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- 저자 : Chien-Chen (검색결과 293 건)
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A Simple Timeout Algorithm for Point-to-Multipoint ABR Service
Lai, Wei-Kuang,Chen, Chien-Ting,Li, Chilin The Korea Institute of Information and Commucation 2004 Journal of communications and networks Vol.6 No.1
The ABR point-to-multipoint connection is now playing a more important role than before. Many consolidation algorithms have been proposed to solve the consolidation noise problem and the slow transient response problem. But few timeout algorithms are proposed to handle the non-responsive branches for the multicast connections. Chen’s algorithm needs exchanging control messages between switches [9]. Besides, it may mistake a responsive branch as a non-responsive branch because of fast changes in source rates, which causes wrong information in BRM cells and may lead to network congestion and data losses in the responsive branch. We propose a simple timeout algorithm which can handle the non-responsive branches without exchanging message between switches. The timeout value for each switch is computed locally. Simulation results show that the proposed timeout algorithm can efficiently handle the non-responsive branches and utilize the available bandwidth within a small period of time. In addition, our algorithm could handle the situation when the source rates change quickly.
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Chen Peng-Ciao,Chen Yu-Ju,Yang Chia-Chen,Lin Ting-Ti,Huang Chien-Chu,Chung Chi-Hsiang,Sun Chien-An,Chien Wu-Chien 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.3
Purpose: Some evidence suggests that male infertility increases the risk of cardiovascular diseases (CVDs). However, the evidence in Asian populations is relatively scarce. The aim of this study is to determine whether male infertility increases the risk of CVDs. Materials and Methods: We used inpatient and outpatient data for the years 2000 to 2015 from the Taiwanese Longitudinal Health Insurance Database. We enrolled 7,016 males over 18 years old and diagnosed with male infertility. Of these, 2,326 matched our inclusion criteria and were assigned to the study group. For each infertility patient, four comparison patients were frequency-matched by age and index date to form a control cohort comprising 9,304 patients. Cox proportional hazards analysis was used to estimate the association between male infertility and CVDs. Results: After a 15-year follow-up, the incidence rate of CVDs was higher in the infertility group than the control group (1,460.23 and 1,073.70 per 100,000 person-years, respectively). The Cox proportional hazards regression analysis revealed that the adjusted HR for CVDs was 1.472 for the infertility group (95% CI, 1.288–1.683; p<0.001) relative to the control group. The Kaplan–Meier analysis of the cumulative incidence of CVDs in the two groups showed that the cumulative risk curve for CVDs was significantly higher for the infertility group than the control group. Conclusions: This study shows that men with infertility have a higher risk of developing incident CVDs. In the future, healthcare providers should pay attention to these patients because of their higher health risks.
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Moscatilin Induces Apoptosis and Mitotic Catastrophe in Human Esophageal Cancer Cells
Chien-An Chen,Chien-Chih Chen,Chien-Chang Shen,Hen-Hong Chang,Yu-Jen Chen 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.10
Moscatilin, a bibenzyl derivative from the orchid Dendrobium loddigesii, has been shown to possess anticancer activity. We examined the effect of moscatilin on human esophageal cancer cells, including squamous cell carcinoma (SCC) and adenocarcinoma (ADC) cells and its possible mechanisms. Moscatilin suppressed the growth of both the histological cell lines in a dose- and time-dependent manner. Morphological changes indicative of apoptosis and mitotic catastrophe were observed following moscatilin treatment. The population of cells in the sub-G1 phase and polyploidy phase significantly increased after treatment. Immunofluorescence revealed multipolar mitosis and subsequent multinucleation in moscatilin-treated cells, indicating the development of mitotic catastrophe. Western blot showed a marked increase in expressions of polo-like kinase 1 and cyclin B1 after exposure to moscatilin. In conclusion, moscatilin inhibits growth and induces apoptosis and mitotic catastrophe in human esophageal SCC- and ADC-derived cell lines, indicating that moscatilin has broad potential against esophageal cancer
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Chien-Chou Chen,Wen-Hwa Wu,Chin-Hui Huang,Gwolong Lai 국제구조공학회 2013 Smart Structures and Systems, An International Jou Vol.11 No.4
Due to its easy operation and wide applicability, the ambient vibration method is commonly adopted to determine the cable force by first identifying the cable frequencies from the vibration signals. With given vibration length and flexural rigidity, an analytical or empirical formula is then used with these cable frequencies to calculate the cable force. It is, however, usually difficult to decide the two required parameters, especially the vibration length due to uncertain boundary constraints. To tackle this problem, a new concept of combining the modal frequencies and mode shape ratios is fully explored in this study for developing an accurate method merely based on ambient vibration measurements. A simply supported beam model with an axial tension is adopted and the effective vibration length of cable is then independently determined based on the mode shape ratios identified from the synchronized measurements. With the effective vibration length obtained and the identified modal frequencies, the cable force and flexural rigidity can then be solved using simple linear regression techniques. The feasibility and accuracy of the proposed method is extensively verified with demonstrative numerical examples and actual applications to different cable-stayed bridges. Furthermore, several important issues in engineering practice such as the number of sensors and selection of modes are also thoroughly investigated.
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Chien-Chou Chen,Wen-Hwa Wu,Chun-Yan Liu,Gwolong Lai 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.2
Under the interference of the temperature effect, the alternation of cable force due to damages of a cable-stayed bridge could be difficult to distinguish. Considering the convenience and applicability in engineering practice, simple air or cable temperature measurements are adopted in the current study for the exclusion of temperature effect from the variation of cable force. Using the data collected from Ai-Lan Bridge located in central Taiwan, this work applies the ensemble empirical mode decomposition to process the time histories of cable force, air temperature, and cable temperature. It is evidently observed that the cable force and both types of temperature can all be categorized as the daily variation, long-term variation, and high-frequency noise in the order of decreasing weight. Moreover, the correlation analysis conducted for the decomposed variations of all these three quantities undoubtedly indicates that the daily and long-term variations with different time shifts have to be distinguished for accurately evaluating the temperature effect on the variation of cable force. Finally, consistent results in reducing the range of cable force variation after the elimination of temperature effect confirm the validity and stability of the developed method.
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Chien-Liang Liu,Ming-Jen Chen,Jiunn-Chang Lin,Chi-Hsin Lin,Wen-Chien Huang,Shih-Ping Cheng,Shan-Na Chen,Yuan-Ching Chang 한국유방암학회 2019 Journal of breast cancer Vol.22 No.2
Purpose: Cancer cells develop acquired resistance induced by chemotherapeutic drugs. In this study, we investigated the effects of brief treatment with cytotoxic drugs on the phenotype of breast cancer cells. Methods: Breast cancer cells MCF7 and BT-474 were briefly treated with paclitaxel or doxorubicin. Clonogenic, migration, and invasion assays were performed on the treated cells. Western blot analysis and RhoA activity assay were also performed. Results: Breast cancer cells when briefly treated with paclitaxel or doxorubicin showed reduced clonogenic ability. Doxorubicin, but not paclitaxel, augmented cell migration and invasion. The invasion-promoting effects of doxorubicin were lost when the two drugs were sequentially used in combination. Myosin light chain (MLC) 2 phosphorylation and RhoA activity were upregulated by doxorubicin and downregulated by paclitaxel. Pretreatment with RhoA inhibitors abolished the migration- and invasion-promoting effects of doxorubicin. Conclusion: Doxorubicin activates the RhoA/MLC pathway and enhances breast cancer cell migration and invasion. Therefore, this pathway might be explored as a therapeutic target to suppress anthracycline-enhanced tumor progression.
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Chen, Chien-Chou,Wu, Wen-Hwa,Huang, Chin-Hui,Lai, Gwolong Techno-Press 2013 Smart Structures and Systems, An International Jou Vol.11 No.4
Due to its easy operation and wide applicability, the ambient vibration method is commonly adopted to determine the cable force by first identifying the cable frequencies from the vibration signals. With given vibration length and flexural rigidity, an analytical or empirical formula is then used with these cable frequencies to calculate the cable force. It is, however, usually difficult to decide the two required parameters, especially the vibration length due to uncertain boundary constraints. To tackle this problem, a new concept of combining the modal frequencies and mode shape ratios is fully explored in this study for developing an accurate method merely based on ambient vibration measurements. A simply supported beam model with an axial tension is adopted and the effective vibration length of cable is then independently determined based on the mode shape ratios identified from the synchronized measurements. With the effective vibration length obtained and the identified modal frequencies, the cable force and flexural rigidity can then be solved using simple linear regression techniques. The feasibility and accuracy of the proposed method is extensively verified with demonstrative numerical examples and actual applications to different cable-stayed bridges. Furthermore, several important issues in engineering practice such as the number of sensors and selection of modes are also thoroughly investigated.
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Optimal Lot-sizing and Pricing with Markdown for a Newsvendor Problem
Chen, Jen-Ming,Chen, Yi-Shen,Chien, Mei-Chen Korean Institute of Industrial Engineers 2008 Industrial Engineeering & Management Systems Vol.7 No.3
This paper deals with the joint decisions on pricing and ordering for a monopolistic retailer who sells perishable goods with a fixed lifetime or demand period. The newsvendor-typed problem is formulated as a two-period inventory system where the first period represents the inventory of fresh or new-arrival items and the second period represents the inventory of items that are older but still usable. Demand may be for either fresh items or for somewhat older items that exhibit physical decay or deterioration. The retailer is allowed to adjust the selling price of the deteriorated items in the second period, which stimulates demand and reduces excess season-end or stale inventory. This paper develops a stochastic dynamic programming model that solves the problem of preseason decisions on ordering-pricing and a within-season decision on markdown pricing. We also develop a fixed-price model as a benchmark against the dual-price dynamic model. To illustrate the effect of the dual-price policy on expected profit, we conduct a comparative study between the two models. Extension to a generalized multi-period model is also discussed.
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