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      • Crocetin Induces Cytotoxicity in Colon Cancer Cells Via p53-independent Mechanisms

        Li,,Cai-Yan,Huang,,Wen-Feng,Wang,,Qun-Li,Wang,,Fan,Cai,,E.,Hu,,Bing,Du,,Jia-Cheng,Wang,,Jing,Chen,,Rong,Cai,,Xiao-Jing,Feng,,Jing,Li,,Hui-Hui Asian Pacific Organization for Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8

        Objective: Crocin has been proposed as a promising candidate for cancer chemoprevention. The purpose of this investigation was to investigate the chemopreventive action and the possible mechanisms of crocin against human colon cancer cells in vitro. Methods: Cell proliferation was examined using MTT assay and the cell cycle distribution fractions were analyzed using fow cytometric analysis after propidium iodide staining. Apoptosis was detected using theTUNEL Apoptosis Detection Kit with laser scanning confocal microscope. DNA damage was assessed using the alkaline single-cell gel electrophoresis assay, while expression levels of p53, cdk2, cyclinA and P21 were examined by Western blot analysis. Results: Treatment of SW480 cells with crocetin (0.2, 0.4, 0.8 mmol/L) for 48 h signifcantly inhibited their proliferation in a concentration-dependent manner. Crocetin (0.8 mmol/L) signifcantly induced cell cycle arrest through p53-independent mechanisms accompanied by P21 induction. Crocetin (0.8 mmol/L) caused cytotoxicity in the SW480 cells by enhancing apoptosis and decreasing DNA repair capacity in a time-dependent manner. Conclusions: This report provides evidence that crocetin is a potential anticancer agent, which may be used as a chemotherapeutic drug.

      • SCIESCOPUSKCI등재

        Capacity Analysis of UWB Networks in Three-Dimensional Space

        Cai,,Lin,X.,Cai,,Lin,Shen,,Xuemin,Mark,,Jon,W. The Korean Institute of Communications and Informa 2009 Journal of communications and networks Vol.11 No.3

        Although asymptotic bounds of wireless network capacity have been heavily pursued, the answers to the following questions are still critical for network planning, protocol and architecture design: Given a three-dimensional (3D) network space with the number of active users randomly located in the space and using the wireless communication technology, what are the expected per-flow throughput, network capacity, and network transport capacity? In addition, how can the protocol parameters be tuned to enhance network performance? In this paper, we focus on the ultra wideband (UWB) based wireless personal area networks (WPANs) and provide answers to these questions, considering the salient features of UWB communications, i.e., low transmission/interference power level, accurate ranging capability, etc. Specifically, we demonstrate how to explore the spatial multiplexing gain of UWB networks by allowing appropriate concurrent transmissions. Given 3D space and the number of active users, we derive the expected number of concurrent transmissions, network capacity and transport capacity of the UWB network. The results reveal the main factors affecting network (transport) capacity, and how to determine the best protocol parameters, e.g., exclusive region size, in order to maximize the capacity. Extensive simulation results are given to validate the analytical results.

      • Significance and Application of Digital Breast Tomosynthesis for the BI-RADS Classification of Breast Cancer

        Cai,,Si-Qing,Yan,,Jian-Xiang,Chen,,Qing-Shi,Huang,,Mei-Ling,Cai,,Dong-Lu Asian Pacific Organization for Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

        Background: Full-field digital mammography (FFDM) with dense breasts has a high rate of missed diagnosis, and digital breast tomosynthesis (DBT) could reduce organization overlapping and provide more reliable images for BI-RADS classification. This study aims to explore application of COMBO (FFDM+DBT) for effect and significance of BI-RADS classification of breast cancer. Materials and Methods: In this study, we selected 832 patients who had been treated from May 2013 to November 2013. Classify FFDM and COMBO examination according to BI-RADS separately and compare the differences for glands in the image of the same patient in judgment, mass characteristics display and indirect signs. Employ Paired Wilcoxon rank sum test was used in 79 breast cancer patients to find differences between two examine methods. Results: The results indicated that COMBO pattern is able to observe more details in distribution of glands when estimating content. Paired Wilcoxon rank sum test showed that overall classification level of COMBO is higher significantly compared to FFDM to BI-RADS diagnosis and classification of breast (P<0.05). The area under FFDM ROC curve is 0.805, while that is 0.941 in COMBO pattern. COMBO shows relation of mass with the surrounding tissues, the calcification in the mass, and multiple foci clearly in breast cancer tissues. The optimal sensitivity of cut-off value in COMBO pattern is 82.9%, which is higher than that in FFDM (60%). They share the same specificity which is both 93.2%. Conclusions: Digital Breast Tomosynthesis (DBT) could be used for the BI-RADS classification in breast cancer in clinical.

      • Fluctuation Power Control Strategy for MMC-based SST to Reduce the Submodule Capacitor Voltage Oscillation

        Xiaolong,Cai,Jianwen,Zhang,Gang,Shi,Xu,Cai,Jianqiao,Zhou,Zhuyong,Li,Jiacheng,Wang,Jiajie,Zang 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

        In the future AC-DC hybrid distribution system, solid state transformer (SST) will take place of conventional transformer, as it could reduce the weight and volume of transformer, and achieve voltage and current regulation, power flow control, power quality enhancement. MMC-based SST is a novel SST topology, which could provide the MVDC port. However, the excessive bulky submodule capacitors limits this topology into practical application. This paper proposes a fluctuation power control strategy for MMC-based SST to reduce the submodule capacitor voltage oscillation, which could optimize the capacitance and reduce the volume and cost of capacitor. The feasibility of this proposed method is verified by MATLAB simulation.

      • KCI등재SCOPUS

        In situ Gelatinization of Starch using Hot Stage Microscopy

        Canhui,Cai,Jinwen,Cai,Lingxiao,Zhao,Cunxu,Wei 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.1

        Starch gelatinization is important in food processingand industrial use. Granule swelling and gelatinizationtemperature of 11 starches from different plants wereinvestigated in situ using hot stage microscopy duringheating. The amylose content, swelling power, pastingtemperature and thermal property of these starches werealso measured. The results showed that hot stage microscopywas suitable for measuring granule swelling and thegelatinization temperature of starch during heating. Thesectional area swelling percentage of starch granulesmeasured using hot stage microscopy was significantlypositively correlated with the swelling power. The gelatinizationtemperature measured using hot stage microscopy wassignificantly positively correlated with the pasting temperatureand with the thermal property for all 11 starches. For ricestarches with the same crystallinity and similar size, thegelatinization temperature was negatively correlated withthe amylose content and positively correlated with theswelling power and the sectional area swelling percentageat 95ºC.

      • KCI등재

        MiR‑15a attenuates peripheral nerve injury‑induced neuropathic pain by targeting AKT3 to regulate autophagy

        Longxue Cai,Xianfa,Liu,Qicai,Guo,Qi huang,Qiong,Zhang,Zuohong,Cao 한국유전학회 2020 Genes & Genomics Vol.42 No.1

        Objective Aim of this study was to detect the expression of miR-15a in rats following chronic constriction injury (CCI) and to investigate the regulatory functions of miR-15a during neuropathic pain (NP) development. Methods CCI was performed in adult Sprague–Dawley rats to set up the rat model of neuropathic pain. MiR-15a agomir and scrambled control were delivered into the implanted catheter of rats. The mechanical allodynia and thermal hyperalgesia were assessed in both CCI- and sham-operated groups. Rat lumbar spinal cord tissues were harvested for mRNA and protein analyses. The primary spinal microglia were isolated from adult Sprague–Dawley rats and transfected with miR-15a mimics, scramble miRNA, miR-15a inhibitor or its corresponding negative control. Cell lysates were collected for mRNA and protein analyses. Results Compared to sham-operated group, the expression of miR-15a in CCI rats was significantly reduced, whereas neuroinflammation in spinal cord tissues was increased. Intrathecal administration of miR-15a agomir significantly attenuated CCI-induced NP and the levels of proinflammatory cytokines, including IL-6, IL-1β, and TNF-α. AKT3 was predicted and confirmed as a miR-15a-regulated gene. We further demonstrated that miR-15a overexpression downregulated the level of AKT3 in primary rat microglia and rat CCI model. Moreover, the upregulation of miR-15a induced the expressions of autophagy-associated proteins, suggesting that the regulation mechanism of miR-15a in NP development involves AKT3mediated autophagy via inhibiting the expression of AKT3. Conclusion Our findings indicated that miR-15a might serve as a promising therapeutic target for the management of NP through the stimulation of autophagic process.

      • KCI등재SCOPUS

        Suppression of P2X7/NF-κB pathways by Schisandrin B contributes to attenuation of lipopolysaccharide-induced inflammatory responses in acute lung injury

        Zhiyong,Cai,Jindi,Liu,Hongliang,Bian,Jinlan,Cai,Gendi,Zhu 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.4

        The aim of the present study was to assess theeffects and mechanisms of Schisandrin B (SchB) onlipopolysaccharide (LPS)-induced acute lung injury (ALI). ALI was induced in mice by intratracheal instillation ofLPS (1 mg/kg), and SchB (25, 50, and 75 mg/kg) wasinjected 1 h before LPS challenge by gavage. After 12 h,bronchoalveolar lavage fluid (BALF) samples and lungtissues were collected. Histological studies demonstratedthat SchB attenuated LPS-induced interstitial edema,hemorrhage, and infiltration of neutrophils in the lung tissue. SchB pretreatment at doses of 25, 50, and 75 mg/kgwas shown to reduce LPS-induced lung wet-to-dry weightratio and lung myeloperoxidase activity. In addition, pretreatmentwith SchB lowered the number of inflammatorycells and pro-inflammatory cytokines including tumornecrosis factor-a, interleukin-1b, and interleukin-6 inBALF. The mRNA and protein expression levels of nuclearfactor kappa B (NF-κB) signaling-related molecules activatedby P2X7 were investigated to determine the molecularmechanism of SchB. The findings presented heresuggest that the protective mechanism of SchB may beattributed partly to the decreased production of pro-inflammatorycytokines through the inhibition of P2X7/NF-κBactivation. The aim of the present study was to assess theeffects and mechanisms of Schisandrin B (SchB) onlipopolysaccharide (LPS)-induced acute lung injury (ALI). ALI was induced in mice by intratracheal instillation ofLPS (1 mg/kg), and SchB (25, 50, and 75 mg/kg) wasinjected 1 h before LPS challenge by gavage. After 12 h,bronchoalveolar lavage fluid (BALF) samples and lungtissues were collected. Histological studies demonstratedthat SchB attenuated LPS-induced interstitial edema,hemorrhage, and infiltration of neutrophils in the lung tissue. SchB pretreatment at doses of 25, 50, and 75 mg/kgwas shown to reduce LPS-induced lung wet-to-dry weightratio and lung myeloperoxidase activity. In addition, pretreatmentwith SchB lowered the number of inflammatorycells and pro-inflammatory cytokines including tumornecrosis factor-a, interleukin-1b, and interleukin-6 inBALF. The mRNA and protein expression levels of nuclearfactor kappa B (NF-jB) signaling-related molecules activatedby P2X7 were investigated to determine the molecularmechanism of SchB. The findings presented heresuggest that the protective mechanism of SchB may beattributed partly to the decreased production of pro-inflammatorycytokines through the inhibition of P2X7/NFjBactivation.

      • Current Balancing Control of High Power Parallel-Connected AFE with Small Current Ripples

        Xinbo,Cai,Zhenbin,Zhang,Liang,Cai,Ralph,Kennel 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6

        Parallel connected Active Front End (AFE) voltage converters are widely employed in high-power grid interfaces for renewable energy applications. With parallel connected two level power converters, the power rating of the system can be easily increased with higher stability and less control efforts than multilevel power converter based solutions. However, due to unmatched modules, unbalanced currents inevitably happen to different modules of the same phase, which seriously impacts the efficiency and performances of the converter. This paper presents an improved current balancing control methods for a high power (600 kVA) parallel connected AFE for wind energy applications. The proposed current balancing method is integrated within a well-known Voltage Oriented Control Scheme with few implementation efforts. The simulation results show that with the proposed strategy the current ripples of each parallelconnected converter leg decrease evidently and the THDs are therefore decreased. Moreover, the effectiveness of the proposed method is also confirmed by experimental results with a grid-code compatible testing set-up.

      • KCI등재SCOPUS

        Experimental investigation and stability analysis on dense-phase pneumatic conveying of coal and biomass at high pressure

        Liang,Cai,Cai,Jiaying,Xu,Guiling,Xu,Pan,Chen,Xiaoping,Zhao,Changsui 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.2

        Conveying characteristics and flow stability are very important for design and control of a conveying system at high pressure. The influences of operating parameters and material properties on conveying characteristics were investigated in an experimental test facility with a conveying pressure up to 4MPa. Wavelet transform and Shannon entropy analysis were applied to analyzing pressure drops through horizontal pipe in order to obtain the stability criterion. Results indicated that the mass flow rate of biomass decreased, while the mass flow rate of pulverized coal increased at first and then decreased with the increase in fluidization velocity. Solid loading ratios for four kinds of powders decreased with the increase in fluidization velocity. Conveying phase diagrams and pressure drops through different test sections of pulverized coal and biomass at high pressure were obtained and analyzed. The influences of coal category,fracture characteristics and particle size on conveying characteristics were determined.

      • KCI등재SCOPUS

        Capacity Analysis of UWB Networks in Three-Dimensional Space

        Lin,X.,Cai,Lin,Cai,센슈민,Jon,W.,Mark 한국통신학회 2009 Journal of communications and networks Vol.11 No.3

        Although asymptotic bounds of wireless network capacity have been heavily pursued, the answers to the following questions are still critical for network planning, protocol and architecture design: Given a three-dimensional (3D) network space with the number of active users randomly located in the space and using the wireless communication technology, what are the expected per-flow throughput, network capacity, and network transport capacity? In addition, how can the protocol parameters be tuned to enhance network performance? In this paper, we focus on the ultra wideband (UWB) based wireless personal area networks (WPANs) and provide answers to these questions, considering the salient features of UWB communications, i.e., low transmission/interference power level, accurate ranging capability, etc. Specifically, we demonstrate how to explore the spatial multiplexing gain of UWB networks by allowing appropriate concurrent transmissions. Given 3D space and the number of active users, we derive the expected number of concurrent transmissions, network capacity and transport capacity of the UWB network. The results reveal the main factors affecting network (transport) capacity, and how to determine the best protocol parameters, e.g., exclusive region size, in order to maximize the capacity. Extensive simulation results are given to validate the analytical results.

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