Importance of the Cell Block Technique in Diagnosing Patients with Non-Small Cell Carcinoma Accompanied by Pleural Effusion

Ugurluoglu, Ceyhan,Kurtipek, Ercan,Unlu, Yasar,Esme, Hidir,Duzgun, Nuri Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7

Background: Cytological examination of pleural effusions is very important in the diagnosis of malignant lesions. Thoracentesis is the first investigation to be performed in a patient with pleural effusion. In this study, we aimed to compare traditional with cell block methods for diagnosis of lung disease accompanied by pleural effusion. Materials and Methods: A total of 194 patients with exudative pleural effusions were included. Ten mililiters of fresh pleural fluid were obtained by thoracentesis from all patients in the initial evaluation. The samples gathered were divided to two equal parts, one for conventional cytological analysis and the other for analysis with the cell block technique. In cytology, using conventional diagnostic criteria cases were divided into 3 categories, benign, malignant and undetermined. The cell block sections were evaluated for the presence of single tumor cells, papillary or acinar patterns and staining with mucicarmine. In the cell block examination, in cases with sufficient cell counts histopathological diagnosis was performed. Results: Of the total undergoing conventional cytological analyses, 154 (79.4%)were reported as benign, 33 (17%) as malignant and 7 (3.6%) as suspicious of malignancy. With the cell block method the results were 147 (75.8%) benign, 12 (6.2%) metastatic, 4 (2.1%) squamous cell carcinoma, 18 (9.3%) adenocarcinoma, 5 (2.6%) large cell carcinoma, 2 (1%) mesothelioma, 3 (1.5%) small cell carcinoma, and 3 (1.5%) lymphoma. Conclusions: Our study confirmed that the cell block method increases the diagnostic yield with exudative pleural effusions accompanying lung cancer.

Does the Use of Rocuronium-Sugammadex Instead of Succinylcholine in Electroconvulsive Therapy Affect Seizure Duration?

Oflezer Ceyhan,Atay Özge,Kaşdoğan Zümrüt Ela,Özakay Gülay,İpekçioğlu Derya,Bahadır Hakan 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.10

Objective We compared retrospectively the seizure variables of electroconvulsive therapy (ECT) patients after administration of rocuronium-sugammadex or succinylcholine as a muscle relaxant with propofol anesthesia.Methods The sample comprised 134 ECT patients. The mean age was 33.6±10.48 years. Anesthesia induction was provided with propofol one mg kg-intravenously (IV) followed by succinylcholine 0.5 mg kg^-1 IV (n=68) (Group S) or rocuronium 0.3 mg kg^-1 IV (n=66) (Group R). For patients who were given rocuronium, reversal of the residual neuromuscular block was accomplished with sugammadex (1.5 mg kg^-1 IV). First session seizure variables were compared between the two groups. We also presented the clinical outcome with Clinical Global Impression-Improvement (CGI-I) and overall adverse effects.Results EEG seizure durations in Group R (55.09±36.11 s) and Group S (47.00±26.33 s) were comparable and were not significantly different (p=0.432). The clinical efficacy of ECT measured by CGI-I in both groups was comparable (p=0.075). There were no major complications or death during or after ECT.Conclusion The results of this study show that the use of rocuronium-sugammadex as a neuromuscular blocker instead of succinylcholine during ECT with propofol anesthesia produces similar results in terms of seizure variables and clinical outcomes.

Practice of Acute and Maintenance Electroconvulsive Therapy in the Psychiatric Clinic of a University Hospital from Turkey: between 2007 and 2013

Melike Ceyhan Balci Sengul,Ays¸e Nur I·nci Kenar,Ezgi Hanci,İbrahim Sendur,Cem Sengul,Hasan Herken 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.1

Objective: Electroconvulsive therapy (ECT) can be given as the form of acute, continuation or maintenance ECT according to the process of administration. We report our 7 years’ observation with acute and maintenance ECT in a university hospital in Turkey. Methods: The medical records of the hospitalized patients treated with acute or maintenance ECT between the years 2007 and 2013 was retrospectively analyzed. The sociodemographic characteristics, diagnosis, data of ECT and the co-administered psychotropic drugs were recorded. The frequency of ECT was calculated by identifying the total number of the hospitalized patients during the study period from the hospital records. Results: A total number of 1,432 female and 1,141 male patients hospitalized in a period of 7 years, with a total number of 111 patients treated with ECT. The ratio of ECT was 4%, maintenance/acute ECT 11%. For acute ECT, affective disorders (65.3%) and psychotic disorders (21.6%) were among the leading diagnoses. Maintenance ECT, the diagnosis was; 6 affective disorders, 4 psychotic disorders and 1 obsessive compulsive disorder. There was a significant difference between the patients receiving acute and maintenance ECT in terms of age, duration of illness, and number of previous hospitalizations and ECTs. Conclusion: The percentage of patients treated with acute ECT is lower in our institution than that in many other institutions from our country. Acute and maintenance ECT should be considered as an important treatment option particularly for patients with long disease duration, a high number of hospitalizations and a history of benefiting from previous ECTs.

Lane by Lane Analysis of Vehicle Time Headways - Case Study of Izmir Ring Roads in Turkey

Ozlem Ceyhan Yigiter,Serhan Tanyel 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.5

The studies on headway characteristics of traffic flow in Turkey are mainly dealing with signalized arterials, intersection approaches or roundabouts. Only a few studies can be found on headway characteristics of uninterrupted flow facilities and nearly none of them are on lane by lane basis. In this study, the authors are modeling headways of vehicles at zmir ring roads by lane by lane principle. The study demonstrates that lognormal distribution is an effective tool to define headways. In addition, the applicability of Cowan M3 distribution to time headways is investigated. Proportion of free vehicles is modeled for different lanes. The results show that traffic flow in the middle lane is highly affected by the vehicles in other lanes. Vehicles in the outer lane can be assumed to arrive randomly, but they are also disturbed by vehicles in other lanes. These results can be used in capacity and performance analysis of freeway segments, ramp junctions and weaving areas.

Cell-specific and post-hoc spatial clustering tests based on nearest neighbor contingency tables

Elvan Ceyhan 한국통계학회 2017 Journal of the Korean Statistical Society Vol.46 No.2

Spatial clustering patterns in a multi-class setting such as segregation and association between classes have important implications in various fields, e.g., in ecology, and can be tested using nearest neighbor contingency tables (NNCTs). A NNCT is constructed based on the types of the nearest neighbor (NN) pairs and their frequencies. We survey the cell-specific (or pairwise) and overall segregation tests based on NNCTs in literature and introduce new ones and determine their asymptotic distributions. We demonstrate that cell-specific tests enjoy asymptotic normality, while overall tests have chi-square distributions asymptotically. Some of the overall tests are confounded by the unstable generalized inverse of the rank-deficient covariance matrix. To overcome this problem, we propose rank-based corrections for the overall tests to stabilize their behavior. We also perform an extensive Monte Carlo simulation study to compare the finite sample performance of the tests in terms of empirical size and power based on the asymptotic and Monte Carlo critical values and determine the tests that have the best size and power performance and are robust to differences in relative abundances (of the classes). In addition to the cell-specific tests, we discuss one(-class)-versus-rest type of tests as posthoc tests after a significant overall test. We also introduce the concepts of total, strong, and partial segregation/association to differentiate different levels of these patterns. We compare the new tests with the existing NNCT-tests in literature with simulations and illustrate the tests on an ecological data set.

A New Charge Analysis Derived From the Results of Semi-Emprical Mo-Lcao Calculation

Yilmaz, Hayriye,Ceyhan, Emre Cahit,Guzel, Yahya Korean Chemical Society 2012 대한화학회지 Vol.56 No.2

In this study we present a new approach for computing the partial atomic charge derived from the wavefunctions of molecules. This charge, which we call the "y_charge", was calculated by taking into account the energy level and orbital populations in each molecular orbital (MO). The charge calculations were performed in the software, which was developed by us, developed using the C# programming language. Partial atomic charges cannot be calculated directly from quantum mechanics. According to a partitioning function, the electron density of constituent molecular atoms depends on the electrostatic attraction field of the nucleus. Taking into account the Boltzmann population of each MO as a function of its energy and temperature we obtain a formula of partial charges.

An Evaluation of Real Situation of Turkish Beekeeping

Emir, M.,Ceyhan, V.,Guler A 한국양봉학회 2014 한국양봉학회 학술대회 자료집 Vol.2014 No.9

Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders

Filiz Karadag,Ceyhan Balci Sengul,Yasar Enli,Kamuran Karakulah,Huseyin Alacam,Bunyamin Kaptanoglu,Ozgur Kalkanci,Hasan Herken 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.2

Objective: We investigated the relationship between serum bilirubin levels and metabolic syndrome (MetS), and the longitudinal effects of baseline serum bilirubin concentrations on MetS in patients with schizophrenia spectrum disorders undergoing atypical antipsychotics. Methods: The sample of this study consisted of 131 patients with schizophrenia spectrum disorders. Waist circumference, blood pressure, and levels of triglycerides, high-density lipoprotein cholesterol, fasting glucose, and insulin were evaluated at baseline and at month six. Serum bilirubin levels were measured at baseline. Serum bilirubin levels of the patients with and without MetS criteria were compared. We also compared patients with high and low bilirubin levels (upper and lower 50th percentiles of serum bilirubin levels) in terms of MetS criteria, MetS frequency, and course of MetS. Results: Serum direct bilirubin levels were more consistently related to MetS and MetS-related variables. The waist circumference and triglyceride criteria for MetS were significantly related to low serum direct bilirubin at baseline; waist circumference and fasting glucose criteria, and insulin resistance were associated with low serum direct bilirubin at follow-up. MetS diagnosis and the presence of the waist circumference criterion were more frequent at the baseline and the follow-up in low bilirubin group. At the end of the follow-up period, the rate of reverse MetS was significantly higher in the high bilirubin group. Conclusion: Our results have suggested that serum direct bilirubin levels showed a more reliable and stable relationship with abdominal obesity for MetS components.in patients with schizophrenia spectrum disorders using antipsychotics. Further studies are required.

The use of platelet rich plasma in the treatment of immature tooth with periapical lesion: a case report

Günseli Güven Polat,Ceren Yıldırım,Özlem Martı Akgün,Ceyhan Altun,Didem Dinçer,Cansel Köse Özkan 대한치과보존학회 2014 Restorative Dentistry & Endodontics Vol.39 No.3

This study describes the treatment of an immature permanent tooth with periapical lesion which was treated with regenerative approach using platelet rich plasma (PRP). The root canal of immature human permanent tooth with periapical lesion was gently debrided of necrotic tissue and disinfected with 2.5% NaOCl, and then medicated with triple antibiotic paste comprised of ciprofloxacin, metronidazole, and tetracycline. When the tooth was asymptomatic, PRP and mineral trioxide aggregate (MTA) were placed into the root canal. Six months after PRP treatment, radiographical examination revealed resolution of the radiolucency and progressive thickening of the root wall and apical closure. Our findings suggest that PRP can be used for the treatment of immature permanent teeth with periapical lesion, as part of a regenerative endodontic treatment procedure.

The use of platelet rich plasma in the treatment of immature tooth with periapical lesion: a case report

Polat, Gunseli Guven,Yildirim, Ceren,Akgun, Ozlem Marti,Altun, Ceyhan,Dincer, Didem,Ozkan, Cansel Kose The Korean Academy of Conservative Dentistry 2014 Restorative Dentistry & Endodontics Vol.39 No.3

This study describes the treatment of an immature permanent tooth with periapical lesion which was treated with regenerative approach using platelet rich plasma (PRP). The root canal of immature human permanent tooth with periapical lesion was gently debrided of necrotic tissue and disinfected with 2.5% NaOCl, and then medicated with triple antibiotic paste comprised of ciprofloxacin, metronidazole, and tetracycline. When the tooth was asymptomatic, PRP and mineral trioxide aggregate (MTA) were placed into the root canal. Six months after PRP treatment, radiographical examination revealed resolution of the radiolucency and progressive thickening of the root wall and apical closure. Our findings suggest that PRP can be used for the treatment of immature permanent teeth with periapical lesion, as part of a regenerative endodontic treatment procedure.