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Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities
Chau Van Minh,Nguyen Xuan Nhiem,Hoang Thi Yen,Phan Van Kiem,Bui Huu Tai,Hoang Le Tuan Anh,Truong Thi Thu Hien,박선주,김나영,김승현 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.8
One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-b-D-glucopyranoside (5), chrysoeriol-7- O-b-D-glucopyranoside (6), 10a-cucurbita5,24-dien-3b-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 lM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 lM.
탄소성 파괴역학에서 균열 성장 예측을 위한 확장유한요소법
( Chau-dinh Thanh ),김지환 ( Kim Ji Hwan ),지광습 ( Zi Goangseup ) 한국구조물진단유지관리공학회 2009 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.13 No.2
In this paper the extended finite element method is applied to numerically simulate crack propagation in aluminum sheets under monotonic increasement of displacement control. J2 plasticity of material model is included. Under elasto-plastic condition, CTOA criterion is employed for modeling stable crack growth during the fracture process. Results show good agreement with experimental measurement.
Long-term anti-cariogenic biofilm activity of glass ionomers related to fluoride release
Chau, N.P.T.,Pandit, S.,Jung, J.E.,Cai, J.N.,Yi, H.K.,Jeon, J.G. Elsevier 2016 Journal of dentistry Vol.47 No.-
<P>Objectives: The aim of this study was to evaluate the difference between anti-cariogenic biofilm activities of glass ionomers (G-Is) during the initial and second fluoride release phases and to define relationships between the anti-biofilm activities and fluoride release. Methods: Fluoride release of three commercially available G-Is in a buffer was evaluated for 770 h, and then 70-h-old Streptococcus mutans UA159 biofilms were formed on the G-Is that had been immersed in the buffer for 0, 100, 200, or 700 h. The dry weight, bacterial cell number, water-insoluble extracellular polysaccharides (EPSs), and accumulated fluoride concentration of the 70-h-old biofilms and fluoride release and acid production rates during biofilm formation were determined. Relationships between the experimental variables and fluoride release rate were also evaluated using linear regression analysis. Results: In this study, fluoride release of the tested G-Is did not exhibit a biphasic pattern during biofilm formation. The release was sustained or did not rapidly decrease even over long immersion periods and was strongly correlated with an increase in accumulated fluoride concentration of the biofilms (R = 0.99, R-2 = 0.98) and reductions in dry weight, water-insoluble EPSs, and acid production rate of the biofilms (R = - 0.99 to - 0.96, R-2 = 0.92-0.98). Conclusions: This study suggests that G-Is can effectively affect acid production, EPS formation, and accumulation of cariogenic biofilms even during the second fluoride release phase, and that the anti-cariogenic biofilm activity is strongly correlated with fluoride release, which may be enhanced by acid production of cariogenic biofilms. (C) 2016 Elsevier Ltd. All rights reserved.</P>