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Denis Cedeño Moreno,,Miguel Vargas-Lombardo 대한의료정보학회 2018 Healthcare Informatics Research Vol.24 No.4
Objectives: This research presents the design and development of a software architecture using natural language processing tools and the use of an ontology of knowledge as a knowledge base. Methods: The software extracts, manages and represents the knowledge of a text in natural language. A corpus of more than 200 medical domain documents from the general medicine and palliative care areas was validated, demonstrating relevant knowledge elements for physicians. Results: Indicators for precision, recall and F-measure were applied. An ontology was created called the knowledge elements of the medical domain to manipulate patient information, which can be read or accessed from any other software platform. Conclusions: The developed software architecture extracts the medical knowledge of the clinical histories of patients from two different corpora. The architecture was validated using the metrics of information extraction systems.
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Dengue and COVID-19 infections in the ASEAN region: a concurrent outbreak of viral diseases.
Wiyono Lowilius,Rocha Ian Christopher,Cedeño Trisha Denise,Miranda Adriana Viola,Lucero-Prisno III Don Eliseo 한국역학회 2021 Epidemiology and Health Vol.43 No.-
Member countries of the Association of Southeast Asian Nations (ASEAN) have faced dengue outbreaks for decades, and the region has one of the highest rates of dengue globally. Outbreaks continue to occur concurrently with the coronavirus disease 2019 (COVID-19) pandemic in the 10 ASEAN countries. Both infectious diseases pose a tremendous burden in these countries related to both infection control and the economy. Increases in the number of dengue cases occurred in part due to disruptions in the pathogen-host-vector relationship caused by changes in human behaviour in response to the COVID-19 pandemic. The spread of dengue was further aggravated by the implementation of lockdowns and social distancing policies. These measures limited the coverage of dengue preventive programs and delayed the medical management of both diseases due to co-infection and misdiagnosis. It is of the utmost importance for the population to remain aware of both diseases, and dengue vector control strategies must be devised to properly address outbreaks using digitalization and remote surveillance. Similarly, critical triage algorithms and further research are also needed to combat co-infection and misdiagnosis. Controlling the spread of COVID-19 though vaccination should also be undertaken to reduce the impact of the pandemic.
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Katrin Willinger,Godoberto Guevara-Rojas,Julia Cede,Kurt Schicho,Tanja Stamm,Clemens Klug 대한악안면성형재건외과학회 2021 Maxillofacial Plastic Reconstructive Surgery Vol.43 No.-
BackgroundToday virtual surgical planning (VSP) is a standard method in maxillofacial corrective surgery and is the key to reach satisfactory esthetic outcomes. The purpose of this study was to evaluate usability of three established virtual surgical planning software applications by comparing feasibility, time consumption, and costs in a standardized workflow for a modified intraoral quadrangular Le Fort II osteotomy (IQLFIIO). ResultsA cross-sectional study was performed based on retrospective and re-planned data of patients with midfacial deficiency treated by modified IQLFIIO, using three software applications: IPS Case Designer ®, Dolphin Imaging ®, and ProPlan CMF ®. Feasibility: All evaluated steps of the VSP procedure could be successfully performed in all three evaluated applications. In all software packages, it was possible to design the surgical splints with CAD/CAM technology. Working time: The mean value of time needed was IPS Case Designer ®, 36.5 min; Dolphin Imaging ®, 33.6 min; ProPlan CMF ®, 45.5 min. We found statistical significant difference between ProPlan CMF ® and Dolphin Imaging ® (p value, 0.02). Costs: Asset costs for acquiring the software, license fee, license possibilities, paying for support services, and service contracts were evaluated and are found in similar ranges. ConclusionAll three tested software applications are usable for virtual planning of an IQLFIIO and splint production by CAD/CAM technology. Successful movement of bone segments and overlaying soft tissues proved feasibility. Time consumption and costs were found in similar ranges.
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Fortin, Dale A.,Tillo, Shane E.,Yang, Guang,Rah, Jong-Cheol,Melander, Joshua B.,Bai, Suxia,Soler-Cedeñ,o, Omar,Qin, Maozhen,Zemelman, Boris V.,Guo, Caiying,Mao, Tianyi,Zhong, Haining Society for Neuroscience 2014 The Journal of neuroscience Vol.34 No.50
<P>Stoichiometric labeling of endogenous synaptic proteins for high-contrast live-cell imaging in brain tissue remains challenging. Here, we describe a conditional mouse genetic strategy termed endogenous labeling via exon duplication (ENABLED), which can be used to fluorescently label endogenous proteins with near ideal properties in all neurons, a sparse subset of neurons, or specific neuronal subtypes. We used this method to label the postsynaptic density protein PSD-95 with mVenus without overexpression side effects. We demonstrated that mVenus-tagged PSD-95 is functionally equivalent to wild-type PSD-95 and that PSD-95 is present in nearly all dendritic spines in CA1 neurons. Within spines, while PSD-95 exhibited low mobility under basal conditions, its levels could be regulated by chronic changes in neuronal activity. Notably, labeled PSD-95 also allowed us to visualize and unambiguously examine otherwise-unidentifiable excitatory shaft synapses in aspiny neurons, such as parvalbumin-positive interneurons and dopaminergic neurons. Our results demonstrate that the ENABLED strategy provides a valuable new approach to study the dynamics of endogenous synaptic proteins <I>in vivo</I>.</P>
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Comparison of atmospheric spectral radiance measurements from five independently calibrated systems
Pissulla, D.,Seckmeyer, G.,Cordero, R.R.,Blumthaler, M.,Schallhart, B.,Webb, A.,Kift, R.,Smedley, A.,Bais, A.F.,Kouremeti, N.,Cede, A.,Hermang, J.,Kowalewski, M. Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.4
A variety of instruments have been developed over the past 50 years to measure spectral radiance in absolute units at UV and visible wavelengths with high spectral resolution. While there is considerable experience in the measurement of spectral irradiance, less emphasis has been given to the reliable measurement of spectral radiance from ground observations. We discuss the methodology and calibration procedures for five instruments capable of making such measurements. Four of these instruments are based on double monochromators that scan each wavelength in turn, and one is based on a single monochromator with a charged coupled device (CCD) allowing the recording of all wavelengths simultaneously. The measured spectral radiance deviates between 3% and about 35% depending on the instruments. The results are compared with radiative transfer calculations when the aerosol characteristics of the atmosphere are known.
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