of neurology resources. Methods Tis was a retrospective cross-sectional study of NILs in a secondary referral hospital over a 12-month period. Results Tere were 853 neurological consultations with a liaison rate of 3% per admission case. Chest medicine, gastroenterology, and infectious disease were the three most frequent specialties requesting liaison, and altered consciousness, seizure, and stroke were the three most frequent disorders for which a NIL was requested. Infection was the most common cause of altered consciousness. Epilepsy, infection, and previous stroke were common causes of seizure disorders. Acute stroke accounted for 44% of all stroke disorders. Electroencephalography was the most recommended study, and was also the most frequently performed. Ninety-fve percent of emergency consultations were completed within 2 hours, and 85% of regular consultations were completed within 24 hours. Te consult-to-visit times for emergency and regular consultations were 44±47 minutes (mean±standard deviation) and 730±768 minutes, respectively, and were shorter for regular consultations at intensive care units (p=0.0151) and for seizure and stroke disorders (p=0.0032). Conclusions Altered consciousness, seizure, and stroke were the most common reasons for NILs. Half of the patients had acute neurological diseases warranting immediate diagnosis and treatment by the consulting neurologists. Balancing increasing neurologist workloads and appropriate health-care resources remains a challenge.

Antiproliferative and Antitumorigenic Activity of Toona sinensis Leaf Extracts in Lung Adenocarcinoma

Chih-Jen Yang,Yu-Jung Huang,Cheng-Yuan Wang,Chuan-Sheng Wang,Pei-Hui Wang,Jen-Yu Hung,Tung-Heng Wang,Hseng-Kuang Hsu,Hurng-Wern Huang,S.P. Anand Kumar,Ming-Shyan Huang,Ching-Feng Weng 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1

Toona sinensis is a traditional Chinese herb, and the extracts of T. sinensis leaf possess a variety of biological functions. This study attempted to test the antiproliferative effect of TSL-1 (a bioactive fraction of T. sinensis) in H441 cells (lung adenocarcinoma). The data showed that the antiproliferative effect of TSL-1 on H441 cells is prominent using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. TSL-1-induced apoptosis was confirmed by cell morphology, sub-G1 peak accumulation, cleavage of poly(ADP)-ribose polymerase, and propidium iodide-annexin V double staining. Furthermore, decreased Bcl-2 accompanied by increased Bax (in western blotting) was found with TSL-1 treatment of H441 cells. TSL-1 treatment-induced G1 arrest was concurrent with the down-regulation of protein levels of cyclin D1 and cyclin-dependent kinase 4 in H441 cells. Peroral and intraperitoneal administrations of TSL-1 were performed to evaluate the therapeutic efficacy, and peroral administration of TSL-1 was also used to elucidate the therapeutic efficacy in the H441 cell xenograft model in vivo. The data revealed that TSL-1 treatment inhibited H441 tumor growth in both therapeutic and preventive experiments. Taken together, these results demonstrate that TSL-1 possesses the capability of preventing and alleviating lung cancer proliferation in vitro and in vivo with proven nephrological and hepatic safety and has the potential to be developed as an anti–lung cancer drug.

The Incremental Cost Matrix Procedure for Locating Repair Service Centers in Multinational Reverse Logistics

Chen, Hsin Min,Hsieh, Chih Kuang,Wu, Ming Cheng,Luo, Shin Wei Korean Institute of Industrial Engineers 2009 Industrial Engineeering & Management Systems Vol.8 No.3

This study provides a heuristic algorithm to solve the locating problem of repair service centers (RSCs). To enhance the customer service level with more satisfaction and quicker responsiveness, the locating problem of RSCs has become one of the important issues in reverse supply chain management. This problem is formulated as a zero-one mixed integer programming in which an exiting distributor will be considered to be an un-capacitated repair service center for the objective of cost-minimizing. Since logistical costs are highly interrelated with the multinational location of distributors and RSCs, the fixed cost for setting a repair service center, variable cost, transportation cost, and exchange rates are considered in this study. Recognizing the selection of un-capacitated RSCs' locations is a combinatorial optimization problem and is a zero-one mixed integer programming with NP-hard complexity, we provide a heuristic algorithm named as incremental cost matrix procedure (ICMP) to simplify the solving procedure. By using the concise and structural cost matrix, ICMP can efficiently screen the potential location with cost advantage and effectively decide which distributor should be a RSC. Results obtained from the numerical experiments conducted in small scale problem have shown the fact that ICMP is an effective and efficient heuristic algorithm for solving the RSCs locating problem. In the future, using the extended ICMP to solve problems with larger industrial scale or problems with congestion effects caused by the variation of customer demand and the restriction of the RSC capacity is worth a further investigation.

The Incremental Cost Matrix Procedure for Locating Repair Service Centers in Multinational Reverse Logistics

Hsin Min Chen,Chih Kuang Hsieh,Ming Cheng Wu,Shin Wei Luo 대한산업공학회 2009 Industrial Engineeering & Management Systems Vol.8 No.3

This study provides a heuristic algorithm to solve the locating problem of repair service centers (RSCs). To enhance the customer service level with more satisfaction and quicker responsiveness, the locating problem of RSCs has become one of the important issues in reverse supply chain management. This problem is formulated as a zero-one mixed integer programming in which an exiting distributor will be considered to be an un-capacitated repair service center for the objective of cost-minimizing. Since logistical costs are highly interrelated with the multinational location of distributors and RSCs, the fixed cost for setting a repair service center, variable cost, transportation cost, and exchange rates are considered in this study. Recognizing the selection of un-capacitated RSCs’ locations is a combinatorial optimization problem and is a zero-one mixed integer programming with NP-hard complexity, we provide a heuristic algorithm named as incremental cost matrix procedure (ICMP) to simplify the solving procedure. By using the concise and structural cost matrix, ICMP can efficiently screen the potential location with cost advantage and effectively decide which distributor should be a RSC. Results obtained from the numerical experiments conducted in small scale problem have shown the fact that ICMP is an effective and efficient heuristic algorithm for solving the RSCs locating problem. In the future, using the extended ICMP to solve problems with larger industrial scale or problems with congestion effects caused by the variation of customer demand and the restriction of the RSC capacity is worth a further investigation.

Early Diagnosis for Mucopolysaccharidosis I - A 6-month-old Female Infant Presenting with Gibbus, Hirsutism and Mongolian Spots in a Well Baby Clinic

Lin, Hsiang-Yu,Chuang, Chih-Kuang,Chang, Jui-Hsing,Lin, Shuan-Pei Association for Research of MPS and Rare Diseases 2016 Journal of mucopolysaccharidosis and rare disease Vol.2 No.1

Mucopolysaccharidosis (MPS) I is a rare, progressive and multisystemic disease with insidious initial signs and symptoms, and making an early diagnosis can be a challenge for the first-line general medical practitioner. We report a 6-month-old girl who was brought to our well baby clinic for regular immunization with the manifestations of lumbar gibbus, hirsutism, large Mongolian spots over back and buttock, and mild bilateral legs spasticity noticed by the general pediatrician, and then newly diagnosed with MPS I after referral to the geneticist in time. Her surgical history included inguinal hernia repair at 1 month old, $CO_2$ laser supraglottoplasty for laryngomalacia and tracheostomy due to chronic respiratory failure with ventilator dependence at 2 months old. Understanding and identification of the early signs and symptoms of this disease have the potential to early diagnosis and timely appropriate treatment, which could contribute to a better clinical outcome.