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Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.
The Transition from Dripping to Jetting of a Water Jet Under Rigid Body Rotation
( Chun-chia Chang ),( Chun-kuei Chen ),( Ta-hui Lin ) 한국액체미립화학회 2017 한국액체미립화학회 학술강연회 논문집 Vol.2017 No.-
This research is dedicated to analyzing the characteristic of a liquid jet under various conditions, for example, different flow rate and rotating speed. In this study, we found out that the imposed rotation would shorten the breakup length of a liquid jet due to its extra disturbance. On the other hand, hysteresis behavior occurs when using relatively large nozzle diameter, which represents that the critical flow rate of the transition from dripping to jetting is different to that from jetting to dripping. Consequently, we further analyzed the critical rotating speed (Jetting→Dripping) and critical flow rate (Dripping→ Jetting) in this hysteresis zone. As for the last part of this study, the breakup patterns had been deducted, we can divided the breakup modes into three distinguished patterns basically by how the droplets are formed, which are steady formation, two-drop coalescence, multiple-drop coalescence, respectively. Last but not least, the mutual interaction between these three patterns and how the rotation affected the outcomes of a liquid jet are concluded in this research.
Gei3ta1 in Taiwan Mandarin--- A Particular Construction
( Chia Chun Lee ) 한국언어정보학회 2007 학술대회 논문집 Vol.2007 No.-
The present paper investigates a particular structure in Taiwan Mandarin, "(NP) + (intensifier) + gei3ta1 "give him/it"+ adjective" in terms of construction grammar. The structure is mostly observed in utterances of younger generation. Though it is not regarded as a grammatical or standard structure, it is still a register of language. The structure lays emphasis on speaker``s attitude toward an undesired, unpleasant event. In most cases, the attitude tends to be negative. The events or propositions must have existed or been completed. The adjectives compatible with this structure belong to category of higher degree. The grammatical usage illustrates semantic bleaching of gei3ta1. And the changes from giving to a grammatical particle denoting subjective belief is a kind of subjectification. Moreover, ta1 could refer to events or situation expressed by a more complicated grammatical structure, or denotes nothing as a dummy word. Though many previous studies paid attention to the newly developed structure resulted from language contact, the adequate account was not provided. It is hoped through this investigation, we will get a better understanding of this particular structure.
Chiang, Chia-Chun,Yu, Bi,Chiou, Peter Wen-Shyg Asian Australasian Association of Animal Productio 2005 Animal Bioscience Vol.18 No.8
A trial was conducted to evaluate the level of wheat substituted for corn in a traditional corn-soy diet and the xylanase supplementation effect on the growth performance and nutrient digestion of broiler chickens. This experiment was a randomized design with a 4${\times}$2 factorial arrangement with four levels of wheat substitution and two levels of enzyme inclusion in the diet. Wheat replaced 0, 25, 50 or 100% corn with or without 1 g/kg xylanase supplementation in iso-nitrogenous and iso-calorific experimental diets. The results showed that in the growing period, broilers attained the highest (p<0.05) body weight gain, feed intake, and relative small intestine weight when wheat was substituted at 25% for corn. The relative caecum weight increased (p<0.05) linearly with increasing levels of wheat substitution for corn. However, during the finishing period and entire experimental period from 0 to 6 weeks, no significant difference was shown in the growth performance among all treatments. Xylanase inclusion significantly improved the body weight gain, fat availability (p<0.01) and diet metabolisable energy (p<0.1) but decreased (p<0.05) the relative GI tract weight during the growing period. The digesta viscosity of 6-week old broilers was also decreased (p<0.05). It appears that wheat substituted for corn did not affect the growth performance, nutrient digestion, and the digesta viscosity of chickens. It is acceptable to completely substitute wheat for corn. Xylanase supplementation improved performance.
Antenatal Depression in East Asia: A Review of the Literature
Mei-Chun Hsiao,Mei-Chun Hsiao,Chia-Yih Liu 대한신경정신의학회 2012 PSYCHIATRY INVESTIGATION Vol.9 No.2
This current study’s goal is to summarize the literature regarding Antenatal Depression (AD) in the East Asian countries of Taiwan, China (including Hong Kong and Macau), Japan, and Korea. The main search utilized a Pub med Chinese Electronic Periodical Service (CEPS) literature review using keywords ‘AD’, and ‘Prenatal Depression’ with searches for ‘Japan’, ‘Korea’, ‘Taiwan’, ‘Hong Kong’ and Macau’. The rates of AD in East Asia appear to be relatively close to those in the Western literature, although certain studies showed slightly decreased rates. Many of the risk factors for AD were the same in the Eastern and Western literature. These risk factors included demographic factors such as younger age, smoking, low education and income, and unemployment. Other risk factors were physical symptoms such as menstrual pains and nausea. Finally, psychological factors such as a poor response to the pregnancy, poor spousal support, and poor family support were associated with AD. With regard to treatment, there were no studies examining the administration of psychotropic medications for AD. The literature from East Asia both confirmed many Western findings and made unique contributions to the literature on AD. The treatment of AD in East Asia appears to be an entity which, despite its morbidity, has not been adequately studied.
Judy Chia-Chun Yuan,Cortino Sukotjo 대한치주과학회 2013 Journal of Periodontal & Implant Science Vol.43 No.2
Implant treatment has become the treatment of choice to replace missing teeth in partially edentulous areas. Dental implants present different biological and biomechanical characteristics than natural teeth. Occlusion is considered to be one of the most important factors contributing to implant success. Most literature on implant occlusal concepts is based on expert opinion,anecdotal experiences, in vitro and animal studies, and only limited clinical research. Furthermore, scientific literature regarding implant occlusion, particularly in implant-supported fixed dental prostheses remains controversial. In this study, the current status of implant occlusion was reviewed and discussed. Further randomized clinical research to investigate the correlation between implant occlusion, the implant success rate, and its risk factors is warranted to determine best clinical practices.
Yuan, Judy Chia-Chun,Sukotjo, Cortino Korean Academy of Periodontology 2013 Journal of Periodontal & Implant Science Vol.43 No.2
Implant treatment has become the treatment of choice to replace missing teeth in partially edentulous areas. Dental implants present different biological and biomechanical characteristics than natural teeth. Occlusion is considered to be one of the most important factors contributing to implant success. Most literature on implant occlusal concepts is based on expert opinion, anecdotal experiences, in vitro and animal studies, and only limited clinical research. Furthermore, scientific literature regarding implant occlusion, particularly in implant-supported fixed dental prostheses remains controversial. In this study, the current status of implant occlusion was reviewed and discussed. Further randomized clinical research to investigate the correlation between implant occlusion, the implant success rate, and its risk factors is warranted to determine best clinical practices.
Pao-Huan Chen(Pao-Huan Chen),Chun-Ming Shih(Chun-Ming Shih),Chi-Kang Chang(Chi-Kang Chang),Chia-Pei Lin(Chia-Pei Lin),Yung-Han Chang(Yung-Han Chang),Hsin-Chien Lee(Hsin-Chien Lee),El-Wui Loh(El-Wui Lo 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: Predicting disease relapse and early intervention could reduce symptom severity. We attempted to identify potential indicators that predict the duration to next admission for an acute affective episode in patients with bipolar I disorder. Methods: We mathematically defined the duration to next psychiatric admission and performed single-variate regressions using historical data of 101 patients with bipolar I disorder to screen for potential variables for further multivariate regressions. Results: Age of onset, total psychiatric admissions, length of lithium use, and carbamazepine use during the psychiatric hospitalization contributed to the next psychiatric admission duration positively. The all-in-one found that hyperlipidemia during the psychiatric hospitalization demonstrated a negative contribution to the duration to next psychiatric admission; the last duration to psychiatric admission, lithium and carbamazepine uses during the psychiatric hospitalization, and heart rate on the discharge day positively contributed to the duration to next admission. Conclusion: We identified essential variables that may predict the duration of bipolar I patients’ next psychiatric admission. The correlation of a faster heartbeat and a normal lipid profile in delaying the next onset highlights the importance of managing these parameters when treating bipolar I disorder.