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토끼에서 Etofenprox와 Spinosad 합제의 국소자극성 시험
황윤환,김명석,송인배,박병권,양승호,임용현,송치용,안성한,남현수,임정교,정상일,명노일,윤효인 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2008 動物醫科學硏究誌 Vol.15 No.1
This study was performed to evaluation the skin and eye irritation of etofenprox 8% and spinosad 4% combination in male New Zealand White rabbits. In skin irritation test, the combination of etofenprox and spinosad did not showed any change of body weight but caused slight skin irritation with the P.I.I. (primary irritation index) value 0.25. The etofenprox and spinosad combination showed severe eye irritation 1 h, 24 h, 48 h, and 72 h after ocular treatment, having the A.O.I. (acute ocular irritation) value of 37.3. Therefore, these result indicated that the combination of etofenprox and spinosad might be irritant formulation on eye and skin.
Chi, Ming Hao,Yim, Jong Eun,Yi, Dong hyun korean Academy of Physical Therapy Rehabilitation 2020 Physical therapy rehabilitation science Vol.9 No.4
Objective: The purpose of this study was to investigate the effect of treadmill exercise on the posture and walking speed of chronic stroke survivors with an ankle-foot orthosis. Design: Randomized controlled trial. Methods: Twenty-four chronic persons with chronic stroke admitted to Bobath Memorial Hospital in Seongnam city were divided into two groups by random blind method. Treadmill exercise with an elastic ankle-foot orthosis was performed in the experimental group and treadmill exercise was performed in the control group. The experiment was carried out for 6 weeks, and the experiment was carried out three times a week for 20 minutes per session. To measure the effect, static balance was measured using the MTD system before and after training, and the Berg Balance Scale (BBS) was used to measure functional balance. Results: There was a statistically significant difference between the 2 groups in the BBS measurement results for confirming the functional balance (p<0.05). Also, there was a significant difference between the 2 groups in single limb support time, step time and step length (p<0.05). Conclusions: In this study, it was found that treadmill exercise with an elastic ankle-foot orthosis in persons with chronic stroke was effective in maintaining functional balance, walking ability, step length, and step time. Therefore, it is necessary to use a flexible ankle-foot orthosis with proper treadmill exercise as a method of improving balance and walking speed of chronic stroke survivors.
Hao Chi Zhang,Monica Tamil,Keshav Kukreja,Shashideep Singhal 대한소화기내시경학회 2020 Clinical Endoscopy Vol.53 No.2
Concomitant malignant gastric outlet obstruction and biliary obstruction may occur in patients with advanced cancers affecting theseanatomical regions. This scenario presents a unique challenge to the endoscopist in selecting an optimal management approach. Wesought to determine the effcacy and safety of endoscopic techniques for treating simultaneous gastric outlet and biliary obstruction(GOBO) with endoscopic ultrasound (EUS) guidance for biliary drainage. An extensive literature search for peer-reviewed publishedcases yielded 6 unique case series that either focused on or included the use of EUS-guided biliary drainage (EUS-BD) withsimultaneous gastroduodenal stenting. In our composite analysis, a total of 51 patients underwent simultaneous biliary drainagethrough EUS, with an overall reported technical success rate of 100% for both duodenal stenting and biliary drainage. EUS-guidedcholedochoduodenostomy or EUS-guided hepaticogastrostomy was employed as the initial technique. In 34 cases in which clinicalsuccess was ascribed, 100% derived clinical benefit. The common adverse effects of double stenting included cholangitis, stent migration,bleeding, food impaction, and pancreatitis. We conclude that simultaneous double stenting with EUS-BD and gastroduodenal stentingfor GOBO is associated with high success rates. It is a feasible and practical alternative to percutaneous biliary drainage or surgery forpalliation in patients with associated advanced malignancies.
Wang, Chi-Mei,Li, Shan-Jen,Wu, Chi-Hao,Hu, Chien-Ming,Cheng, Hui-Wen,Chang, Jung-Su Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Chronic liver diseases, including cancer, are characterized by inflammation and elevated serum ferritin (SF). However, the causal-relationship remains unclear. This study used primary rat hepatic stellate cells (HSC) as a model to investigate effects of physiological SF concentrations (10, 100 and 1000 pM) because HSCs play a central role in the development and progression of liver fibrosis. Physiological concentrations of SF, either horse SF or human serum, induced pro-inflammatory cytokine $IL1{\beta}$, IL6 and $TNF{\alpha}$ secretion in rat activated HSCs (all p<0.05). By contrast, treatment did not alter activation marker ${\alpha}SMA$ expression. The presence of SF markedly enhanced expression of Grp78 mRNA (p<0.01). Furthermore, transient knock down of Grp78 by endotoxin EGF-SubA abolished SF-induced $IL1{\beta}$ and $TNF{\alpha}$ secretion in activated HSCs (all p<0.05). In conclusion, our results showed that at physiological concentrations SF functions as a pro-inflammatory mediator in primary rat HSCs. We also provide a molecular basis for the action of SF and identified Grp78-associated ER stress pathways as a novel potential therapeutic target for resolution of fibrosis and possible prevention of liver cancer.
중국 소비자의 미리 포장된 식사 구매 의도에 대한 이론적 기반 및 실증적 검증: 소비자 혁신성 관점에서 확장된 TPB 모델
Hao-Jie Jiang,Chi Gong,Shuai Jiang 사회혁신기업연구원 2024 혁신기업연구 Vol.9 No.1
COVID-19 팬데믹의 영향으로 중국의 미리 포장된 식사 산업이 빠른 성장 단계에 진입하여 소비자들로부터 점점 더 많은 호감을 얻고 있습니다. 이 연구는 중국 소비자들이 미리 포장된 식사를 구매하는 데 영향을 미치는 요인을 탐색하는 것을 목표로 합니다. 우리는 계획된 행동 이론(TPB)과 소비자 혁신성을 사용하여 구조방정식 모델을 구축했습니다. 이 정량적 연구는 비확률 샘플링 온라인 설문조사를 통해 293개의 유효 데이터 포인트를 수집하고 SPSS 27.0 및 AMOS 26.0을 사용하여 모델 검증을 수행했습니다. 결과는 소비자의 도구적 및 정서적 태도가 구매 의도에 중요하게 긍정적인 영향을 미친다는 것을 보여줍니다. 서술적 규범도 구매 의도에 중요한 긍정적인 영향을 미칩니다, 반면 지시적 규범은 중요한 영향을 보이지 않습니다. 소비자의 자기 통제력과 외부 조건은 모두 구매 의도와 행동에 중요한 긍정적인 영향을 미칩니다. 구매 의도는 구매 행동에 중요한 영향을 미치며 자기 통제력과 외부 조건에서의 매개 효과를 가집니다. 소비자 혁신성은 구매 의도와 행동 사이에서 중요한 조절 역할을 합니다. 제품 디자인과 홍보를 강화하기 위해 소비자들에게 매력을 높이는 것이 필수적입니다. 추가 연구를 위한 제안이 제시됩니다. Owing to the impact of the COVID-19 pandemic, the pre-made food industry in China has entered a rapid growth phase, gaining increasing favor from consumers. This study aims to explore the factors influencing Chinese consumers' purchase of pre-made food. We employed the Theory of Planned Behavior (TPB) and consumer innovativeness to construct a structural equation model. This quantitative study gathered 293 valid data points through non-probability sampling online surveys and employed SPSS 27.0 and AMOS 26.0 for model validation. Results reveal that consumers' instrumental and affective attitudes significantly positively influence purchase intention. Descriptive norms also exert a significant positive impact on purchase intention, while injunctive norms do not show a significant effect. Consumers' self-control and external conditions both have significant positive influences on purchase intention and behavior. Purchase intention significantly affects purchase behavior and mediates effects in self-control and external conditions. Consumer innovativeness plays a significant moderating role between purchase intention and behavior. To enhance product design and promotion, it is imperative to increase attractiveness to consumers. Suggestions for further research are presented.
( Hao Jin ),( Wen Yi Jiang ),( Jin Huai Chi ),( Sung Hee Lee ),( Jae Hoon Jahng ),( Young Bum Cho ),( Geom Seog Seo ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: A role for autophagy, a conserved cellular response to stress, has recently been demonstrated in human cancers. Heme oxygenase-1 (HO-1) is a stress-inducible enzyme with anti-apoptotic property. In this study, we investigated the association between isoliquiritigenin (ISQ) and autophagy in HCT-116 cells. In addition, we determined whether the anti-apoptotic effects are mediated by HO-1-dependent autophagy. Methods: The protein expression of HO-1, LC3B-II, ATG5, ATG7, Benclin-1, PARP were analyzed by western blot analysis. Autophagy was assessed by acridine orange staining, immunofl uorescence (LC3 puncta). Knock-down of HO-1 expression was achieved with siRNA. Results: ISQ signifi cant induced LC3B-II, Beclin-1, ATG5, ATG7, PARP cleavage, expression compared to control values. Treatment with bafi lomycin A1 (BaF), autophagy inhibitor, significantly enhanced ISQ-induced accumulation of the autophagosomal marker LC3B-II and PARP cleavage. ISQ induce autophagy which inhibits against ISQ-induced apoptosis in HCT-116 cells. Furthermore, HO-1 knockdown by siRNA abolished the effects of anti-apoptotic and decreased LC3-II/LC3-I ratio in HCT-116 cells. The protective role of autophagy was dependent on HO-1 in HCT-116. Conclusions: Our results demonstrated that ISQ induce autophagy which is mediated by induction of HO-1 expression. ISQ-induced autophagy followed by apoptosis in HCT-116 cells.
Chi-Jung Chang,Yu-Chieh Kao,Jem-Kun Chen,Hao-Cheng Zhang,Shu-Yii Wu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.124 No.-
Since a large amount of waste polyester-cotton blended textiles can cause environmental pollution problems,it is crucial to develop sustainable technology for recycling textile wastes and producing valueaddedproducts. In this research, regenerated cellulose and polyester were obtained from thepolyester-cotton jean wastes by a sustainable process through the selective dissolving of cellulose fibersusing an ionic liquid (ILs), 1-butyl-3-methylimidazolium chloride ([Bmim]Cl). We developed an environmentallybenign decoloration approach without the bleaching or leaching processes. Instead, cellulose,polyester, and ILs were recycled from the selective degradation of indigo carmine (IC) or indigo dye inthe dye/ILs solution using the Bi11VO19 photocatalyst without impairing the dissolution capability ofILs. The selective decoloration of dye solution extracted from waste textiles involves interactions amongphotocatalysts, colorants, fibers, and media (ILs). The changes of dye and ILs molecules during the photocatalysisreaction were analyzed. FTIR and Raman spectra of the recycled ILs reveal that the chemicalstructure of ILs remains unchanged after the photocatalytic decoloration process. The ILs and photocatalystscan be recycled for repeated production of regenerated cellulose from waste jeans.
Chi He,Zhengping Hao,Xinyan Zhang,Shaokai Gao,Jinsheng Chen 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.5
Mesoporous silica supported catalysts with highly dispersed Pd particles located in their pore channels were synthesized via a novel and simple two-solvents approach. It is found that the support morphology has significant effect on active phase dispersion. Both the pore diameter and pore length of the silica hosts are critical for the catalytic performances of prepared catalysts. Catalyst with plateletlike morphology (Pd/S-P) shows the highest catalytic activity with 90% toluene conversion at 192 8C. The catalytic performances of the synthesized catalysts are closely correlated with Pd dispersion, CO2desorption capability, pore diameter and pore length of the host materials.