http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
개별검색 DB통합검색이 안되는 DB는 DB아이콘을 클릭하여 이용하실 수 있습니다.
통계정보 및 조사
예술 / 패션
<해외전자자료 이용권한 안내>
- 이용 대상 : RISS의 모든 해외전자자료는 교수, 강사, 대학(원)생, 연구원, 대학직원에 한하여(로그인 필수) 이용 가능
- 구독대학 소속 이용자: RISS 해외전자자료 통합검색 및 등록된 대학IP 대역 내에서 24시간 무료 이용
- 미구독대학 소속 이용자: RISS 해외전자자료 통합검색을 통한 오후 4시~익일 오전 9시 무료 이용
※ 단, EBSCO ASC/BSC(오후 5시~익일 오전 9시 무료 이용)
Cheong‑Weon Cho,Gi‑Ho Son,Hye‑Jin Lee,Young‑Guk Na,Hong‑Ki Lee,Sung‑Jin Kim,Hyun‑Wook Huh,Kyung‑Tae Kim,Jong‑Seong Kang,Young‑Ho Kim,Chang‑Seon Myung,Min‑Ho Yoon,Seok Jin Kim,Hyun So Cho,Jae‑Young Lee 한국약제학회 2019 Journal of Pharmaceutical Investigation Vol.49 No.6
It has reported that Morus alba has properties to treat fever, protect liver damage, improve eyesight, strengthen the joint, facilitate discharge of urine, and prevent high blood pressure. Extracts from herbal plants, have hygroscopic and low flowability characteristics. Due to these properties, it is difficult to develop the formulation using herbal extracts in pharmaceutics. In this study, Morus alba leaf extract (MLE) was fermented by Viscozyme ® (MLE-V) and Pectinex ® (MLE-P) as well as non-fermented MLE (MLE-C). Physicochemical properties of MLEs were evaluated for optimization of formulation. As a result, cell viability was higher MLE-V than MLE-P, although there was no difference in flowability depending on the enzyme type. Based on the pre-formulation study, MLE-V was selected. Wet granulation method was used to overcome the poor flowability of MLE and MLE tablet was developed by statistical-based experimental design method. A Box-Behnken design, one of the models of experimental design, was constructed using lactose content in lactose plus microcrystalline cellulose (X1), disintegration agent (X2), and binding agent (X3). The dependent variables were hardness (Y1), friability (Y2), and disintegration time (Y3). Finally, MLE tablet with hardness (11.83 ± 0.36 Kp), friability (0.26 ± 0.01%) and disintegration time (1395.56 ± 49.84 s) were optimized. This is the first work to report the formulation design using herbal extracts fermented with enzyme through quality by design.
Gemcitabine is used in the treatment of several solid tumors as one of anticancer nucleoside analogues and is necessary to administer high doses to achieve the desired therapeutic response. However, this treatment may be related to severe side effects. For improvement of the encapsulation efficiency of gemcitabine for gemcitabine-loaded nanoparticle composed of biodegradable polymer and reducing the side effects due to the high concentration of gemcitabine, we formulated gemcitabine- loaded PLGA particles using chitosan and different type of surfactant. The gemcitabine-loaded particles were prepared using a double emulsion solvent evaporation technique. The effects of surfactants to modify the size of gemcitabine-loaded particles were different. The mean diameters of gemcitabine-loaded particles ranged from 400.8 nm to 1712.7 nm. The surface charge of gemcitabine particles was − 5.62 mV to 1.46 mV. The encapsulation efficiency of gemcitabine-loaded particles was found to be 29.56–34.38%. Interestingly, the addition of surfactant could be improved an encapsulation efficiency of gemcitabine.
Skin whitening products are commercially available for cosmetic purposes in order to obtain a lighter skin appearance. They are also utilized for clinical treatment of pigmentary disorders such as melasma or postinflammatory hyperpigmentation. Whitening agents act at diverse levels of melanin synthesis in the skin. Many of them are known as competitive inhibitors of tyrosinase, the key enzyme in melanogenesis. Others inhibit the transformation of this activated enzyme or the transport of melanosomes from melanocytes to surrounding keratinocytes. To avoid systemic absorption, whitening agent is need to create optimal formulation such as liposome, microemulsion, solid lipid nanoparticles (SLN) and NLC (Nanostructure liquid crystal) as well as patch. Functional ingredients and innovative delivery systems are driving the new product development in the field of cosmetics. In this review we present an overview of whitening products that may decrease skin pigmentation by their interference with the pigmentary processes and may formulate cosmetic delivery systems possessing potential as smarter carrier systems.
Ginsenosides saponins are phytochemically extracted from red ginseng, and have been regarded as the principal components manifesting the pharmacologic activities. Saponins are very soluble in water but poorly absorbed when administrated orally. Moreover, they have some disadvantages including the decomposition in acid medium. Therefore various designs and techniques have been studied for development of optimal formulation and modification of release profile. This review focused on pH-response polymer and bioadhesive polymer considering the low stability in acid medium and the low permeability in mucosal membrane of saponins. The application of these polymers are considered as potential strategy for improvement of bioavailability in oral delivery of saponins.
Alendronate, one of bisphosphonates is widely used in the clinical treatment of systemic metabolic diseases, such as osteoporosis and Paget's disease as well as the sequela of malignancies including hypercalcemia. However, alendronate has no chromophore, so the method of derivatization with FMOC(9-fluorenylmethyl chloroformate) in a citrate buffer(pH 11.9) using HPLC was developed. In this study, we developed UV-VIS spectrophotometric assays for availability, simplicity and cost-effectiveness of the required instrumentation. The stoichiometric ratio of alendronate to Fe^(+3) in the chromophoric complex was determined to be 1:1.
The purpose of this study is to develop the microneedle using biodegradable and biocompatible polymer and to pioneer the new route of drug delivery through the research to apply the most desirable administration form of small molecules, peptides, proteins, genes, biological products including vaccines. Various biocompatible microneedles were manufactured. To apply drug to microneedle, drug formulation using ethylene vinyl acetate patch or polyacryl acid gel was developed. Drug permeation into rat skin based on the application method of patch or gel with microneedle was studied using Franz diffusion cell system. In vitro drug permeation results showed that the permeation by the application of hollow microneedle was not increased compared with solid microneedle. When G60 or G60*2 microneedle was used, the permeated amount of calcein was increased compared to when solid microneedle was used. The permeated amount of lidocaine HCl in 12 hr was increased when microneedle was used was increased. Skin irritation followed by microneedle showed there was little difference in the decrease of redness after microneedle application based on application time.
Despite the advantages of drug delivery through the skin, such as easy accessibility, convenience, prolonged therapy, avoidance of the liver first-pass metabolism and a large surface area, transdermal drug delivery is only used with a small subset of drugs because most compounds cannot cross the skin at therapeutically useful rates. Recently, a new concept was introduced known as microneedles and could be pierced to effectively deliver drugs using microsized needles in a minimally invasive and painless manner. This review suggests that a biocompatible microneedle might be a suitable tool for transdermal drug delivery system of hydrophilic molecules with possible applications to macromolecules such as proteins and peptides.
Nanotechnology affects on various aspects including medicine and pharmaceutics. This nanocrystal technology which transforms to nano-sized material is able to develop the innovational formulation strategy for poorly water-soluble drugs due to the change of physicochemical properties of drug. Scale-up methods using pearl milling or high pressure homogenizer was described and commercialized products based on nanotechnology were introduced in this manuscript.
The amphiphilic block copolymers forms the self -assembled micelles in aqueous solution. that is called as polymeric micelle. Polymeric micelles as drug delivery carriers can protect the drug against bio-logical environments (eg. low pH. enzymes). allow drug ellcapsulation in the hydrophobic inner center. in-crease the solubility of hydrophobic drugs). facilitate drug targeting. and reduce the side effects of chemotherapy. Another advantage is that polymeric micelles can prolong the circulation time of the drug us-ing the ligand for the specific target because the surface properties of the drug delivery system affect the circulation time in the blood and are related to the life span of the drug delivery system. Recent advances in the properties and application of polymeric micelles as drug delivery carriers for poorly soluble drug have been discussed in this review.