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운동 프로그램이 유방암 환자의 자연살해세포 활성에 미치는 효과
채영란,최명애,김미정 대한기초간호자연과학회 2002 Journal of korean biological nursing science Vol.4 No.2
The purpose of this study was to determine the effect of exercise program on natural killer cell cytotoxic activity(NKCA) in breast cancer patients who had been radiation therapy after surgery. The subjects in the experimental group consisted of 11 breast cancer patients, while the subjects in the control group consisted of 15. Subjects in the experimental group participated in exercise program for 8 weeks. Exercise program consisted of shoulder stretching, arm weight training and treadmill walking exercise. They started to exercise on treadmill for 20 minutes per day, 3 times a week 40% of maximum heart rate, and increased intensity and duration of exercise so that they were running 30 minutes/day at 60% of maximum heart rate from the 3rd week to the 8th week. Natural killer cell cytotoxic activity were determined before and after tht: exercise program. For measuring the natural killer cell cytotoxic activity, 8ml to 10ml blood was collected from the subjects. Mononuclear cell was isolated by centrifuge of the blood and cultured by putting Cr^(51) , and reacted with target cell, K562 cell. Baseline demographic and medical data were compared between groups with the Fisher's exact test and Mann-Whitney U test. For effects of the exercise program, repeated measures ANOVA was used. The result was as follows ; Natural killer cell cytotoxic activity(NKCA) in experimental group comparing with control group significantly increased after the exercise program in case of effector cell : target cell ratio is 100 : 1(p<0.05). The above result suggest that the exercise program for breast cancer patients undergoing radiation therapy after breast surgery may increase the natural killer cell cytotoxic activity.
채영란,김금순,최명애,안경애,김명애,서순림,홍해숙,정재심,박금화,이성희 대한기초간호자연과학회 2002 Journal of korean biological nursing science Vol.4 No.2
This study was aimed to analyze the variables measuring stress and imnnune responses, to identify the relationship between stress and imnnune responses, and to find out the effect of nursing interventions associated with stress and immune responses by reviewing thirty-four published articles since 1970 in Korea. The articles were selected in the field of nursing, stress management, and masters or doctoral dissertations and limited to human subject. Among these, the thirty-one articles were published since 1996 and mainly distributed in nursing(44.1%) and medicine(44.1%). The prevailing research design was nonequivalent control pre-post experimental design (41.1%). The research subjects were 55.9% for patients and 44.1% for healthy general persons including 20.6% of university students. To evaluate stress, both physiologic and psychosocial measures were adapted together in 35.3% of the articles. The most frequent two variables measuring stress and immune response were cortisol leve1(15.9%) and number or activity of natural killer ce11(25.9%). The relation between stress and immune responses was positive in 4 articles, negative in 9 cases, and none in 12 cases. Decreased stress and enhanced immune function have been found when massage, abdominal breathing, exercise, relaxation, and touch were provided as nursing interventions. The articles to investigate the relationship between stress and immune function were limited and the tested variables were diverse. Also there was no consistent evidence to correlate the stress and immune function at present. Further studies are needed to construct a valid research design and to investigate the relationship between stress and immune responses. Nursing interventions to decrease stress should be developed to result in the increased immune function and the effect of these interventions would be verified.
국내 유방암 환자의 삶의 질 측정 도구 개발에 관한 연구
채영란,최명애 성인간호학회 2001 성인간호학회지 Vol.13 No.3
The purpose of this study was to develop a Quality of Life(QOL) scale for breast cancer patients in Korea and to test the validity and reliability of the instrument. To achieve the purpose of the study, a questionnaire was developed to interview 10 breast cancer patients and distributed to 155 patients with breast cancer in Korea. For data analysis. SPSS WIN 8.0/PC were used. Item analysis and factor analysis were carried out to test validity of the QOL scale. Cronbach's α and Guttman split half coefficient were used to test reliability of the scale The results were as follows ; As a result of the item analysis, 27 items were selected from the total of 34 items. 6 factors were selected by factor analysis. Six factors were labeled as 'response to cancer diagnosis and treatment', 'family well-being', 'physical concerns', 'psychological well-being', 'spiritual well-being', and 'economic concerns'. Six factors were explained by 72.236% out of the total variance. The first factor explained 20.738% and the second factor explained 16.593%. which were major factors for Korean breast cancer patients. Chronbach's α coefficient of the tool was .9120. and Guttman split-half coefficient was .8148. The scale was identified to be a tool with a high degree of reliability and validity. Therefore, this scale can be effectively utilized for assessment of Quality of Life of patients with breast cancer in Korea.
Chae Hun Ra(라채훈),Ki Myong Kim(김기명),Pil Woo Hoe(허필우),Mi Ran Choi(최미란),Sung-Koo Kim(김성구) 한국생명과학회 2008 생명과학회지 Vol.18 No.2
본 연구는 플라스크 배양을 통해 B. indica L3 균주를 가지고 PS-7을 생산할 수 있는 최적 조건을 조사하기 위해서 수행하였다. RSM을 통한 배지의 최적화 실험에서는 whey lactose, glucose, ammonium nitrate 세 가지의 독립변수의 조성에 따라 배양 72시간에 해당하는 DCW, PS-7, 그리고 점도의 변화에 대한 결과를 관찰하였다. 결정 계수(R square)의 값은 PS-7생산량, DCW, 점성에서 각각 0.72, 0.64, 0.85로 신뢰성 있는 값을 획득하였다. Whey lactose와 glucose의 조합에 따른 PS-7 생산에 미치는 효과를 살펴보면 whey lactose (2%), glucose (1%)에서 최적의 PS-7 생산을 나타내었다. 결론적으로 glucose에 whey lactose를 기반으로 하는 배지 첨가와 C/N 비율이 PS-7의 생산에 큰 영향을 미침을 알 수 있었다. The production of heteropolysaccharide-7 (PS-7) by Beijerinckia indica (B. indica L3) was evaluated in shaker flask culture. The medium optimization was studied using response surface methodology (RSM). A five-level three-factor central composite design was employed to determine the maximum PS-7 yield at optimum levels for whey lactose, glucose and ammonium nitrate contents. The validity of the model could be determined by the regression coefficient, R². The values of R² were 0.72, 0.64 and 0.85 in PS-7, DCW and viscosity, respectively. The optimal medium combinations of whey lactose, glucose and ammonium nitrate concentrations on the PS-7 production were whey lactose (2%), glucose (1%) and ammonium nitrate 5 mM, respectively. The result indicated that PS-7 production was affected significantly by the addition of glucose to whey lactose based on medium and C/N ratio.
Chae-Wong Lim,Seajin Han,Bumseok Kim,Umanets Alexander,Young-Ran Lee,박태건,박겸준,Doo Nam Kim,손호선,Du- Hae An,Hyeon-CheolKIM,Cheolho Sim,SI-Yun Ryu,Bae-Keun PARK 한국임상수의학회 2016 한국임상수의학회지 Vol.33 No.3
The trematodes of Genus Nasitrema are the most common infection in the heads of small odontocetes. Five species of Nasitrema have been described in Asia. But those parasites has been not surveyed in the East Sea of Korean peninsula. There are no evidence of pathology associated with Nasitrema attenuate. To determine the infection ratio of N. attenuata in the dolphin, it was surveyed 9 long-beaked common dolphin, Delphinus capensis, caught incidentally from Samcheok to Pohang, East Sea, Korea. Five males and four females, estimated to be between 1 to 10 years old, were examined. The quantity of N. attenuata harvested by aspiration from pterygoid sinuses ranged from 10 to 100 with a 100% (9/9) infection with older dolphins exhibiting higher parasite counts. The body of trematoda was elongated with tegumental patches resembling the leaves of lilies and oral sucker located ventrally at the anterior terminal. Esophagus was absent and intestinal bifurcation arose immediately from the posterior of pharynx. The undulated intestinal caeca transversed the entire body and terminated at the posterior extremity of the worm. The genital pore opened anterior to the ventral sucker. This report confirms the prevalence and morphology of N. attenuata in the dolphins from the East Sea, Korea.