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      • KCI등재SCOPUS

        A multi-institutional analysis of sequential versus ‘sandwich' adjuvant chemotherapy and radiotherapy for stage IIIC endometrial carcinoma

        Cem,Onal,Sezin,Yuce,Sari,Berna,Akkus,Yildirim,Guler,Yavas,Melis,Gultekin,Ozan,Cem,Guler,Serap,Akyurek,Ferah,Yildiz 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.3

        Objective: To analyze the outcomes of sequential or sandwich chemotherapy (ChT) and radiotherapy (RT) in patients with node-positive endometrial cancer (EC). Methods: Data from 4 centers were collected retrospectively for 179 patients with stage IIIC EC treated with postoperative RT and ChT (paclitaxel and carboplatin). Patients were either treated with 6 cycles of ChT followed by RT (sequential arm; 96 patients) or with 3 cycles of ChT, RT, and an additional 3 cycles of ChT (sandwich arm; 83 patients). Prognostic factors affecting overall survival (OS) and progression-free survival (PFS) were analyzed. Results: The 5-year OS and PFS rates were 64% and 59%, respectively, with a median followup of 41 months (range, 5–167 months). The 5-year OS rates were significantly higher in the sandwich than sequential arms (74% vs. 56%; p=0.03) and the difference for 5-year PFS rates was nearly significant (65% vs. 54%; p=0.05). In univariate analysis, treatment strategy, age, International Federation of Gynecology and Obstetrics (FIGO) stage, pathology, rate of myometrial invasion, and grade were prognostic factors for OS and PFS. In multivariate analysis, non-endometrioid histology, advanced FIGO stage, and adjuvant sequential ChT and RT were negative predictors for OS, whereas only non-endometrioid histology was a prognostic factor for PFS. Conclusion: Postoperative adjuvant ChT and RT for stage IIIC EC patients, either given sequentially or sandwiched, offers excellent clinical efficacy and acceptably low toxicity. Our data support the superiority of the sandwich regimen compared to the sequential strategy in stage IIIC EC patients for OS.

      • KCI등재
      • KCI등재

        Protective Effect of All-Trans Retinoic Acid in Cisplatin-Induced Testicular Damage in Rats

        Cem,Yucel,Fatma,Demet,Arslan,Sumeyye,Ekmekci,Volkan,Ulker,Erdem,Kisa,Elcin,Erdogan,Yucel,Murat,Ucar,Yusuf,Ozlem,Ilbey,Orcun,Celik,Banu,Isbilen,Basok,Zafer,Kozacioglu 대한남성과학회 2019 The World Journal of Men's Health Vol.37 No.2

        Purpose: To investigate the effects of all-trans retinoic acid (ATRA) in cisplatin (CP)-induced testicular damage in rats. Materials and Methods: Twenty-eight male Wistar rats were divided into four groups: Control, ATRA alone, ATRA+CP, and CP alone. Body weight, testicular weight, sperm count, sperm motility, percentage of abnormal sperm, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI) in testicular tissue, and testicular histopathology were compared among groups. Results: The sperm count and motility significantly decreased and the percentage of abnormal sperm significantly increased in the CP group compared to the control and ATRA groups. CP+ATRA administration significantly increased the sperm count and motility, but reduced the abnormal sperm count. CP administration significantly increased TOS and OSI compared to the control group and the other groups. Administering CP+ATRA significantly decreased TOS and the OSI in testicular tissue and reduced spermatogenesis, but increased the Johnsen score. Conclusions: The destructive effects of CP treatment on testicular tissue and spermatogenesis were reduced by administering ATRA.

      • SCIESCOPUSKCI등재

        Methylphenidate Induced Lip and Tongue Biting

        Cem,Gokcen,Mehmet,Karadag,Ihsan,Aksoy 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.2

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        Attention deficit hyperactivity disorder (ADHD) is a life-long neurodevelopmental disorder and treatment depends on pharmacotherapy because of its biological origin. Stimulant drugs are the most commonly used treatment for ADHD and they have various side effects. Herein, we report a case who bit off the tip of her tongue with Osmotic Release Oral System methylphenidate (OROS MPH) 36 mg/day, bit the tip of her lower lip with immediate release (IR) MPH 10 mg/day and lateral part of her tongue with IR MPH 20 mg/day. A diagnosis of epilepsy was unlikely because of the normal neurological examination and electroencephalography findings. This case was considered as an atypical side effect of MPH such as perseverative/compulsive behaviours and movement disorders. Clinicians should be aware of that stimulant medications may cause lip and tongue biting behavior and this may effect treatment compliance tremendously.

      • KCI등재SCOPUS

        A Comparative Study of AISC-360 and EC3 Strength Limit States

        Cem,Topkaya,Serkan,Şahin 한국강구조학회 2011 International Journal of Steel Structures Vol.11 No.1

        A study has been undertaken to evaluate the similarities and differences between the steel building design specifications used in the United States and Europe. Expressions for nominal strength presented in the AISC-360 Specification and the Eurocode 3 Specification were compared for fundamental limit states. In particular, rules for cross-section classification, tension members,compression members, I-shaped members subjected to flexure, I-shaped members subjected to shear, and fasteners were studied. Results of the investigation revealed that, in general, both specifications provide nominal capacities that are close to each other. Significant differences were reported for some limit states such as flexure in I-shaped members with non-compact flanges, shear and lateral torsional buckling in I-shaped members, and bearing strength at bolt holes. In this paper, the details of the comparative study are presented along with observations that are useful for practicing engineers

      • KCI등재SCOPUS

        Characterization of the physical properties of a self-flowing low-cement castable based on white-fused alumina

        Cem,,tas,Akln,Odabasl,Levent,Sezera,Filiz,Çlnarb,Sule,Günerc,Niyazi,Eruslua,Necip,Ünlü 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.1

        A white-fused low cement refractory castable was prepared from pure refractories that consisted of 77 wt.% white fused alumina, 10 wt.% calcined alumina, 8 wt.% microsilica, 5 wt.% cement and 0.05 wt.% dispersant. Optimum self-leveling flowability was achieved by using 5.6 wt.% water. To determine the effect of the firing temperature on the white-fused low cement refractory castable, studies of apparent porosity (AP), bulk density (BD), water absorption (WA), cold crushing strength (CCS), hardness, X-ray diffraction (XRD) and microstructural-based evaluation using electron probe microanalyser (EPMA) were performed. The present castable heat treated at 1500℃ for 2 h exhibited the following properties: the AP −14%, the BD −3.12 gcm−3, the WA −2.5%, the CCS −2000 kgcm−2 and the hardness −3185 kg㎟. The new white-fused alumina castable presents unique properties that would make it desirable to use in industrial refractory applications. A white-fused low cement refractory castable was prepared from pure refractories that consisted of 77 wt.% white fused alumina, 10 wt.% calcined alumina, 8 wt.% microsilica, 5 wt.% cement and 0.05 wt.% dispersant. Optimum self-leveling flowability was achieved by using 5.6 wt.% water. To determine the effect of the firing temperature on the white-fused low cement refractory castable, studies of apparent porosity (AP), bulk density (BD), water absorption (WA), cold crushing strength (CCS), hardness, X-ray diffraction (XRD) and microstructural-based evaluation using electron probe microanalyser (EPMA) were performed. The present castable heat treated at 1500℃ for 2 h exhibited the following properties: the AP −14%, the BD −3.12 gcm−3, the WA −2.5%, the CCS −2000 kgcm−2 and the hardness −3185 kg㎟. The new white-fused alumina castable presents unique properties that would make it desirable to use in industrial refractory applications.

      • KCI등재SSCI

        The effect of web-based portfolio use on academic achievement and retention

        Cem,Oktay,Gu¨,zeller 서울대학교 교육연구소 2012 Asia Pacific Education Review Vol.13 No.3

        The web-based portfolio emerged as a result of the influence of technological developments on educational practices. In this study, the effect of the web-based portfolio building process on academic achievement and retention is explored. For this purpose, a study platform known as a computer-assisted personal development portfolio was designed for 30 Turkish students who participated in a web-based portfolio process. The academic achievements of the students were examined through an experimental design in which participants were divided into an experimental group and a control group and given a pre-test and a post-test. The results of the study revealed that the levels of both academic achievement and retention in the experimental group were significantly higher than those in the control group. Similar practices can be applied to the teaching of medicine, economics, physical sciences, humanities and other subjects in order to extend students' performance and achievement levels.

      • KCI등재SCOPUS

        Methylphenidate Induced Lip and Tongue Biting

        Cem,Gokcen,Mehmet,Karadag,Ihsan,Aksoy 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.2

        Attention deficit hyperactivity disorder (ADHD) is a life-long neurodevelopmental disorder and treatment depends on pharmacotherapy because of its biological origin. Stimulant drugs are the most commonly used treatment for ADHD and they have various side effects. Herein, we report a case who bit off the tip of her tongue with Osmotic Release Oral System methylphenidate (OROS MPH) 36 mg/day, bit the tip of her lower lip with immediate release (IR) MPH 10 mg/day and lateral part of her tongue with IR MPH 20 mg/day. A diagnosis of epilepsy was unlikely because of the normal neurological examination and electroencephalography findings. This case was considered as an atypical side effect of MPH such as perseverative/compulsive behaviours and movement disorders. Clinicians should be aware of that stimulant medications may cause lip and tongue biting behavior and this may effect treatment compliance tremendously.

      • KCI등재후보SCOPUS

        A single horn endometrial carcinoma of a uterus bicornis unicollis

        Cem,Dane,Zeynep,Tatar,Banu,Dane,Murat,Erqinbas,Ahmet,Cetin 대한부인종양학회 2009 Journal of Gynecologic Oncology Vol.20 No.3

        In this report, we describe a case of endometrial carcinoma arising in one horn of a bicornuate uterus. The diagnosis of this rare combination can be missed unless an unrecognized postmenopausal bleeding alerts the gynecologist to make a careful search for both endometrial cavities that may be curetted. Physicians should remember the possible existence of a separate uterine cavity when endometrial cancer is clinically suspected but histology fails to confirm the diagnosis. In this report, we describe a case of endometrial carcinoma arising in one horn of a bicornuate uterus. The diagnosis of this rare combination can be missed unless an unrecognized postmenopausal bleeding alerts the gynecologist to make a careful search for both endometrial cavities that may be curetted. Physicians should remember the possible existence of a separate uterine cavity when endometrial cancer is clinically suspected but histology fails to confirm the diagnosis.

      • KCI등재SCOPUS

        Preparation of ultra-homogeneous mullite precursor and evaluation of mullite formation

        Cem,ÖZGÜR,Remzi,GÖREN 한양대학교 세라믹연구소 2015 Journal of Ceramic Processing Research Vol.16 No.3

        The objective of this study is to present firstly the preparation of atomically ultra-homogeneous mullite precursors by ultrasonic spray pyrolysis technique and then to investigate the evaluation of mullite formation via calcination temperature and soaking time. At a temperature of as low as 500 o C for 15 days, the temperature was very close to the formation temperature of mullite (477 o C) is energetically possible; the structure of the precursor has been preserved as amorphous. It is possible to obtain single phase of mullite crystals at a temperature of 1000 o C without soaking time, while the crystallization required a temperature of 900 o C for 12 hours.

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