전립선암의 조기진단을 위한 염색체 이상에 관한 연구 : Fluorescence In Situ Hybridizatioan법을 중심으로

박종윤,박정덕,홍연표,장임원 중앙대학교 의과대학 의과학연구소 1994 中央醫大誌 Vol.19 No.1

To detect the numerical changes of the chromosome 13 and 17, containing tumor suppressor genes (retinoblastoma gene and p53) in normal tissue, intraepithelial neoplasm and carcinoma of the prostate, the Fluorescence In Situ Hybridization technique with paraffin embedded tissue was done. Materials observed in this study consisted of 14 cases of lacalized carcinoma(TB1NOMO) and 1 case of locally infiltrating cancer(TC1NOMO)> The chromosomal number changes were counted at normal tissue, intraepithelial neoplasm and neoplastic gland at the same radical prostatectomy specimen. From the 4 patients, studied prospectively, fresh cancer tissue and peripheral whole blood were collected for the primary culture of the cancer cells and lymphocytic culture. There cultured cells were used fro karyotyping. The results were as follows : 1. There were no significant chromosomal number changes between 13 and 17 in each group. 2. The normal non-neoplastice duct, intraepithelial neoplasm and neoplastic gland of experimental group showed no significant difference in chromosomal change. 3. There were significant changes more than 30% in chromosomal numbers between control Y chromosome and experimental chromosome 13 and 17 in each group. 4. The karyotyping on primary cultured prostate cancer cells and lymphocyte showed significant difference in chromosomal number in spite of the same host, representing local chromosomal changes.

만성 췌장염의 임상적 연구

김창덕,현진해,정문기 대한소화기학회 1998 대한소화기학회지 Vol.30 No.2

Background/Aims: Chronic pancreatitis is a chronic inflammatory process leading to destruction of exocrine tissue, fibrosis, and in some patients, loss of endocrine tissue. A multiplicity of causes may lead to chronic pancreatitis; however, chronic alcohol abuse appears to be the etiologic basis in 70-80% of adult patients. As the problem of chronic alcoholism has grown in the our country, the prevalence of chronic pancreatitis is increasing. However, few reliable studies have been performed concerning the clinical features of chronic pancreatitis in Korea. So we investigate the clinical characteristics and diagnostic accuracy of imaging studies in chronic pancreatitis. Methods: We analyzed the 91 patients with chronic pancreatitis who were diagnosed and managed at Anam Hospital, Korea University in Seoul frorn January 1988 to December 199i. Results: The sex incidence showed male predominance with a male to female ratio of 4.7:1 and peak age groups were 5th and 6th decades. Most common cause of chronic pancreatitis was chronic alcohol consumption(54.9%), and the other causes were biliary disease, anomaly of the pancreas, hyperlipidemia, and hyperparathyroidism. Cause was not identified in 20.9% of patients. Most of patients complaints abdominal pain(91%), and other eomplaints were indigestion(73.6%), weight loss (39.6%), jaundice(13.2%) or diarrhea(8.8%). Elevated serum amylase and fasting sugar level were shown in 39.6% and 29.7% of patients respectively. Sensitivity of abdorninal sonogram, CT scan, and ERCP were 59%, 78% and 89% in diagnosis of chronic pancreatitis respectively. CT scan was supetior to other methods in detection of pancreatic calcification and smail cystic lesions, and ERCP was superior to others in detection of minor ductal change. Twenty-one cases were accompanied by complications such as pseudocysts, biliary stenosis, duodenal obstruction, splenic vein thrombosis & pseudoaneurysm. Endoscopic treatment was given in 12 cases and surgical operation was performed in 19 cases due to complicaiton. Conclusions: Chronic alcohol comsumption is a major cause of chronic pancreatitis. CT and ERCP are essential diagnostic tool in evaluating morphological changes of chronic pancreatitis.

국내 송이산업이 당면한 문제

具昌德,金載水,朴在仁 충북대학교 농업과학기술연구소 2001 農業科學硏究 Vol.18 No.-

Pine mushroom (Songyi, Tricholoma matsutake (S. Ito et Imai) Sing.) industry in Korea has confronted with several difficulties in the light of marketing, i.e. its supply quantity, quality, price and promotion. In this essay we discussed the problems with four topics related to the mushroom: long term decreasing production by 7% per year, relatively dropping quality and prices in changing Japanese markets that import the mushroom from 11 contries and needed promotion. For these, we suggest first that pine mushroom production forests be managed on a sustainable basis in the present production sites. Second, harvesting and packing need to be done at the production sites so that its quality may not be damaged. Third, it should be understood that pine mushroom markets in Japan have been greatly changed. That is, Korea supply only 10% of Japanese pine mushroom impact. Forth, our own brand names for pine mushroom need to be developed. For solve these problems our critical and creative efforts and needed.

社會體育에 있어 餘暇敎育

閔昌基,陳潤洙,南悳鉉 忠南大學校體育科學硏究所 1987 體育科學硏究誌 Vol.5 No.1

Because of economic growth and the change of social structure, humans come to desire leisure education. And affluent living and the increase of leisure times forster the development of sport for all. Having perceived above tendency, I studied both sport for all and leisure education. Consequently, I yielded the following desirable results; 1. The development of sport for all rests on the leisure education in the system of school education, as a part of lifelong education. 2. Sport for all can change the sense of value and restore human qualities through bettering the way of thinking about leisure. 3. Sport for all and leisure education need leisure life at home. Also they play a great role in guiding youth. 4. Sport for all and leisure education need a variety of programs and capable leaders.

초음파 처리가 Polyester 직물의 알칼리 감량가공시 물성 및 Handle에 미치는 영향

류덕환,한교창 啓明大學校 生活科學硏究所 1998 科學論集 Vol.24 No.-

The alkali process was first handled with changing both the process time(20, 30, 40, 60min) and the handling temperature(50, 60, 70, 80, 90, 100℃), washed with distilled water, rising with 80℃ and 40℃ warm water in a serial order. Then the sample of the alkali processed one is put in nature dryness for more than 12 hours. Finally, it was fully dried for more than three hours in the 60℃ hot wind dryer. The appliances used in the ultrasonic weight-loss tester were JIU-600, BLT, 100volt(5A), 600W and 28KHz. I came to the following conclusion by measuring the ability of dying in the ultrasonic processed PET fabric, and its catabolistic distinctive features such as weight-loss rate, intensity, frictional pressure, air permeability, surface observation and mechanical property. 1. When I take advantage of the ultrasonic wave to get the same weight-loss rate, the processing time can be shortened by 5-6min and its temperature can be lowered by 4-5℃ 2. The air permeability rised as the weight-loss rate increases while the bending rigidity and hysteresis decrease. But those combined with the ultrasomec wave were revealed a little higher in the same weight-loss rate. Also, the tensile strength decreased in proportion to the weight-loss rate. The correlation is TS=-0.629WL+40.147. 3. The frictional pressure increased as the weight-loss rate increased and was found as the highest(15%). In the process, what is used in combination with the ultrasonic wave is about 9,000V, while what was opposite was about 8,500V. Such a change did not occur significantly in the case of more than 15%. 4. K/S is found as about 5.5 in the 20% weight-loss rate. But when it exceeded the point, it remained unchanged. Because the inner and outer alien materials of are thoroughly removed, the outlook of on the fabric surface was distinctly seen when it was used in combination with the ultrasonic wave. 5. THV(Total Hand Value) of fabric combined with the ultrasonic wave was found as about 4.0% higher than the one used in alkali processing itself Especially Shari Hand Value have greatly advanced.

무통분만시 수막강내 Sufentanil에 첨가된 Bupivacaine의 효과

김수창,최덕환,김지애 대한마취과학회 1999 Korean Journal of Anesthesiology Vol.37 No.6

Background : The combination of a local anesthetic and an opioid has been shown to produce effective epidural labor analgesia. It was reported that the combination of intrathecal opioid and bupivacaine could produce labor analgesia with longer duration and less side effects. This study was done to evaluate the effect of intrathecal bupivacaine mixed with sufentanil for labor analgesia. Methods : Eighty women requesting labor analgesia were randomly assigned to receive intrathecal 10 mcg of sufentanil (S group, n = 40) or 2.5 mg of bupivacaine plus 10 μg of sufentanil (SB group, n = 40) diluted in a total volume of 2.2 ml with normal saline. The analgesia was performed using combined spinal-epidural technique in the lateral position. Visual analogue scales (VAS) for pain, sensory changes to cold, duration of analgesia, motor block, hypotension, fetal heart rate, pruritus, and other side effects were assessed for 30 minutes after intrathecal drug injection. Results : There were no significant differences in he VAS pain scores and sensory levels at 5 minutes after intrathecal drug injection between groups. However, VAS pain scores were significantly lower and sensory levels higher in the SB group at 15 minutes and 30 minutes after intrathecal drug injection. The duration of analgesia provided by intrathecal sufentanil (n = 31) was 103.4 41.1 min, by intrathecal sufentanil plus bupivacaine (n = 29) 113.0 32.1 min (P = 0.30). Motor block assessed by a modified Bromage scale was significantly frequent in the SB group (P< 0.001). Not only adverse effects such as hypotension, fetal bradycardia, pruritus, and nausea, but also satisfaction scores were similar in both groups. Conclusions : The addition of bupivacaine to intrathecal sufentanil produced more frequent motor block and extensive sensory block, but better analgesia. However, duration of analgesia, side effects and satisfaction score did not change. (Korean J Anesthesiol 1999; 37: 1068∼1073)

신장수여자의 수술경과시간에 따른 자기존경감, 희망감, 염려 및 스트레스원의 차이

이 철,김창윤,한오수,박인호,유희정,한덕종 울산대학교 의과대학 1993 울산의대학술지 Vol.2 No.2

This study attempted to examine the differences of self - esteem, hopes, concerns and total stress scores of 110 kidney recipients in before(N=32) and fellowing kidney transplantation [1 to 6 months(N=29), 6 to 12 months(N=23), 12 to 36 months(N=26)] and utilizing severity rating scale of 44 potential stressors on a 5-point scale of 110 kidney recipients in before(N=32) and following kidney transplantation operation [1 to 6 months(N=29), 6 to 12 months(N=23), 12 to 24 months(N=15) and 24 to 36 months(N=11)]. On scores of hopes and total stress, pretransplant group exhibited significantly higher scores than three posttransplant recipient groups. But, it was found that there was no significant differences among four transplant kidney recipient groups on the scores of self - esteem and concerns. In the pretransplant group, craving for foods was identified as the most stressful event, on the contrary, changes in friends was identified as the lowest stressful events. In the 1 to 6 months posttransplant group, side effect of medications was identified as the most stressful event, however, loss of contact with dialysis patients was identified as the lowest stressful event. In the 6 to 12 months posttransplant group, cost of medication, changes in body appearance were identified as the most stressful event, on the other hand, managing of medications at home was identified as the lowest stressful event. In the 12 to 24 months posttransplant group, cost of medication and insurance coverage were identified as the most stressful event, but possibility of dying and competence of nursing staff were identified as the lowest stressful event. In the 24 to 36 months posttransplant group, changes of body appearance was identified as the most stressful event, on the contrary, possibility of infection was identified as the lowest stressful event. Insurance coverage was a continuing concern throughout posttransplant period.

만성 췌장염의 임상적 연구

정문기,김창덕,현진해 大韓消化器病學會 1997 大韓消化器病學會誌 Vol.30 No.2

Effects of the Aromatherapy Program Using Fir Needle Essential Oil on Stress, Sleep Quality and Fatigue in Middle-Aged Women

Jong-Suk Hong,Woo-Yeol Kim,Chang-Duck Koo 인간식물환경학회 2018 인간식물환경학회지 Vol.21 No.5

The purpose of this study was to investigate the effect of aromatherapy program using fir needle essential oil on stress, sleep quality, and fatigue of middle aged women. Twenty middle-aged women were divided into experimental group and control group. The experimental group inhaled the fir needle fragrance for 5 minutes and received a back massage with sunflower oil mixed with fir essential oil for 20 minutes. The control group took a rest for 5 minutes instead of inhaling the fragrance of essential oils and received a back massage with only sunflower oil. The experiment was conducted total eight times (twice a week) for four weeks. For the measurement of stress, fatigue, and sleep quality, questionnaires were used to collect data in the pre-test survey and post-test survey. As a result, the scores of physical and psychological stress in the experimental group and the control group were significantly decreased. However, the physical stress was more decreased in the experimental group treated with fir oil aromatherapy. In addition, both groups showed a significant difference in the quality of sleep. Fatigue measurements showed significant changes in both groups, but the fatigue reduction was more significant in the experimental group. These results suggest that massage therapy for the middle-aged women has a positive effect on relieving physical and psychological stress, improving sleep quality and reducing fatigue by assisting metabolism and blood circulation. This study proved that fir needle essential oil can be a good material for aromatherapy to promote health of middle aged women undergoing physical, psychological, and social changes.

The role of hLHX6-HMR as a methylation biomarker for early diagnosis of cervical cancer

정삼일,정동준,김진선,Lisha Yi,구근호,이재혁,이순덕,박진화,BOOGI CHANG,김창환,김창진,이명숙 Sookmyung Women's University Research Institute of 2010 여성과 건강 Vol.6 No.1