흰쥐의 위산 분비 및 실험적 괴양에 미치는 향정신성물질의 영향

白尙昌 大韓神經精神醫學會 1974 신경정신의학 Vol.13 No.1

Introduction of psychotropic agents to the field of psychiatry brought tremendous change and new implication in the therapeutic aspect as well as the concept of psychosomatic medicine. Reserpine was introduced by Sen & Bose(1931), and Vakil(1949) and Hakim(1953) has proved it to release biogenic amine (serotonin, norepinephrine, epinephrine, dopamin) at brain cell and peripheral tissues. Chlorpromazine was proved to have tranquilizing effect by Laborit et al(1952), and tremendons therapeutic effect to treat the psychiatric patient was shown by Delay (1952 a&b) and Courvoisier(1653). Jn 1961, Gey and Pletscher, and Axelrod found that chlorpromazine reduced the permeability of granular membrane, where the biogenic amine was stored. Haloperidol, a derivative of butyrophenone was synthesized by Janssen(1958). In 1966 Glowinski and Axelrod and in 1967 Janssen and Schildkraut et.al. reported that haloperidol reduced the shift of catecholamine from neuron and granular membrane. Meprobamate, one of the minor tranquilizers, has been used widely as an antianxiety agent and antiulcer agent as well. But recently it seemed that the derivatives of benzodiazepine replaced meprobamate as antianxiety and antiulcer agent. In 1952, Delay reported the iproniazid showed anti-depressive effect and Zeller explained that iproniazid had M.A.O. inhibitory action (1952). In 1958, Kuhn reported imipramine, which has similar chemical structure of phenothiazine, showed M.A.O. inhibitory action and antidepressive action. Until recently many psychotropic agents has been introduced and used widely in the field of psychiatry. Author tried to find the influence of various psychotropic agents on gastric secretion and experimentally-induced peptic ulcer in rat. White male rat, average 180g of body weight was used as experimental animal. Experiment on gastric secretion was carried out with the method of Shay(1945), With the centrifuged gastric secretory material, the P.H. was measured by Radiometer, Titrator TTT₂(Copenhagen), and gastric secretion amount was measured by Autoburett, ABU11 (Radiometer). Experiment of artificial gastric ulcer was carried out through the stress givent by ① pyloric ligation ② shaking ③ restraint with upside down position. Pathological change on the mucous membrane of rat stomach including hemorrhage, erosion and perforation etc. was observed by Stereoscope. Result (1) Diazepam inhibited gastric secretion (especially gastric acid) and lowered the acidity. Yet meprobamate on the contrary, raised gastric secretion and acidity, which might possibly be due to its peripheral effect. (2) Chlorpromazine markedly depressed the gastric secretion. But Prochlorperazine, Haloperidol, and Reserpine did not show any significant change on gastric secretion, which might be due to their limited dosage to influence on gastric secretion. (3) Tranylcypromine, and M.A.O. inhibitor, markedly reduced gastric secretion and gastric acidity. The Imipramine, tricyclic antidepressant with similar chemical structure of chlorpromazine, lowered the free acid of stomach in rat. (4) The stress of pyloric ligation showed ulcerative change on rumen of stomach. Diazepam and Chlorpromazine premedicated rat did not reveal much change. But Tranylcypromine premedicated rat showed severe degree of ulcer change on all experimented rats and two of them were dead of perforation of stomach, which seemed to be the result of stomach, which seemed to be the result of stomach, which seemed to be the result of peripheral effect or decreased mucus of gastric secretion as an effect of relax action. (5) The stress of shaking the rat brought erosion and edematous change on rumen but no ulcerative change took place. Diazepam premedicated group has not showed change on mucous membrane. Chlorpromazine premedicated group showed mild degree of change. But Reserpine treated group showed marked degree of ulcer change on the rumen and 4 of this group died of gastric perforation. (6) The stress of restraint of rat with upside down position revealed marked degree of erosion and hemorrhage on glandular portion, but no change on rumen. But Diazepam, Chlorpromazine and Imipramine premedicated group of rats showed lesser degree above changes. As shown above, varions psychotropic agents influenced on gastric secretion and experimentally induced gastric ulcer in rats. It might be explained that most of the psychotropic agents could influence on biogenic amine metabolism of brain and on regulating anxiety, which prevent hypersecretion of stomach. But as a few of the exception for instance. Tranylcypromine and Reserpine brought severe degree of ulcer change, which might possible be due to the peripheral effect. Above two psychotropic agents are to be alarmed to use to the patient with peptic ulcer.

금연실천단계의 영향변인에 대한 연구

장성옥,박창승 고려대학교 2001 간호학논집 Vol.3 No.-

Changes of Landscape Structure for the Recent 20 Years in the Wangsuk Stream Basin of the Central Korea

Lee, Chang-Seok,Cho, Yong-Chan,Shin, Hyun-Chul,Lee, Seon-Mi The Ecological Society of Korea 2006 Journal of Ecology and Environment Vol.29 No.4

Landscape changes for 20 years between 1981 and 2001 in the Wangsuk stream basin located on the central Korea were investigated on the basis of physiognomic vegetation map made from the aerial photograph interpretation and field check. Changes of landscape structure were noticeable in agricultural field and forest landscape elements. Changes in the agricultural fields due to transformation of agricultural pattern into the institutional agriculture dominated landscape change, although urbanization also contributed to such change. The former change due to change of food production structure originated from socio-economic development during this period and the latter to the overpopulation of Seoul. As energy sources for heating and cooking, fertilizer, and fodder for livestock transform from plant materials to fossil fuel, manufactured one, and grain, succession of forest escaped from direct human disturbance dominated change of landscape structure in forested land. Differently from the positive landscape change in the upper area, change in the lower area deteriorated landscape quality by increasing artificial land. It was estimated that such landscape deterioration in the Wangsuk stream basin would influence water quality of the stream. In order to realize sustainable land-use against such environmental degradation, systematic environmental management based on landscape ecological perspective such as "an eco-plan for creating riparian vegetation belt," which is under preparation by Ministry of Environment, was recommended.

대표농도경로 (RCP) 시나리오에 따른 회야강 유역의 미래 유출 및 유사 변화 분석

황창수(Hwang, Chang Su),최철웅(Choi, Chul Uong),최지선(Choi, Ji Sun) 대한공간정보학회 2014 대한공간정보학회지 Vol.22 No.3

본 연구는 미래 기후변화 및 토지피복변화가 유역 내 유출량과 유사량의 거동에 가져올 영향을 분석하는데 목적이 있다. 기상자료는 IPCC 5차 평가보고서를 위해 새롭게 논의된 RCP 시나리오 중 서로 상반되는 4.5 및 8.5 시나리오의 기후전망 (2011~2100년) 이 사용되었으며, 토지피복지도는 RCP 4.5 및 8.5 시나리오의 사회ㆍ경제 스토리라인과 로지스틱 회귀모형 (LR)을 이용하여 개발 된 모델에 의해 구축되었다. 기후변화만 고려한 경우, 토지피복변화만 고려한 경우, 기후변화 및 토지피복변화 모두 고려한 경우의 세 가지 시나리오를 설정하고, 각 시나리오에 따른 유출량 및 유사량을 모의한 결과 계절적으로 매우 명확한 변화를 나타내었다. 기후변화는 봄과 겨울에 유출량을 증가시키고 여름과 가을에 유출량을 감소시키는 것으로 나타났으며, 유사량 역시 유출량과 동일한 변화의 양상을 보였다. 토지피복변화는 유출량을 증가시키는 반면 유사량은 감소시키며, 이는 도시화로 인한 불투수 면적의 증가에 의한 것으로 판단된다. 토지피복변화는 기후변화에 비해 유출량에 적은 영향을 끼치나, 기후변화에 의해 초래된 유출량 문제를 더욱 극대화 시킬 수 있다. 따라서 지속적인 수자원 관리를 위하여 기후변화의 잠재적 영향을 파악하고, 토지피복변화에 따른 적절한 수자원 대응 정책 마련이 필요할 것으로 판단된다. This study is analyze future climate and land cover change affects behaviors for amount of streamflow and sediment discharge within basin. We used the climate forecast data in RCP 4.5 and 8.5 (2011-2100) which is opposite view for each other among RCP scenarios that are discussed for 5th report for IPCC. Land cover map built based on a socialㆍeconomic storyline in RCP 4.5/8.5 using Logistic Regression model. In this study we set three scenarios: one scenario for climate change only, one for land cover change only, one for Last both climate change and land cover change. It simulated amount of streamflow and sediment discharge and the result showed a very definite change in the seasonal variation both of them. For climate change, spring and winter increased the amount of streamflow while summer and fall decreased them. Sediment showed the same pattern of change steamflow. Land cover change increases the amount of streamflow while it decreases the amount of sediment discharge, which is believed to be caused by increase of impervious Surface due to urbanization. Although land cover change less affects the amount of streamflow than climate change, it may maximize problems related to the amount of streamflow caused by climate change. Therefore, it"s required to address potential influence from climate change for effective water resource management and prepare suitable measurement for water resource.

사회변화에 따른 유니버설디자인 적용 방향성

장혜진 ( Hae Jin Chang ) 한국디자인트렌드학회 2020 한국디자인포럼 Vol.25 No.1

연구배경 효과적인 유니버설디자인 관련 정책수립과 적용을 위해서는 우리의 삶에 영향을 끼치는 사회변화의 양상에 대한 진단이 선행되어야 한다. 이에, 본 연구는 사회변화에 따라 변모하게 될 유니버설디자인 관련 이슈들을 예측하고, 현재 국내 유니버설디자인 관련 현황을 진단한 후 사회변화의 양상에 적합한 유니버설디자인 적용 방향성을 제안하는 것을 그 목표로 한다. 연구방법 본 연구에서는 향후 우리 사회에 미치는 영향이 큰 주요한 사회변화를 선정하고 이에 따라 변모하게 될 유니버설디자인 관련 이슈를 예측하였다. 유니버설디자인 관련 연구논문, 정책보고서, 문헌, 법령 등을 통해 선행연구와 정책 동향을 분석하여 현재 국내 유니버설 디자인 관련 법률, 조례, 가이드라인 등을 중심으로 국내 유니버설디자인 적용 현황을 파악하였다. 이를 바탕으로 사회변화를 고려한 유니버설디자인 적용 방향성을 제안했다. 연구결과 유니버설디자인의 적용 방향성을 도출하기 위해 고려해야 할 주요한 사회변화로 초고령화 사회 진입, 사회통합 추구, 지속 가능한 발전 추구, 신기술 출현 및 산업 다변화 등을 들 수 있다. 현재 국내 유니버설디자인 관련 법률, 조례, 가이드라인을 사회변화 양상에 비추어 점검한 결과, 향후 우리 사회가 추구해야 할 유니버설디자인의 적용 방향성을 크게 다음과 같은 네 가지로 도출하였다. 사회 구성원 간 공존의 가치 추구, 지속 가능성의 추구, 공공영역에서 민간영역으로의 확장, 유니버설디자인 적용 영역 다양화가 그것이다. 결론 본 연구의 연구결과는 미래 사회변화에 대응한 유니버설디자인 정책수립 및 디자인 분야의 유니버설디자인 연구개발을 위한 기초 자료로 활용될 수 있을 것이다. Background For the effective establishment of policies and application related to universal design, the comprehensive study on the aspect of social changes that influences on human lives must be performed in priority. Therefore, this study purposes to predict universal design-related issues that will change according to social change, evaluate the current status of universal design in Korea, and suggest the application direction of universal design considering the social change. Methods This study selected major social changes that have a significant impact on our society in the future, and predicts universal design-related issues that would be transformed by the social changes. Through the research papers, policy reports, literature, and laws related to universal design, previous studies and policy trends were analyzed to identify the current status of universal design in Korea, focusing on current laws, ordinances, and guidelines related to universal design. Based on such, the application direction of universal design considering the social changes was suggested. Result The major social changes to be considered in deriving the direction of universal design include the entry into an aging society, the pursuit of social integration, the pursuit of sustainable development, the emergence of new technologies and the diversification of industries. As a result of inspecting the laws, ordinances and guidelines regarding the current domestic universal design, the application direction of universal design which our society should pursue in the future are derived into four directions; pursuance of coexistence value between social members, pursuance of sustainability, expansion from public areas to private areas, and diversification of universal design application areas. Conclusion The results of this study could be used as the foundation materials for the establishment of universal design policies and research and development of universal design in design areas corresponding to the future social changes.

What are the Characteristics and Qualities of Secondary Physical Education Teachers that Contribute to the Positive Changes in Students` Character?

( Eui Chang Choi ),( Soon Jung Choi ) 한국체육학회 2015 국제스포츠과학 학술대회 Vol.2015 No.1

Purpose: The purpose of this study was to examine what characteristics and qualities of a teacher bring out positive changes in students. In order to this, researcher investigated positive changes of students and PE teacher`s characteristics and qualities that promote students` changes. Method: This study used qualitative complex case study. Participants were 5 PE teachers who participate in community focusing on students` character development, and their 10 students. Non-participant observation and in-depth interview were used. In addition, open questionnaire was administered with 200 students. Collected data were analyzed using inductive thematic analysis. Triangulation, member checks, and peer debriefing were conducted to enhance the trustworthiness of this study. Result: First, character of students have changed in various way. Students internalized 4 virtues of In, Eui, Ye, Gi categorized as most comprehensive range. They made an effort to become those who are filled with love(In), justice(Eui), courtesy(Ye), wisdom(Gi). Second, positive change effects are not based on single dimension but it depends on overall dimensions such as health, wisdom, emotion, morality, and spirituality. Health as qualities of PE teacher is concerned with achieving excellence in sport performance and keeping in good shape. Wisdom is concerned with having knowledge about the methods of PE class and preparing, being well-informed of character education and applying it to PE class, and noticing and managing students` changes in character. Emotion is associated with believing relationship with student important and being contented with students` enjoyment. Morality is concerned with trying to become a whole person a good model. Spirituality is associated with cherishing PE, students, themselves, and god, and pursuing students` development to become a whole person. These characteristics and qualities of PE teachers influenced to students on the whole process such as preparation, execution, and reflection of PE classes. It showed a stronger influence on the students` character changes when PE teachers exert to reflect and compliment themselves. Conclusion: Character development in students is not based on teacher`s content knowledge and instructional techniques. Character of students can be positive only when PE teachers` wholeness involved on the whole. It should reflect to in-service education for PE teachers about students` character. Furthermore we must research more in depth about what types of qualities of teachers give students` change in some types of pathways.

텍스트마이닝을 활용한 우리나라 기후변화 리스크 평가 및 적응 대책 논의

강영은(Kang, Youngeun),신지영(Shin, Jiyoung),박창석(Park, Chang Sug) 한국도시설계학회 2016 도시설계 : 한국도시설계학회지 Vol.17 No.2

기후변화 연구는 광범위한 영향 범위와 불확실성 때문에, 장기적인 관점에서 기후변화 리스크를 평가하고 예측하여 효율적으로 대비하는 것이 필수적이다. 본 연구는 텍스트마이닝 기법을 활용하여 1990년대 이후 기후변화 영향 관련 신문기사 4,150건에 대해 연관되는 기후변화 리스크 항목을 매칭하고, 리스크 항목별 매칭 빈도 및 피해 크기(피해액)를 분석하였다. 연구 결과, 주요 리스크 항목들의 기후 동인들은 태풍/호우에 의한 영향이 많았으며, 피해 유형에서는 인명 피해, 인프라 시설 파괴 및 훼손, 농경지 피해 등의 비중이 높은 것으로 나타났다. 기 수행된 리스크 평가의 주요 리스크 항목과 비교에서는 42.4%의 중복 비율이 도출되었으며, 중복되지 않은 항목분석 결과, 본 연구의 결과가 직접적인 피해(1차적인 리스크)에 보다 집중되고 있는 경향을 파악할 수 있었다. 본 연구에서는 기존 연구에서 한계점으로 제기되었던 리스크의 ‘발생가능성’과 ‘결과의 크기’ 의 과학적 증거 부족을 보완했다는 측면에서 충분한 의의가 있다. 향후 기후변화 적응 대책 반영을 위한 바람직한 리스크 평가를 위해서는 본 연구에서 도출한 내용과 전문가 평가결과가 절충되어 리스크 평가의 신뢰성과 타당성을 동시에 확보할 수 있어야 할 것이다. Climate change adaptation plans and related studies have played a major role in reducing the risks of climate change. The studies, associated with climate change in particular, assess and predict the long run influence of climate change risk on society, the economy, and the environment in the long run, due to its extensive impact and uncertainty. This study evaluates the consequences and probability of climate change risk based on 4,150 newspapers articles after the 1990s related to climate change impact through text-mining. This study revealed that the climate drivers causing high recorded climate change risks include typhoons, heavy rains, and others. In addition, risk consequence categories were focused on casualties, damages to infrastructure and agricultural land. The percentage of risk overlapping between this study and the previous studies was 42.4%. The risks, that did not overlap, illustrate that this study has a tendency to focus on direct rather than indirect risks like social group vulnerability, social disparities, and so on. This study’s originality is illustrated through its supplementary concrete evidence for climate change risk assessment. From this step forward, climate change adaptation plans have to reflect not only the result of observed climate change risks like those identified in this study but also experts’ survey based risk for minimizing uncertainty.

입원환자 낙상예방 프로그램에서 근력운동의 효과: 낙상 고위험군 노인환자를 중심으로

이현옥 ( Hyun-ok Lee ),이병화 ( Byung-hwa Lee ),이창희 ( Chang-hee Lee ) 한국보건정보통계학회(구 한국보건통계학회) 2017 보건정보통계학회지 Vol.42 No.4

Objectives: The purpose of this study is to analyze the changes in the indices of body muscle strength, the indices of muscle strength associated with physical balance, and index of the pain relief between the intervention group who performed the muscle strength exercise and control group who not performed the muscle strength exercise. The study period was from September 7, 2016 to May 12, 2017, and it was conducted after receiving Institutional Review Board approval. Methods: Among 40 participants who were recruited in this study, the final analysis subjects were a total of 39 people, excluding the one people who dropped out during the 2-week. For analysis, the changes were compared with baseline and after two weeks by comparing three types of body muscle strength indices, four types of physical balance indices, and one type of pain relief index. Finally, we analyzed whether there is a difference between the groups in the each changes. Results: In the body muscle strength index change analysis, the change of muscle mass relative to weight was not statistically significant, but the difference between the groups regard to change was statistically significant (p<0.05). The lower body strength and the bone mineral were statistically significant in both the intervention and control group, but the difference between the groups regard to change was not statistically significant. In the index of muscle strength associated with physical balance change analysis, the intervention group showed improvement much higher in the right arm, left arm, right leg, and left leg of muscle mass than the control group. Also, the muscle mass of the right arm and the left arm was statistically significant in the analysis of the difference between the groups regard to change (p<0.05). Analysis of changes in pain relief index showed that the intervention group showed significantly improvement higher than the control group, and the difference between the groups regard to change was statistically significant (p<0.05). Conclusions: In the elderly patients in the hospital where the fall prevention program was provided, it was concluded that the intervention group higher improved the muscle strength associated with physical balance and the pain relief compared with the control group.

干支와 遅氣에 關한 硏究

尹暢烈,朴賛国 慶熙大學校韓醫科大學韓醫學硏究所 1987 慶熙韓醫大論文集 Vol.10 No.-

Brain Topological Correlates of Motor Performance Changes After Repetitive Transcranial Magnetic Stimulation

Park, Chang-hyun,Chang, Won Hyuk,Yoo, Woo-Kyoung,Shin, Yong-Il,Kim, Sung Tae,Kim, Yun-Hee Mary Ann Liebert 2014 Brain connectivity Vol.4 No.4

<P>Repetitive transcranial magnetic stimulation (rTMS) influences the brain temporally beyond the stimulation period and spatially beyond the stimulation site. Application of rTMS over the primary motor cortex (M1) has been shown to lead to plastic changes in interregional connectivity over the motor system as well as alterations in motor performance. With a sequential combination of rTMS over the M1 and functional magnetic resonance imaging (fMRI), we sought changes in the topology of brain networks and specifically the association of brain topological changes with motor performance changes. In a sham-controlled parallel group experimental design, real or sham rTMS was administered to each of the 15 healthy subjects without prior motor-related dysfunctions, over the right M1 at a high frequency of 10 Hz. Before and after the intervention, fMRI data were acquired during a sequential finger motor task using the left, nondominant hand. Changes in the topology of brain networks were assessed in terms of global and local efficiency, which measures the efficiency in transporting information at global and local scales, respectively, provided by graph-theoretical analysis. Greater motor performance changes toward improvements after real rTMS were shown in individuals who exhibited more increases in global efficiency and more decreases in local efficiency. The enhancement of motor performance after rTMS is supposed to be associated with brain topological changes, such that global information exchange is facilitated, while local information exchange is restricted.</P>