Lipid Profile Change after Thyroidectomy

Chih Hao Chu,Soo Young Kim,Yong Sang Lee,Hang-Seok Chang 대한갑상선-내분비외과학회 2020 The Koreran journal of Endocrine Surgery Vol.20 No.3

Purpose: Thyroid diseases and lipid metabolic abnormalities have been reported to be correlated. In patients with thyroid cancer, thyroid stimulating hormone levels are suppressed to prevent recurrence. Many studies have reported dyslipidemia associated with thyroid function, although its extent before and after thyroidectomy remains to be studied. This study aimed to determine the lipid levels for administering accurate lipid treatment in thyroid cancer patients post thyroidectomy. Methods: In total, 1,203 patients with thyroid cancer who underwent thyroidectomy between June 1, 2016 and December 31, 2016 at the Thyroid Cancer Center, Gangnam Severance Hospital, Yonsei University, were enrolled in the study. Of these, patients aged <19 years and taking medication for dyslipidemia were excluded. Finally, we enrolled 295 thyroid cancer patients who underwent thyroidectomy and whose lipid profiles were confirmed pre- and post-operatively. Results: The total cholesterol levels in the lobectomy group without levothyroxine supplementation were significantly increased 1 year after surgery than those before surgery (168.17±29.19 mg/dL vs. 182.50±34.03 mg/dL, P=0.003). Additionally, the triglyceride (TG) levels were significantly decreased in the lobectomy with levothyroxine supplementation and total thyroidectomy groups, whereas cholesterol and low-density lipoprotein-cholesterol (LDL-C) levels showed no significant change. No significant changes in the levels of cholesterol, LDL-C, and TG were observed in all the 3 groups. Conclusion: Extent of surgery and levothyroxine supplementation had an insignificant impact on the levels of cholesterol, LDL-C, TG, and high-density lipoprotein-cholesterol compared pre- and post-operatively.

Osteogenesis and Chondrogenesis of Primary Rabbit Periosteal Cells under Non-uniform 2-Axial Tensile Strain

Chih-Hao Chiu,Yun-Wen Tong,Jen-Fang Yu,Kin Fong Lei,Alvin Chao-Yu Chen 한국바이오칩학회 2020 BioChip Journal Vol.14 No.4

Periosteal cells are the major cell sources of skeletal progenitors for fracture callus. In order to promote bone repair and cartilage formation, besides the application of exogenous growth factors, physical stimulation is an alternative approach to guide cell differentiation. Investigation of appropriate conditions is essential for forming bone and cartilage. In this work, a membrane-type micro-system was developed to provide cell culture environment and cell stretching stimulation during culture course. Circular and oval culture wells were designed to respectively generate uniform and non-uniform 2-axial tensile strain for stretching primary rabbit periosteal cells. Cell orientation and differentiation were studied after cycling stretching for 2 days. The cells aligned to the stretching axis with high tensile strain in the oval culture wells; while the cells expressed random orientation in the circular culture wells. Different responses were significantly shown when the cells were respectively stimulated by uniform and non-uniform 2-axial tensile strains. On the other hand, osteogenic differentiation was shown when the cells were under either uniform or non-uniform 2-axial tensile strain. However, only non-uniform 2-axial tensile strain could induce mature osteoblasts. In addition, the result revealed chondrocytes could be differentiated only under a large and nearly single dimensional tensile strain. In summary, differentiation of the periosteal cells is highly influenced by 2-dimensional distribution of the tensile strain. This work provides some in-sights of the control of axial tensile strain for periosteal cell differentiation.

Design Customization of Respiratory Mask based on 3D Face Anthropometric Data

Chih-Hsing Chu,Szu-Hao Huang,Chih-Kai Yang,Chun-Yang Tseng 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.

This study presents a machine learning based method for design customization of a 3D respiratory mask. A parametric model of a3D human face was constructed from an anthropometric database consisting of 495 facial models. An AdaBoost.R algorithm wasapplied to identify a set of measurable parameters most related to the facial geometry. The correlation between parameters wasestimated using principal component analysis and linear regression. With those parameter values as input, the parametric modelgenerates 3D meshes of a human face that serve as a design reference for the construction of a customized respiratory mask of agood fit. We conducted a series of experiments with 10-fold cross-validation to validate the effectiveness of the proposed method.

Incarceration of the Long Head of the Biceps Tendon: a Case Series

Chih-Hao Chiu 대한견주관절의학회 2021 대한견주관절학회 학술대회논문집 Vol.2021 No.3

Introduction and Background To present the clinical and imaging findings and results of treatment in patients with intra-articular long head of the biceps tendon (LHBT) adhesion to the undersurface of the rotator cuff. Material and Method Patients with intra-articular LHBT adhesion to the undersurface of the rotator cuff found incidentally during arthroscopy were included with a minimal 2-year follow-up. Demographic data, images, and physical examinations were recorded. LHBT release, tenotomy, or tenodesis were performed according to the patient’s age and surgeon’s preference. Results Twelve patients were included in the study. All of them presented with chronic anterior shoulder pain and positive Speed and O’Brien tests. The average age was 46.8 17 years (range 20-79 years) and the pain sustained from 6 to 96 (average 25.5 28.6) months. Before the operation, 6 patients had a positive Jobe’s test, 1 had a positive lift-off test, and all had positive O’Brien and Speed tests and tenderness over the LHBT. Three release, 4 tenotomy, and 5 LHBT tenodesis were done in addition to other procedures if needed. All range of motion except external rotation, pain visual analog score, and functional outcome scores showed significant improvement at 6 months after surgery. There were no significant differences in range of motion and functional scores between 6 months and 12 months postoperatively. No difference was found in LHBT scores at 6 and 12 months after the operation. Magnetic resonance imaging revealed thickened coracohumeral ligament overlying the LHBT. Conclusions Patients who had intra-articular LHBT adhesion to the undersurface of the rotator cuff and underwent release of the adhesion around LHBT, tenotomy, or tenodesis all had good clinical outcomes. The lesion was observed in 2.2% of all shoulder arthroscopies. Although difficult to diagnose before surgery, surgeons should be aware of this unusual condition in patients with chronic and insidious anterior shoulder pain.

Maintenance of Stroke Care Quality amid the Coronavirus Disease 2019 Outbreak in Taiwan

Chih-Hao Chen,Chi-Hung Liu,Nai-Fang Chi,Pi-Shan Sung,Cheng-Yang Hsieh,Meng Lee,Sung-Chun Tang,Jiann-Shing Jeng,Taiwan Stroke Society Investigators 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.3

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A Comprehensive Method for Seismic Impact Chain Assessment of Urban Lifeline Infrastructure: A Case Study of Taipei Area, Taiwan

Chih-Hao Hsu,Min-Cheng Teng,Siao-Syun Ke 대한토목학회 2021 KSCE JOURNAL OF CIVIL ENGINEERING Vol.25 No.10

Infrastructure refers to an aggregation of numerous facilities that constitute the backbone of urban operations. The lifeline systems are usually interdependent; thus, any damage to one system can cause a chain reaction, triggering failures in related and connected systems, leading to a cascade of disasters. Taiwan is located in the Circum-Pacific seismic zone, where earthquakes occur frequently. Moderate-to-large earthquakes can adversely affect the lifeline systems, severely impairing most urban functions. Therefore, understanding the effects of earthquakes of this intensity on lifeline systems as well as how these effects contribute to disaster scenarios in urban areas is a critical requirement for the Taiwanese government. From the disaster management perspective, this study constructed a seismic impact chain module for lifeline systems on the basis of an analysis of the direct and indirect impacts of seismic activity. Furthermore, the factor of infrastructure impact was examined using the matrix method. Simulations of 6.6 magnitude earthquakes along the Shanchiao fault were used to assess the impact chain of the lifeline system and the effectiveness of a hospital disaster rescue service. In the simulation, the lifeline systems in the epicentral area were directly damaged, whereas critical infrastructure was indirectly affected. Therefore, the study results will assist the authorities in making intelligent decisions regarding lifeline infrastructure and resource management.

Classifying Endemic Fagaceae Species in Taiwan using Leaf Images

( Hao-chun Hsu ),( Cheng-hao Lee ),( Chih-kai Yang ),( Fang-hua Chu ),( Ming-jer Tsai ),( Yan-fu Kuo ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1

Fagaceae is one of the plant family which dominate the broad-leaved forests in Taiwan and have considerable value in economy and ecology. Traditionally, plant species identification based on leaf morphologies and is conducted using naked-eye observation. This study is proposed to distinguish the Fagaceae species using image processing and machine learning. In this study, leaf images of 10 Fagaceae species were collected. A serial of traits relevant to leaf morphologies, such as morphological, color, shape, and venation traits, were quantified from the leaf images. A support vector machine classifier was then developed to identify the species using the quantified traits. The proposed approach reached an identification accuracy of 95.8%.

일반논문 : 탈냉전시기 북한-대만관계의 복합구조 연구

린치하오 ( Chih Hao Lin ),유호열 ( Ho Yeol Yoo ) 동국대학교 북한학연구소 2015 북한학연구 Vol.11 No.2

본 연구는 1992년부터 시작된 북한과 대만관계의 흐름을 살펴보는 것이다. 1990년 초 탈냉전 시기, 한중관계와 북중관계는 서로의 차이점이 발생하게 된다. 당시 한국과 중국은 경제관계를 주축으로 수교가 이루어지고 있었고, 북한과 중국은 지역전략과 전통적 혈맹관계에 기반을 두어 수교가 이루어지는 상황이었다. 한중수교 이후 북한과 대만은 동시에 외교적 충격을 받았다. 이 동병상련의 상황에서 북한과 대만 사이의 수면 아래 교류는 점차 부상되었다. 당시 중국국민당이 집권한 대만정부에서는 북한과 직접무역을 하기 위해 국민당의 기업(회사)을 통해 북한과 관물자원 등 무역거래를 했다. 그 이후 양측의 왕래무역은 점점 규모가 확장되었다. 1996~1997년 기간에는 대만정부가 북한의 요청을 받아서 2차례의 농업기술지원단을 파견하기도 하였다. 1998년 대만전력공사는 북한정부와 핵폐기물이전합의를 맺었다. 특히 이 핵폐기물이전합의는 한국, 미국, 일본, 중국 등 주변국가의 우려 및 불신 등 원인으로 인해, 결국 북한-대만간 의 핵폐기물합의는 제대로 실행될 수 없었다. 본 연구는 이러한 역사적 흐름을 통해 동아시아에 있는 남북한 관계 및 양안관계의 교차관계를 구성함으로써 북한-대만 관계의 지위를 분석하려고 한다. This treatise will focus North Korea and Taiwan’s relationship and relation process in the post-cold war, And it is not to figured out what different of North Korea and Taiwan’s diplomatic strategy but also try to find out Taiwan’s Korea peninsula strategy between North and South Korea during 1990s. After 1992, cross-strait relations and North-South Korea relations were changed to another system, China having successful in implementing its “One China Policy” and then Taiwan was tried to establish informal relations with North Korea, After Since the establishment of diplomatic between Korea and China, Taiwan changed its foreign policy to eliminate international isolation Almost at the same time, North Korea were also to tried new relationship with USA, Japan and the other country which without diplomatic relations. we can find that North Korea and Taiwan were in the same boat Until Kim Jung Il visited China in 2000. This treatise’s references is according to the formal history data from Taiwan, Korea, North Korea. and also found by Taiwan newspaper “China Times”, North Korea newspaper “Rodong Sinmun” and memoir books wrote by Lin Qiu Shan who was a Taiwan government’s negotiator with North Korea government. This treatise will review North Korea and Taiwan’s relationships from the Taiwan’s view position.

Feline mammary carcinoma-derived extracellular vesicle promotes liver metastasis via sphingosine kinase-1-mediated premetastatic niche formation

Yi-Chih Chang,Hao-Ping Liu,Hsiao-Li Chuang,Jiunn-Wang Liao,Pei-Ling Kao,Hsun-Lung Chan,Ter-Hsin Chen,Yu-Chih Wang 한국실험동물학회 2023 Laboratory Animal Research Vol.39 No.4

Background: Feline mammary carcinoma (FMC) is one of the most prevalent malignancies of female cats. FMC is highly metastatic and thus leads to poor disease outcomes. Among all metastases, liver metastasis occurs in about 25% of FMC patients. However, the mechanism underlying hepatic metastasis of FMC remains largely uncharacterized. Results: Herein, we demonstrate that FMC-derived extracellular vesicles (FMC-EVs) promotes the liver metastasis of FMC by activating hepatic stellate cells (HSCs) to prime a hepatic premetastatic niche (PMN). Moreover, we provide evidence that sphingosine kinase 1 (SK1) delivered by FMC-EV was pivotal for the activation of HSC and the formation of hepatic PMN. Depletion of SK1 impaired cargo sorting in FMC-EV and the EV-potentiated HSC activation, and abolished hepatic colonization of FMC cells. Conclusions: Taken together, our findings uncover a previously uncharacterized mechanism underlying liver-metastasis of FMC and provide new insights into prognosis and treatment of this feline malignancy.

Toposequence for Distribution and Transformation of Phosphorus Fractions in Humid Subalpine Forests

Shih-Hao Jien,Yue-Ming Chen,Chih-Chieh Hu,Tsai-Huei Chen,Chih-Yu Chiu 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6