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Serum Sclerostin in Hepatitis C Virus Infected Patients
E. González-Reimers,Javier López-Prieto,Ricardo Pelazas-González,M.Remedios Alemán-Valls,María José de la Vega-Prieto,Carlos Jorge-Ripper,M. Carmen Durán-Castellón,F Santolaria-Fernández 대한골대사학회 2014 대한골대사학회지 Vol.21 No.1
Background: Sclerostin inhibits osteoblast functions, differentiations, and survival rates. As an endogenous inhibitor of the Wnt/β-catenin pathway, the sclerostin should be re-lated to decreased bone masses, although several studies indicate opposite results. Inaddition, it may be related to insulin resistances and carbohydrate metabolisms, a rela-tion shared with other markers of bone metabolisms, such as osteocalcin. Hepatitis C vi-rus (HCV) infected patients may present osteoporosis, and frequently show liver steato-sis, which is a consequence of insulin resistance. The behaviour of sclerostin in these pa-tients is yet unknown. The aim of this work is to analyse the relationships between se-rum sclerostin and osteocalcin levels and bone mineral density (BMD), liver functions,the intensity of liver steatosis and biochemical markers of bone homeostasis and insulinresistance in HCV-infected patients. Methods: Forty HCV patients with 20 years of ageand gender-matching controls were included in this study and underwent bone densi-tometry. Serum sclerostin, osteocalcin, collagen telopeptide, adiponectin, leptin, insulin,resistin, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were determined. Liver fatwas histomorphometrically assessed. Results: Sclerostin levels were slightly higher inpatients than in controls, and were directly related to BMD at different parts of the skele-ton, also to the serum telopeptide, and to the liver steatosis and TNF-α. On the contrary,osteocalcin showed a significant direct relationship with serum adiponectin, and an in-verse one with IL-6. Conclusions: Serum sclerostin levels were within the normal rangein HCV patients, and correlated directly with BMD and serum telopeptide. In addition,the relationships of sclerostin and osteocalcin with variables associated with insulin re-sistance suggested the role of bones for intermediary metabolisms.
( Uni Wong ),( Erik B Person ),( Donald O Castell ),( Erik Von Rosenvinge ),( Jean-pierre Raufman ),( Guofeng Xie ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2018 Journal of Neurogastroenterology and Motility (JNM Vol.24 No.4
Background/Aims Swallows with viscous or solid boluses in different body positions alter esophageal manometry patterns. Limitations of previous studies include lack of standardized viscous substrates and the need for chewing prior to swallowing solid boluses. We hypothesize that high-resolution impedance manometry (HRiM) using standardized viscous and super-viscous swallows in supine and upright positions improves sensitivity for detecting esophageal motility abnormalities when compared with traditional saline swallows. To establish normative values for these novel substrates, we recruited healthy volunteers and performed HRiM. Methods Standardized viscous and super-viscous substrates were prepared using “Thick-It” food thickener and a rotational viscometer. All swallows were administered in 5-mL increments in both supine and upright positions. HRiM metrics and impedance (bolus transit) were calculated. We used a paired two-tailed t test to compare all metrics by position and substrate. Results The 5-g, 7-g, and 10-g substrates measured 5000, 36 200, and 64 700 mPa·sec, respectively. In 18 volunteers, we observed that the integrated relaxation pressure was lower when upright than when supine for all substrates (P < 0.01). The 10-g substrate significantly increased integrated relaxation pressure when compared to saline in the supine position (P < 0.01). Substrates and positions also affected distal contractile integral, distal latency, and impedance values. Conclusions We examined HRiM values using novel standardized viscous and super-viscous substrates in healthy subjects for both supine and upright positions. We found that viscosity and position affected HRiM Chicago metrics and have potential to increase the sensitivity of esophageal manometry. (J Neurogastroenterol Motil 2018;24:570-576)