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Vitor Hugo Candido Ferreira,Aristilia Tahara Kemp,Joana Vendruscolo,Laurindo Moacir Sassi,Juliana Lucena Schussel 대한구강악안면외과학회 2021 대한구강악안면외과학회지 Vol.47 No.1
Objectives: The aim of this study was to evaluate the profile of patients on antiresorptive therapies for cancer treatment and assess presence of oral lesions, oral hygiene status, and knowledge regarding medication-related osteonecrosis of the jaw (MRONJ). Materials and Methods: This was an observational cross-sectional study that evaluated patients treated with antiresorptive medication at a single cancer hospital. Clinical data were collected and oral examination was performed to assess patient oral health. Results: From July 2017 to December 2018, 90 patients were assessed; 64 were female and 26 were male, and the mean age was 61 years. The most common drug was an intravenous bisphosphonate, zoledronic acid. Among the 90 patients, 47 presented with some type of oral disease, isolated or associated. Among these 47 patients, 9 patients (10%) developed osteonecrosis. Oral hygiene was evaluated, and most patients, with or without MRONJ, presented with regular to poor condition. Regarding patient knowledge of the risks of MRONJ and the risks associated with dental surgery, 60% stated that they were not aware of the risks. Conclusion: Identifying the profile of patients and their needs facilitates not only the preventive process, but also the emergence of new therapeutic options. Our study shows that most patients are weakened both by metastatic disease and antineoplastic treatment as well as by issues associated with aging because most were over 60 years of age. Collectively, this information should be considered for management of preventive and therapeutic measures.
The Role of Black Rice (Oryza sativa L.) in the Control of Hypercholesterolemia in Rats
Jocelem Mastrodi Salgado,Anderson Giovanni Candido de Oliveira,Debora Niero Mansi,Carlos M. Donado-Pestana,Candido Ricardo Bastos,Fernanda Klein Marcondes 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.6
Cardiovascular disease is a serious public health problem; it is the first “cause of death” in Brazil and in developed countries. Thus, it is essential to search for alternative sources such as some functional foods to prevent and control the risks of this disease. The purpose of this study was to evaluate the lipidemic parameters in hypercholesterolemic rats fed diets containing black rice variety IAC 600 or unrefined rice. Adult male Wistar rats (Rattus norvegicus var. albinos) were used, weighing about 200–220g. The animals were divided into four groups: the first received a control casein diet, the second received hypercholesterolemic diet, and the other two groups, after induction of hypercholesterolemia, received the test diets, the first containing 20% black rice and the second 20% unrefined, for 30 days. It was observed that diet containing black rice reduced the level of plasma cholesterol, triglycerides, and low-density lipoprotein. For high-density lipoprotein values, the diet that provided an increase in the levels was the black rice. The diet containing black rice was more effective in controlling the lipidemia in rats compared with the whole rice diet.
Prediction of Micro-scale Forces in Dry Grinding Process Through a FEM—ML Hybrid Approach
Flavia Lerra,Antonio Candido,Erica Liverani,Alessandro Fortunato 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.23 No.1
Grinding process modeling represents a great challenge due to its stochastic nature. The uncertainty factor of grinding technology is mainly attributable to the undefined grain morphology, with the influence of this aspect becoming more pronounced in a dry configuration. Even though grinding has always used lubricants, nowadays the reduction or complete elimination of this element could mean a significant reduction in environmental pollution. Many modeling approaches have been used in literature to investigate phenomena related to grinding but each exhibits some disadvantages. In this paper a hybrid FEM—ML approach is proposed to forecast forces generated by the action of a single grain in dry conditions, overcoming the main modeling limitations observed to date. Experiments and force measurements were performed on a CNC surface grinding machine using sintered aluminum oxide grains of size 60. FEM simulations were developed in DEFORM 3D to predict grinding forces and increase the data set. ML algorithms were proposed to increase model prediction productivity and optimize the control of process parameters.
Feed Restriction and Compensatory Growth in Guzerá Females
Neto, S. Gonzaga,Bezerra, L.R.,Medeiros, A.N.,Ferreira, M.A.,Filho, E.C. Pimenta,Candido, E.P.,Oliveira, R.L. Asian Australasian Association of Animal Productio 2011 Animal Bioscience Vol.24 No.6
This study examined the effect of restricting feed intake and the subsequent compensatory growth in Guzera females. Eighteen animals with an initial age of 21 months and a mean weight of 268.17 kg were placed in three groups according to the alimentary regime: feed ad libitum; feed restricted to 20% dry matter; and feed restricted to 40% dry matter. In the restricted feed phase, the dry mater intake decreased as the restriction levels increased, influencing the reduction in intake of other nutrients. In the realimentation phase, the 40% restricted feed group ingested more dry matter (% BW) and crude protein ($weight^{0.75}$) than the group fed ad libitum (p<0.001). The serum nutrient concentrations were inversely proportional (p<0.001) to the restriction level, and there was no difference (p>0.001) in the realimentation phase. In the restricted feed phase, the final live weight decreased (p<0.05) as the restriction level increased. For the daily mean weight gain in the control group, there was no difference (p>0.05) compared to the animals with 20% feed restriction, but this was higher than in the group with 40% feed restriction. In the re-alimentation phase, the group with 40% feed restriction achieved higher weight gain rates, which was different from the control and 20% restriction groups. In both phases, the animals in the group with 40% feed restriction presented better feed conversion which was different (p<0.05) from the control group. In the feed restriction phase, it was observed that the intake of N, nitrogen excreted in feces and urine, nitrogen balance and nitrogen retention decreased (p<0.05) with the restriction level. None of the variables were influenced in the re-alimentation phase. These results show that feed restriction by 40% can be adopted as a nutritional management practice.