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녹음 구어 제시가 중도정신지체 성인여성의 목욕 능력 개선에 미치는 효과
鄭如意,陳明聰,陳政見 대구대학교 특수교육재활과학연구소 2006 再活科學硏究 Vol.24 No.2
1. This study aimed to explore the effect of recorded auditory prompts on helping an adult with profound mental retardation to take bath independently. 「A-B-C-A-C」design, a kind of single-subject experiment was adopted. Three phases, baseline phase, intervention phase(B): auditory prompt, and intervention phase(C): recorded auditory prompt were included. A female with profound mental retardation participated in the experiment. It took over seven months to finishing the intervention. The results of the experiment indicated that auditory prompts, whether human auditory prompt or recorded prompt, could help the client to take bath more independently. The families of the client also regarded recorded auditory prompt was a feasible solution. Based on the result, there were some suggestions for the further research. 본 연구의 목적은 녹음 구어 제시를 이용해서 극 중도 지능장애 성인 여성 스스로 목욕 동작을 완성 할 수 있도록 도와주는 효과에 대한 연구입니다. 본 연구에 사용하는 연구법은 ⌜A-B-A-C-A-C⌟역 설계이다. 기선기의(A)개입一(B)인공구어제시 개입二(C)녹음 구어 제시로 나누어졌다. 실험기간은 모두 7개월 반이었다. 연구결과는 피 실험자가 스스로 목욕할 때와 비교했을 때 인공구어 제시와 녹음구어 제시는 모두 피 실험자가 목욕 동작을 완성 하는 데에 효과가 있는 것으로 나타났다. 이 외에도 녹음 구어 제시는 피 실험자 가족들도 받아들일 수 있다. 본 연구 결과에 근거해서 연구자들은 미래 응용과 연구에 대한 건의도 제출하였다.
Analysis, Design, and Implementation of a High-Performance Rectifier
Chien-Ming Wang,Chin-Wang Tao,Yu-Hao Lai 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.3
A high-performance rectifier is introduced in this study. The proposed rectifier combines the conventional pulse width modulation, soft commutation, and instantaneously average line current control techniques to promote circuit performance. The voltage stresses of the main switches in the rectifier are lower than those in conventional rectifier topologies. Moreover, conduction losses of switches in the rectifier are certainly lower than those in conventional rectifier topologies because the power current flow path when the main switches are turned on includes two main power semiconductors and the power current flow path when the main switches are turned off includes one main power semiconductor. The rectifier also adopts a ZCS-PWM auxiliary circuit to derive the ZCS function for power semiconductors. Thus, the problem of switching losses and EMI can be improved. In the control strategy, the controller uses the average current control mode to achieve fixed-frequency current control with stability and low distortion. A prototype has been implemented in the laboratory to verify circuit theory.
Chien-Yeh Ho,Chien-Ming Wang,Chang-Hua Lin 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5
This paper proposes a novel multi-phase PWM dimming control scheme which possesses two-phase, four-phase, six-phase, and eight-phase for backlight inverter. Each phase driving circuit can control the lamp current of two ccfls at least. From the experimental results for four-phase and six-phase PWM dimming control, we got a conclusion which power efficiency η (%) is directly proportional to No. of phases and lamp current error E (%) is inversely proportional to No. of phases. Hence higher phases dimming will achieve uniform output lamp currents which is called current equalization. We develop a design rule which compare system parameters in multi-phase dimming control for backlight inverter. We conclude that the experimental results also can apply for two-phase and eight-phase PWM dimming control.
Chien-Tai Hong,Lung Chan,Chaur-Jong Hu,Chien-Min Lin,Chien-Yeh Hsu,Ming-Chin Lin 한국유방암학회 2017 Journal of breast cancer Vol.20 No.4
Purpose: Whether tamoxifen affects the risk of neurodegenerative disease is controversial. This nationwide population-based study investigated the risk of Parkinson’s disease (PD) associated with tamoxifen treatment in female patients with breast cancer using Taiwan’s National Health Insurance Research Database. Methods: A total of 5,185 and 5,592 female patients with breast cancer who did and did not, respectively, receive tamoxifen treatment between 2000 and 2009 were included in the study. Patients who subsequently developed PD were identified. A Cox proportional hazards model was used to compare the risk of PD between the aforementioned groups. Results: Tamoxifen did not significantly increase the crude rate of developing PD in female patients with breast cancer (tamoxifen group, 16/5,169; non-tamoxifen group, 11/5,581; p=0.246). Tamoxifen did not significantly increase the adjusted hazard ratio (aHR) for subsequently developing PD (aHR, 1.310; 95% confidence interval [CI], 0.605–2.837; p= 0.494). However, tamoxifen significantly increased the risk of PD among patients followed up for more than 6 years (aHR, 2.435; 95% CI, 1.008–5.882; p=0.048). Conclusion: Tamoxifen treatment may increase the risk of PD in Taiwanese female patients with breast cancer more than 6 years after the initiation of treatment.
Chien-Liang Liu,Ming-Jen Chen,Jiunn-Chang Lin,Chi-Hsin Lin,Wen-Chien Huang,Shih-Ping Cheng,Shan-Na Chen,Yuan-Ching Chang 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2
Purpose: Cancer cells develop acquired resistance induced by chemotherapeutic drugs. In this study, we investigated the effects of brief treatment with cytotoxic drugs on the phenotype of breast cancer cells. Methods: Breast cancer cells MCF7 and BT-474 were briefly treated with paclitaxel or doxorubicin. Clonogenic, migration, and invasion assays were performed on the treated cells. Western blot analysis and RhoA activity assay were also performed. Results: Breast cancer cells when briefly treated with paclitaxel or doxorubicin showed reduced clonogenic ability. Doxorubicin, but not paclitaxel, augmented cell migration and invasion. The invasion-promoting effects of doxorubicin were lost when the two drugs were sequentially used in combination. Myosin light chain (MLC) 2 phosphorylation and RhoA activity were upregulated by doxorubicin and downregulated by paclitaxel. Pretreatment with RhoA inhibitors abolished the migration- and invasion-promoting effects of doxorubicin. Conclusion: Doxorubicin activates the RhoA/MLC pathway and enhances breast cancer cell migration and invasion. Therefore, this pathway might be explored as a therapeutic target to suppress anthracycline-enhanced tumor progression.
A High Performance Soft-Switching AC/DC Converter
Chien-Ming Wang,Chang-Hua Lin,Chi-Hsiang Cheng,Bo-Han Wu 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
This paper introduced a high performance single stage soft-switching AC/DC converter. The introduced soft-switching AC/DC converter uses four switches fullbridge circuit construct to achieve the input power factor correction and the output DC voltage regulation. The introduced soft-switching AC/DC converter adopts interleaved operation mode in ac input side to reduce the input current harmonic and increase the supply power level. Moreover, the introduced soft-switching AC/DC converter can get soft-switching function on its main power switches without soft-switching auxiliary circuit. Thus, the cost of circuit in low. A simple phase-shift control strategy is used to synthesize a suitable low harmonics sinusoidal waveform for the ac input current and achieve well dynamic regulation. A design example of 1000W high performance DC power supply system is examined to assess its performance.
( Ming-lung Yu ),( Ming-lun Yeh ),( Chi-yi Chen ),( Pin-nan Cheng ),( Ming-jong Bair ),( Jyh-jou Chen ),( Ching-chu Lo ),( Chi-ming Tai ),( Ching-yang Tsai ),( Kuo-chih Tseng ),( Chien-hung Chen ),( C 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Insufficient data regarding the treatment strategy for partial response to nucleot(s)ide analogue (NUC) raised the aim of investigating tenofovir alafenamide (TAF) switching for chronic hepatitis B (CHB) patients with advanced fibrosis and partial response to other NUCs. Methods: CHB patients with advanced fibrosis (stage 3 or 4) and under NUC (except TAF) therapy with detectable hepatitis B virus (HBV) DNA for >52 weeks are enrolled to TAF 25 mg/day for 96 weeks. The objectives are viral suppression, alanine aminotransferase (ALT) normalization and safety. Results: From Feb. 2019, 34 patients, including 21 (61.8%) with entecavir, 10 (29.4%) TDF and 3 (8.8%) lamivudine or adefovir, were enrolled (15 [44.1%] male, median 53 years). The fibroscan demonstrated a mean of 10.5 kPa (7 [20.6%] cirrhotic). Sixteen (47.1%) patients were HBV e antigen positive, seven (20.6%) had YMDD mutation. The median HBV DNA level declined from 68.5 IU/mL at enrollment to 27.0 IU/mL at 4<sup>th</sup> week, and undetectable at 12<sup>th</sup>, 24<sup>th</sup>, 36<sup>th</sup> week, respectively, after TAF switching, with undetectable HBV DNA in 14/34 (41.2%), 17/33 (51.5%), 15/25 (60.0%), and 9/15 (60.0%) patients and rate of ALT normalization (≤40 U/L) of 85.3%, 85.3%, 84.8%, 92.0%, and 80.0%, respectively, after TAF switching. (figure 1) Two patients experienced transient virological breakthrough and another one developed at the final time follow up. Serum creatinine and eGFR levels were stable after TAF switching (figure 1). Two patients early terminated including one at 12<sup>th</sup> week due to personal reason, and another one accidently died at 20<sup>th</sup> week due to acute heart attack. Others suffered only mild degrees of adverse events which were considered unrelated to treatment. Conclusions: The preliminary results demonstrated the TAF switching is effective and safe in viral suppression for CHB patients with advanced fibrosis and partial virologic responses to other NUCs.
Chien-Ming Wu,Hsiao-Chun Lin,Fang-Yi Cheng,Mu-Hua Chien 한국기상학회 2019 Asia-Pacific Journal of Atmospheric Sciences Vol.55 No.4
In this study, we aim to evaluate the impact of fast land-atmosphere interactions on the afternoon thunderstorm in Taiwan through high-resolution meteorological simulations. For this purpose, the Noah land surface model (LSM) is implemented into the vector vorticity equation cloud-resolving model (VVM) with corresponding realistic land surface data of Taiwan into the coupling system, called TaiwanVVM. Two idealized experiments are conducted by giving the same surface forcing but one with direct land-atmosphere coupling from Noah LSM (called Coupled experiment) and the other with prescribed surface fluxes (called Prescribed experiment). Our results show that the fast land-atmosphere interaction over complex topography has a significant influence on rainfall intensity, especially in the heavy precipitating region where the interaction is strong.Without direct coupling between the land surface and the atmosphere in the Prescribed experiment, the diurnal intensity is suppressed by 50%over whole Taiwan and 70% for East Taiwan. Our findings demonstrate that the intensity of the afternoon thunderstorm is sensitive to fast land-atmosphere interactions by modifying local circulation in the mountainous region of Taiwan.