Graves 병 환자에서 항갑상선제 투여에 의한 TSH 수용체 항체의 변동에 관한 연구 : 치료 용량 및 기간에 따른 차이 및 임상상과의 관계 its relation to dose and duration of treatment~and clinical features

이문호,조보연,문대혁,고창순,민헌기,서교일 대한내과학회 1986 대한내과학회지 Vol.30 No.3

We undertook a prospective study of 59 patients with Graves' disease in order to clarify the influence of antithyroid drug on the immunological indices and to determine the association of the changes of TSH receptor antibodies activities with drug dosage, duration of treatment and clinical features according to mode of antitbyroid drugs treatment. Patients were divided into two groups. High dose group included 28 patients and conventional dose group 31 patients. We measured TBII activities, antimicrosomal antibodies, and the size of goiter every 3 months, comparing them with clinical features and laboratory findings. TBII activities declined from R months until 9 months following drug treatment. Therafter no significant change of TBII activities were observed. Antimicrosomal antibodies showed the same pattern of change. There was no statistically significant difference of declining rate of TBII activities, antimicrosomal antibodies, and reduction of size of thyroid between two treatment groups. TBII activities fell into normal range in 15 patients among those 44 patients who had been followed for more than 9 months (8 high dose group, 7 conventional dose group). In those 15 patients, TBII activities and frequency of exophthalmos were less than those whose TBII activity did not normalized. We conclude that TSH receptor antibodies activities and antithyroid autoantibodies are diminished by antithyroid drug treatment in patients with Graves disease and there is no relationship between dose of drug and declining of TBII activities. We suggest that changing levels of TBII activities might be secondary phenomenon which can be achieved by control of thyroid function by antithyroid drug rather than direct immunosuppressive effect of antithyroid drug per se.

山火跡地의 植物群集 構造 및 植生 變化分析

李敏渟,尹相旭,金昌浩 동국대학교 농림과학연구소 1988 農林科學 論文集 Vol.12 No.-

This study is carried out to clarify the changes in the forest vegetational structure as time goes by after the fire. The results obtained are as follows; 1. The Soil pH decreased, the soil organic matter and water content increased, and the soil structure was hardly changed as time goes by after the fire. 2. By analyzing the soil profile, the soil deepness was shallow in general, and the formation of the organic matter was gradually increased. nced. 3. In relative density, relative cover, relative frequency, Quercus spp., Alnus hirsuta, Lespedeza spp. showed the high value, but that of Lespedeza was decresed as time goes by, and for herbaceous plants Cymbopogon tortilis, Festuca ovina was very high value over all the plot. 4. Importance value of Quercus spp. and Alnus hirsuta was gradually increased, and that of herbaceous plants - Cymbopogon tortilis, Festuca ovina, and Pteridium aquilinum - also was gradually increased, but was decreased in the fifth year. 5. The species diversity showed the low value shortly after the fire, but was increased after the second year, and the eveness index was decreased as time goes by.

권력교체와 언론법제: 언론과 권력의 민주적 관계 설정에 관한 연구

장호순 ( Ho Soon Chang ) 순천향대학교 사회과학연구소 2008 사회과학연구 Vol.14 No.2

만주화 이후 한국사회에도 선거를 통한 권력교체가 이루어지고 있다. 그러나 권력교체기 마다 권력의 언론장악 혹은 권력과 언론의 결탁의 우려가 제기된다. 보다 민주적인 권력과 언론의 관계다 구축되려면, 권력과 언론간의 관계를 합리적으로 조정해주는 “게임의 룰”을 만들어야 한다. 그 “게임의 룰”에서 가장 중요한 원칙은 “언론자유 여역”은 권력의 교체와 무관하게 늘 보호받아야한다는 것이다. 그러나 언론의 모든 영역과 행위가 언론자유에 해당하지 않는다. 언론의 자유를 확장하거나 국민 복리를 위해서 정부가 융통성 있게 추진할 수 있는 “언론자유 이외의 영역”이 존재한다. 그러나 “언론자유 이외의 영역”이라고 해서 권력이 마음대로 할 수 있는 영역은 아니다. 간접적으로도 언론자유를 침해할 수 있기 때문에, 언론관련 정책은 국민적 합의가 필수적이다. 권력은 선거를 통해 확인된 언론정책, 즉 선거에서 제시한 공약만을 우선 집행해야한다 선거공약에 포함되진 않은 언론정책은 국민적 합의절차를 거친 후에 신중하게 집행해야 권려교체기 마다 발생하는 권력과 언론의 불편한 관계가 해소 될 것이다. As democracy settles in Korea, elections brought leadership changes government. However, every governmental transition created worries of political control of the press or of conspiracy between government and the press. In order to establish democratic relationship between government and the press, rational rules of games are needed during those volatile transitional times. The most important principle among those rules should be that free press should be protected regardless of governmental changes. Not all the activities of the press, however, are to be protected. Government can use its power to extend the freedom of the press or can take actions against the press in order to promote general welfare. Even in those cases, governmental power should be carefully exercised for its possible infringment of free press. In terms of government policy on the press, national consensus always should be sought. New government should only execute campaign promises, and press policies not included in them should wait until national consensus is reached

韓國産 미꾸리에 關한 育種·繁殖學的 硏究 : Ⅵ. Histological Changes of Pituitary Gland and Oocytes from March to May Ⅵ. 계절에 따른 암컷의 腦下垂體와 卵母細胞의 組織學的 變化

姜京來,盧淳昌,尹鍾萬,朴弘陽,李相鎬 건국대학교 동물자원연구센터 1993 動物資源硏究誌 Vol.18 No.-

1992년 3월부터 1992년 5월까지 자연적인 채광상태에서 溫度를 유지시킨 후 채취된 미꾸리 암컷의 腦下垂體, 肝 및 卵巢 組織의 번식주기에 일어나는 미세구조의 변화를 광학 및 투과형 전자현미경을 이용하여 살펴보고, 이것들의 相互 聯關性을 알기 위하여 본 연구를 실시하였다. 본 연구에서 얻어진 결과는 다음과 같다. 성숙된 개체의 뇌하수체는 수많은 작은 분비과립과 커다란 분비구 및 불규칙한 형태의 과립들이 관찰되었다. 핵소체가 핵막 주변에 위치헤 있는 후기 단계(LMO)의 난모세포가 난황이 축적되는 성숙초기 단계(EMO)의 난모세포로 변형되는 시기를 난황의 형성이 개시되는 시기로 본다. 난모세포가 성장함에 따라 핵소체의 크기와 난황과립의 수가 증가하게 된다. 난황과립은 결정상의 과립으로 난세포질에 치밀하지 않은 상태로 축적된다. 성숙초기(EMO) 및 말기단계(LMO)에 난소는 커지고 투명하며 과립형태로서 색깔이 연노란색을 나타낸다. 따라서 난 내부를 쉽게 관찰할 수 있다. 방사대(ZR)는 성숙초기단계(EMO)에 단층으로부터 입방형태로 변화된다. 과립막 세포와 난모세포로 부터 유래된 미세융모는 난황형성이 진행되는 동안에 성장하게 되며, 방사대의 pore canals의 구멍을 통해서 서로 연결되어 있다. 따라서 외부로부터 물질의 이동이 있게 된다. 난모세포가 완전하게 성숙되어 방사대가 단단해 지면 미세융모는 그 기능이 상실된다. This study was undertaken to understand the development stages of pituitary gland, liver and ovary of Korean loach(Misgurnus anguillicaudatus) under natural circumstances from March to May 1922. Expecially, the light microscopic and ultrastructural changes of ooplasm and follicular membranes of oocytes, were observed by light and transmission electron microscope during the reproductive cycle. In pituitary gland of mature individuals, there were observed a number of secretory granules,large globules, and irregular masses.The vitellogenic phase began as these late perinucleolus oocytes became transformed into early maturing oocytes through the accumulation of yolk. The size of the nucleoli and number of the yolk granules increased as the oocyte growed. Yolk granules were loosely deposited in the oocyte as crystalline granules. Due to the presence of early and late maturing oocytes, their ovaries were enlarged transparent, granular and yellowish in color. Zona radiata change a squamous into cuboid shape in EMO stage. Microvilli from the granulosa cells and from the oocyte grow and make contact with each other in the pore canals of the zona radiata during vitellogenesis, but are withdrawn as the zona radiata becomes more compact during oocyte maturation.

피치각 조정형 송풍-역풍 겸용 축류팬에서 배연용 피치각 선정을 위한 실험적 연구

장택순(Taek-Soon Chang),허진혁(Jin-Huek Hur),문승재(Seung-Jae Moon),이재헌(Jae-Heon Lee),유호선(Ho-Sun You),임윤철(Yun-Chul Im) 대한설비공학회 2008 대한설비공학회 학술발표대회논문집 Vol.2008 No.2

In this study, the experimental study has carried out to select pitch angle on the backward flow in an axial fan that has adjustable pitch blades. With the change of pitch angle of axial fan with adjustable blade, air flow rate, pressure and air flow direction can be changed. Because of this merit, adjustable axial fan can be used in the backward flow. For the selection of the backward flow pitch angle, fan performance test method is selected by KS B 6311. Dynamic pressure, static pressure, electric current and voltage are measured in each pitch angles of axial fan that are 36°, -16°, -21°, -26°, -31° and -36°. In the result of test, fan performance curves at several pitch angle has been investigated. Finally, pitch angle of -26° has been selected to get largest flow rate at backward flow situation.

Characterization of changes in global gene expression in the brain of neuron-specific enolase/human Tau23 transgenic mice in response to overexpression of Tau protein.

Woo, Jong-Min,Park, So Jung,Kang, Ho Il,Kim, Byoung Guk,Shim, Sun Bo,Jee, Seung Wan,Lee, Su Hae,Sin, Ji Soon,Bae, Chang Joon,Jang, Mee Kyung,Cho, Chunghee,Hwang, Dae Youn,Kim, Chuel Kyu D.A. Spandidos 2010 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.25 No.5

<P>Tau is a neuronal phosphoprotein responsible for the formation of the neurofibrillary tangles in Alzheimer's disease. To characterize the changes in global gene expression in the brain of transgenic mice that overexpress human Tau23 protein in response to the increase of Tau23 phosphorylation, total RNA extracted from the hippocampus of 12-month-old transgenic and wild-type mice was converted to cDNA, labeled with biotin and hybridized to oligonucleotide microarrays. The microarray results were confirmed by real-time RT-PCR and Western blotting method. It was determined that 43 genes were up-regulated and 8 genes were down-regulated by Tau23 in transgenic mice compared to controls, based on the arbitrary difference in the 2-fold change. Among the up-regulated transcripts, those encoding for transporter and oxidoreductase were dramatically over-represented, followed by those related to regulatory molecule, cytoskeletal protein, signaling molecule, and extracellular matrix protein. Genes encoding for transcription factor, regulatory molecule, miscellaneous function, and chaperone were significantly reduced in the down-regulated group. The major genes in the up-regulated categories included Ecrg4, Folr1, Defb11, Aqp1 and Soctdc1. The major genes in the down-regulated categories were Ncor1, Gpm6a, and Hspd1. These results indicate that the microarray analysis identifies several gene functional groups and individual genes that respond to a sustained increase in Tau23 phosphorylation levels in the brain of transgenic mice. In addition, the results suggest the microarray test is a useful tool for increased understanding of the role of Tau23 protein in regulating neurodegenerative disorders.</P>

Biomechanical analysis of lumbar decompression surgery in relation to degenerative changes in the lumbar spine – Validated finite element analysis

Li, Quan You,Kim, Ho-Joong,Son, Juhyun,Kang, Kyoung-Tak,Chang, Bong-Soon,Lee, Choon-Ki,Seok, Hyun Sik,Yeom, Jin S. Elsevier 2017 Computers in biology and medicine Vol.89 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>There are no studies about the biomechanical analysis of lumbar decompression surgery in relation to degenerative changes of the lumbar spine. Therefore, the purpose of this study was to compare, by using finite element (FE) analysis, the biomechanical changes of the lumbar spine in terms of annulus stress and nucleus pressure after two different kinds of lumbar decompression surgery in relation to disc degenerative changes.</P> <P><B>Methods</B></P> <P>The validated intact and degenerated FE models (L2-5) were used in this study. In these two models, two different decompression surgical scenarios at L3-4, including conventional laminectomy (ConLa) and the spinous process osteotomy (SpinO), were simulated. Therefore, a total of six models were simulated. Under preloading, 7.5 Nm moments of flexion, extension, lateral bending, and torsion were imposed. In each model, the maximal von Mises stress on the annulus fibrosus and nucleus pressure at the index segment (L3-4) and adjacent segments (L2-3 and L4-5) were analyzed.</P> <P><B>Results</B></P> <P>The ConLa model and disc degeneration model demonstrated a larger annulus stress at the decompression level (L3-4) under all four moments than were seen in the SpinO model and healthy disc model, respectively. Therefore, the ConLa model with moderate disc degeneration showed the highest annulus stress at the decompression level (L3-4). However, the percent change of annulus stress at L3-4 from the intact model to the matched decompression model was less in the moderate disc degeneration model than in the healthy disc model.</P> <P><B>Conclusions</B></P> <P>Although the ConLa model with moderate disc degeneration showed the highest annulus stress, the degenerative models would be less influenced by the decompression technique.</P>

기관내 삽관을 위한 Atracurium 의 적정량에 대한 임상적 고찰

이혜원,신정순,장성호,임혜자,김종욱,정형근 대한마취과학회 1990 Korean Journal of Anesthesiology Vol.23 No.6

The usefulness of a nondepolarizing muscle relaxant for endotracheal intubation is limited by its relatively slow onset of neuromuscular block compared to that achieved with succinylcholine. Several attempts have been made to produce a more rapid onset of muscle relaxation for endotracheal intubation. A large dose of nondepoarizing muscle relaxant may produce rapid onset but cauae undesirable side effects and a prolonged duration of neuromuscular block. The authors observed the degree of vocal cord relaxation and intubation condition 2 minutes after administration of atracurium and measured changes in mean arterial blood pressure and heart rate at the time of arrival in the operating room, just before abministration of atracurium, 2minutes after administration, and 5mins after intubation. The 40 of patients in this observation were divided into four groups. Group 1; 10patients, received 0.3 mg/kg of atracurium Group 2; 10patients, received 0.4 mg/kg of atracurium Group 3; 10patients, received 0.5 mg/kg of atracurium Group 4; 10patients, received 0.6 mg/kg of atracurium The results were as follows; 1) There were better intubating conditions in Group 3 and 4 than in Group 1 and 2(p$lt;0.001). 2) Mean arterial blood pressure and heart rate did not change significantly after administration of atracurium in all four groups. From the above results we conclude that 0.5~0.6 mg/kg of atracurium provides satisfactory intubation condition 2 minutes after administration without hemodynamic changes.

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

기후변화 시나리오에 따른 지역별 확률강우량

김영호,여창건,서근순,송재우,Kim. Young-Ho,Yeo. Chang-Geon,Seo. Geun-Soon,Song. Jai-Woo 한국방재학회 2011 한국방재학회논문집 Vol.11 No.3

본 연구는 A1B 기후변화 시나리오를 고려하여 지역별 확률강우량을 산정하고 관측소별 기존 관측자료의 특성을 고려한 적정 방법을 제안하였다. 이를 위하여 우리나라 주요 지점 강우관측소를 연구 대상지점으로 선정하여 선정된 주요 지점 관측소에 대해 24시간 연최대강우량 평균값과 매개변수의 관계를 분석하여 2100년의 빈도별 확률강우량을 산정하였다. 2100년 빈도별 확률강우량은 기상청 실측강우량 자료를 활용하여 산정하는 방법, 확률분포의 매개변수는 실측 강우자료를 활용하고, 2100년까지의 강우자료는 A1B 시나리오를 활용하는 방법, A1B 시나리오를 활용하여 확률강우량을 산정하는 3가지 방법을 적용하였다. A1B 시나리오에 의한 강우 예측값은 실측값 보다 과소 추정되어 이를 활용하는 경우에는 보정이 필요하며, 분위 사상법을 적용하여 보정한 결과 모든 관측소에서 약 2.3~3.0배의 강우량이 평균적으로 상향조정 되었다. 실측강우 자료만으로 산정한 확률 강우량의 경우, 강우량이 지속적으로 증가하여 과대 산정되어 증가하는 경향이 강하며, A1B 시나리오 자료를 활용하여 산정한 확률강우량의 경우 대체적으로 기존 관측자료의 증감율과 유사하게 산정되기는 하지만 지역적 특성을 정확히 반영하지 못하는 경우가 다소 발생하였다. 각 지점별로 24시간 연 최대 강우량 평균 증가율과 방법별로 산정된 확률강우량의 증가율을 비교하여 기후변화를 고려한 관측지점별 확률강우량 산정 방법을 선정하였다. This research proposes the suitable method for estimating the future probable rainfall based in 2100 on the observed rainfall data from main climate observation stations in Korea and the rainfall data from the A1B climate change scenario in the Korea Meteorological Administration. For all those, the frequency probable rainfall in 2100 was estimated by the relationship between average values of 24-hours annual maximum rainfalls and related parameters. Three methods to estimate it were introduced; First one is the regressive analysis method by parameters of probable distribution estimated by observed rainfall data. In the second method, parameters of probable distribution were estimated with the observed rainfall data. Also the rainfall data till 2100 were estimated by the A1B scenario of the Korea Meteorological Administration. Last method was that parameters of probable distribution and probable rainfall were estimated by the A1B scenario of the Korea Meteorological Administration. The estimated probable rainfall by the A1B scenario was smaller than the observed rainfall data, so it is required that the estimated probable rainfall was calibrated by the quantile mapping method. After that calibration, estimated probable rainfall data was averagely became approximate 2.3 to 3.0 times. When future probable rainfall was the estimated by only observed rainfall, estimated probable rainfall was overestimated. When future probable rainfall was estimated by the A1B scenario, although it was estimated by similar pattern with observed rainfall data, it frequently does not consider the regional characteristics. Comparing with average increased rate of 24-hours annual maximum rainfall and increased rate of probable rainfall estimated by three methods, optimal method of estimated future probable rainfall would be selected for considering climate change.