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Identification of occult tumors by whole-specimen mapping in solitary papillary thyroid carcinoma
Park, Seog Yun,Jung, Yuh-S,Ryu, Chang Hwan,Lee, Chang Yoon,Lee, You Jin,Lee, Eun Kyung,Kim, Seok-Ki,Kim, Tae Sung,Kim, Tae Hyun,Jang, Jeyun,Park, Daeyoon,Dong, Seung Myung,Kang, Jae-Goo,Lee, Jin Soo,R Society for Endocrinology 2015 Endocrine-related cancer Vol.22 No.4
<P>We undertook this study to estimate an accurate incidence and spread patterns of occult papillary thyroid carcinoma (PTC) in patients with a preoperative diagnosis of solitary PTC by using whole-specimen mapping of all specimens after a total thyroidectomy. Enrolled prospectively in this whole-thyroid mapping study are 82 consecutive patients who underwent a total thyroidectomy under a preoperative diagnosis of solitary PTC. All thyroidectomy specimens were serially sectioned in 2 mm thickness and whole-thyroid mapping was carried out for additional foci of occult PTC. The frequencies of occult lesions detected in the whole and contralateral lobe were determined, and clinicopathologic factors associated with multifocality were assessed. Whole-thyroid mapping revealed 66 occult PTC lesions missed by preoperative ultrasound in 37 (45.1%) of the 82 patients. The great majority (92.5%) of the occult PTC was smaller than 3 mm in size and 25 patients (30.5%) had contralateral lesions. We found that the male sex was an independent predictor of multifocality (odds ratio (OR), 3.00; 95% CI, 1.11–8.14), adjusting for preoperative findings. Analysis with pathologic parameters showed that the male sex (OR, 5.03; 95% CI, 1.68–15.08) and extrathyroidal extensions (OR, 3.03; 95% CI, 1.03–8.95) were associated with multifocal PTC. However, none of the clinicopathologic factors evaluated predicted contralateral PTC. Our study demonstrates the diagnostic limitations of ultrasound for the detection of multifocal PTC and the need to consider the possibility of occult lesions in the management of solitary PTC, especially in male patients.</P>
통합해석기법을 활용한 공대공 및 지대공 적외선 미사일 대응 초음속 항공기의 중적외선 및 원적외선 신호 분석
김태환,배지열,김태일,정대윤,황창수,조형희,Kim, Taehwan,Bae, Ji-Yeul,Kim, Taeil,Jung, Daeyoon,Hwang, Chang Su,Cho, Hyung Hee 한국군사과학기술학회 2014 한국군사과학기술학회지 Vol.17 No.6
The stealth performance of supersonic aircraft in recent air battlefield is one of the most significant feature for latest fighters. Especially, as the technology is advancing, the IR stealth capability becomes more important because of its passive characteristic. To design an aircraft with stealth capability, we must know how much the IR signature is generated from the aircraft. Also, predicting the IR signature of enemy's aircraft is tactically crucial. In this study, we calculated MWIR and LWIR infrared signature of $5^{th}$ generation supersonic aircraft against air-to-air and surface-to-air threat using IR simulation code and CFD coupled procedure.
Byung Seok Moon,김상욱,Tae Sup Lee,Soon Hyuk Ahn,Kyo Chul Lee,Gwang Il An,Seung Dae Yang,DaeYoon Chi,Chang Woon Choi,Sang Moo Lim,Kwon Soo Chun* 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.1
O-(3-[18F]Fluoropropyl)-L-tyrosine (L-[18F]FPT) was synthesized by nucleophilic radiofluorination followed by acidic hydrolysis of protective groups and evaluated with 9 L tumor bearing rat. L-[18F]FPT is an homologue of O-(2-[18F]fluoroethyl)-L-tyrosine (L-[18F]FET) which recently is studied as a tracer for tumor imaging using positron emission tomography (PET). [18F]FPT was directly prepared from the precursor of O-(3-ptoluenesulfonyloxypropyl)- N-(tert-butoxycarbonyl)-L-tyrosine methyl ester. FPT-PET image was obtained at 60 min in 9 L tumor bearing rats. The radiochemical yield of [18F]FPT was 40-45% (decay corrected) and the radiochemical purity was more than 95% after HPLC purification. The total time elapsed for the synthesis of [18F]FPT was 100 min from EOB (End-of-bombardment). A comparison of uptake studies between [18F]FPT and [18F]FET was performed. In biodistribution, [18F]FPT showed similar pattern with [18F]FET in various tissues, but [18F]FPT showed low uptake in brain. Furthermore, [18F]FPT showed higher tumor-to-brain ratio than [18F]FET. In conclusion, [18F]FPT seems to be more useful amino acid tracer than [18F]FET for brain tumors imaging with PET.