정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Carotid Siphon 질환의 경안와 초음파와 자기공명 혈관조영술의 진단적 가치

배희준,윤병우,노재규 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

사람 성상세포종 세포주에서 사이토카인에 의한 Fas 및 FasL mRNA의 발현 조절

김옥준,임정희,최철희,최인홍,이병인,최일생 대한신경과학회 1999 대한신경과학회지 Vol.17 No.1

중이진주종에서 플라스미노젠 활성인자 발현의 임상적 의의

김형종,김진환,임현준 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.2

대퇴골두 골괴사를 동반한 슬관절 골괴사 : 증례 보고

송준민,이병일,나수균,신영수,최창욱,박종석,권희 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

본 순천향대학교 의과대학 정형외과학 교실에서는 2명의 환자에서 발견된 대퇴골두 골괴사와 함께 발생한 양측 슬관절 골괴사를 경험하였기에 보고하는 바이다. 대퇴골두 골괴사가 있는 환자에서 슬관절 동통을 호소하는 경우 연관통 등으로 여겨 간과하기 쉬우며, 대개 고관절의 통증으로 체중부하 보행이 어려운 경우가 많아 통증이 약하게 나타나기도 하기 때문에 관심을 가지고 슬관절 골괴사를 동반하는지 여부를 판단하여야 할 것이다. Osteonecrosis of the knee associated with osteonecrosis of the femoral head was very rare and reported cases were quite rare. We have experienced two cases of osteonecrosis of both knees associated with osteonecrosis of the femoral head. One is a 44-year-old man who had avascular necrosis of the righ femoral head and osteonecrosis of both knees, femoral condyle and metaphysis of proximal tibia. Another case is a 39-year-old man who had osteonecrosis of both femoral head and osteonecrosis of the both knees, medial condyles of both tibias. They were treated with total hip replacement arthroplasty for avascular necrosis of the femoral head and conservatively for osteonecrosis of the knee. If a person complains of pain in hip and knee simultaneously, we should pay attention and rule out osteonecrosis of the knee.

S-d 相互作用에서의 Spinmoment의 觀測問題

河秉俊 慶熙大學校 材料科學技術硏究所 1991 材料科學技術硏究論集 Vol.4 No.-

The electron state of an foreign ion in an alloy, particularly the Friedel-Anderson theory on the localized moment in the s-d interaction is discussed, and the relation between the fluctuation times of the localized spin moment and observation time scales are analyzed.

내열성 액정 고분자의 합성 및 복합재료

조병욱,전옥철,김윤준,한철,최재곤 조선대학교 생산기술연구소 1999 生産技術硏究 Vol.21 No.2

A new thermotropic liquid crystalline copolyester(TLCP) was synthesized by condensation polymerization of 2,6-naphthalene dicarbonyl chloride with the corresponding diol having a tetramethylene and a hexarnethylene group. The blends of the TLCP with PEN were prepared by the coprecipitation from a common solvent. The TLCP and blends (2, 5, 10 and 20wt% TLCP) were characterized in terms of their thermal, mechanical properties and morphology. The TLCP in the melt state showed nematic mesophase identified by thread-like optical texture. The glass transition temperature (T_(g)) and cold crystallization temperature (T_(c)) of PEN in the blends decreased with increasing the content of TLCP and the TLCP acted as anucleating agent for the matrix polymer. Interfacial adhesion between the TLCP and PEN seemed to be poor. The modulus of TLCP/PEN blends was enhanced as the TLCP content increased.

韓國産 脣形(꿀풀)科 植物에 關한 本草學的 硏究

盧炳圭,金裕鎭,金台睍,宋昊埈,辛民敎 한국전통의학연구소 1999 한국전통의학지 Vol.9 No.1

A Herbalogical Study in the Plants of Labiatae in Korea. For the purpose of developing Korean Herbgalogy with the plants of Labiatae which grow wild and is planted in korea, the these and writings on herbalogy, from literature of successive generations, have been throughly investigative and the results obtained were as follows: 1. There were totaled to 27 genera and 86 species in Korea and among them medical plants are 24 genera, 59 species, some 68% in total but, the number of species may be added because of the similar plants. 2. According to the oriental names which can be used for medical purpose, the medical plants belonging to the Labiatae family were classified as Herba 29, Radix 4, Fructus 3, Folium 2, Lignum 2, Semen 1 and Flos 1. 3. According to sum of 86 species in Labiatae family, they were classified into Scutellaria genera 10, Salvia genera 6, Ajuga genera 5, Clinopodium genera 5, Elsholtzia genera 5 and Mosla 5. Thus it was noticed that Scutellaria genera was the main kind, some 12% in total. 4. According to the number of species of the original plants about each chinese materia medicals, they were classified into HERBA AGASTACHIS 5 and HERBA AJUGAE, HERBA SCUTELLARIAE, HERBA LYCOPI 3 each. 5. According to nature and flavour of medical plants, they were classified into warmth, heat: 20 each, cold, cool: 16 each, balance 4 and unidentified 2. Thus it was noticed that warmth and heat is the main in nature and flavour medicinal plants. 6. According to the Properties and Principal curative action, they were classified into drugs for clearing up heat and toxin 8, drugs for clearing up heat and dispelling pathogenic heat from blood, drugs for clearing up heat and heatstroke 3 each, drugs for activating the blood and removing blood stasis, drugs which is sudorific and pungent in nature and flavour for dispelling wind and cold in the treatment of exterior symptom complex 4 each. Thus it was noticed that drugs for clearing up heat was the main kind. 7. Comparing to whole medical plants 42 kinds, toxic drugs include minor toxin were 3 kinds, 7% of the whole. Thus toxic drugs were rare. From this result, it was revealed that the plants for medical purpose in Labiatae was 68% of the whole, in which HERBA was mostly abundunt and toxic plants was so rare that it will be used for clinical treatment more easily. It is considered that many experiements and clinical approches must be continued to use Labiatae plants widely.

탄성 저항운동의 수직점프에 대한 운동학적 분석

조병준 한국운동역학회 2001 한국운동역학회지 Vol.11 No.3

The purpose of this study was to analyze before and after the elastic resistance training and give the information of various mechanical variable in vertical jump through training. The subject of this research was 14 male in K university. Leg squat and leg flexion and extension was executed the progressive over load method of 8 weeks as Metal spring-Tubex combined training. The intensity of exercise was 60 - 70 % Max S. The frequency of exercise was three times in a week. The time of exercise was about 20 minutes. Cinematographic analysis and ground reaction force were measured by pre and post experiments. After analyzing Cinematographic and ground reaction force, the following findings are obtained: 1. The time of jump was a little shortened through elastic resistance training. 2. The velocity of motion and ability of recoil action and extension power of lower limb were increased. 3. Impulse was a little decreased, but no significant difference. The height of jump was appeared to significant increase. 4. The change of velocity appeared similarly before and after training, but the velocity of decreasing appeared rapidly after training. The velocity of increasing appeared similar pattern, but after training appeared rapidly after knee maximum flexion. 5. The change of acceleration pattern appeared to delay remarkably knee maximum flection.

학교 경제교육의 교수ㆍ학습 모형 및 방법에 관한 반성적 고찰

최병모,박형준,김경모,황상주 한국경제교육학회 2004 경제교육연구 Vol.11 No.1