아세틸 콜린 유발 검사시 허혈성 심전도 변화와 흉통의 발생이 내피세포 기능장애에 미치는 영향

최철웅(Cheol Ung Choi),나승운(Seung-Woon Rha),김선원(Sun Won Kim),나진오(Jin Oh Na),임홍의(Hong Euy Lim),김진원(Jin Won Kim),김응주(Eung Ju Kim),한성우(Seong Woo Han),박창규(Chang Gyu Park),서홍석(Hong Seog Seo),오동주(Dong Joo Oh) 대한임상노인의학회 2010 대한임상노인의학회지 Vol.11 No.4

연구배경: 아세틸 콜린 유발 검사시 발생하는 흉통과 허혈성 심전도 변화가 아세틸 콜린에 의해 발생하는 관상동맥의 내피세포 기능에 어떤 영향을 주는지 알아보고자 했다. 방법: 흉통으로 내원하여 관상동맥 조영술과 아세틸 콜린 유발검사를 시행받은 1,085명의 환자를 대상으로 하였다. 아세틸 콜린 유발 검사를 하는 동안 허혈성 심전도 변화 및 흉통의 발생 유무에 따른 관상동맥 내피세포 기능의 특징을 비교하였다. 결과: 539명의 환자에서 아세틸 콜린 검사시 내피세포 기능 장애가 발생 하였다. 허혈성 심전도 변화가 있었던 그룹이 심전도 변화가 없었던 그룹보다 흉통이 더 많았고(78.1% vs. 60.8%, P=0.007), 관상동맥 조영술상 다발성 관상동맥 경련이 빈번하였고(59.4% vs. 40.6%, P=0.004), 관상동맥의 경련 정도도 더 심하였다(64.1% vs. 46.5%, P=0.006). 흉통이 있었던 그룹이 흉통이 없었던 그룹보다 허혈성 심전도 변화의 빈도가 더 높았다(14.7% vs. 7.5%, P=0.007). 또한 흉통이 있었던 그룹이 관상동맥 경련이 다발성으로 발생하는 경우가 많았고 (50.7% vs. 29.5%, P<0.001), 미만성으로 발생하는 경우가 많았고(87.1% vs. 75%, P<0.001), 관상동맥의 경련의 정도도 더 심하였다(51.6% vs. 43.5%, P=0.041). 결론: 아세틸 콜린 유발검사시 발생하는 허혈성 심전도 변화와 흉통은 관상동맥 경련의 정도와 경련이 발생하는 관상동맥 개수와 연관이 있다. Background: ECG changes and chest pain during acetylcholine (Ach) provocation tests may constitute important clinical parameters for Ach-induced endothelial dysfunction. We investigated the association between ischemic ECG changes and chest pain during the Ach-provocation test and angiographic characteristics of Ach-induced endothelial dysfunction. Methods: A total of 1,085 patients with anginal symptoms underwent diagnostic coronary angiography (CAG) and Ach-provocation tests. We compared angiographic characteristics of Ach-induced endothelial dysfunction according to the presence of ECG change and chest pain. Results: A total of 539 patients experienced Ach-induced endothelial dysfunction. Patients who experienced ECG change group suffered more frequent chest pain (78.1% vs. 60.8%, P=0.007), angiographically more frequent multiple coronary artery spasm (59.4% vs. 40.6%, P=0.004), and more severe coronary artery spasm (64.1% vs. 46.5%, P=0.006) than patients without ECG change. However, there was no difference in the length of endothelial dysfunction between the groups. The incidence of ischemic ECG changes in patients with chest pain was higher than in patients without chest pain (14.7% vs. 7.5%, P=0.007). Patients who experienced chest pain more often experienced multiple (50.7% vs. 29.5%, P<0.001), diffuse (87.1% vs. 75%, P<0.001), and severe coronary artery spasm (51.6% vs. 43.5%, P=0.041) than patients without chest pain. Conclusion: Ischemic ECG changes and chest pain during the Ach-provocation test are associated with multi-vessel involvement and severe coronary artery spasm. Chest pain is associated with the length of endothelial dysfunction, but ischemic ECG change is not.

스포츠센터 강사들의 조직공정성 인식과 조직변화저항, 혁신행동의 영향관계

서효민 ( Hyo Min Seo ),김태희 ( Tae Hee Kim ),장경로 ( Kyung Ro Chang ) 한국스포츠산업경영학회 2015 한국스포츠산업경영학회지 Vol.20 No.4

본 연구는 스포츠센터 강사들이 지각하는 조직공정성과 조직변화저항, 그리고 혁신행동의 영향관계를 규명하는데 그 목적을 두고 있다. 서울·경기 지역의 스포츠센터에 종사하는 스포츠강사 300명을 대상으로 설문조사를 실시하였으며, 총 234부의 자료가 실제분석에 사용되었다. 자료처리를 위해 SPSS 18.0 프로그램과 AMOS 18.0 프로그램을 이용하였으며, 빈도분석, 신뢰도분석, 상관관계분석, 확인적 요인분석, 그리고 구조방정식모형 분석을 실시하여 다음과 같은 연구결과를 도출하였다. 첫째, 절차공정성은 조직변화저항에 부정적인 영향을 미치는 반면에 분배공정성은 조직변화저항에 유의미한 영향을 미치지 않는 것으로 나타났다. 둘째, 분배공정성과 절차공정성 모두 혁신행동에 긍정적인 영향을 미치는 것으로 나타났다. 셋째, 조직변화저항은 혁신행동에 부정적인 영향을 미치는 것으로 나타났다. 넷째, 조직변화저항은 절차공정성과 혁신행동의 관계에서 부분매개 역할을 하는 것으로 나타났다. 이상의 연구결과를 통해 스포츠센터 강사들의 혁신행동을 증대시키기 위해서는 조직공정성의 확보와 조직변화에 대한 저항 관리가 매우 중요하다는 사실을 확인하였으며, 이는 스포츠센터 내 혁신역량 강화를 위한 중요한 이론적 근거가 될 것으로 생각된다. The purpose of this study was to investigate the relationships among perceived organizational Justice, resistance to organizational change, and Innovative behavior of sports center instructors. Specially, We examined the mediating effects of resistance to organizational change between organizational justice and innovative behavior. Total 300 questionnaires were distributed and 234 samples were used for practical analysis. The data were analyzed by frequency analysis, reliability analysis, correlation analysis, confirmatory factor analysis, and structural equation modeling using SPSS 18.0 and AMOS 18.0. The results of this study were as followers: first, procedural justice had a negative effect on resistance to organizational change, but distributive justice had no significant effect on resistance to organizational change. Seconds, distributive justice and procedural justice had a positive effect on innovative behavior. Third, resistance to organizational change had a negative effect on innovative behavior. Fourth, the relationship between procedural justice and innovative behavior was partially mediated by resistance to organizational change. In conclusion, we confirmed that enhancing the organizational justice and managing the resistance to organizational change are important for sports instructor`s innovative behavior and it can provide the theoretical basis for strengthening innovation capability of sport organization.

X-ray Irradiation Induced Reversible Resistance Change in Pt/TiO₂/Pt Cells

Chang, Seo Hyoung,Kim, Jungho,Phatak, Charudatta,D’Aquila, Kenneth,Kim, Seong Keun,Kim, Jiyoon,Song, Seul Ji,Hwang, Cheol Seong,Eastman, Jeffrey A.,Freeland, John W.,Hong, Seungbum American Chemical Society 2014 ACS NANO Vol.8 No.2

<P>The interaction between X-rays and matter is an intriguing topic for both fundamental science and possible applications. In particular, synchrotron-based brilliant X-ray beams have been used as a powerful diagnostic tool to unveil nanoscale phenomena in functional materials. However, it has not been widely investigated how functional materials respond to the brilliant X-rays. Here, we report the X-ray-induced reversible resistance change in 40-nm-thick TiO<SUB>2</SUB> films sandwiched by Pt top and bottom electrodes, and propose the physical mechanism behind the emergent phenomenon. Our findings indicate that there exists a photovoltaic-like effect, which modulates the resistance reversibly by a few orders of magnitude, depending on the intensity of impinging X-rays. We found that this effect, combined with the X-ray irradiation induced phase transition confirmed by transmission electron microscopy, triggers a nonvolatile reversible resistance change. Understanding X-ray-controlled reversible resistance changes can provide possibilities to control initial resistance states of functional materials, which could be useful for future information and energy storage devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-2/nn405867p/production/images/medium/nn-2013-05867p_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn405867p'>ACS Electronic Supporting Info</A></P>

고려말 조선시대 암막새의 변천과정

서창호(Seo Chang Ho) 중부고고학회 2010 고고학 Vol.9 No.1

암막새는 고려말 조선시대로 들어오면서 그 이전과 비교하여 衷面 布目痕의 등장, 평면형태와 막새면의 意匠표현 등 많은 변화가 이루어진다. 한국 와전사에 있어 이렇게 많은 변화가 보인 적은 없었다. 衷面에 布目痕이 확인되는 암막새들 중 평면형태, 문양과 문자의 意匠표현 등을 주속성으로 하여 유적 내에서 속성의 관찰이 가능한 암막세에 적용시켜 형식 분류를 시도하였다. Ⅰ단계는 고려말인 14세기 전반에서 15세기 후반으로 衷面에 布目痕이 있다는 것을 제외하고는 이전 시기에 비해 평면형태와 문양 등에 있어 큰 차이를 보이지 않았다. II 단계는 15세기 후반에서 16세기 후반으로 굴곡이 1회 또는 2회의 역삼각형태이고, 중앙문자구확대가 확인된다. III단계는 15세기 후반에서 17세기 후반으로 평면형태는 굴곡이 2회 이상의 역삼각형이며 연주문이 사라지고, 문자배치는 C, D식으로 막새면의 意匠이 본격적으로 문양에서 문자중심으로 변화되고 있다 IV단계는 16세기 후반부터 19세기 전반까지로 막새면 의 全面에 등간격의 문자구확대를 배치하여 문자위주의 意匠이 표현되고, 문자배치에 있어 정형성을 보인다. 이러한 변화의 원인을 먼저 고려말 원 간섭기에 유입된 원식 암막새에서 찾아보았는데 Ⅰ단계의 衷面 布目痕 막새의 제 작기법과 원식암막새의 속성이 결합하여 II 단계부터는 본격적인 변화가 진행되는 것을 알 수 있다. 막새 衷面에 布目痕이 있는 암막새는 막새와 평가와의 각도를 일정하게 맞춘 받침과 거치대를 사용하였기 때문에 동일한 접합기법 및 접합각도로 제작이 가능하다. 이는 접할 시 막새와 평가와의 조정 및 보강이 생략됨으로 공정의 축소화와 규격화를 위한 기술의 발전으로 설명할 수 있다. 16세기를 전후로 암막새의 장식이 문양에서 문자로 변화되면서 문자가 막새면의 全面에 걸쳐 자리 잡기 시작하는데 그 요인에 대해 당시 억불정책의 영향에 따른 사원경제사적인 측면에서 접근해보았다. 이 시기 암막새의 문자에는 대부분 시주, 화주, 인명, 관직명 등의 내용이 포함되어 있다. 암막새는 지붕의 정면을 장식하는 시각적 효과가 있어 막새면에 시주자의 이름을 새기게 되고, 시주자는 신앙적 효과를 제공받게 된다. 시주자의 대부분은 관인사대부나 지방의 유력자로서 국가의 지원 없이도 시원경제가 지속되는데 있어 경제적인 도움을 제공하였을 것이다. 또한 제와수공입적인 측면으로 볼 때 시주가 목적인 주문자(민간, 관인시대부)의 요구를 받아 암막새애 인명 등의 시주내용을 全面에 새겨 넣는 것은 별와요로 대표되는 관설제와장이 16세기를 전후로 시설제와 장으로 변질되고 있음을 말해주는 고고학적 증거라고 생각된다. Compared to the flat roof-end tiles of the previous period, those of the late Goryeo to Joseon Dynasty illustrate significant changes in terms of manufacturing technique, shape and decoration. These are thought to be important changes that can help establish chronology when researching flat roof-end tiles. However, Korean researchers have only considered the material in a fragmentary manner and have lacked a diachronic approach to change. However, the flat roof-end tiles of the late Goryeo to joseon Dynasty were reconsidered by Japanese researchers, which suggests the need to carry out a similar endeavor within Korea. Accordingly, focusing on those which have yielded traces of linen and cotton, this study examines the changing nature of the shape (in cross-section) and decoration of flat roof-end tiles. The results of the study suggest that flat roof-end tiles can be divided into 6 types which changed over 4 stages. These changes appear to have been influenced by the flat roof-end tiles of the Yuan dynasty which have been excavated within the Korean peninsula. The flat roof-end tiles of the Goryeo Dynasty began to be influenced by the flat roof-end tiles of the Yuan dynasty in Stage 1, and this generated the changes which can be observed from Stage 2. Finally, the presence of linen and cotton traces on the backs of the flat roof-end tiles was considered. Tiles without linen and cotton traces required adjusting and reinforcing when joined with plain roof-tiles. However, those with linen and cotton traces were manufactured using a rest which matched the angle between the flat roof-end tiles and the plain roof-tiles, and so such tiles could be joined according to a similar technique and angle. Therefore, the presence of linen and cotton traces can be taken to indicate standardization in manufacturing technique, and consequently development in mass production technology.

보조호르몬요법을 받는 여성 유방암 환자의 모발 변화와 치료 실태에 대한 기초 연구

이재경 ( Jae Kyung Lee ),김창현 ( Chang-hyun Kim ),홍동균 ( Dongkyun Hong ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),이진선 ( Jin Sun Lee ),권인선 ( In Sun Kwon ),박상현 ( Sanghyun Park ),이영 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7

Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective: We investigated the effects of long-term adjuvant hormone therapy on hair in patients with breast cancer, in addition to patients’ concerns and current treatment for hair loss. Methods: Patients completed a questionnaire that included information on self-perceived hair changes after each adjuvant therapy session, distress, and current treatment for hair loss. Using a folliscope, we measured hair density and thickness in each patient and in healthy controls. Results: The study included 93 patients with breast cancer (mean age 51.9±9.8 years). The density and hair thickness were 106.36±21.85 hairs/cm2 and 0.07±0.01 mm in the patient group and 147.86±30.67 hairs/cm2 and 0.07±0.01 mm in the control group (n=98, mean age 52.10±8.40 years), respectively. The mean hair density was significantly lower in the patient group than in the control group; however, no statistically significant intergroup difference was observed in hair thickness. Among 76 patients who perceived hair changes after adjuvant therapy, 71.1% (n=54) were distressed with regard to hair changes. However, only 7.8% of the patients, including two who were treated by dermatologists, currently received treatment for hair changes. Conclusion: Dermatologists should be familiar with hair changes in patients with breast cancer and provide appropriate education to encourage patients to consult dermatologists for hair loss and thinning after breast cancer treatment. (Korean J Dermatol 2021;59(7):521∼526)

A Study on the Correlation of Left Atrial Volume Change according to Left Ventricular Contraction in Atrial Fibrillation

Sung Kwan Kim,Hee Chang Chae,Choong Beom Seo,Eun Hee Seo,Chang Min Dae,Tae Eun Kim 대한CT영상기술학회 2022 대한CT영상기술학회지 Vol.24 No.1

The purpose of this study was to increase accuracy and success rate of radiofrequency catheter ablation by analysis of left atrial volume change relative to left ventricular volume change and left atrial diameter change relative to left atrial volume change. 20 patients with normal heart rhythm were set as the control group, and 20 patients with diagnosed atrial fibrillation were set as the experimental group. The cardiac cycle was divided into 10 stages ranging from 0% to 90%, and left ventricular volume, left atrial volume, left atrial diameter, pulmonary vein diameter were measured for each group. the correlation between the left ventricular volume and the left atrial volume was analyzed, and the correlation between the left atrial volume and left atrial diameter was analyzed. The diameter of the pulmonary veins was measured. As a result of analyzing the correlation between left ventricular volume and left atrial volume through Spearman correlation, the control group showed a negative correlation.(P<0.001) The experimental group were not correlated.(P=0.075) As a result of analyzing the correlation between the left atrial volume and the left atrial diameter, both groups showed a positive correlation.(P<0.001) As a result of analyzing the diameter of the pulmonary vein by Wilcoxon signed-rank test, both groups showed a significant difference in the maximum diameter and the minimum diameter.(P<0.001) Because the volume and diameter of the left atrium in patients with atrial fibrillation change irregularly, the radiologist check all cardiac cycle and reconstruct to increase the accuracy and success rate of radiofrequency catheter ablation.

Assessment of Aortic Annulus Dimensions for Patients with Hypertrophic Cardiomyopathy in Pre-TAVI Planning CT

송민철(Min-Cheol Song),김태은(Tae-Eun Kim),채희창(Hee-Chang Chae),서충범(Choong-Beom Seo),서은희(Eun-Hee Seo),대창민(Chang-Min Dae) 대한CT영상기술학회 2023 대한CT영상기술학회지 Vol.25 No.2

본 연구는 비후성 심근증 환자의 심장 주기에 따른 대동맥판륜의 형태학적 크기 변화를 측정하여 TAVI planning 3차원 영상처리시 대동맥판륜의 크기 측정 오류와 합병증을 최소화하고자 연구를 진행하였다. 2021년 4월부터 2022년 6월까지 본원을 내원하여 심전도 동조화 기법 TAVI planning CT 검사를 진행한 환자 중 심실중격 두께가 정상인 환자를 대조군 41명(78.92 ± 12.6세, 남성 44%), 비후성 심근증 환자를 실험군 31명(74.92 ± 10.8세, 남성 61%)으로 설정하였다. 심장 주기의 10% 간격으로 영상재구성하여 대동맥판륜의 면적, 둘레, 유효 직경, 면적 기반 직경, 둘레 기반 직경을 측정하여 비교 분석 하였다. 분석 결과, 심장 주기 동안 대동맥판륜의 면적, 둘레, 유효 직경, 면적 기반 직경, 둘레 기반 직경의 상대적인 변화는 각각 27.3%, 10.4%, 11.9% 12.6% 11.1%로 유의한 크기 변화를 나타냈다.(P<0.001) 대조군은 전체 심장 주기 중 수축기에서 대동맥판륜 각 측정인자의 최대값이 나타났으며, 실험군은 전체 심장 주기에서 측정 인자의 최대값이 불규칙적으로 나타났다. 또한 두 그룹 간 심장 주기 동안 대동맥판륜 측정 인자의 최대값 빈도 분포 분석 결과는 유의한 차이를 나타냈다.(P<0.05) TAVI 3차원 영상처리에 있어 비후성 심근증 환자의 경우 전체 심장 주기를 확인하여 대동맥판륜 크기가 가장 큰 심장 주기에서 측정하는 것이 정확한 크기의 인공판막 선택과 추후 합병증을 최소화하는데 큰 기여를 할 것으로 사료된다. The purpose of this study was to minimize the undersizing of aortic annulus size and reduce complications by analysis the size change of aortic annulus during the cardiac cycle in patients with hypertrophic cardiomyopathy. Patients were prospectively underwent an ECG-gated TAVI Planning CT. Retrospective study was conducted 41 normal group (78.92 ± 12.6 years; 44% males) and 31 hypertrophic cardiomyopathy group (74.92 ± 10.8 years; 61% males). The annulus plane was identified on reconstructions at 10% intervals of the cardiac cycle. Based on semi-automatically defined Aortic annulus, area, perimeter, effective diameter, area-derived diameter, perimeter-derived diameter were measured. The area, perimeter, effective diameter, area-derived diameter and perimeterderived diameter were significantly changes during the cardiac cycle with a relative change of 27.3%, 10.4%, 11.9%, 12.6% and 11.1% respectively. (all p < 0.001) During the cardiac cycles of groups normal and Hypertrophic myopathy, aortic annulus showed different dynamic changes. Different group showed a significant difference in the maximum values distribution plot. (p < 0.05) In patients with hypertrophic cardiomyopathy, reconstructing the entire cardiac cycle and selecting the largest annulus to TAVI planning is considered to contribute greatly to the accurate selection of the size of prosthesis in the procedure and minimizing TAVI complications.

가강수량의 변화패턴과 기후인자와의 상관성 분석

이다래 ( Darae Lee ),한경수 ( Kyung Soo Han ),권채영 ( Chaeyoung Kwon ),이경상 ( Kyeong Sang Lee ),서민지 ( Minji Seo ),최성원 ( Sungwon Choi ),성노훈 ( Noh Hun Seong ),이창석 ( Chang Suk Lee ) 대한원격탐사학회 2016 大韓遠隔探査學會誌 Vol.32 No.3

수증기는 지구 장파 복사에너지의 주요 흡수인자이다. 따라서 수증기량의 변화를 모니터링하고 변화의 원인을 세밀하게 조사하는 것은 필수적이다. 본 연구에서는 위성관측에 의해 얻어지는 Total Precipitable Water (TPW)자료를 사용하여 가강수량의 변화패턴을 모니터링 하고자 한다. 또한 기후인자들 중 수증기를 통해 생성되어 수증기의 변화패턴을 분석하는데 있어 중요한 역할을 하는 강수량과 다른 기후인 자들에 비해 비교적 주기적으로 나타나는 엘니뇨를 통해 가강수량의 변화패턴과 기후인자와의 상관성분석을 실시하고자 한다. 본 연구에서는 TERRA/AQUA 위성의 Moderate-Resolution Imaging Spectroadiometer (MODIS) 센서를 통해 관측된 TPW의 장기적인 변화와 한반도 중남부지방의 강수량변화를 정량적으로 분석 하고, 이들의 관계를 엘니뇨와 함께 비교하였다. 이를 통해 엘니뇨의 발생이 한반도 중남부지방의 강수량과 TPW의 변화에 영향을 주고 있는 지에 대해 조사하고자 한다. 먼저, 시계열 분석을 통해 TPW와 중남부지방 강수량의 변화를 정량적으로 산출하고 anomaly분석을 통해 이들의 변화를 세밀하게 분석한 결과 서로 반대 의 양상을 띠는 부분이 발견되어 엘니뇨의 anomaly분석결과와 비교하였다. 그 결과 대부분 같은 양상을 띠고 있던 TPW와 강수량이 엘니뇨가 발생한 후 서로 반대의 양상을 띠는 것을 확인하였다. Water vapor is main absorption factor of outgoing longwave radiation. So, it is essential to monitoring the changes in the amount of water vapor and to understanding the causes of such changes. In this study, we monitor temporal variability of Total Precipitable Water (TPW) which observed by satellite. Among climate variables, precipitation play an important part to analyze temporal variability of water vapor because it is produced by water vapor. And El Nino is one of climate variables which appear regularly in comparison with the others. Through them, we analyze relationship between temporal variability of TPW and climate variable. In this study, we analyzed long-term change of TPW from Moderate-Resolution Imaging Spectroadiometer (MODIS) data and change of precipitation in middle area of Korea peninsula quantitatively. After these analysis, we compared relation of TPW and precipitation with El Nino. The aim of study is to research El Nino has an impact on TPW and precipitation change in middle area of Korea peninsula. First of all, we calculated TPW and precipitation from time series analysis quantitatively, and anomaly analysis is performed to analyze their correlation. As a result, TPW and precipitation has correlation mostly but the part had inverse correlation was found. This was compared with El Nino of anomaly results. As a result, TPW and precipitation had inverse correlation after El Nino occurred. It was found that El Nino have a decisive effect on change of TPW and precipitation.

간암환자 67례에 대한 임상보고

서상훈,손창규,조종관 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.3

The purpose of this study was to evaluate the efficacy of oriental medicine therapy for 67 patients who have suffered from hepatoma from January 1st 1998 to September 30th 2000. Methods: Oriental medicine was administered to patients for over 3 months continuously. We checked improvement of clinical symptoms, hematological changes, and antitumor effects. The results obtained are summarized as follows. Oriental medicine has significant effect on the improvement of clinical symptoms and hematological changes. And according to the analysis of antitumor effects, the rates of maintenance and improvement were over 85%. From the above results, it is suggested that oriental medicine has significant effects of antitumor and immune activity, also could be usefully applied for hepatoma patients by combination with western therapy or alone.

Clinicopathological study on metastatic skin cancer

( Chang Il Kwon ),( Seo Mi Gon Jeong ),( Young Bin Shin ),( Yun Sun Moon ),( Eui Chang Jung ),( Chi Yeon Kim ),( Tae Jin Yoon ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1

Background: Various primary tumors can cause metastatic skin cancer. Metastatic skin lesion should be distinguished from other skin lesion. Objectives: We studied patients with metastatic skin cancer to find out average age, gender distribution, frequency of primary tumor, time interval between manifestation and primary cancer, and their clinical appearance, location and other metastatic sites. Methods: We reviewed the medical records, clinical photographs and histopathologic records of patients who had been diagnosed with metastatic skin cancer. Results: In the comparison according to clinical records, the mean age at the time of diagnosis was 60.6 years. The ratio of men to women was 1.05:1. The most frequent primary tumors were breast cancer (22.0%), lung cancer (17.0%), head and neck cancer (17%), melanoma (17.0%), gastrointestinal cancer (11%), urologic cancer (11%), and gynecologic cancer (6%). Metastatic skin cancers usually presented as discrete, painless, hard nodules, with sudden onset (88%). Conclusion: Based on the results of this study, it is believed that it is important to recognize the metastatic lesion between various skin lesion such as infections and granulomatous changes of other cause due to drugs and reactive changes.