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Hung, Hsiu-Chi,Chien, Tsui-Wei,Tsay, Shiow-Luan,Hang, Hewi-Ming,Liang, Shu-Yuan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Objective: The aim of the current study was to evaluate changes in treatment outcomes in terms of health-related quality of life (HRQoL) and symptom burden at zero, one, three, and six months after an initial diagnosis of colorectal cancer. The demographic and clinical characteristics that account for outcome changes in patients were investigated using a repeated measures framework. Methods and Materials: A cohort study was performed of 134 colorectal cancer patients followed from diagnosis to 6 months post-treatment in Central Taiwan. HRQoL and symptoms were assessed at diagnosis and one, three, and six months thereafter. The Functional Assessment of Cancer Therapy-Colon (FACT-C) questionnaire, VAS pain, and the Memorial Symptom Assessment Scale (MSAS) were used for data collection. A generalized estimating equation (GEE) was applied for statistical analysis. Results: The majority of the patients were male (55%) and married (91.5%). The mean age was 60.4 years (SD = 11.71). Most were diagnosed stage III and IV colorectal cancer (54.5%). All underwent surgery; some also received chemotherapy (CT) or concurrent chemoradiation therapy (CCRT). The results of the GEE showed that overall, the HRQoL, pain, and symptoms of the patients significantly improved over the treatment period. Patients with stage IV disease who had received surgery and CCRT showed the worst HRQoL. Females, patients with comorbidity, and stage IV patients had higher pain scores over time. Female and stage IV patients had more severe physical symptoms, whereas stage II and IV patients had worse psychological symptoms over time. Conclusion: The patients' HRQoL, pain, and symptoms significantly improved over the 6-month treatment period. Certain patient and clinical variables accounted for changes in treatment outcomes regarding HRQoL and symptom burden in colorectal cancer patients.
Detecting small lung tumors in mouse models by refractive-index microradiology
Chien, Chia-Chi,Zhang, Guilin,Hwu, Y.,Liu, Ping,Yue, Weisheng,Sun, Jianqi,Li, Yan,Xue, Hongjie,Xu, Lisa X.,Wang, Chang Hai,Chen, Nanyow,Lu, Chien Hung,Lee, Ting-Kuo,Yang, Yuh-Cheng,Lu, Yen-Ta,Ching, Y Springer-Verlag 2011 ANALYTICAL AND BIOANALYTICAL CHEMISTRY Vol.401 No.3
Chien-Hsuan Chang,Chun-An Cheng,En-Chih Chang,Hung-Liang Cheng 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
A typical photovoltaic (PV) grid-connection power system is usually consisted of multi-stage converters to perform multiple functions simultaneously. In order to simplify system configuration, reduce cost, and improve conversion efficiency, this paper proposes to adopt two-switch buck-boost (TSBB) dc-dc converters, and then develops families of buck-boost typed inverters via the connection with an H-bridge unfolding circuit with linecommuted operation. The proposed inverters have both step-up and step-down functions so that they are suitable for the applications with wide voltage-variation range. Depending on the conditions of dc input-voltage and ac output-voltage, the proposed circuits can work functionally as either buck-typed or boost-typed inverter. Due to operating with buck or boost principle, partial energy can be directly delivered to output to improve efficiency. Besides, since only one power switch operates with high-frequency, switching losses can be reduced significantly. Finally, one of the proposed TSBB inverters, named buck-cascaded buck-boost (BuCBB) inverter, is then implemented accordingly to generate 110 Vrms / 60 Hz output voltage. Experimental results have verified the validity of theoretical predictions and the feasibility of proposed inverters.
Improving Varying-Pseudonym-Based RFID Authentication Protocols to Resist Denial-of-Service Attacks
Hung-Yu Chien,Tzong-Chen Wu 한국정보보호학회 2008 정보보호학회논문지 Vol.18 No.b6
Applying Varying Pseudonym (VP) to design of Radio Frequency Identification (RFID) authentication protocol outperforms the other existing approaches in several respects. However, this approach is prone to the well-known denial-of-service (DOS) attack. In this paper, we examine the de-synchronization problems of VP-based RFID authentication protocols, and propose effective solutions to eliminate such weaknesses. We shall show that the proposed solutions indeed improve the security for these protocols, and moreover, these solutions require O(1) computational cost for identifying a tag and O(1) key space on the tag. These excellent performances make them very attractive to many RFID applications.
Characterization of Protein Arginine Methyltransferases in Porcine Brain
Hung, Chien-Jen,Chen, Da-Huang,Shen, Yi-Ting,Li, Yi-Chen,Lin, Yi-Wei,Hsieh, Mingli,Li, Chuan Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.5
Protein arginine methylation is a posttranslational modification involved in various cellular functions including cell signaling, protein subcellular localization and transcriptional regulation. We analyze the protein arginine methyltransferases (PRMTs) that catalyze the formation of methylarginines in porcine brain. We fractionated the brain extracts and determined the PRMT activities as well as the distribution of different PRMT proteins in subcellular fractions of porcine brain. The majority of the type I methyltransferase activities that catalyze the formation of asymmetric dimethylarginines was in the cytosolic S3 fraction. High specific activity of the methyltransferase was detected in the S4 fraction (high-salt stripping of the ultracentrifugation precipitant P3 fraction), indicating that part of the PRMT was peripherally associated with membrane and ribosomal fractions. The amount and distribution of PRMT1 are consistent with the catalytic activity. The elution patterns from gel filtration and anion exchange chromatography also indicate that the type I activity in S3 and S4 are mostly from PRMT1. Our results suggest that part of the type I arginine methyltransferases in brains, mainly PRMT1, are sequestered in an inactive form as they associated with membranes or large subcellular complexes. Our biochemical analyses confirmed the complex distribution of different PRMTs and implicate their regulation and catalytic activities in brain.
Improving Varying-Pseudonym-Based RFID Authentication Protocols to Resist Denial-of-Service Attacks
Chien, Hung-Yu,Wu, Tzong-Chen Korea Institute of Information Security and Crypto 2008 정보보호학회논문지 Vol.18 No.b6
Applying Varying Pseudonym (VP) to design of Radio Frequency Identification (RFID) authentication protocol outperforms the other existing approaches in several respects. However, this approach is prone to the well-known denial-ofservice (DOS) attack. In this paper, we examine the de-synchronization problems of VP-based RFID authentication protocols, and propose effective solutions to eliminate such weaknesses. We shall show that the proposed solutions indeed improve the security for these protocols, and moreover, these solutions require 0(1) computational cost for identitying a tag and 0(1) key space on the tag. These excellent performances make them very attractive to many RFID applications.
Hung, Kun-Chien,Lin, David W. The Korea Institute of Information and Commucation 2007 Journal of communications and networks Vol.9 No.2
We consider channel-coded multi-input multi-output (MIMO) orthogonal frequency-division multiplexing (OFDM) transmission and obtain a condition on its signal for it to attain the maximum diversity and coding gain. As this condition may not be realizable, we propose a suboptimal design that employs an orthogonal transform and a space-frequency interleaver between the channel coder and the multi-antenna OFDM transmitter. We propose a corresponding receiving method based on block turbo equalization. Attention is paid to some detailed design of the transmitter and the receiver to curtail the computational complexity and yet deliver good performance. Simulation results demonstrate that the proposed transmission technique can outperform the conventional coded MIMO OFDM and the MIMO block single-carrier transmission with cyclic prefixing.