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Cassiano, Eduardo Cuellar Orlandi,Perna, Flavio Junior,Barros, Tarley Araujo,Marino, Carolina Tobias,Pacheco, Rodrigo Dias Lauritano,Ferreira, Fernanda Altieri,Millen, Danilo Domingues,Martins, Mauric Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.1
Objective: Feed additives that modify rumen fermentation can be used to prevent metabolic disturbances such as acidosis and optimize beef cattle production. The study evaluated the effects of liquid and powdered forms of polyclonal antibody preparation (PAP) against Streptococcus bovis and Fusobacterium necrophorum on rumen fermentation parameters in ruminally cannulated non-lactating dairy cows that were adapted or unadapted to a high concentrate diet. Methods: A double 3×3 Latin square design was used with three PAP treatments (control, powdered, and liquid PAP) and two adaptation protocols (adapted, unadapted; applied to the square). Adapted animals were transitioned for 2 weeks from an all-forage to an 80% concentrate diet, while unadapted animals were switched abruptly. Results: Interactions between sampling time and adaptation were observed; 12 h after feeding, the adapted group had lower ruminal pH and greater total short chain fatty acid concentrations than the unadapted group, while the opposite was observed after 24 h. Acetate:propionate ratio, molar proportion of butyrate and ammonia nitrogen concentration were generally greater in adapted than unadapted cattle up to 36 h after feeding. Adaptation promoted 3.5 times the number of Entodinium protozoa but copy numbers of Streptococcus bovis and Fibrobacter succinogens genes in rumen fluid were not affected. However, neither liquid nor powdered forms of PAP altered rumen acidosis variables in adapted or unadapted animals. Conclusion: Adaptation of cattle to highly fermentable carbohydrate diets promoted a more stable ruminal environment, but PAP was not effective in this study in which no animal experienced acute or sub-acute rumen acidosis.
Seismic behaviour of gravity load designed flush end-plate joints
David Cassiano,Mario D’Aniello,Carlos Rebelo 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.26 No.5
Flush end-plate (FEP) beam-to-column joints are commonly used for gravity load resisting parts in steel multistorey buildings. However, in seismic resisting structures FEP joints should also provide rotation capacity consistent with the global structural displacements. The current version of EN1993-1-8 recommends a criterion aiming at controlling the thickness of the end-plate in order to avoid brittle failure of the connection, which has been developed for monotonic loading conditions assuming elastic-perfectly plastic behaviour of the connection's components in line with the theory of the component method. Hence, contrary to the design philosophy of the hierarchy of resistances implemented in EN1998-1, the over strength and the hardening of the plastic components are not directly accounted for. In light of these considerations, this paper describes and discusses the results obtained from parametric finite element simulations aiming at investigating the moment-rotation response of FEP joints under cyclic actions. The influence of bolt diameter, thickness of end-plate, number of bolt rows and shape of beam profile on the joint response is discussed and design requirements are proposed to enhance the ductility of the joints.
Influence of seismic design rules on the robustness of steel moment resisting frames
David Cassiano,Mario D’Aniello,Carlos Rebelo,Raffaele Landolfo,Luís S. da Silva 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.21 No.3
Seismic design criteria allow enhancing the structural ductility and controlling the damage distribution. Therefore, detailing rules and design requirements given by current seismic codes might be also beneficial to improve the structural robustness. In this paper a comprehensive parametric study devoted to quantifying the effectiveness of seismic detailing for steel Moment Resisting Frames (MRF) in limiting the progressive collapse under column loss scenarios is presented and discussed. The overall structural performance was analysed through nonlinear static and dynamic analyses. With this regard the following cases were examined: (i) MRF structures designed for wind actions according to Eurocode 1; (ii) MRF structures designed for seismic actions according to Eurocode 8. The investigated parameters were (i) the number of storeys; (ii) the interstorey height; (iii) the span length; (iv) the building plan layout; and (v) the column loss scenario. Results show that structures designed according to capacity design principles are less robust than wind designed ones, provided that the connections have the same capacity threshold in both cases. In addition, the numerical outcomes show that both the number of elements above the removed column and stiffness of beams are the key parameters in arresting progressive collapse.
Lycopene and Tomato Sauce Improve Hepatic and Cardiac Cell Biomarkers in Rats
Vanessa Azevedo de Jesuz,Monique de Barros Elias Campos,Vanessa Rosse de Souza,Teresa Palmiciano Bede,Bianca Portugal Tavares de Moraes,Adriana Ribeiro Silva,Cassiano Felippe Gonc¸alves de Albuquerque 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.11
This study evaluated the effects of tomato sauce and lycopene on hepatic and cardiac cell biomarkers in rats fed a high-fat diet. Animals were split into five groups: control group, high-fat group (HG), high-fat tomato sauce group, high-fat lycopene 2 mg, and high-fat lycopene 4 mg. Food and water were offered ad libitum, whereas tomato sauce and lycopene (2 and 4 mg/day) were offered daily for 60 days. Body, heart, and liver weights, cardiosomatic and hepatosomatic indices, and serum parameters were also analyzed in rats. The animals' hearts and liver were processed, and cells were examined by flow cytometry. Results showed that the groups receiving tomato sauce and lycopene had lower glycemia. The serum concentration of high-density lipoprotein cholesterol, hepatic enzymes, and tumor necrosis factor-α did not change upon treatment. Tomato sauce and lycopene supplementation did not increase interleukin-1β in response to a high-fat diet. Cell cycle analysis of cardiac and liver cells showed a lower percentage of cells in the G0/G1 phase and an increase in the G2/M phase in HG. Both lycopene and tomato sauce reversed this effect. Both lycopene and tomato sauce reversed this effect and prevented high-fat diet-stimulated cardiac and liver cell death. Supplementation of tomato sauce and lycopene showed beneficial effects on cardiac and liver cell metabolism; therefore, it is suggested as a nutritional approach for the prevention and treatment of cardiovascular diseases and nonalcoholic hepatic steatosis.
Rocha Vinícius Magno da,Mariana Balardino Bogado Faria,Francisco de Assis dos Reis Júnior,Carla Ormundo Gonçalves Ximenes Lima,Rossano Kepler Alvim Fiorelli,Keila Mara Cassiano 대한골대사학회 2020 대한골대사학회지 Vol.27 No.3
Background: The present study performed a systematic review and meta-analysis of clinical trials using bisphosphonates for bone demineralization in human immunodeficiency virus (HIV) patients. Methods: A comprehensive literature search was performed from January 2004 to January 2020 considering the bone mineral density (BMD) of the lumbar spine (LS) as the main outcome. Out of 214 titles that met criteria, 9 studies fulfilled the selection criteria. Results: A total of 394 patients were identified, and they were allocated into 2 groups: the intervention group (200 patients), to whom a combination of alendronate or zoledronate with calcium and vitamin D was administered; and control group (194 patients), to whom only calcium and vitamin D was administered. Clinical profile and indicators of bone metabolism of the participants were evaluated regarding effect size, homogeneity, and consistency. No substantial heterogeneity between the groups was found for the baseline variables, and there was high consistency to the main outcome. The meta-analysis shows a significant difference in post-treatment BMD, favoring the intervention over the control treatment. The intervention improved LS density up to 0.227 g/cm², raising the average to the levels of general population. Adverse effects related to intervention were fever immediately after zoledronate administration and gastrointestinal complaints during alendronate usage. Other adverse effects were barely reported and poorly connected to intervention by studies’ authors, despite all of them have been successfully resolved. Conclusions: This study provides evidence that BMD post-treatment is better in HIV patients who used bisphosphonates combined with calcium and vitamin D.
Pathological fracture induced by Halicephalobus gingivalis (Nematoda: Rhabditida) in a horse limb
Ticiana Meireles Sousa,Hugo Shisei Toma,Antonio de Pádua Lima,Antonio Carlos Cunha Lacreta Junior,Maira Meira Nunes,Ana Paula Cassiano da Silva,Daniel Wouters,Adriana Silva Albuquerque,Mary Suzan Vara 대한기생충학ㆍ열대의학회 2024 The Korean Journal of Parasitology Vol.62 No.1
Halicephalobus gingivalis is a free-living nematode that occasionally causes infections inhorses. We report a rare case of limb fracture of horse caused by infection with H. gingivalis. An 8-year-old mare was referred to the Veterinary Hospital of the Federal Universityof Lavras with claudication grade 5 of the right hind limb, that had been started 3months ago. The patient had aseptic arthritis in the tarsal joint and edema that extendedto the quartile. The radiographic examination showed punctate osteolysis with exacerbation of bone trabeculation along the calcaneus, talus, proximal epiphysis of the thirdmetatarsal and distal epiphysis of the tibia. Treatment for arthritis was initiated, and theanimal showed a slight improvement in limb function. However, 21 days after hospitalization, due to a comminuted fracture of the tibia, it was euthanized. At necropsy, yellowish masses were found from the metatarsal to the tibia, and around the tarsal bonesand joint. Similar masses were also found in the left kidney. Numerous nematodes compatible with H. gingivalis were identified. This is the first description of a pathologicalfracture caused by H. gingivalis infection in an equine limb.