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GO-27 : Meta-analysis of the effects of beta blocker on survival time in cancer patients
( Chel Hun Choi ),( Tae Jong Song ),( Tae Hyun Kim ),( Jun Kuk Choi ),( Jin Young Park ),( Aera Yoon ),( Yoo Young Lee ),( Tae Joong Kim ),( Duk Soo Bae ),( Jeong Won Lee ),( Byoung Gie Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Knowledge of the role of beta blockers on cancer survival may be helpful for cancer patients.This study was to elucidate the potential benefit of beta blockers on cancer survival. We comprehensively searched PubMed, Embase, and the Cochrane Library from their inception to April 2013. Two authors independently screened and reviewed the eligibility of each study and coded the participants, treatment, and outcome characteristics. The primary outcomes were overall survival (OS) and disease-free survival (DFS). Twelve studies published between 1993 and 2013 were included in the final analysis. Four papers reported results from 10 independent groups, resulting in a total of 18 comparisons based on data obtained from 20,898 subjects. Effect sizes (hazard ratios) were heterogeneous and random effects models were used in the analyses. The meta-analysis demonstrated that beta blocker use can improve OS (HR=0.79; 95% CI 0.67 - 0.93; p=0.004) and DFS (HR=0.69; 95% CI 0.53 - 0.91; p=0.009). Although statistically not significant, the effect size was greater in patients with low stage cancer or cancer treated primarily with surgery than in patients with high stage cancer or cancer treated primarily without surgery (HR: 0.60 vs. 0.78, and 0.60 vs. 0.80, respectively). Although only two study codes were analyzed, the studies using nonselective beta blockers showed that there was no overall effect on OS (HR = 0.52, 95% CI: 0.09 - 3.04). This meta-analysis provides evidence that beta blocker use can prolong the survival of cancer patients, especially patients with early stage cancer treated primarily with surgery.
Chel-hun Woo,Jae-soo Kim,이경환 대한기계학회 2008 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.22 No.3
Unlike the steady closed- type supersonic cavity flow, open- type cavity flow is divided into internal and external flows by turbulent shear layer. The cavity flow may cause resonance phenomena due to pressure oscillation, depending on the cavity geometry and the flow conditions. These phenomena may induce noise generation, structural damage, and aerodynamic instability. In this research, the flow characteristics of three-dimensional supersonic cavity flow of Mach number 1.5 were analyzed with the variations of aspect ratio and width ratio. Three-dimensional unsteady compressible Reynolds-averaged Navier-Stokes (RANS) equations were used with a turbulence model. For numerical calculations, the 4th-order Runge-Kutta method and the FVS method with van Leer's flux limiter were applied. The numerical calculations were performed by using a parallel processing program with 16 CPUs. The sound pressure level (SPL) spectra of pressure variations were analyzed at the point of cavity leading edge. The correlation of pressure distribution (CPD) was also analyzed for the propagation of dominant oscillation pressure waves with respect to the reference point of the cavity leading edge. The dominant oscillation frequency was compared with the oscillation modes of Rossiter's formula. Oscillation Mode 2 appeared as a dominant oscillation frequency regardless of the aspect ratio of cavity in the two-dimensional flow. Oscillation Modes1 and 2 appeared in three-dimensional cavities of small aspect ratios. However, as the aspect or the width ratio increases, only the mode 2 or 3 frequency appeared as a dominant oscillation frequency.
Analysis of Two Dimensional and Three Dimensional Supersonic Turbulence Flow around Tandem Cavities
Chel Hun Woo,Jae Soo Kim,Kyung Hwan Lee 대한기계학회 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.8
The supersonic flows around tandem cavities were investigated by two-dimensional and three-dimensional numerical simulations using the Reynolds-Averaged Navier-Stokes (RANS) equation with the k-ω turbulence model. The flow around a cavity is characterized as unsteady flow because of the formation and dissipation of vortices due to the interaction between the freestream shear layer and cavity internal flow, the generation of shock and expansion waves, and the acoustic effect transmitted from wake flow to upstream. The upwind TVD scheme based on the flux vector split with van Leer's limiter was used as the numerical method. Numerical calculations were performed by the parallel processing with time discretizations carried out by the 4th-order Runge-Kutta method. The aspect ratios of cavities are 3 for the first cavity and 1 for the second cavity. The ratio of cavity interval to depth is 1. The ratio of cavity width to depth is 1 in the case of three dimensional flow. The Mach number and the Reynolds number were 1.5 and 4.5 × 10?, respectively. The characteristics of the dominant frequency between two-dimensional and three-dimensional flows were compared, and the characteristics of the second cavity flow due to the first cavity flow was analyzed. Both two dimensional and three dimensional flow oscillations were in the 'shear layer mode', which is based on the feedback mechanism of Rossiter's formula. However, three dimensional flow was much less turbulent than two dimensional flow, depending on whether it could inflow and outflow laterally. The dominant frequencies of the two dimensional flow and three dimensional flows coincided with Rossiter's 2nd mode frequency. The another dominant frequency of the three dimensional flow corresponded to Rossiter's 1st mode frequency.
( Chel Hun Choi ),( Nam Kyeong Kim ),( Kidong Kim ),( Yong Jae Lee ),( Keun Ho Lee ),( Jong-min Lee ),( Kwang Beom Lee ),( Dong Hoon Suh ),( Sunghoon Kim ),( Min Kyu Kim ),( Seok Ju Seong ),( Myong Ch 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: To identify the effect of subcutaneous (SQ) drain on wound dehiscence and infection in patients who underwent midline laparotomy for gynecological disease. Methods: Patients planned to undergo midline laparotomy for gynecologic disease, BMI< 35, age >18 years and ECOG performance status 0-2 were 1:1 randomized to case (with SQ drain) vs. control (without SQ drain) at 9 institutes in Korea, from February 2021 to December 2021. We compared the incidence of wound dehiscence at 4 weeks post-surgery and cumulative incidence of wound dehiscence and infection up to 4 weeks post-surgery between case and control group. Results: Of the 174 randomized patients (case 84, control 90), 12 patients were dropped due to follow-up loss (case 5, control 7) and 162 patients (intention-to-treat [ITT] cohort: case 79, control 83) were included. Fourteen patients (case 10, control 4) did not follow assigned intervention depending on the operator’s decision because the SQ layer was either too thick or too thin, and were excluded from per-protocol [PP] analysis (case 69, control 79). In ITT cohort, the frequency of cancer surgery (63/79 [79.7%] vs. 64/83 [77.1%]; p=0.683) and surgery time (mean ± standard deviation = 227.7±133.9 minutes vs. 226.7±118.2 minutes; p=0.960) were comparable in the case and control group. Mean wound length was also similar in both groups (case vs. control; 24.2 cm vs. 24.3 cm; p=0.933). There were no significant differences in the incidence of wound dehiscence at 4 weeks post-surgery (1/79 [1.3%] vs. 2/83 [2.4%]; p>0.999), the cumulative incidence of wound dehiscence (7/79 [8.9%] vs. 5/83 [6.0%]; p=0.491), and the cumulative incidence of wound infection (1/79 [1.3%] vs. 0/83 [0.0%]; p=0.488) between case and control group. PP analysis showed similar result to ITT analysis. Conclusion: SQ drain insertion did not decrease wound dehiscence and infection in patients who underwent midline laparotomy for gynecological disease.
Direct inhibition of eIF4E reduced cell growth in endometrial adenocarcinoma
Choi, Chel Hun,Lee, Ji-Soo,Kim, Seong Rim,Lee, Yoo-Young,Kim, Chul-Jung,Lee, Jeong-Won,Kim, Tae-Joong,Lee, Je-Ho,Kim, Byoung-Gie,Bae, Duk-Soo Springer-Verlag 2011 Journal of cancer research and clinical oncology Vol.137 No.3
Choi, Chel Hun,Lee, Jeong-Won,Lee, Yoo-Young,Kim, Ha-Jeong,Song, Taejong,Kim, Min-Kyu,Kim, Tae-Joong,Kim, Byoung-Gie,Bae, Duk-Soo Raven Press 2012 Annals of surgical oncology Vol.19 No.12
<P>The aim of this study was to compare the surgical and oncologic outcomes of laparoscopic-assisted radical vaginal hysterectomy (LARVH) with that of laparoscopic radical hysterectomy (LRH) for early-stage cervical cancer.</P>
Analysis of Two Dimensional and Three Dimensional Supersonic Turbulence Flow around Tandem Cavities
Woo Chel-Hun,Kim Jae-Soo,Lee Kyung-Hwan The Korean Society of Mechanical Engineers 2006 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.20 No.8
The supersonic flows around tandem cavities were investigated by two-dimensional and three-dimensional numerical simulations using the Reynolds-Averaged Navier-Stokes (RANS) equation with the k- ω turbulence model. The flow around a cavity is characterized as unsteady flow because of the formation and dissipation of vortices due to the interaction between the freestream shear layer and cavity internal flow, the generation of shock and expansion waves, and the acoustic effect transmitted from wake flow to upstream. The upwind TVD scheme based on the flux vector split with van Leer's limiter was used as the numerical method. Numerical calculations were performed by the parallel processing with time discretizations carried out by the 4th-order Runge- Kutta method. The aspect ratios of cavities are 3 for the first cavity and 1 for the second cavity. The ratio of cavity interval to depth is 1. The ratio of cavity width to depth is 1 in the case of three dimensional flow. The Mach number and the Reynolds number were 1.5 and $4.5{\times}10^5$, respectively. The characteristics of the dominant frequency between two- dimensional and three-dimensional flows were compared, and the characteristics of the second cavity flow due to the first cavity flow was analyzed. Both two dimensional and three dimensional flow oscillations were in the 'shear layer mode', which is based on the feedback mechanism of Rossiter's formula. However, three dimensional flow was much less turbulent than two dimensional flow, depending on whether it could inflow and outflow laterally. The dominant frequencies of the two dimensional flow and three dimensional flows coincided with Rossiter's 2nd mode frequency. The another dominant frequency of the three dimensional flow corresponded to Rossiter's 1st mode frequency.