Propagating and evanescent waves in a functionally graded nanoplate based on nonlocal theory

Cancan Liu,Jiangong Yu,Bo Zhang,Xiaoming Zhang,Xianhui Wang Techno-Press 2023 Advances in nano research Vol.14 No.5

The purpose of this paper is to present the analysis of propagating and evanescent waves in functionally graded (FG) nanoplates with the consideration of nonlocal effect. The analytical integration nonlocal stress expansion Legendre polynomial method is proposed to obtain complete dispersion curves in the complex domain. Unlike the traditional Legendre polynomial method that expanded the displacement, the presented polynomial method avoids employing the relationship between local stress and nonlocal stress to construct boundary conditions. In addition, the analytical expressions of numerical integrations are presented to improve the computational efficiency. The nonlocal effect, inhomogeneity of medium and their interactions on wave propagation are studied. It is found that the nonlocal effect and inhomogeneity of medium reduce the frequency bandwidth of complex evanescent Lamb waves, and make complex evanescent Lamb waves have a higher phase velocity at low attenuation. The occurrence of intersections of propagating Lamb wave in the nonlocal homogeneous plate needs to satisfy a smaller Poisson's ratio condition than that in the classical elastic theory. In addition, the inhomogeneity of medium enhances the nonlocal effect. The conclusions obtained can be applied to the design and dynamic response evaluation of composite nanostructures.

Identification of Medium-Length Antineurofilament Autoantibodies in Patients with Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Shisi Wang,Cancan Xu,Xiaobo Sun,Yifan Zhou,Yaqing Shu,Shangzhou Xia,Zhengqi Lu,Wei Qiu,Xiaofen Zhong,Lisheng Peng 대한신경과학회 2020 Journal of Clinical Neurology Vol.16 No.3

Background and Purpose Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a severe central nervous system disorder mediated by NMDAR antibodies that damages neurons. We investigated the correlation between cytoskeletal autoantibodies and the clinical severity in patients with anti-NMDAR encephalitis. Methods Non-NMDAR autoantibodies were identified by screening matched cerebrospinal fluid (CSF) and the serum samples of 45 consecutive patients with anti-NMDAR encephalitis and 60 healthy individuals against N-methyl-D-aspartate receptor 1-transfected and nontransfected human embryonic kidney 293T cells. Immunocytochemistry was performed to assess antibody binding in rat brain sections and primary cortical neurons. Cell-based assays and Western blotting were applied to identify autoantibodies targeting medium neurofilaments (NFMs). We compared clinical characteristics between patients with NMDAR encephalitis who were positive and negative for anti-NFM-autoantibodies. Results Anti-NFM autoantibodies were detected in both the serum and CSF in one patient (2%) and in the serum only in six patients (13%). No antibodies were detected in the serum of healthy controls (7/45 vs. 0/60, p=0.0016). Four of the seven patients with anti-NFM autoantibodies in serum were children (57%), and three (43%) had abnormalities in brain magnetic resonance imaging. These patients responded well to immunotherapy, and either no significant or only mild disability was observed at the last follow-up. Anti-NMDAR encephalitis did not differ with the presence of anti-NFM autoantibodies. Conclusions Anti-NFM autoantibodies may be present in patients with anti-NMDAR encephalitis, indicating underlying neuronal damage. A large cohort study is warranted to investigate the clinical differences between patients with NMDAR encephalitis according to their anti- NFM antibody status.

Insights into deactivation mechanism of Cu–ZnO catalyst in hydrogenolysis of glycerol to 1,2-propanediol

Yan Dua,Cancan Wangb,Hong Jiang,Changlin Chen,Rizhi Chen 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.35 No.-

The deactivation mechanism of Cu–ZnO catalyst was investigated in detail. During the glycerolhydrogenolysis cycles, the morphology of Cu–ZnO catalyst was firstly changed from sphericalnanoparticles to lamellar structure and then to rod-like structure, and the uniform surface compositionwas deteriorated. The obvious aggregation of Cu and ZnO crystallite sites led to the decrease in specificsurface area and pore volume. Furthermore, the Cu content on the catalyst surface significantlydecreased with the increase of the number of reaction cycle. These findings provide in-depth insights onthe deactivation of Cu–ZnO catalyst and the obvious decrease in glycerol conversion.

Couple-group L2-L∞ Consensus of Nonlinear Multi-agent Systems with Markovian Switching Topologies

Xiao Li,Cancan Zhou,Jianping Zhou,Zhen Wang,Jianwei Xia 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.3

The paper is devoted to the couple-group L2-L∞ consensus problem of nonlinear multi-agent systemsaffected by external disturbances. The interaction topologies among agents obey a continuous-time Markovianprocess with unknown transition probabilities. By a system transformation, the problem of couple-group L2-L∞ consensus is converted into a L2-L∞ control issue. Then, by Lyapunov stability theory and graph theory, sufficientconditions for the couple-group L2-L∞ consensus are obtained. The control gains can be acquired via the solutionsof a group of linear matrix inequalities. Moreover, the present method is extended to the multi-group L2-L∞consensus. Finally, an example is provided to illustrate the effectiveness of the results.

Multi‑DoF wireless power transfer systems based on magnetic dipole coils with multiple receivers

Xiaobo Liu,Cancan Rong,Xiong Tao,Conghui Lu,Yingyin Zeng,Renzhe Liu,Minghai Liu 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.3

To improve the degree of freedom (DoF), and the multi-terminal power supply capability of wireless power transfer (WPT) systems, multi-DoF WPT systems for multiple pickups based on magnetic dipole coils are proposed in this paper, which can simultaneously charge multiple receivers regardless of the position degree. First, the equivalent circuit model of the magnetic dipole coils is provided. The critical factors of the proposed multi-load systems are analyzed, such as transfer efficiency, power distribution, and optimal load. Second, a multi-load wireless power transfer system with equal transmitting (TX) and receiving (RX) coil is designed, and the misalignment tolerance of lateral and rotating occasions for the RX coils is discussed. In particular, a multi-load WPT system with miniaturized step-laminated receivers is implemented based on the magnetic dipole coils. Finally, experimental prototypes are established. The obtained results indicate that the output power for the equal dual-load WPT system can reach more than 78 W with a total efficiency of more than 80% under a transfer distance of length of the receiving coil winding. In addition, the output power of the non-equal four-load WPT system can reach 30 W with a total efficiency of 86%. The proposed systems provide practical guidance for the future development of multi-DoF WPT systems for use in portable devices, unmanned intelligent systems, and smart household applications.

Fuzzy comprehensive performance evaluation method of rolling linear guide based on improved analytic hierarchy process

Yali Ma,Jiayong Wei,Cancan Li,Chen Liang,Guochao Liu 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.7

Aiming at the problem that the multi-objective evaluation of performance and the weighting coefficients of indexes is difficult to find, a fuzzy comprehensive performance evaluation method of rolling linear guide (RLG) is proposed. Considering the static and dynamic indexes, a structure model containing nine weighting coefficients was constructed. The performance evaluation function was established by the compromise programming method and the average power method, while weighting coefficients were determined by the improved analytic hierarchy process (I-AHP); the mathematical model was obtained to evaluate the RLG in a certain application. The evaluation results show that the confidence of the static, dynamic and comprehensive performance of the RLG is 59.21 %, 81.97 %, and 63.34 %, respectively. The feasibility of the method was verified by numerical simulation. This method indicates the pros and cons of the performance of the RLG and also indicates the direction for its optimized design.

A novel immune-related LncRNA prognostic signature for cutaneous melanoma

Hu Nan,Huang Cancan,He Yancheng,Li Shuyang,Yuan Jingyi,Zhong Guishu,Chen Yan 대한독성 유전단백체 학회 2024 Molecular & cellular toxicology Vol.20 No.2

Backgrounds Among tumor microenvironment, the immune components in it have an important influence on gene expression and clinical efficacy. We aim to find out the role of those in skin cutaneous melanoma (SKCM). Objectives Gene expression profile and homologous clinical information of SKCM patients were obtained by TCGA (The Cancer Genome Atlas) and UCSC Toil. SsGSEA method was used to evaluate the immune cell infiltration of 468 TCGA-SKCM samples divided into high immune cell infiltration group (HICI) and low immune cell infiltration group (LICI). We used the Edger packet to conduct difference analysis on normal samples (GTEx) and cancer samples (TCGA), and combined it with the difference of the HICI group and LICI group, to find out the common differential expression of lncRNA in both groups. The prognostic value of immune-related lncRNAs was studied by univariate Cox, Lasso-Cox and multivariate Cox regression analysis, and a prognostic model was established. C index and calibration diagram were used to judge the accuracy of the model, and DCA was used to judge the net benefit. Results Six prognostic markers of immune-related lncRNA genes were established, which could be used as independent prognostic factors. The net benefit and prediction accuracy are significantly higher than TNM Stage. Conclusion The prognostic model identified in this study is a reliable biomarker for SKCM. The Nomogram survival prediction model based on it is a reliable way to predict the median survival time of patients, which may lay the foundation for future treatment of this disease. Backgrounds Among tumor microenvironment, the immune components in it have an important influence on gene expression and clinical efficacy. We aim to find out the role of those in skin cutaneous melanoma (SKCM). Objectives Gene expression profile and homologous clinical information of SKCM patients were obtained by TCGA (The Cancer Genome Atlas) and UCSC Toil. SsGSEA method was used to evaluate the immune cell infiltration of 468 TCGA-SKCM samples divided into high immune cell infiltration group (HICI) and low immune cell infiltration group (LICI). We used the Edger packet to conduct difference analysis on normal samples (GTEx) and cancer samples (TCGA), and combined it with the difference of the HICI group and LICI group, to find out the common differential expression of lncRNA in both groups. The prognostic value of immune-related lncRNAs was studied by univariate Cox, Lasso-Cox and multivariate Cox regression analysis, and a prognostic model was established. C index and calibration diagram were used to judge the accuracy of the model, and DCA was used to judge the net benefit. Results Six prognostic markers of immune-related lncRNA genes were established, which could be used as independent prognostic factors. The net benefit and prediction accuracy are significantly higher than TNM Stage. Conclusion The prognostic model identified in this study is a reliable biomarker for SKCM. The Nomogram survival prediction model based on it is a reliable way to predict the median survival time of patients, which may lay the foundation for future treatment of this disease.

Illuminating the hepatotoxic mechanism of norcantharidin in rats using metabolomics analysis

Cheng Weina,Chen Qihong,Wang Xiaoning,Liu Liu,Li Xiaofei,Duan Cancan,Zhang Jianyong 대한독성 유전단백체 학회 2023 Molecular & cellular toxicology Vol.19 No.3

Norcantharidin (NCTD) has multiple antitumor effects. However, NCTD can induce significant hepatotoxicity and the mechanism of hepatotoxicity is not clear for now.This study aimed to explore the hepatotoxicity of NCTD in rat by ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight (Q-TOF)-MS (UPLC/Q-TOF-MS) metabolomics.Serum biochemical indices including alanine aminotransferase (ALT) and total bilirubin (T-BIL) were significantly increased. Histopathological and ultrastructure results revealed that hepatocytes were damaged. Furthermore, the metabolomics results showed that 11 metabolites in serum and 8 metabolites in liver were differential metabolites for NCTD hepatotoxicity. Four metabolic pathways including the sphingolipid metabolism, purine metabolism, arachidonic acid metabolism, and glycerophospholipid metabolism were the key metabolic pathways related to NCTD hepatotoxicity.The metabolomics analysis in this study reveal new clues on the hepatotoxicity mechanism of NCTD in rats. These findings have potential applications in the toxicity study of NCTD.

Activating SIRT3 in peritoneal mesothelial cells alleviates postsurgical peritoneal adhesion formation by decreasing oxidative stress and inhibiting the NLRP3 inflammasome

Shen Tianli,Wu Yunhua,Wang Xingjie,Wang Zijun,Li Enmeng,Zhou Cancan,Yue Chenyang,Jiang Zhengdong,Wei Guangbing,Lian Jie,Xu Qinhong,Li Xuqi 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Peritoneal adhesions (PAs) are a serious complication of abdominal surgery and negatively affect the quality of life of millions of people worldwide. However, a clear molecular mechanism and a standard therapeutic strategy for PAs have not been established. Here, we developed a standardized method to mimic the pathological changes in PAs and found that sirtuin 3 (SIRT3) expression was severely decreased in adhesion tissues, which was consistent with our bioinformatics analysis and patient adhesion tissue analysis. Thus, we hypothesized that activating SIRT3 could alleviate postsurgical PAs. Sirt3-deficient (Sirt3−/−) mice exhibited many more PAs after standardized abdominal surgery. Furthermore, compared with wild-type (Sirt3+/+) mice, Sirt3-deficient (Sirt3−/−) mice showed more prominent reactive oxygen species (ROS) accumulation, increased levels of inflammatory factors, and exacerbated mitochondrial damage and fragmentation. In addition, we observed NLRP3 inflammasome activation in the adhesion tissues of Sirt3−/− but, not Sirt3+/+ mice. Furthermore, mesothelial cells sorted from Sirt3−/− mice exhibited impaired mitochondrial bioenergetics and redox homeostasis. Honokiol (HKL), a natural compound found in several species of the genus Magnolia, could activate SIRT3 in vitro. Then, we demonstrated that treatment with HKL could reduce oxidative stress and the levels of inflammatory factors and suppress NLRP3 activation in vivo, reducing the occurrence of postsurgical PAs. In vitro treatment with HKL also restored mitochondrial bioenergetics and promoted mesothelial cell viability under oxidative stress conditions. Taken together, our findings show that the rescue of SIRT3 by HKL may be a new therapeutic strategy to alleviate and block postsurgical PA formation.

Identification of a novel cytoplasmic male sterile line M2BS induced by partial-length HcPDIL5-2a transformation in rice (Oryza sativa L.)

Danfeng Tang,Peng Chen,Gang Jin,Min Li,Cancan Wang,Zhenlan Bin,Jinghua Qian,Zizheng Wang,Ruiyang Zhou 한국식물학회 2017 Journal of Plant Biology Vol.60 No.2

A cytoplasmic male sterile line (designated as M2BS) was obtained from an indica rice maintainer M2B induced by partial-length HcPDIL5-2a (Hibiscus cannabinus protein disulfide isomerase-like) transformation. The anther of M2BS was short, slender, hygrophanous, and fissured. I2-KI staining method showed that there was typical and spherical abortion in pollen grains. M2BS was found abortive at middle and late stage of monocyte by the modified carbol fuchsin stained observation and paraffin section observation. The tapetum was observed pre-degenerated in M2BS. Hereditary analysis indicated that the male sterility of M2BS was a maternally inherited inability after six backcross generations with M2B and the combinations of M2BS hybridized with other two male fertile materials. The M2BS could be affirmed a cytoplasmic male sterile (CMS) type. Moreover, it was a transgenic plant confirmed by PCR, Southern blot and RT-PCR detection. M2BS could be distinguished from M2B and its CMS line M2A by RFLP analysis. The overall mitochondrial genome sequencing results showed, that in M2BS, the main differences of mitochondrial gene sequence were located in nad4, nad5, nad7, orf194 and intergenic region, relatively to those of M2A. The obtained results indicate that M2BS is a novel cytoplasmic male sterile line.