VRE 감염증의 임상상, 미생물학적 특성 분석 및 유전적 관련성 비교 : 전국 6개 병원에서 분리된 VRE를 중심으로

정희진,박정원,엄중식,하경임,신종희,김정미,이혜수,박영희,김우주,박승철 대한감염학회 2002 감염 Vol.34 No.5

이부기형을 동반한 부교교합에서의 이부골성형술의 응용

장영일,서정훈,남동석,이하진 대한치과교정학회 1996 대한치과교정학회지 Vol.26 No.3

턱은 인간의 성격을 나타내는 요소의 하나로 적절하게 돌출된 턱은 심미적인 안모를 위해 대단히 중요하다. 이부골성형술은 턱의 형태재형성을 목적으로 하며 이를 통해 고정치료 목적의 하나인 안모의 심미성 향상에 기여할 수 있다. 이부골성형술은 수직, 수평적으로 턱의 크기를 확대시키는 축조이부골성형술과 축소시키는 축소이부골성형술로 나눌수 있으며 그활용하는 예는 다음과 같다. 1. 후퇴된 턱의 전진 2. 전방 돌출된 턱의 후퇴 3. 수직고경의 조절 4. 비대칭의 개선 The chin is one of the factors which express human character, and appropriately protruding chin is very important to harmonious profile, the purpose of genioplasty is to reshape the chin and improve the facial esthetics which is one of the purposes of orthodontic treatment, It can be classified as augmentation genioplasty which enlarge the chin vertico-horizontally and reduction genioplasty whcih smallen it. The examples to apply this procedure are as follows. 1. advancement of retruded chin 2. reduction of chin prominence 3. control of chin vertical dimension 4. correction of asymmetry

Summary of clinically diagnosed amniotic fluid embolism cases in Korea and disagreement with 4 criteria proposed for research purpose

( Jin-ha Kim ),( Hyun-joo Seol ),( Won Joon Seong ),( Hyun-mee Ryu ),( Jin-gon Bae ),( Joon Seok Hong ),( Jeong In Yang ),( Ji-hee Sung ),( Suk-joo Choi ),( Soo-young Oh ),( Cheong-rae ) 대한산부인과학회 2021 Obstetrics & Gynecology Science Vol.64 No.2

Objective This study aimed 1) to investigate the clinical characteristics of amniotic fluid embolism (AFE) cases clinically diagnosed by maternal fetal medicine (MFM) specialists in Korea, 2) to check the disagreement with 4 recently proposed criteria by the Society for Maternal-Fetal Medicine (SMFM) for research purpose, and 3) to compare maternal outcomes between cases satisfying all 4 criteria and cases with at least 1 missing criterion. Methods This study included 12 patients clinically diagnosed with AFE from 7 referral hospitals in Korea. We collected information, including maternal age, symptoms of AFE, the amount of transfusion, and maternal mortality. Results The median maternal age was 33 years (range, 28-40 years). Regarding symptoms, cardiovascular arrest, hypotension, respiratory compromise, clinical coagulopathy, and neurologic signs were observed in 41.7%, 83.3%, 83.3%, 100%, and 66.7% of the cases, respectively. Among the 12 cases, 5 women died and 2 suffered severe neurologic disability, showing an intact survival rate of 41.7%. Disagreement with all 4 criteria proposed by the SMFM was found in 66.7% of the cases, due to the lack of criteria for disseminated intravascular coagulation or strict onset time (<30 minutes after delivery). There was no difference in maternal mortality and the amount of transfusion between cases satisfying all 4 criteria and cases with at least 1 missing criterion. Conclusion Two-thirds of clinically confirmed AFE cases did not satisfy all 4 criteria proposed by the SMFM, despite similar rates of maternal mortality with cases satisfying all 4 criteria. Our study suggests that there may be some discrepancy between the clinical diagnosis of AFE and the recent diagnostic criteria proposed by the SMFM for research purpose.

Photosensitization Behavior of Ir(III) Complexes in Selective Reduction of CO₂ by Re(I)-Complex-Anchored TiO₂ Hybrid Catalyst

Cheong, Ha-Yeon,Kim, So-Yoen,Cho, Yang-Jin,Cho, Dae Won,Kim, Chul Hoon,Son, Ho-Jin,Pac, Chyongjin,Kang, Sang Ook American Chemical Society 2017 Inorganic Chemistry Vol.56 No.19

<P>A series of cationic Ir(III) complexes ([Ir(btp)<SUB>2</SUB>(bpy-X<SUB>2</SUB>)]<SUP>+</SUP> (<B>Ir-X</B><SUP><B>+</B></SUP>: btp = (2-pyridyl)benzo[<I>b</I>]thiophen-3-yl; bpy-X<SUB>2</SUB> = 4,4′-X<SUB>2</SUB>-2,2′-bipyridine (X = OMe, <SUP><I>t</I></SUP>Bu, Me, H, and CN)) were applied as visible-light photosensitizer to the CO<SUB>2</SUB> reduction to CO using a hybrid catalyst (TiO<SUB>2</SUB>/ReP) prepared by anchoring of Re(4,4′-Y<SUB>2</SUB>-bpy)(CO)<SUB>3</SUB>Cl (ReP; Y = CH<SUB>2</SUB>PO(OH)<SUB>2</SUB>) on TiO<SUB>2</SUB> particles. Irradiation of a solution containing <B>Ir-X</B><SUP><B>+</B></SUP>, TiO<SUB>2</SUB>/ReP particles, and an electron donor (1,3-dimethyl-2-phenyl-1,3-dihydrobenzimidazole) in <I>N</I>,<I>N</I>-dimethylformamide at greater than 400 nm resulted in the reduction of CO<SUB>2</SUB> to CO with efficiencies in the order X = OMe > <SUP><I>t</I></SUP>Bu ≈ Me > H; <B>Ir-CN</B><SUP>+</SUP> has no photosensitization effect. A notable observation is that <B>Ir-</B><SUP><I><B>t</B></I></SUP><B>Bu</B><SUP>+</SUP> and <B>Ir-Me</B><SUP>+</SUP> are less efficient than <B>Ir-OMe</B><SUP>+</SUP> at an early stage of the reaction but reveal persistent photosensitization behavior for a much longer period of time unlike the latter. Comparable experiments showed that (1) the <B>Ir-X</B><SUP><B>+</B></SUP> sensitizers are commonly superior compared to Ru(bpy)<SUB>3</SUB><SUP>2+</SUP>, a widely used transition-metal photosensitizer, and (2) the system comprising <B>Ir-OMe</B><SUP>+</SUP> and TiO<SUB>2</SUB>/ReP is much more efficient than a homogeneous-solution system using <B>Ir-OMe</B><SUP>+</SUP> and Re(4,4′-Y′<SUB>2</SUB>-bpy)(CO)<SUB>3</SUB>Cl (Y′ = CH<SUB>2</SUB>PO(OEt)<SUB>2</SUB>). Implications of the present observations involving reaction mechanisms associated with the different behavior of the photosensitizers are discussed in detail.</P><P>The binary hybrid catalytic system (photosensitizer + TiO<SUB>2</SUB>/Re(I)) serves the first direct route from light-capturing by homogeneous photosensitization to heterogeneous catalytic site, showing efficient photocatalytic CO<SUB>2</SUB> to CO conversion efficiency (a turnover number of >300 for 10 h).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2017/inocaj.2017.56.issue-19/acs.inorgchem.7b01963/production/images/medium/ic-2017-01963s_0013.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic7b01963'>ACS Electronic Supporting Info</A></P>

Summary of clinically diagnosed amniotic fluid embolism and disagreement with structured definition based on 4 criteria proposed for use in research

( Jin-ha Kim ),( Hyun-joo Seol ),( Won Joon Seong ),( Hyun-mee Ryu ),( Jin-gon Bae ),( Joon Seok Hong ),( Jung In Yang ),( Suk-joo Choi ),( Soo-young Oh ),( Cheong-rae Roh ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-

Objective: Amniotic fluid embolism (AFE) is usually diagnosed based on clinical findings and has truly high mortality. Recently, a structured definition of AFE based on 4 criteria was proposed for use in research by the Society for Maternal-Fetal Medicine (SMFM). The aim of this study was 1) to investigate the clinical characteristics of AFE cases clinically diagnosed by maternal fetal medicine (MFM) specialists in our country and 2) to check the disagreement with 4 criteria provided by SMFM. Methods: This study included 11 cases clinically diagnosed as AFE from seven tertiary hospitals in Korea. We collected information including maternal age, symptoms and onset of AFE, the amount of transfusion, disseminated intravascular coagulation (DIC) laboratory, mode of delivery, and maternal mortality. We applied the definition proposed by the SMFM to each case of AFE and checked the disagreement. Results: Mean maternal age was 32 years. As for symptoms, cardiovascular arrest, hypotension, respiratory compromise, clinical coagulopathy, and neurologic sign was observed in 36.3%, 81.8%, 81.8%, 100%, 63.6%, respectively. The onset of intrapartum period and during delivery was 18% in each. The onset of postpartum period accounts for 63.6%, among which 71.4% were occurred within < 30min after delivery and 28.6% were between 1 and 2 hour after delivery. Mean amount of transfusion was 19 RBCs, 23 platelets, 16 FFP, and 3 cryoprecipitate. Among 11 cases, 5 women died and 1 woman had severe maternal neurologic disability, showing intact maternal survival was 45.5%. Disagreement with all 4 criteria proposed by SMFM was found in 54.5%, due to unsatisfying the criteria of DIC or strict onset of time (<30min after delivery). Conclusion: 1) Our data showed that the chance of intact maternal survival of AFE is less than a half. 2) More than a half of AFE cases, which was clinically confirmed by MFM specialists, did not satisfy all 4 criteria proposed by SMFM for use in research.

CASE REPORT : Large Mature Cystic Teratoma of the Third Ventricle in Infancy: A Case Report and Review of Literatures

( Byeong Jin Ha ),( Young Soo Kim ),( Jin Hwan Cheong ) 대한뇌종양학회 대한신경종양학회 2016 Brain Tumor Research and Treatment Vol.4 No.1

Teratomas of the central nervous system are rare and are frequently found in children and young adults. Cystic teratomas found in infancy is a well-recognized but infrequent entity. Intracranial teratomas, like teratomas in general, tend to arise from midline structures such as the pineal gland, but has rarely been found in the third ventricle. We report a rare case of a 6-month-old infant with a mature cystic teratoma of the third ventricle with a review of literatures.

Antioxidant and Antifibrotic Effect of a Herbal Formulation <i>In Vitro</i> and in the Experimental Andropause via Nrf2/HO-1 Signaling Pathway

Bae, Woong Jin,Zhu, Guan Qun,Choi, Sae Woong,Jeong, Hyun Cheol,Bashraheel, Fahad,Kim, Kang Sup,Kim, Su Jin,Cho, Hyuk Jin,Ha, U Syn,Hong, Sung Hoo,Lee, Ji Youl,Oh, Hyun-A,Koo, Hye Cheong,Kim, Do Ram,Hw Hindawi 2017 Oxidative medicine and cellular longevity Vol.2017 No.-

<P>The Korean herbal formulation Ojayeonjonghwan is used for improving late-onset hypogonadism (LOH) symptoms such as erectile dysfunction (ED). A previous research suggested that a modified Ojayeonjonghwan (KH-204) could be used as an alternative to the treatment for ED. The pharmacological effects were examined in different conditions, including in vitro and in vivo. We measured the survival rate of TM3 Leydig cells under the oxidative stress condition. The s.c. injection of leuprorelin was used to induce androgen deprivation. We measured serum testosterone levels, oxidative stress, and apoptosis. The results of the treatment by KH-204 (1) preserved TM3 cells from oxidative stress by improving the expression of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1); (2) lowered the expression of transforming growth factor-beta (TGF-<I>β</I>) 1/SMAD; (3) increased the average of serum testosterone in androgen-deprived male rats; (4) kept the activation of spermatogenesis; (5) upgraded the contents of 8-hydroxy-20-deoxyguanosine (8-OHdG) and degraded the contents of superoxide dismutase (SOD); and (6) reduced apoptosis. We studied that KH-204 improved testicular dysfunction in LOH. It is likely, at least in part, to degrade oxidative stress through the Nrf2/HO-1 pathway. These findings may offer credible evidences for the use of new alternative therapies to treat LOH.</P>

The Effect of Seoritae Extract in Men with Mild to Moderate Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia

Bae, Woong Jin,Park, Hyo Jung,Koo, Hye Cheong,Kim, Do Ram,Ha, U-Syn,Kim, Kang Sup,Kim, Su Jin,Cho, Hyuk Jin,Hong, Sung Hoo,Lee, Ji Youl,Hwang, Sung Yeoun,Kim, Sae Woong Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-

<P>We evaluated the effects of Seoritae extract (SE) on mild to moderate lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH). Seventy-six subjects with mild to moderate LUTS suggestive of BPH were prospectively recruited from the urology outpatient clinic and assigned to either SE (4200 mg or 6 tablets 3 times a day) or matching placebo. The primary outcome variable, the International Prostatic Symptom Score (IPSS), was evaluated at baseline and at 4 and 12 weeks. Postvoid residual volume (PVR), maximum urine flow rate (<I>Q</I><SUB>max</SUB>), and prostate-specific antigen (PSA) levels were evaluated. IPSSs decreased significantly from baseline to 12 weeks within the SE group. Significant improvements in IPSS voiding scores at 4 and 12 weeks were also observed in the SE group compared to the placebo group. IPSS storage and quality of life scores were also significantly decreased at 12 weeks in the SE group. There was no change in <I>Q</I><SUB>max</SUB> or PVR in both groups after 12 weeks. Administration of SE for 12 weeks led to significant improvements in LUTS, and it can be concerned as a reasonable and safe alternative for men with mild to moderate LUTS.</P>

A case of apocrine hidrocystoma on palm

( Cheong Ha Woo ),( Ho Yeol Lee ),( Ji Young Seo ),( Sik Haw ),( Hai Jin Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

Apocrine hidrocystoma is a rare, benign, cystic tumor derived from the secretory portion of the apocrine gland. It usually presents as superficial, solitary, cutaneous nodule on the head and neck, especially at the external canthus of the eyes. It is extremely rare for apocrine hidrocystoma developing on palm. A 65-year-old female presented with 1 cm X 1 cm sized, erythematous to purplish patch with central cysts on her right palm for 2 years. The histopathologic examination showed multilocular cystic spaces with papillary projections in the dermis. The epithelial lining of the cyst was composed of double layersof cells which are an outer layer of myoepithelial cells and an inner layer of columnar cells with decapitation secretion, consistent with apocrine hidrocystoma. Herein we reported a rare case of apocrine hidrocystoma on palm.

[P271] A case of cutaneous infection caused by Mycobacterium chelonae

( Cheong Ha Woo ),( Hee Jae Park ),( Seung Pil Ham ),( Mira Choi ),( Hai-jin Park ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Mycobacterium chelonae(M. chelonae) is rapidly growing atypical mycobacterium. Cutaneous M. chelonae infections can be classified into two types according to patient immune status. In immunocompetent patients, lesions usually follow trauma. However, in immunocompromised patients, lesions frequently develop without any trauma,and show a sporotrichoid or disseminated pattern. A 70-year-old female presented with a 3-month history of multiple erythematous painful nodule over the left lower leg. Her past medical history included type II diabetes mellitus and hypertension. She denied any history of trauma or invasive procedures. The histologic findings showed localized neutrophilic and granulomatous inflammation in dermis and subcutaneous tissue. The patient was treated with oral steroids, dapsone, and antibiotics. However, the lesions were wax and wane and finally progressed to fluctuant painful nodules. We performed second biopsy with AFB stain and tissue culture from the fluctuant nodule. The histologic findings showed central non caseous necrosis with neutrophilic infiltration surrounded by abundant histiocytes in dermis and lobular panniculitits. The AFB stain was positive and the culture of the tissue resulted in the isolation of M. chelonae. We treated with intravenous tobramycin, imipenem and oral clarithromycin. The lesions were slowly improved. Herein, we report a rare case of cutaneous infection caused by M. chelonae.