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Shu-Tsen Liu(Shu-Tsen Liu),Sheng-Che Lin(Sheng-Che Lin),Jane Pei-Chen Chang(Jane Pei-Chen Chang),Kai-Jie Yang(Kai-Jie Yang),Che-Sheng Chu(Che-Sheng Chu),Chia-Chun Yang(Chia-Chun Yang),Chih-Sung Liang( 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.
Che-Sheng Chu,Chih-Kuang Liang,Ming-Yueh Chou,Yu-Te Lin,Chien-Jen Hsu,Chin-Liang Chu,Po-Han Chou 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.3
ObjectiveaaPostoperative delirium (POD) is a highly prevalent complex neuropsychiatric syndrome in elderly patients. However, its pathophysiology is currently unknown. Early detection and prevention of POD is important; therefore, the aim of this study was to investigate the link between preoperative insulin growth factor 1 (IGF-1) levels in the serum and POD in the Chinese elderly patients. MethodsaaOne hundred and three patients who were undergoing an orthopedic operation took part in the study. Preoperative serum IGF-1 levels were measured. POD was determined daily using the Confusion Assessment Method (CAM) and DSM-IV TR. Baseline serum IGF-1 levels were compared between patients who did and did not develop POD. Correlation coefficients were calculated to evaluate relationship between baseline characteristics and serum IGF-1 levels. The relationship between baseline biomarkers and delirium status was investigated using logistic regression analysis, adjusting for potential confounding variables. ResultsaaTwenty-three patients developed POD. The POD group had lower MMSE scores and higher CCI scores and proportions of acute admission. Preoperative serum IGF-1 levels were correlated with MMSE scores and age (MMSE: r=0.230, p<0.05; age: r=-0.419, p<0.001). Baseline serum IGF-1 levels did not differ between patients who did and did not develop POD, even after adjusting for potential confounding factors, MMSE score, and age. ConclusionaaNo association was found between preoperative IGF-1 levels and POD, suggesting that they are not direct biomarkers of the incidence of POD among the Chinese elderly population. Further research with larger sample sizes is warranted to clarify the relationship.
Che-Sheng Chu,Dian-Jeng Li,Chin-Liang Chu,Chih-Ching Wu,Ti Lu 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.7
Objective Schizophrenia (SZ) has been associated with the inflammatory-related and immunological pathogenesis. This study investigates the aberration of cytokines in patients with SZ. Methods Thirty patients with SZ without antipsychotic treatment for at least two weeks participated. We measured the serum levels of fourteen cytokines at hospital admission and after 8-week antipsychotic treatment. Severity was measured by expanded version of 24-items brief psychiatric rating scale (BPRS-E). Repeated measure analyses of variance were conducted. Results The interleukin-1 receptor antagonist (IL-1ra) was significantly decreased after 8-week antipsychotic treatment than those of before antipsychotic treatment (F=12.15, df=1/30, p=0.002). Neural cell adhesion molecule 1/CD56 (NCAM-1/CD56) was significantly decreased (F=6.61, df=1/30, p=0.016) among those with second-generation antipsychotics but not first-generation antipsychotics treatment. The changes of BPRS-E-manic and BPRS-E-anxiety scores correlated with the baseline IL-1ra (r=-0.393), IL-6 (r=-0.407), and insulin like growth factor binding protein 3 (r=-0.446). Additionally, the changes of BPRS-E and BPRS-E-negative scores correlated with the changes of brain-derived neurotrophic factor (r=0.372) and interferon-gamma (r=0.375). Conclusion Our study supports that IL-1ra and NCAM-1/CD56 may be considered as markers of developing SZ.
Che-Sheng Chu,Shu-Li Cheng,Ya-Mei Bai,Tung-Ping Su,Shih-Jen Tsai,Tzeng-Ji Chen,Fu-Chi Yang,Mu-Hong Chen,Chih-Sung Liang 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.9
Objective Individuals with dementia are at a substantially elevated risk for mortality; however, few studies have examined multimorbidity patterns and determined the inter-relationship between these comorbidities in predicting mortality risk.Methods This is a prospective cohort study. Data from 6,556 patients who were diagnosed with dementia between 1997 and 2012 using the Taiwan National Health Insurance Research Database were analyzed. Latent class analysis was performed using 16 common chronic conditions to identify mortality risk among potentially different latent classes. Logistic regression was performed to determine the adjusted association of the determined latent classes with the 5-year mortality rate.Results With adjustment for age, a three-class model was identified, with 42.7% of participants classified as “low comorbidity class (cluster 1)”, 44.2% as “cardiometabolic multimorbidity class (cluster 2)”, and 13.1% as “FRINGED class (cluster 3, characterized by FRacture, Infection, NasoGastric feeding, and bleEDing over upper gastrointestinal tract).” The incidence of 5-year mortality was 17.6% in cluster 1, 26.7% in cluster 2, and 59.6% in cluster 3. Compared with cluster 1, the odds ratio for mortality was 9.828 (95% confidence interval [CI]=6.708–14.401; p<0.001) in cluster 2 and 1.582 (95% CI=1.281–1.953; p<0.001) in cluster 3.Conclusion Among patients with dementia, the risk for 5-year mortality was highest in the subpopulation characterized by fracture, urinary and pulmonary infection, upper gastrointestinal bleeding, and nasogastric intubation, rather than cancer or cardiometabolic comorbidities. These findings may improve decision-making and advance care planning for patients with dementia.
Thermal dehydration tests of FLiNaK salt for thermal-hydraulic experiments
Che Shuai,Zhang Sheng,Burak Adam,Sun Xiaodong 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.3
Fluoride-salt-cooled High-temperature Reactor (FHR) is a promising nuclear reactor technology. Among many challenges presented by the molten fluoride salts is the corrosion of salt-facing structural components. Higher moisture contents, in the FLiNaK (LiF-NaF-KF, 46.5–11.5-42 mol%) salt, aggravate intergranular corrosion and pitting for the given alloys. Therefore, several thermal dehydration tests of FLiNaK salt were performed with a batch size suitable for thermal-hydraulic experiments. Thermogravimetric Analysis (TGA) was performed for the three constituent fluoride salts individually. Preliminary thermal dehydration plans were then proposed for NaF and KF salts based on the TGA curves. However, the dehydration process may not be required for LiF since its low mass loss (<1.3 wt%). To evaluate the performance of these thermal dehydration plans, a batch-scale salt dehydration test facility was designed and constructed. The preliminary thermal dehydration plans were tested by varying the heating rates, target temperature, and holding time. The sample mass loss data showed that the high temperatures (>500 ◦C) were necessary to remove a significant amount of moisture (>1 wt%) from NaF salt, while relatively low temperatures (around 300 ◦C) with a long holding time (>10 h) were sufficient to remove most of the moisture from KF salt.
Guanghua Sheng,Jiatong Dai,Hong Pan,Siyu Che 글로벌지식마케팅경영학회 2020 Global Marketing Conference Vol.2020 No.11
Actively promoting pro-environmental behavior not only can effectively reduce degree of environmental pollution, but also is a necessary step for the sustainable development of social economy. Although scholars have had in-depth discussions on influencing factors and promoting mechanism of pro-environmental behavior, research concerning effects of external situational factors on pro-environmental behavior is relatively insufficient, and impacts of natural environment conditions, say, air quality is seldom considered. With the development of China’s economy, industrial growth and advancing urbanization, air quality continues to deteriorate when acid rain, haze and other harsh weathers occur more frequently, seriously affecting and endangering people’s health and daily life. So, does air quality also affect people’s pro-environmental behavior? And if so, how is that impact? What is the internal mechanism? Based on the above questions, this paper designed two studies, in combination with spatial distance, and explored the impacts of air quality on Chinese residents’ pro-environmental behavior. It also demonstrated the internal impact mechanism from the perspective of environmental emotion, and expanded research on impact mechanism of air quality on pro-environmental behavior.
Siyu Che,Guanghua Sheng,Chang Ji 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
The economic harm and survival fear caused by environmental conflicts are most likely to become the psychological lever to drive individuals to adopt environmentally friendly behaviours. From the perspective of environmental conflict, this paper will explore the transmission mechanism of environmental conflict on individuals’ pro-environmental behaviour through three experiments.
N. Jeyaprakash,Che‑Hua Yang,Sheng‑Po Tseng 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.6
Stainless steel material has been widely used in aeronautical, chemical and nuclear industries due to good corrosion resistance. However, the material has less hardness and wear resistance. In this study, two various depositions namely Colmonoy-6and Stellite-6 have produced on 304 Stainless steel. Besides, the coating was examined to reveal their metallurgical, mechanicaland tribological properties. In addition, wear mechanism, wear debris and roughness averages were studied. The outcomesindicate that both coatings show with dendrite structure due to rapid cooling rates. Hardness of the clad surface has improvedthan substrate material. The results of friction coefficient of specimen with Colmonoy-6 is lower than that of specimensStellite-6 and substrate. Also, wear resistance of Colmonoy-6 has increased 49 times than substrate sample, which revealsthat Colmonoy-6 laser cladding plays role on wear resistance. Adhesive and abrasive are the major wear mechanisms in thepresent study.
Chang Ji,Guanghua Sheng,Siyu Che 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
Green product experience has become an important marketing strategy for corporations to tap potential green consumers. Based on the theory of planned behavior, this article explores the influence of attitude, subjective norm, and perceived behavioral control on consumers’ green purchasing intentions from the perspective of green product experience with consumers in China, Japan, and Korea as the research objects. Our findings suggest that green product experience of consumers in the three countries can directly affect consumers' green purchasing intentions. Green product experience has an indirect influence on consumers’ green purchasing intention through the mediating effect of attitude, subjective norm and perceived behavioral control. The multiple group comparison shows the external validity of TPB through an examination of green purchasing behavior in different cultural settings, which will help enterprises implement effective experience marketing strategies.