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( Kui Young Park ),( Eun Jung Ko ),( In Su Kim ),( Kap Sok Li ),( Beom Joon Kim ),( Seong Jun Seo ),( Myeung Nam Kim ),( Chang Kwun Hong ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.6
Background: The most common adverse effects of oral isotretinoin are cheilitis, skin dryness, dry eyes, and conjunctivitis, whereas evening primrose oil (EPO) is known to improve skin moisture and transepidermal water loss (TEWL) in healthy adults and atopic patients. Objective: To evaluate the clinical efficacy and safety of EPO in preventing xerotic cheilitis in acne patients being treated with oral isotretinoin. Methods: Forty Korean volunteers of Fitzpatrick skin types III and IV, having moderate acne, were enrolled and randomized to receive either isotretinoin with or without EPO for 8 weeks. The efficacy of treatment was evaluated on the basis of global acne grading system scores, number of inflammatory and noninflammatory lesions, TEWL, corneometry, physician’s global assessment, and patient satisfaction. Results: The results after 8 weeks of treatment showed that the TEWL of the lip increased significantly during isotretinoin treatment, whereas the TEWL of the hand dorsum showed no significant change. The increase of the TEWL of the lip was more definite in the control group than in the experimental group. The number of acne lesions decreased significantly in both groups, and there were no differences between them. Conclusion: Our study suggests that the addition of EPO improved xerotic cheilitis in acne patients being treated with oral isotretinoin. However, besides TEWL and corneometry assessments, additional studies are required for a complete understanding of the role of EPO in xerotic cheilitis in acne patients being treated with oral isotretinoin. (Ann Dermatol 26(6) 706∼712, 2014)
계태아연속계대에 의한 내열성 Newcastle disease virus 분리주의 약독화
박정우,장경수,정용성,김귀현,송희종,전무형 충남대학교 수의과대학 동물의과학연구소 1997 動物醫科學硏究誌 Vol.5 No.-
In the cases of Newcastle disease(ND) outbreaks in the pheasant farms located in Chungchung area, five heat-stable Newcastle disease viruses(NDV) have been isolated from the diseased pheasants, and the various biological properities of the isolates have been reported. In this study, we attempted attenuation of a heat-stable NDV isolate, CBPI by serial subpassages in SPF chick-embryo and examined its pathogenicity and immunogenicity. When CBPI isolate was subpassaged by the 153rd levels, the heat stability was not changed as compared with that of the parent virus. However, its virulence was reduced according to increasing level of subpassage. The chicken infected with the attenuated CBPI at age of 1, 2 and 5 weeks showed no mortality with mild respiratory signs in all age groups tested, and significantly decreasing body weight gains in the 5 week-old chicken, while parent virus showed 100% mortality in all age groups. In comparison of adverse reactions between the attenuated CBPI and B1 strain in 1 week-old chicken with NDV maternal antibody(HI antibody titer>1:8). both viruses manifested no specific clinical signs, but significantly lower body weight gain in the group of chicken inoculated with CBPI. When the attenuated CBPI or B1 strains were inoculated into the 3 week-old chicken vaccinated primarily with B1 strain, both of viruses showed no specific side effects and changes in body weight. However, the HI antibody titers in the chicken inoculated with the attenuated CBPI were slightly higher than that of the chicken inoculated with B1 vaccine.
꿩에서 분리된 Newcastle Diesase Virus 내열성주 (CBP)의 Fusion(F) 유전자 클론닝과 염기서열 분석
장경수,전무형,송희종,김귀현,박종현 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-
The gene encoding F protein of CBP-1 strain, a heat-stable Newcastle disease virus (NDV) isolated from the diseased pheasants in Korea, was characterized by reverse transcriptionpolymerase chain reaction (RT-PCR), nucleotide and amino acid sequences. Virus RNA was prepared from the chorioallatoic fluid infected with NDV CBP-1 virus and cDNA was amplified by RT-PCR, cloned and sequenced to analyze. The PCR was sensitive as to detect the virus titer above 2^5 hemagglutination unit. 1.7kb (1,707bp) size of the cDNA was amplified and cloned into BamHI site of pVL1393 Baculo transfer vector. The uncleotide sequences for F protein were determined by dye terminator cyclic sequencing using four pairs of primers, and 553 amino acid sequences were predicted. In comparison of the nucleotide sequence of F gene of CBP-1 with those of other NDV strains, the homology revealed 88.8%, 98.5% and 98.7% with Kyojungwon (KJW), Texas GB and Beaudette C strains, respectively. As the deduced 553 amino acid sequences of F protein of CBP-1 were compared with those of other NDV strains, the homology appeared 89.9%, 98.7% and 98.9% with KJW, Texas GB and Beaudette C strains, respectively. The putative protease cleavage site (112-116) was R-R-Q-K-R, indicating that CBP-1 strain is velogenic type. The amino acid sequences include 6 sites of N-asparagine-linked glycosylation and 13 cysteine residues. These data indicate that the genotype of CBP-1 strain is more closely associated with the strains of Texas GB and Beaudette C than KJW strain.
최근 충청지역 환축으로부터 분리된 병원세균의 약제 감수성
장경수,정용성,김귀현,전무형 충남대학교 수의과대학 동물의과학연구소 1997 動物醫科學硏究誌 Vol.5 No.-
During the past three years, the antimicrobial susceptibility for the major pathogenic bacteria isolated from the swine herds and dairy farms located in Chungchong area has been examined. The major bacterial species isolated from the respiratory lesions of the diseased pigs during the periods were B. bronchiseptica, Haemopilus spp, P. multocida, Streptococcus spp., A pleuropneumonia. And from the fecal specimens of the pigs with diarrhoea, E. coli, Salmonella spp., Campylobacter spp., Streptococcus spp. and Clostridium spp. were isolated and investigated for the drug susceptibility. The major isolates from the milk samples of the dairy cattle with mastitis were Staphylococcus spp., Streptococcus spp., E. coli, Pseudomonas spp., Corynebacterium spp., Clostridium spp. and P. multocida. The total of 311 isolates were examined for 24 kinds of antimicrobial drugs. Of the isolates from the swine respiratory lesions, B. bronchiseptica and Haemophilus spp. showed 83% to 92% of suscepibility to ciprofloxacin(CIP), amikacin(AN) and norfloxacin(NOR). The isolates of P. multocida revealed 80% to 90% of susceptibility to AN, CIP, NOR and gentamycin(GM) and all of A pleuropneumonia isolates, susceptible to AN, CIP, GM, kanamycin(K), NOR and sulfamethoxazole-trimethoprim(SXT). Of the isolates from the pigs with diarrhoea, most isolates of E. coli showed the high susceptibility to AN, CIP and GM. And Salmonella spp. revealed 71% to 94% of susceptibility to GM, cephalothin(CF), AN and CIP, Campylobacter spp., 79% to 95% of susceptibility to AN, CIP and GM, and all of Clostridium spp., to AN, CIP, GM and information(FM), Of the isolates from the dairy cattle, Staphylococcus spp. and Streptococcus spp. showed 81% to 95% of susceptibility to AN, CF, CIP, FM, and AN, CIP, SXT, FM, K, respectively. E coli isolates showed 81% to 94% of susceptibility to CIP, AN, FM, and Pseudomonas spp., 83% to 94% of susceptibility to AN, AM and CIP. Campylobacter spp. and Clostridium spp. showed 89% and 100% of susceptibility to CIP, respectively. In measuring the MIC range of the major isolates for the drugs showing high sensitivity, the isolates from swine showed ≤0.06-64 ㎍/㎖ in CIP, 0.06-128 ㎍/㎖ in NOR and 0.5-256 ㎍/㎖ in AN, and the pathogens from the dairy cattle, ≤0.06-128 ㎍/㎖ in CIP, 0.25-256 ㎍/㎖ in AN and 0.12-512 ㎍/㎖ in NOR.
정창주,진국범,이동근,윤성필,김귀희,김영조 大韓顎顔面成形再建外科學會 1994 Maxillofacial Plastic Reconstructive Surgery Vol.16 No.1
The functional deformity following removal of the maxilla is considerable, especially following maxilla cancer excision. Rehabilitation of oral and maxillofacial region used to be very difficult with prosthesis or traditional flaps. Temporal muscle and fascia flaps have been described for immediate reconstruction following hemi-maxillectomy, but not total maxillectomy. The muscle and superficial fascia of the temporal area differ in their physical characteristics, vascular supply and clinical applications. Both can be employed independently or simultaneously as regional flaps in the reconstruction of a variety of complex craniofacial defects. Four case is presented in which 3 case maxilla cancer, one case non-union after maxilla fracture, and all case showed successful use of this flap. Only one patient developed partial necrosis of the flap ; significant necrosis did not occur in any other patient. This present paper reviews the anatomy, surgical technique and utilisation of temporal muscle and fascia flaps.
장기간 수영운동에 참가한 중년여성의 신체구성과 건강체력 특성에 대한 연구
전종귀,성민철,이창규,현광석,조병준 충남대학교 체육과학연구소 2000 體育科學硏究誌 Vol.18 No.1
The purpose of this study was to identify the effects of swimming exercise career on the middle-aged women. The number of sujects were 44 postmenopausal women(45-60 age group). The number of exercise group were 27(3 years average career) and that of control group were 17, Percent body fat physical development score, back strength, grip strength, trunk flexion, endurance were measured. The results were as followings; 1. The percent body fat, physical development score, back strength, grip strength, endurance of swimming exercise group was higher than that of control group. The difference showed the statistical significance. The trunk flexion and grip strength of swimming exercise group were lower than that of control group. The difference didn't showed the statistical significance. 2. The back strength, muscle endurance, endurance of swimming exercise 7 years average career group was higher than that of 3 years average career group. The difference showed the statistical significance. As the above, the regular participation of swimming exercise help the middle-aged women to promote their health-related fitness. Also the exercise prevent obesity, back pain.
Classical Swine Fever (Hog cholera) Virus 약독순화주 (Suri 주)의 gp55 Gene 염기서열 분석
김귀현,장경수,강경임,이병형,박종현,안수환,전무형 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-
An attenuated classical swine fever virus (CSFV), Suri strain, is a variant derived from a vaccine virus, LOM strain. This study was performed to elucidate the molecular biologcal properties of CSFV Suri strain, and to obtain the basic data for molecular epidemiological approaches for the disease. The truncated form of gp55 gene without the C-terminal trasmembrane domain, in size of 1,023bp, was amplified by RT-PCR and sequenced by dye terminator cyclic sequencing method, and inserted into BamHI site of pAcGP67B baculovirus vector, establishing a cloned pAcHEG plasmid. By the nucleotide sequences determined, 341 amino acid sequences were predicted. As compard the nucleotide and amino acid sequences of gp55 of Suri with the various CSFV, Suri strain showed the high homology over 99.1% with ALD and LOM strains, but comparably the lower homology with Alfort and Brescia. In comparison of amino acid sequence in variable domain of gp55 protein, the similar tendency of homology was observed. In hydrophobicity analysis, all of four CSFV strains revealed the analogous patterns of hydrophobicity. The numbers and locations of N-glycosylation site and cysteine residuse in gp55 were analyzed, those of Suri strain being coincident with ALD and LOM strains. The results suggest that gp55 in Suri strain has the high similarity to those in ALD and LOM strains in terms of the nucleotide and amino acid sequences and the functional properties of gp55 protein.
中學生의 學級內, 社會的 地位의 高·下集團間 體型 및 運動能力의 差
全鍾貴,閔昌基,李鍾虎 충남대학교 자연과학연구소 1983 忠南科學硏究誌 Vol.10 No.1
The purpose of the present investigation was to extend the comparison of groups of popular and unpopular students to include somatotype and motor characteristics. The subjects were 20 boys and 20 girls who attended one of middle schools enrolled at random. They were selected on the basis of their social status indices of acceptance-rejection ((acceptance-rejection)/(N-1)) derived from a sociometric questionaire. The 10 boys and girls with the highest sociometric status indices of the total group of students(N=60) formed the high social status groups ; the students with the lowest indices formed the low social status groups. The somatotype of each subject was determined according to the Heath-Carter's anthropometric method. The motor characteristics were composed of 100m dash, standing broad jump, throwing, pull-up(for boys), chinning(for girls), and sit-up being often used for physical fitness assessment in schools in Korea. The somatotypes of the boys and girls in the popular and unpopular groups were plotted on somatocharts. The t test were taken to determine the discrepancies or differences in somatotypes and motor characteristics between groups. The authors reached the following conclusions ; 1. The high social status students were older than the low status in age. 2. The high social status students were taller than the low status in body height. 3. The high social status boys were not hevier than the low status in body weight, but the girls with the high social status were hevier than the low status girls. 4. The low social status students were more endo-mesomorphic than the high status. 5. The high social status boys were generally superior to the low status in motor ability. 6. The high social status girls were more skillful than low status in 100m dash and chinning. 7. The low social stauts girls were superior to the high status in standing broad jump, throwing, and sit-up performance.
男子大學生에 있어서 體型과 有無酸素的 運動能力間의 關係 및 各 體型集團別 運動能力의 差
閔昌基,全鍾貴 충남대학교 자연과학연구소 1981 忠南科學硏究誌 Vol.8 No.1
One hundred fifty randomly sampled male students (mean age 20.3 ±1.72 years) of Chungnam National University in Daejeon served as subjects. Theses students were divided into three groups of 8 endomorphs, 86 mesonlorpils, 32 ectomorphs according to me most dominant characteristic among their somatotype components. As a result of this grouping, 24 students were not belong to any one somatotype group because they had more man two dominant somatotype components. The objective Health-Carter's anthropmetric method was used. Fifty meter dash and 2000 distance run were adopted to measure aerobic and anaerobic motor ability respectively. Product-moment correlation coefficients and t ratios were calculated to determine the relationship of somatotype to motor ability and its statistical signicance. To determine the difference of motor ability among somatotype groups with me significance statistically, F ratios were computed. The authors reached me following conclusions: 1. Themean somatotype of college freshmanwas ectomesomorph. 2. The low relationships existed between somatotype components and anaerobic motor ability. 3. The low relationship existed between the third component of somatotype and aerobic motor ability. 4. The first and me second somatotype component were not related to anaerobic motor ability. 5. The differences of anaerobic motor ability among somatotype groups did not appear. 6. Mesomorphs were superior to both endomorphs and ectomorphs m aerobic motor ability. 7. Ectomorphs were superior to endomorphs m aerobic motor abu1ty.