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PAOLO CANONICO,STEFANO CONSIGLIO,ERNESTO DE NITO,GIANLUIGI MANGIA 한국행정학회 2012 International Review of Public Administration Vol.17 No.1
In this paper, we analyze the mechanisms adopted by criminal firms in order to thrive in the business of public works. We submit that resource dependency theory (RDT) can shed light on this area. We find that criminal firms use a variety of techniques to alter the behavior of actors in procurement processes. We claim that the best way to analyze this phenomenon is by integrating the traditional RDT strategies codified in Pfeffer and Salancik (1978) with an understanding of these criminal techniques. We adopt a qualitative research methodology, relying on official judiciary sources in order to develop and validate the concept’s objects of analysis. Our work has been supported by leading Italian magistrates actively engaged in combating the penetration of criminal firms into legal businesses.
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Testosterone levels and cause-specific mortality in the older French men without metabolic syndrome
Nasser Laouali,Sylvie Brailly-Tabard,Catherine Helmer,Marie-Laure Ancelin,Christophe Tzourio,Alexis Elbaz,Anne Guiochon-Mantel,Marianne Canonico 한국역학회 2020 Epidemiology and Health Vol.42 No.-
OBJECTIVES: Previous studies have reported controversial findings regarding the association of testosterone with mortality in older men. This heterogeneity might be partially explained by comorbidities and the presence of metabolic syndrome, as well as differential associations according to causes of death. METHODS: We used data from a random subsample of the Three-City study, in which hormone levels were measured in 338 men ≥65 years without metabolic syndrome who were followed-up for 12 years. Vital status was determined for all participants from different sources. We used inverse-probability-weighted Cox regression to estimate the hazard ratios (HRs) of cause-specific mortality and 95% confidence intervals (CIs). RESULTS: Over the follow-up period, 130 men died (30 from cardiovascular disease, 45 from cancer, 55 from other causes). The association of testosterone with mortality showed significant heterogeneity across causes of death (p=0.027 and p=0.022 for total and bioavailable testosterone, respectively). Higher testosterone levels were associated with increased cardiovascular mortality (HR for 1-standard deviation increase, 1.86; 95% CI, 1.28 to 2.71 and 1.50; 95% CI, 1.04 to 2.17 for total and bioavailable testosterone, respectively). By contrast, there were no significant associations of testosterone with mortality from cancer and other causes. CONCLUSIONS: Our data suggest that the association of testosterone with mortality in men without metabolic syndrome might be differential according to the cause of death. These findings may partially explain the heterogeneity across studies on the relationship between testosterone levels and mortality.
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Salvatore Terrazzino,Letizia Deantonio,Sarah Cargnin,Laura Donis,Carla Pisani,Laura Masini,Giuseppina Gambaro,Pier Luigi Canonico,Armando A. Genazzani,Marco Krengli 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2
Purpose This study was conducted to investigate the role of four polymorphic variants of DNA methyltransferase genes as risk factors for radiation-induced fibrosis in breast cancer patients. We also assessed their ability to improve prediction accuracy when combined with mitochondrial haplogroup H, which we previously found to be independently associated with a lower hazard of radiation-induced fibrosis. Materials and Methods DNMT1 rs2228611, DNMT3A rs1550117, DNMT3A rs7581217, and DNMT3B rs2424908 were genotyped by real-time polymerase chain reaction in 286 Italian breast cancer patients who received radiotherapy after breast conserving surgery. Subcutaneous fibrosis was scored according to the Late Effects of Normal Tissue–Subjective Objective Management Analytical (LENT-SOMA) scale. The discriminative accuracy of genetic models was assessed by the area under the receiver operating characteristic curves (AUC). Results Kaplan-Meier curves showed significant differences among DNMT1 rs2228611 genotypes in the cumulative incidence of grade 2 subcutaneous fibrosis (log-rank test p-value= 0.018). Multivariate Cox regression analysis revealed DNMT1 rs2228611 as an independent protective factor for moderate to severe radiation-induced fibrosis (GG vs. AA; hazard ratio, 0.26; 95% confidence interval [CI], 0.10 to 0.71; p=0.009). Adding DNMT1 rs2228611 to haplogroup H increased the discrimination accuracy (AUC) of the model from 0.595 (95% CI, 0.536 to 0.653) to 0.655 (95% CI, 0.597 to 0.710). Conclusion DNMT1 rs2228611 may represent a determinant of radiation-induced fibrosis in breast cancer patients with promise for clinical usefulness in genetic-based predictive models.
KCI
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