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      • Linguistic Imperialism and native English teachers in South Korea

        Chase Karcher 경희대학교 대학원 2017 국내석사

        RANK : 247359

        This thesis explores the identities and interactions of native English teachers in South Korea in terms of linguistic imperialism. South Korean life in the 21st century has been powerfully shaped by the so-called ‘English Fever’ (Park 2009) that still grips the country today. In parallel to the growth of this phenomenon, the population of native English teachers living and working in Korea exploded in the first decade of the 21st century. This thesis explains the causes and effects of the growth of this population through the lens of linguistic imperialism, and seeks to identify the discourses, identities and ‘interpretive repertoires’ (Wetherell & Potter 1988, Talja 1999) at work in the lives of native English teachers and their Korean students. It contributes to the ongoing discussion of English in Korea by conducting a discourse analysis of interview data of these two groups. Chapter 1 briefly outlines the initial questions that arose as a result of living, working, and studying in South Korea for several years. These questions developed and evolved over time, ultimately crystallizing into three core questions outlined in chapter 2.4. Chapter 2 begins by introducing the theory of linguistic imperialism—its definition, core tenets, and the key theoretical concepts that form its foundation. The chapter goes on to explore the relationship between linguistic imperialism and globalization, and how the theory applies to South Korea in particular. Chapter 3 outlines the contextual elements that led to the rise in the native English teacher population in Korea, beginning with the inception of programs aimed at equipping Korea with a greater command of English in order to compete in the global economy. This chapter includes both structural elements (national curriculum reforms, policy changes, etc.) as well as cultural elements (via interview data) which show why native English teachers made the choice to teach in Korea. Chapter 4 contains a detailed description of the research methodology, discourse analysis. This chapter provides an overview of discourse analysis, a discussion on the evolution of the concept of ‘discourse’, as well as a thorough explanation of how the interview data of the present research was collected and analyzed. Chapter 5 presents the core of this study. The interview data of the two aforementioned groups—native English teachers and Korean students—is analyzed, interpreted and discussed in detail. The specific discourses or interpretive repertoires identified in the process of analysis of the data are broken down and interpreted, which is followed by a comprehensive summary and discussion. Specifically, the native English teacher participants operated through competing interpretive repertoires marked by either frustration or guilt, while the Korean participants exhibited interpretive repertoires marked by resistance or inevitability. Ultimately, an ambivalence emerges in both groups which helps shed light on the complex ways both native English teachers and Koreans are bound up with linguistic imperialism in South Korea.

      • The Dynamic Functional Assembly of Torsins and its Modulation by Cofactors

        Chase, Anna Regina ProQuest Dissertations & Theses Yale University 2017 해외박사(DDOD)

        RANK : 247343

        소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Torsins are the only known AAA+ (ATPases associated with a variety of cellular activities) in the continuous membrane compartment of the endoplasmic reticulum (ER) and the perinuclear space. Four Torsin isoforms are encoded in the human genome.

      • Regulatory mechanisms controlling HIV-1 induced immune activation

        Chase, Amanda Jewell The Johns Hopkins University 2008 해외박사(DDOD)

        RANK : 247343

        소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        Human immunodeficiency virus type 1 (HIV-1) infection leads to a massive depletion of CD4+ T lymphocytes. The actual mechanisms of CD4+ T cell depletion remain to be understood. CD4 +CD25+ regulatory T cells (Tregs) help limit the HIV-induced immune activation that precedes collapse of the immune system. Tregs downmodulate chronic inflammation by suppressing the activation and proliferation of effector lymphocytes. It is thought that by suppressing HIV-specific effector cells, Tregs may also contribute to viral persistence. To elucidate the role of Tregs in HIV-1-induced depletion of CD4+ T cells, we use an SIV/pigtailed macaque model of HIV-1 disease to determine the distribution of Tregs in a setting of acute infection, using FoxP3 as a marker for Tregs. FoxP3 is exclusively and constitutively expressed by Tregs and is essential to their development and function. From this model, we learned that Tregs play a significant role in controlling the apoptotic loss of CD4+ T cells resulting from high levels of generalized immune activation. Using assays developed in the macaque model, we next studied the role of Tregs in elite suppressors (ES) who are untreated HIV-1-infected individuals that maintain normal CD4 + T cell counts and control viremia to levels below the limit of detection of current assays. We developed an in vitro co-culture system to ask what immune factors or viral gene products lead to high levels of immune activation. Using flow cytometric analysis, we assayed for immune activation when quiescent, resting CD4+ T cells were exposed to HIV-1 infected blasts. The co-culture assay taught us that resting CD4+ T cell activation in the setting of HIV-1 infection is dependent on (1) cell contact, (2) the presence of non-CD4+ immune effector cells in the blast population and not just activated CD4+ T cells, and (3) initial virus binding as a fusion inhibitor did not prevent activation. During acute HIV-1 infection more than 50% of CD4+ T cells are depleted from the gastrointestinal lamina propria. We used an SIV/pigtailed macaque model of HIV-1 disease to elucidate the role of Tregs in HIV-1-induced depletion of CD4+ T cells in the gut-associated lymphoid tissue (GALT) during the acute phase of infection. CD4+ T cells from the GALT, lymph nodes, and peripheral blood were isolated on days 4, 14, and 114 post-inoculation from SIV-infected pigtailed macaques. Quantitative real-time RT-PCR was used to quantitate FOXP3 copy number in SIV-infected and uninfected control macaques. Expression of FOXP3 in the ileal lamina propria was significantly decreased at all stages of infection compared to levels in uninfected control macaques. In addition, functional analysis of ileal CD4+ T cells from SIV-infected macaques revealed a lack of suppressive activity, suggestive of the absence of Tregs in that compartment. These results indicate that Tregs are rapidly depleted in the GALT of SIV-infected macaques defining a role for the loss of Treg-mediated suppression in the early events in the pathogenesis of the disease. Next, we sought to determine the role of Tregs in the long-term control of viremia in ES. We found that a high frequency of FOXP3+ Tregs in the peripheral blood (PB) of ES correlated with low CD4+ T cell activation. In addition, preservation of Tregs in the PB of ES suggested that they are regulated from trafficking into tissues where they could potentially limit an antiviral immune response. This was in contrast to patients on highly active antiretroviral therapy (HAART) whose Tregs maintained functionality but were depleted from the PB. We observed that in both subsets of patients Tregs serve as a reservoir for HIV-1 in vivo, but not preferentially so compared to resting CD4+ T cells. These data suggest that both direct infection by HIV and tissue redistribution are possible explanations for declining PB FoxP3+ Tregs in progressive HIV infection. Furthermore, the maintenance of PB Tregs may account for the non-progressive nature of HIV-1 infection in ES.

      • Mujeres ingeniosas [resourceful women]: HIV+ Puerto Rican women and the urban health care system

        Chase, Sabrina Marie Rutgers The State University of New Jersey - New B 2005 해외박사(DDOD)

        RANK : 247343

        소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        This ethnographic study explores the help-seeking strategies of poor HIV+ Puerto Rican women living in the greater Newark area. A group of eighteen participants were accompanied to their health care appointments and the throughout the course of their daily lives. The project sought to answer four questions: (a) how is HIV disease managed by Puerto Rican women dependent on the public health care system? (b) which help-seeking, economic and treatment strategies do they employ most frequently in order to circumvent access and treatment barriers? (c) which of these strategies appear to result in better quality of life? and finally, (d) what role does CAM (complementary and alternative medicine) play in their treatment strategies? Drawing on the work of French sociologist Pierre Bourdieu, I argue that the range of cultural capital that my informants have accumulated over the course of their lives largely determines their ability to generate social capital in the form of collaborative alliances with health care professionals of all kinds, social service workers and other resource gatekeepers. Such alliances can literally mean the difference between life and death for impoverished minority women facing a serious, heavily stigmatized illness. In this way, social capital moderates the impact of structural constraints and structural violence such as poverty, ethnic balkanization, limited resources and lack of adequate medical care; it also promotes the expression of agency in the form of self-advocacy. Additionally, I found that those women who had accumulated the most diverse forms of cultural and social capital also used the greatest number of CAM modalities, although almost all of the women with whom I worked used at least one. Thus, women with greater cultural and social capital also tended to adhere to more multifaceted treatment strategies. Deployment of the concepts of cultural and social capital clarify why the medical, mental health and economic help-seeking strategies generated by the most successful women were so effective at preserving both the quality and length of their lives; it also helps to explain why the least successful women whom I encountered so often fell short of achieving their treatment and health promotion goals.

      • Dangerous bodies, resistant spaces: An ethnographic study of women's rugby

        Chase, Laura Frances The University of Iowa 2002 해외박사(DDOD)

        RANK : 247343

        소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        In this dissertation I explore the ways in which theories of the body and cultural geographic understandings of space intersect and can he used to further understand the gendered and sexualized body in women's rugby. The purpose of this research was to explore how women experience the sport of rugby. Through the use of ethnographic methods I examine the body and physicality in women's rugby and the social construction of rugby space. This is a multi-site ethnographic study of women's rugby in the Midwestern United States that involved players from four different states. In-depth interviews, participant or non-participant observations were all used in this research. My findings suggest that women involved in rugby were actively searching for a sport that was more physical and allowed them to be aggressive. Many of the women in this study rejected normative feminine body ideals and worked to become stronger and bigger. They valued and reinforced a wide range of female body types and felt good about their bodies. I found that most of these women and their respective teams struggled to have acceptable access to quality fields and officiating. But despite their lack of field space and metaphorical exclusion from the game these women saw rugby as central to who they were and made rugby a priority in their lives. They actively worked to construct rugby as an accepting space where all women could feel at home, accepted and valued.

      • The Casa delle Zitelle: Gender and architecture in Renaissance Venice (Italy, Andrea Palladio)

        Chase, Vanessa Scharven Columbia University 2002 해외박사(DDOD)

        RANK : 247343

        소속기관이 구독 중이 아닌 경우 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        This dissertation provides an account of the architectural development of the Casa delle Zitelle, 1575–1597. It elucidates how the patronage and purpose of the institution were critical determinants for the location, organization and image of the building. The Casa delle Zitelle was founded in 1559 by a group of patrician women to educate Venetian girls they had saved from becoming prostitutes. Because these women supervised the construction of the building, the Casa delle Zitelle also presents a rich site for exploring the impact of gender in Renaissance architecture. The principal documents for this inquiry, the building accounts preserved at the Istituzioni di Ricovero ed Educazione, Venice, show that construction proceeded in four campaigns. During the first, 1575–77, a fourteenth-century palace on the Giudecca purchased in 1561 was renovated; the patrons relied on traditional convent design as a model for this structure. During the second, 1581–88, the central-plan church of Santa Maria della Presentazione was built. The patrons employed the architectural idiom of Andrea Palladio to position the Casa delle Zitelle as a modest, virginal component of the image of civic piety created by the neighboring churches of San Giorgio Maggiore and the Redentore. During the third, 1589–91, the east wing of the building was constructed on property acquired in 1586; in the final campaign, 1596–97, the west wing was completed. For these final stages, the patrons adopted an H-plan similar to projects for the new charitable hospitals of the Incurabili in Rome and Venice. At the Zitelle, however, this design generated a building whose function is embodied in its form. Each of the three symmetric floors contained an aspect of the girls' education: household management, education and industry, and chastity; the church at the center regulated their lives. Built by women for women, the Casa delle Zitelle reflected the range of women's experiences in early modern Venice.

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