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In vitro Amoebicidal Activity of Borage (Borago officinalis) Extract on Entamoeba histolytica
Catalina Leos-Rivas,M. Julia Verde-Star,Lidia Osuna Torres,Azucena Oranday-Cardenas,Catalina Rivas-Morales,M. Porfiria Barron-Gonzalez,Mario R. Morales-Vallarta,Delia E. Cruz-Vega 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.7
Borage (Borago officinalis) is a plant with nutritional value that is also used in traditional medicine to treat gastrointestinal disease. This study investigated the amoebicidal activity of a methanol extract of borage. The 50% inhibitory concentration (IC_50) of the extract for Entamoeba histolytica was 33 μg/mL. The 50% lethal dose of the extract for brine shrimp was greater than 1,000 μg/mL. The IC_50 of the extract for Vero cells was 203.9 μg/mL. These results support the use of borage to prevent diseases associated with E. histolytica infection.
Catalina Stanciu 한국학중앙연구원 한국학중앙연구원 2014 THE REVIEW OF KOREAN STUDIES Vol.17 No.2
This article discusses the effects of war and the strategies for salvation in postwar Korean circumstances as reflected in Jang Yonghak 張龍鶴 (1921-1999)’s story entitled The Poetry of John (요한詩集 1955). First of all, I attempt to argue that the effects of war are double-faceted: on one hand, there are the psychologically traumatic effects of war, and on the other hand there are the existential effects which accompany them. Therefore, war and postwar circumstances do not only imply victims’ psychological trauma, but also a state of existential angst in which victims question the value of human existence and doubt the chance for salvation. However, in those circumstances, the possibility for salvation might come with the finding of a “proper space.” The “proper space” shall be here bestowed with a metaphorical connotation of a location within which one can finally make full sense of oneself and of the world. Death is also been conferred a symbolic meaning of a possible space of salvation.
Catalina-Suzana Stingu,Klaus Eschrich,Juliane Thiel,Toralf Borgmann,Reiner Schaumann,Arne C. Rodloff 대한진단검사의학회 2017 Annals of Laboratory Medicine Vol.37 No.5
Two matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS)-based methods were compared for their ability to identify viridans streptococci. One approach employed a reference database and software developed in-house. All in-house measurements were performed using an Autoflex II Instrument (Bruker Daltonics GmbH, Germany). The other system, a VITEK-MS (BioMérieux, France) was operated on the commercially available V2.0 Knowledge Base for Clinical Use database. Clinical isolates of viridans streptococci (n=184) were examined. Discrepant results were resolved by 16S rDNA sequencing. Species-level identification percentages were compared by a chi-square test. The in-house method correctly identified 179 (97%) and 175 (95%) isolates to the group and species level respectively. In comparison, the VITEK-MS system correctly identified 145 (79%) isolates to the group and species level. The difference between the two methods was statistically significant at both group and species levels. Using the Autoflex II instrument combined with an extraction method instead of whole cell analysis resulted in more reliable viridans streptococci identification. Our results suggest that combining extraction with powerful analysis software and the careful choice of well-identified strains included into the database was useful for identifying viridans streptococci species.
Places of Initiation in Yun Heunggil’s House of Twilight
Catalina Stanciu 한국학중앙연구원 한국학중앙연구원 2016 THE REVIEW OF KOREAN STUDIES Vol.19 No.2
This article deals with one of Yun Heunggil’s (b. 1942) novels, The House of Twilight (1970). The purpose of this article is to depict the child narrator’s process of initiation during the Korean War (1950-1953) in relation with two particular places in Jeongeup, a city in North Jeolla Province. Accompanied by a child named Gyeongju, the child narrator pays visits to an iron foundry and Gyeongju’s tavern house. Against the backdrop of these two spatial settings, the narrator interacts for the first time with the traumatic social impact of the War. He is introduced to the reality of death by Gyeongju’s recollection of her family’s trauma and through initiation into her sadistic games. Further analyzed in the article, these places, along with their ambivalent connotations, anticipate the narrator’s maturation.
Hometown: The Topography of Initiation and Catharsis in Yun Hǔnggil’s “Road to Soradan”
( Catalina Stanciu ) 서울대학교 규장각한국학연구원 2015 Seoul journal of Korean studies Vol.28 No.2
This paper deals with one of Yun Hǔnggil’s (b. 1942) latest short stories, “Road to Soradan” (Soradan kanǔn kil) (2002), and it has two purposes. The first is to depict the child narrator’s process of initiation during the Korean War (1950-1953) in relation to his hometown topography. More specifically, I will argue that being initiated into the surrounding world and the war circumstances is reflected through the child narrator’s direct interaction with Soradan, a pine tree groove in his hometown. At Soradan, the encounter between the child narrator (Yi Kigon) and Pak Chǔngsǒ has both a psychological and formative impact on the child narrator psyche. The second aim of this study is to interpret the adult narrator’s homecoming journey as endowed with cathartic connotations. Together with his former schoolmates, the narrator travels back both in space and in time, attempting to stitch back together the shattered memories of his traumatic childhood. Arguing the significance of Soradan in relation to the story’s narrator, I will suggest that it has multiple symbolic functions. On the one hand, how it affects the child narrator’s inner world and contributes to his understanding of life, circumstances of national division, and himself as an integrated part of this particular landscape; and on the other hand, the role of Soradan as the testimony for the Korean War’s legacy.
Catalina Carrasco-Pozo,Marı´a Jose Cires,Martin Gotteland 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.8
Obesity is a worldwide epidemic, which is characterized by the excess accumulation of adipose tissue and to an extent that impairs both the physical and psychosocial health and well-being. There are several weight-loss strategies available, including dietary modification, pharmacotherapy, and bariatric surgery, but many are ineffective or not a long-term solution. Bioactive compounds present in medicinal plants and plant extracts, like polyphenols, constitute the oldest and most extensive form of alternative treatments for the prevention and management of obesity. Their consumption is currently increasing in the population due to the high cost, potential adverse effects, and limited benefits of the currently available pharmaceutical drugs. A great number of studies has explored how dietary polyphenols can interfere with the different mechanisms associated with obesity development. They suggest that these compounds can decrease energy and food intake, lipogenesis, and preadipocyte differentiation and proliferation, while increasing energy expenditure, lipolysis, and fat oxidation. Both quercetin, one of the most common dietary flavonols in the western diet, and epigallocatechin gallate (EGCG), the most abundant polyphenol in green tea, exhibit antiobesity effects in adipocyte cultures and animal models. However, the extrapolation of these potential benefits to obese humans remains unclear. Although quercetin supplementation does not seem to exert any beneficial effects on body weight, this polyphenol could prevent the obesity-associated mortality by reducing cardiovascular disease risk. An important consideration for the design of further trials is the occurrence of gene polymorphisms in key enzymes involved in flavanol metabolism, which determines a subject's sensitivity to catechins and seems, therefore, crucial for the success of the antiobesity intervention. Although the evidence supporting antiobesity effects is more consistent in EGCG than with quercetin studies, they could still be beneficial by reducing the cardiovascular risk of obese subjects, rather than inducing body weight loss.
Catalina Quintero-Quiroz,Luz E. Botero,Diana Zárate-Triviño,Natalia Acevedo-Yepes,Jorge Saldarriaga Escobar,Vera Z. Pérez,Luis Javier Cruz Riano 한국생체재료학회 2020 생체재료학회지 Vol.24 No.3
Background: The presence of skin problems in patients using external lower limb prosthesis is recurrent. This has generated the need to develop interfaces for prosthesis with the ability to control microbial growth. Silver nanoparticles (AgNPs) have been implemented in the development of biomaterials because of their high antimicrobial activity. This article discusses the development of an AgNP-containing polymer composite with antimicrobial activity for developing prosthetic liners. Methods: AgNPs were synthesized using a photochemical method and certain physicochemical properties were characterized. Furthermore, the antimicrobial activity of AgNPs against Staphylococcus aureus ATCC 25923 and methicillin-resistant Staphylococcus aureus (MRSA), was assessed on the basis of their minimum inhibitory concentrations (MICs). AgNPs were incorporated into a silicon elastomer to assess certain physicomechanical properties, antimicrobial activity and cytotoxic effect of the material. Results: Themaximum antimicrobial activity of the material against Staphylococcus aureus ATCC 25923 andMRSA was 41.58% ±2.97% at AgNP concentration of 32.98 μg/mL and 14.85% ±5.94% at AgNP concentration of 16.49 μg/mL, respectively. Additionally, the material exhibited tensile yield strength, rupture tensile strength, and tensile modulus of elasticity of 0.70 - 1.10 MPa, 0.71–1.06 MPa, and 0.20 - 0.30 MPa, respectively. The mechanical characteristics of the material were within the acceptable range for use in external lower limb prosthetic and orthotic interfaces. Conclusions: It was possible to incorporate the AgNPs in a silicone elastomer, finding that the composite developed presented antimicrobial activity against Staphylococcus aureus ATCC 25923 and MRSA when compared to non-AgNP material samples.